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Obtaining More Information about Precipitation Biases over East Asia from Hourly-Scale Evaluation of Model Simulation

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Journal of Meteorological Research 2020年第3期34卷 515-528页

作者： nina LI Jian LI Xinyao RONG Haoming CHEN Yufei XIN Jingzhi SU Nanjing University of Information Science&Technology Nanjing 210044 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081

The hourly summer precipitation simulations over East Asia by the Chinese Academy of Meteorological Science Climate System Model(CAMS-CSM)high-resolution Atmospheric Model Intercomparison Project(AMIP)runs(T255,~50 km)were evaluated based on the merged hourly precipitation product released by the China Meteorological Administration(CMA).The results show that the simulation biases are closely related to the topography,with the precipitation amount and frequency overestimated(underestimated),and duration of precipitation events being longer(shorter),over the western high-altitude(eastern plain)regions of *** regions with large discrepancies were further *** terms of the frequency-intensity structure,the overestimation of precipitation frequency is mainly due to the excessive simulated weak precipitation over the four regions with positive biases:the southern edge of the Tibetan Plateau(STP),the northeastern edge of the Tibetan Plateau(NETP),the eastern periphery of the Tibetan Plateau(EPTP),and the mountainous area of North China(NCM);while the underestimation of frequency is mainly due to the insufficient precipitation with moderate intensity over the two regions with negative biases:lower reaches of the Yangtze River(LYR)and the South China coast(SCC).Based on the duration-diurnal structure analysis,two kinds of precipitation events with different natures can be *** long-duration night to early morning precipitation events have a significant contribution to the precipitation amount biases for all the six key regions,and this kind of precipitation mainly affects the precipitation diurnal variation over the mountainous areas or steep *** the short-duration afternoon precipitation events only have a greater contribution to the precipitation amount biases over the SCC region,this kind of precipitation affects the diurnal variation over the NCM region and the two key regions with negative *** a detailed hourly-scale evalua

关键词： precipitation simulation fine-scale evaluation frequency–intensity structure diurnal variation duration

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Co-Seismic Surface Rupture and Recurrence Interval of Large Earthquakes along Damaoyaba-Litang Segment of the Litang fault on the Eastern Margin of the Tibetan Plateau in China

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Journal of Earth Science 2021年第5期32卷 1139-1151页

作者： Shiyuan Wang Rongjun Zhou Mingjian Liang Shao Liu nina Liu Jianyu Long Sichuan Earthquake Agency^Chengdu 610041 China School of Geological Engineering and Geomatics Chang'an UniversityXi'an 710054China

The Litang fault is a left-lateral secondary shear zone in the Sichuan-Yunnan active block that accommodates the tectonic deformation associated with the eastward extrusion of the upper crust of the Tibetan Plateau. Based on 1 : 50 000 geological mapping of active faults, the Litang fault consists of three geometric segments, the Cuopuhu, Damaoyaba, and Litang segments, in the west of Litang, which are divided by the of Haizi Mountain uplift and the wide-angle bending and branching of the fault near Jinchanggou. This study also identifies the surface rupture of the A.D. 1890 earthquake, which is distributed intermittently along the ~28 km long Damaoyaba segments and ~25 km long Litang segments. The maximum horizontal displacement is 4.1 m along Damaoyaba segments, and 4 m along Litang segments. The rupture involves typical left-lateral shear movement. The two ruptures are divided by discontinuous segments or gaps that are ~18 km long;thus, the total surface rupture is approximately 71 km long. The estimated moment magnitude was M_(w)7.3±0.1. A comprehensive analysis of data obtained from 5 trenches excavated along the Damaoyaba and Litang segments and the trench data by Xu et al.(2005) identifies age constraints of the 4 most recent paleoseimic events occurred B.C. 1468±54–1340±25, B.C. 52±25–A.D. 76±47, A.D. 1115±90, and A.D. 1890, respectively. The recurrence intervals are 1 415±80, 1 104±104, and 775±90 a, which are consistent with quasi-periodic earthquake recurrence behavior. The average recurrence interval is 1 098±112 a.

关键词： Litang fault surface rupture active fault recurrence intervals paleoearthquake eastern Tibetan Plateau

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Validity of long-term and short-term recall of occupational sitting time in finnish and Chinese office workers

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Journal of Sport and Health Science 2020年第4期9卷 345-351页

作者： Ying Gao Neil J.Cronin nina Nevala Taija finni Neuromuscular Research Center Faculty of Sport and Health SciencesUniversity of Jyv€askyl€aJyv€askyl€a FI-40014Finland finnish Institute of Occupational Health Helsinki FI-00250Finland

Background:As sedentary behavior is a global health issue,there is a need for methods of self-reported sitting *** accuracy and reliability of these methods should also be tested in various populations and different cultural *** study examined the validity of longterm and short-term recall of occupational sitting time in finnish and Chinese ***:Two cohort groups of office-based workers(58.6%female,age range 2267 years)participated:a finnish group(fIN,n=34)and a Chinese group(CHI,n=36).Long-term(past 3-month sitting)and short-term(daily sitting assessed on 5 consecutive days)single-item measures were used to assess self-reported occupational sitting *** from each participant were compared to objectively measured occupational sitting time assessed via thigh-mounted accelerometers,with Spearman’s rho(r)used to assess validity and the Bland-Altman method used to evaluate *** of variation depicted day-to-day variability of time spent on sitting at ***:In the total study sample,the results showed that both long-term and short-term recall correlated with accelerometer-derived sitting time(r=0.532,95%confidence intervals(CI):0.3360.684,pf-reported occupational sitting time was 2.4%(95%CI:0.5%to 5.3%,p=0.091)and 2.2%(95%CI:0.7%3.6%,p=0.005)greater for long-term and short-term recall,*** agreement level was within the range21.2%to 25.9%for long-term recall,and24.2%to 28.5%for short-term *** a 5-day work week,day-to-day variation of sitting time was 9.4%§11.4%according to short-term recall and 10.4%§8.4%according to accelerometry-derived occupational sitting ***:Overall,both long-term and short-term self-reported instruments provide acceptable measures of occupational sitting time in an office-based workplace,but their utility at the individual level is limited due

关键词： Accelerometry Daily recall Office workers Questionnaire Self-report Sitting time Validity

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艾司奥美拉唑、阿莫西林二联方案与含铋剂四联方案治疗幽门螺杆菌感染初治患者的效果比较

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中国实用医刊 2024年第4期51卷 99-102页

作者：梁素花范学科张妮娜晋城市人民医院消化内科晋城048000

目的比较艾司奥美拉唑+阿莫西林大剂量二联方案与含铋剂常规四联方案治疗幽门螺杆菌(HP)感染初治患者的效果及安全性。方法随机对照研究。抽取2021年1月至2022年12月于晋城市人民医院消化内科就诊的HP感染初治患者200例,按照随机数字表... 详细信息

目的比较艾司奥美拉唑+阿莫西林大剂量二联方案与含铋剂常规四联方案治疗幽门螺杆菌(HP)感染初治患者的效果及安全性。方法随机对照研究。抽取2021年1月至2022年12月于晋城市人民医院消化内科就诊的HP感染初治患者200例,按照随机数字表法分为二联组和四联组,每组100例,后二联组剔除11例、四联组剔除6例。二联组予以大剂量艾司奥美拉唑+阿莫西林治疗,四联组予以常规艾司奥美拉唑+阿莫西林+胶体果胶铋+呋喃唑酮治疗。比较两组患者的HP根治率、治疗依从性、不良反应发生率及治疗费用等指标。结果二联组HP根除率为84.27%(75/89),稍低于四联组的87.23%(82/94),但差异未见统计学意义(P=0.566)。二联组治疗依从性良好率(88.76%,79/89)高于四联组(76.60%,72/94),差异有统计学意义(P=0.030)。二联组患者药物相关不良反应总发生率(17.98%,16/89)与四联组(23.40%,22/94)比较,差异未见统计学意义(P=0.366)。二联组患者的治疗费用[(883.56±95.47)元]高于四联组[(779.38±81.25)元],差异有统计学意义(P<0.001)。结论艾司奥美拉唑、阿莫西林大剂量二联方案治疗HP感染初治患者的HP根治率、不良反应与常规四联方案一致,但治疗依从性更高。

关键词：幽门螺杆菌艾司奥美拉唑阿莫西林铋剂呋喃唑酮

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工科专业实践类课程质量标准体系研究

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高等建筑教育 2024年第3期33卷 74-80页

作者：郑妮娜谢强王志军卢黎重庆大学土木工程学院重庆400045

工科专业实践类课程的质量对达成本科人才培养目标非常重要。工程教育专业认证标准对实践类课程的设置及质量提出了要求,但目前实践类课程的质量标准体系存在缺失、内容不完备或标准不统一等问题。基于工程认证对实践类课程的相关要求,... 详细信息

工科专业实践类课程的质量对达成本科人才培养目标非常重要。工程教育专业认证标准对实践类课程的设置及质量提出了要求,但目前实践类课程的质量标准体系存在缺失、内容不完备或标准不统一等问题。基于工程认证对实践类课程的相关要求,结合面向产出的教育理念,分析得到影响实验类、实习类、设计类(含课程设计和毕业设计)课程质量的共性因素有教学基本条件、教学实施过程及教学效果三项,并将其作为质量标准的一级指标。在一级指标中又列出具体观测点作为二级指标,二级指标在总体一致的基础上以个别指标考虑个性因素。最后分析了基于质量标准,按照不同评价目的制定质量评价表的方法。建立的质量标准体系内容全面、指标统一,便于进行横向比较,可促进实践类课程质量的监控和持续改进。

关键词：工程认证实践类课程质量标准质量评价表

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Dynamics of annual growth of Pinus sylvestris on industrial wastes of mining companies

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Journal of forestry Research 2021年第4期32卷 1385-1393页

作者： Svetlana Bakhtina Yulai Yanbaev Aleksey Kulagin nina Redkina Ilgam Masalimov Shamil fayzrakhmanov Scientific and Educational Center Federal State Budgetary Educational Institution of Higher EducationBashkir State Agrarian University50-Letia Octyabrya Str.34UfaRussia 450001 Department of forestry and Landscape Design Federal State Budgetary Educational Establishment of Higher EducationBashkir State Agrarian University50-Letia Octyabrya Str.34UfaRussia 450001 Laboratory of forestry Ufa Institute of BiologyUfa Research Center of Russian Academy of SciencesProspect Octyabrya69UfaRussia 450054 Department of Ecology and Life Safety Federal State Budgetary Educational Institution of Higher EducationBashkir State UniversityZaki Validi Str.32UfaRussia 450076 Department of Mechanics and Engineering Graphics Federal State Budgetary Educational Establishment of Higher EducationBashkir State Agrarian University50-Letia Octyabrya Str.34UfaRussia 450001 Department of Mechanics and Machine Design Federal State Budgetary Educational Establishment of Higher EducationBashkir State Agrarian University50-Letia Octyabrya Str.34UfaRussia 450001

The development of the mining industry has led to the appearance in many parts of the world of vast technogenic territories from which toxic heavy metals enter the environment and food ***,chemical,and biological methods of cleaning industrial land due to technological complexity and hi gh cost are relatively little used on a large *** forest overgrowth of mining sites and the removal of heavy metals by woody plants can be an effective form of ***,the study of this process is of significant scientific and practical *** analysis of the annual growth in height and width of the annual rings of the stem of Scots pine(Pinus sylvestris L.) in 2004-2019 was made on the territory of the Uchalinsky mining and processing plant(South Ural,Russia) contaminated with heavy *** hi gh concentrations of copper and zinc were found in soils,roots,bark,young shoots,comparable to exceeding the maximum allowable *** the spatial uniformity of the heavy metal content in the stands,the tree samples significantly differed in terms of annual *** suggest that the lack of nutrients and not stress from exposure to heavy metals is the main reason for relatively low growth rates on slopes of industrial *** was confirmed by studying the annual growth in height of the undergrowth in habitats with different soil cover *** data prove the relatively high potential of Scots pine for the natural recovery of industrial lands polluted with heavy metals by mining enterprises.

关键词： Annual growth Pinus sylvestris Heavy metals Phytoremediation

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Inducible protein-10 as a predictive marker of antiviral hepatitis C treatment:A systematic review

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World Journal of Hepatology 2017年第14期9卷 677-688页

作者： Bastian Neesgaard Morten Ruhwald nina Weis Department of Infectious Diseases Copenhagen University Hospital Hvidovre Department of Infectious Disease Immu-nology Section of Human ImmunologyStatens Serum Institute Department of Clinical Medicine Faculty of Health and Medical SciencesUniversity of Copenhagen

To investigate interferon-γ-inducible protein-10’s (IP-10) potential to anticipate rapid (RVR)- and sustained virological responses (SVR) to chronic hepatitis C (CHC) treatment. METHODSWe included case series examining RVR or SVR in relation to 24 or 48 wk treatment for CHC, in patients treatment free for at least six months, with genotype 1 or 4, and in relation to 24 wk treatment for genotype 2 and 3, with pegylated interferon in combination with ribavirin. Patients had to have both a baseline IP-10 level as well as a hepatitis C virus (HCV)-RNA determination 4 wk after treatment initiation or 24 wk after end of treatment. Studies including patients with liver diseases other than CHC, human immunodeficiency virus-infection, treatment with immunosuppresents or cytostatica, alcohol dependency or active intravenous drug-use were excluded. We found 81 articles by searching the MEDLINE and EMBASE databases. Eight studies were eligible for inclusion. Their quality were assesed using an 18 point checklist for case series, developed using a modified Delphi technique. Information was extracted from the articles, and no raw data was requisitioned. The review protocol was registered at the International Prospective Register of Systematic Reviews (reg. number: CRD42014008736). RESULTSThree studies reported on baseline IP-10 level in association with RVR. A signigficant association was found for HCV genotype 1 infection by two studies. Only two studies reported on HCV genotype 4 infected and genotype 2 and 3 infected patients, respectively. A trend was seen for an association between RVR and baseline IP-10 for genotype 4, while no association was found for genotype 2 and 3. Seven studies provided information regarding baseline IP-10 and SVR. following the pattern regarding rapid virological response all five studies examining SVR in relation to baseline IP-10 levels for HCV, genotype 1 infected patients showed a significant association. Likewise a significant association was s

关键词： Chronic hepatitis C Inducible protein-10’s Sustained virological response Interferon-γ-inducible protein-10 CXCL-10 Chemokine Genotype Pegylated interferon Ribavirin Rapid virological response

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Market-Making Practices of Private Tutoring in finland:Commercialization of Exam Preparation for Admission to Higher Education

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ECNU Review of Education 2021年第3期4卷 590-614页

作者： Suvi Jokila nina Haltia Sonja Kosunen University of Turku University of Helsinki

Purpose:This study focuses on courses that prepare applicants for universities’highly competitive entrance examinations in *** analysis clarifies the market-making practices and the construction of this ***/Approach/Methods:To understand these processes,we useÇalişkan and Callon’s five framings for studying marketization as a heuristic *** our analysis,we combine different data sets,including data on course provision,thematic interviews,documents,and ethnographic ***:In this article,we argue that the preparatory course markets in finland are an example of private tutoring which operates in the privacy of the university applicants’exam preparation process,thus commercializing this *** market making of this type of private tutoring is an assemblage of a variety of agents that interact in parallel with each ***/Value:This study aims to contribute to the systemic understanding of the assemblage of private tutoring markets in an equality-focused Nordic country by providing new heuristic lenses from economic sociology through which to view private tutoring.

关键词： Commercialization entrance examination finland market-making practice private tutoring

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Rational design, synthesis, and biological evaluation of novel C6-modified geldanamycin derivatives as potent Hsp90 inhibitors and anti-tumor agents

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Chinese Chemical Letters 2023年第2期34卷 434-439页

作者： Ruxuan Wang Rentao Zhang Haoran Yang nina Xue Xiaoguang Chen Xiaoming Yu State Key Laboratory of Bioactive Substance and function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Heat shock protein 90(Hsp90) is an appealing anticancer drug target that provoked a tremendous wave of investigations. Geldanamycin(GA) is the first identified Hsp90 inhibitor that exhibited potent anticancer activity, but the off-target toxicity associated with the benzoquinone moiety hampered its clinical application. Until now, structure optimization of GA is still in need to fully exploit the therapeutic value of Hsp90. Due to the structural complexity and synthetic challenge of this compound family, conventional optimization is bound to be costly but high efficiency is expected to be reachable by combining the art of rational design and total synthesis. Described in this paper is our first attempt at this approach aiming at rational modification of the C6-position of GA. The binding affinities towards Hsp90 of compound 1(C6-ethyl) and 2(C6-methyl) were designed and predicted by using Discovery Studio. These compounds were synthesized and further subjected to a thorough in vitro biological evaluation. We found that compounds1 and 2 bind to Hsp90 protein with the IC_(50) of 34.26 nmol/L and 163.7 nmol/L, respectively. Both compounds showed broad-spectrum antitumor effects. Replacing by ethyl, compound 1 exhibited more potent bioactivity than positive control GA, such as in G2/M cell cycle arrest, cell apoptosis and client proteins degradations. The results firstly indicated that the docking study is able to provide a precise prediction of Hsp90 affinities of GA analogues, and the C6 substituent of GA is not erasable without affecting its biological activity.

关键词： Hsp90 inhibitors Geldanamycin derivatives Total synthesis Structure-activity relationship Anticancer

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Catchment soils as a factor of trace metal accumulation in sediments of the reservoir Klingenberg(eastern Ore Mountains, Germany)

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Journal of Environmental Sciences 2019年第12期31卷 1-14页

作者： Jens Hahn Christian Opp Raphael Ganzenmuller Anntke Ewert Birgit Schneider nina Zitzer Gabriela Laufenberg Philipps-University of Marburg Working Group for Hydro-and Soil GeographyDeutschhausstr.1035037 MarburgGermany University of Leipzig Institute of GeographyPhysical GeographyJohannisallee 19a04103 LeipzigGermany Philipps-Uniuersity o/Marbitrg Mass SpectrometryMarbacher Weg 6-1035037 MarburgGermany

The release and accumulation dynamics of trace metals in soils and aquatic sediments were exemplarily investigated in the catchment area of the Reservoir Klingenberg(Germany).Catchment soils were examined for mobilizable and total concentrations of arsenic(As),cadmium(Cd),chrome(Cr),iron(fe),manganese(Mn),nickel(Ni),lead(Pb),and zinc(Zn)and compared with trace metal quantities accumulated in riverbed and reservoir *** comparison of all samples showed relatively small variations of Cr(7.96–46.0 mg/kg),fe(7.79–40.4 g/kg),and Ni(6.06–56.5 mg/kg),while stronger differences were found for As(11.2–164 mg/kg),Cd(0.14–30.5 mg/kg),Mn(0.08–1.84 g/kg),Pb(20.7–183 mg/kg),and Zn(69.1–916 mg/kg).The catchment soils were slightly enriched by Cd,Pb,and *** Cd and Zn were characterized by large mobilizable *** mean trace metal concentrations in riverbed sediments were higher than in catchment soils,while reservoir sediments accumulated the highest amounts of the analyzed *** enrichment of trace metals in reservoir sediments was generally determined by the sedimentation of fine particles,while the distribution of As,fe,and Mn was additionally impacted by redox *** Cd and Zn,which in comparison were most enriched in riverbed and reservoir sediments,a significant release from soils by leaching processes was *** accumulation of As and Pb in reservoir sediments was influenced to a greater extent by soil erosion and by anthropogenic or chalcogen sources in the catchment.

关键词： Trace metals Exchangeable forms Soil Sediment Catchment Sources

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