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Multiplex Rapid Test with Acceptable Diagnosis Performance as a Solution to Increase Diagnosis of Hepatitis B and C Viruses in Pregnant Women in an Area of High Prevalence of Both Hepatitis Viruses Associated with HIV

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Open Journal of Medical Microbiology 2024年第1期14卷 50-65页

作者： Catherine Boni-Cisse nina Esther Onstira Ngoyi Hermione Dahlia Mossoro-Kpinde Noella Packo Rabi Senekian Hermann Ndoidet Koutou Coretha Bokia-Baguida Christelle Luce Bobossi-Gadia Arthur Simplice Sombot-Ndicky Daniel Yvon Gonessa freddy Samuel Ngbonga Konzapa Voulou Christian Diamant Mossoro-Kpinde Alassane OUATTARA National Center of Medical Oncology and Radiotherapy Abidjan Ivory Cost Department of Microbiology UFR of Medical Sciences University of Cocody Abidjan Ivory Cost Laboratory of Bacteriology-Virology of Teaching Hospital Center of Brazzaville Brazzaville Republic of Congo faculty of Health Sciences Marien NGOUABI University Brazzaville Republic of Congo Department of Labor Medicine Service of HIV and STDs Control in the Workplace Bangui Central African Republic (CAR) faculty of Health Sciences University of Bangui Bangui Central African Republic National Reference Center of Sexually Transmitted Diseases and Antiretroviral Therapy Bangui Central African Republic National Laboratory of Clinical Biology and Public Health Bangui Central African Republic Medicine Department District Hospital of Alindao Alindao Ouaka Prefecture Central African Republic Doctoral School of Sciences and Technology University of Bangui Bangui Central African Republic Coordination of Specialized Study of Clinical Biology University of Bangui Bangui Central African Republic Doctors without Borders Hospital Sica BanguiCRA Laboratory of Medical Analysis of Teaching Hospital Center Mother Elisabeth DOMITIEN of Bimbo Bimbo Central African Republic

Background and Objective: HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) are very widespread in the world, however, less than 20% of the people affected are diagnosed and treated. This study aimed to determine the prevalence of HIV, HCV and HBV co-infections in pregnant women at Bangui Community University Hospital and the cost of screening. Methods: A cross-sectional study involving consenting pregnant women who came for antenatal care was performed. HIV, HCV antibodies and HBV antigens were detected using Exacto Triplex? HIV/HCV/HBsAg rapid test, cross-validated by ELISA tests. Sociodemographic and professional data, the modes of transmission and prevention of HIV and both hepatitis viruses were collected in a standard sheet and analyzed using the Epi-Info software version 7. Results: Pregnant women aged 15 to 24 were the most affected (45.3%);high school girls (46.0%), and pregnant women living in cohabitation (65.3%) were the most represented. Twenty-five (16.7%) worked in the formal sector, 12.7% were unemployed housewives and the remainder in the informal sector. The prevalence of HIV, HBV, and HCV viruses was 11.8%, 21.9% and 22.2%, respectively. The prevalence of co-infections was 8.6% for HIV-HBV, 10.2% for HIV-HCV, 14.7% for HBV-HCV and 6.5% for HIV-HBV-HCV. All positive results and 10% of negative results by the rapid test were confirmed by ELISA tests. The serology of the three viruses costs 39,000 fCfA (60 Euros) by ELISA compared to 10,000 fCfA (15.00 Euros) with Exacto Triplex? HIV/HCV/AgHBs (BioSynex, Strasbourg, france). Conclusion: The low level of education and awareness of hepatitis are barriers to development and indicate the importance of improving the literacy rate of women in the Central African Republic (CAR). Likewise, the high prevalence of the three viruses shows the need for the urgent establishment of a national program to combat viral hepatitis in the CAR.

关键词： HIV-HCV-HBV Co-Infection Multiplex Immunochromatographic Rapid Test Central Africa Serology Test Cost Diagnostic Accessibility

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Aeration performances and air—Water mass transfer on steep stepped weirs with horizontal and inclined steps

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Journal of Hydrodynamics 2022年第5期34卷 904-916页

作者： Yvan Arosquipa nina Rui Shi Davide Wüthrich Hubert Chanson The University of Queensland School of Civil EngineeringBrisbaneAustralia Department of Hydraulic Engineering Delft University of TechnologyDelftThe Netherlands

At hydraulic structures,some strong interactions may develop between fast flowing waters and the air adjacent to the water in motion that enhance the air-water transfer of atmospheric and volatile gases in the *** turn,in-stream structures may contribute to the aeration and re-oxygenation during *** present study aims to characterize the aeration performance of a steep stepped weir,based upon a detailed physical investigation of air-water interfacial properties across a relatively wide range of *** data showed a strong fragmentation of the air-water flows,a very broad range of entrained bubbles and drops,and a large amount of particle *** results implied a monotonic increase in re-aeration with increasing rate of energy dissipation,while the largest aeration efficiency was observed on the horizontal step weir chute,with the smallest on the 1V:2.33H inclined downward ***,the study showed that a steep stepped chute can make a sizeable contribution to the re-oxygenation of the waters,although the downward inclined steps reduce the re-aeration performances.

关键词： Stepped weirs aeration re-oxygenation physical modeling flow fragmentation

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硅改性酚醛树脂物理性能的分子动力学模拟

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计算物理 2024年第3期41卷 345-356页

作者：许铋立景昭刘骁代波姬广富张魁宝葛妮娜西南科技大学环境友好能源材料国家重点实验室四川绵阳621010 北京航天长征飞行器研究所北京100076 中国空气动力研究与发展中心四川绵阳621000 中国工程物理研究院流体物理研究所四川绵阳621900

采用分子动力学模拟方法研究纳米SiO2以及甲基苯基二甲氧基硅烷改性酚醛树脂的物理性能。研究表明:300 K下未改性酚醛树脂玻璃转化温度为362 K,弹性模量、剪切模量分别为5.45 GPa和2.19 GPa,热导率和热膨胀系数分别为0.37 W·(m·k)-1和... 详细信息

采用分子动力学模拟方法研究纳米SiO2以及甲基苯基二甲氧基硅烷改性酚醛树脂的物理性能。研究表明:300 K下未改性酚醛树脂玻璃转化温度为362 K,弹性模量、剪切模量分别为5.45 GPa和2.19 GPa,热导率和热膨胀系数分别为0.37 W·(m·k)-1和3.8×10-5 K-1,添加纳米SiO2后玻璃转化温度提高了1.6%,弹性模量、剪切模量分别提高了34.9%和28.8%,热导率和热膨胀率分别降低了11%和31.6%。SiO2表面接枝3%、5%、7%和10%硅烷偶联剂以及甲基苯基二甲氧基硅烷改性酚醛树脂玻璃转化温度分别提高了10.5%、15.2%、16.8%、19.3%和1.5%,弹性模量分别提高了44.4%、53.2%、53.8%、63.5%和13.4%,而热导率分别降低了12.4%、13.5%、11.2%、7%和10%。此外甲基苯基二甲氧基硅烷改性的酚醛树脂的热膨胀系数较未改性酚醛树脂提高15.7%。研究表明:掺杂纳米SiO2、SiO2表面接枝硅烷偶联剂以及甲基苯基二甲氧基硅烷改性都能够提高酚醛树脂的玻璃转化温度,机械性能同时降低热导率,而对于热膨胀系数,纳米SiO2掺杂使其减小,甲基苯基二甲氧基硅烷改性则会使其明显增大。

关键词：硅改性酚醛树脂玻璃转化温度热导率力学性能分子动力学模拟

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Juvenile hominoid cranium from the terminal Miocene of Yunnan,China

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Chinese Science Bulletin 2013年第31期58卷 3771-3779页

作者： JI XuePing JABLONSKI nina G SU Denise f DENG ChengLong fLYNN Lawrence J YOU YouShan KELLEY Jay Department of Paleoanthropology Yunnan Institute of Cultural Relics and Archaeology Yunnan Key Laboratory for Paleobiology Yunnan University Department of Anthropology The Pennsylvania State University University ParkPA 16802 USA Department of Paleobotany and Paleoecology Cleveland Museum of Natural HistoryCleveland OH 44106 USA State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Peabody Museum of Archaeology and Ethnology Harvard UniversityCambridge MA 02138 USA Zhaotong Institute of Cultural Relics Institute of Human Origins and School of Human Evolution and Social Change Arizona State UniversityTempe AZ 85287 USA

fossil apes are known from several late Miocene localities in Yunnan Province,southwestern China,principally from Shihuiba(Lufeng)and the Yuanmou Basin,and represent three species of *** mostly comprise large samples of isolated teeth,but there are also several partial or complete adult crania from Shihuiba and a single juvenile cranium from *** we describe a new,relatively complete and largely undistorted juvenile cranium from the terminal Miocene locality of Shuitangba,also in *** is only the second ape juvenile cranium recovered from the Miocene of Eurasia and it is provisionally assigned to the species present at Shihuiba,Lufengpithecus *** has most often been linked to the extant orangutan,Pongo pygmaeus,but recent studies of the crania from Shihuiba and Yuanmou have demonstrated that this is *** new cranium reinforces the view that Lufengpithecus represents a distinct,late surviving lineage of large apes in the late Miocene of East Asia that does not appear to be closely affiliated with any extant ape *** substantially increases knowledge of cranial morphology in Lufengpithecus and demonstrates that species of this genus represent a morphologically diverse radiation of apes,which is consistent with the dynamic tectonic and biotic milieu of southwestern China in the late Miocene.

关键词：晚中新世禄丰古猿中国云南头盖骨少年终端中国西南地区元谋盆地

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Does intra-ruminal nitrogen recycling waste valuable resources? A review of major players and their manipulation

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Journal of Animal Science and Biotechnology 2018年第3期9卷 497-517页

作者： Thomas Hartinger nina Gresner Karl-Heinz Südekum Institute of Animal Science University of Bonn

Nitrogenous emissions from ruminant livestock production are of increasing public concern and, together with methane, contribute to environmental pollution. The main cause of nitrogen-(N)-containing emissions is the inadequate provision of N to ruminants, leading to an excess of ammonia in the rumen, which is subsequently excreted. Depending on the size and molecular structure, various bacterial, protozoal and fungal species are involved in the ruminal breakdown of nitrogenous compounds(NC). Decelerating ruminal NC degradation by controlling the abundance and activity of proteolytic and deaminating microorganisms, but without reducing cellulolytic processes, is a promising strategy to decrease N emissions along with increasing N utilization by ruminants. Different dietary options, including among others the treatment of feedstuffs with heat or the application of diverse feed additives, as well as vaccination against rumen microorganisms or their enzymes have been evaluated. Thereby, reduced productions of microbial metabolites, e.g. ammonia, and increased microbial N flows give evidence for an improved N retention. However, linkage between these findings and alterations in the rumen microbiota composition, particularly NC-degrading microbes, remains sparse and contradictory findings confound the exact evaluation of these manipulating strategies, thus emphasizing the need for comprehensive research. The demand for increased sustainability in ruminant livestock production requests to apply attention to microbial N utilization efficiency and this will require a better understanding of underlying metabolic processes as well as composition and interactions of ruminal NC-degrading microorganisms.

关键词： Ammonia Bacteria Deamination Hyper-ammonia producing Nitrogen efficiency Protein Proteolysis Protozoa Ruminant

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Bistable Stochastic Resonance Enhanced 4-ary PAM Signal Detection under Low SNR

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China Communications 2019年第4期16卷 196-207页

作者： Linlin Liang nina Zhang Haiyan Huang Zan Li School of Telecommunications Engineering Xidian University Xianyang Detachment of Chinese Armed Police force School of Electronic and Information Engineering Lanzhou Jiaotong University The Collaborative Innovation Center of Information Sensing and Understanding at Xidian University

To boost the performance of 4-ary pulse amplitude modulated(PAM) at low signal-to-noise ratio(SNR), bistable stochastic resonance(BSR) system is introduced into digital communications system and get a reliable signal detection scheme. In this paper, we first analyse BSR system for different amplitudes of 4-ary PAM signals. The steadystate of the bistable system will be statistically distinct, and the feasibility of the proposed detection scheme is confirmed. On this basis, we present a detailed study on steady-state transitions of the BSR system, and an explicit expression of the bistable system parameters is derived. By setting the bistable system parameters, bistable system, 4-ary PAM signal, and noise reach the resonance state, and the BSR-based detection scheme is implemented. Moreover, we derive an analytical expression to calculate the symbol error rate(SER) of 4-ary PAM signals with the BSR-based detection under additive white Gaussian noise(AWGN). finally, the simulation results validate that BSR-based detection scheme can improve the detection performance while efficiently reducing the symbol error rate.

关键词： 4-ary pulse amplitude modulated signal detection Low SNR Symbol error rate(SER) Bistable stochastic resonance(BSR)

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Multi-objective energy management system for DC microgrids based on maximum membership degree principle

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Journal of Modern Power Systems and Clean Energy 2018年第4期6卷 668-678页

作者： Panbao WANG Wei WANG nina MENG Dianguo XU School of Electrical Engineering and Automation Harbin Institute of Technology

With the increasing quantity of DC electrical equipment, DC microgrids have been paid more and more attention. This paper proposes an approach to multi-objective optimisation of an energy management system(EMS) for a DC microgrid that includes a hybrid energy storage system(HESS). The operating and maintenance cost and the loss of power supply probability(LPSP) of the system are used as optimisation targets. The power flows of all distributed generators(DGs) in the DC microgrid during operating period are optimized. Based on the improved differential evolution(DE) algorithm, and by using the multi-objective non-dominated sorting method and the maximum membership degree principle(MMDP) of fuzzy control, the overall satisfaction degree of Pareto solutions to power flow optimization can be obtained. Simulation results verify the effectiveness of the proposed EMS optimization scheme, which is able to achieve an effective trade-off between the economy and the reliability of microgrid operation.

关键词： DC microgrids Energy management system Multi-objective optimization Differential evolution algorithm Maximum membership degree

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Influence of atmospheric circulation on precipitation in Altai Mountains

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Journal of Mountain Science 2017年第1期14卷 46-59页

作者： MALYGINA Natalia PAPINA Tatiana KONONOVA nina BARLYAEVA Tatiana Institute for Water and Environmental Problems Siberian Branch of the Russian Academy of SciencesBarnaul 656038Russia Institute of Geography Russian Academy of SciencesMoscow 117312Russia Laboratoire d'Astrophysique de Marseille UMR 7326 CNRS-INSUMarseille13388France

We analyzed the changes in precipitation regime in the Altai Mountains for 1959-2014 and estimate the influence of atmospheric circulations on these changes. Our study showed that during last 56 years the changes in the precipitation regime had a positive trend for the warm seasons(April-October),but weakly positive or negative trends for the cold seasons(November-March). It was found that these changes correspond to the decreasing contribution of "Northern meridional and Stationary anticyclone(Nm-Sa)" and "Northern meridional and East zonal(Nm-Ez)" circulation groups and to the increasing contribution of "West zonal and Southern meridional(Wz-Sm)" circulation groups,accordingly to the Dzerdzeevskii classification. In addition,it was found that the variation of precipitation has a step change point in 1980. for the warm seasons,the precipitation change at this point is associated with the reduced influence of "West zonal(Wz)","Northern meridional and Stationary anticyclone(Nm-Sa)" and "Northern meridional and Southern meridional(Nm-Sm)" circulation groups. for the cold seasons,a substantialincrease of "Wz-Sm" and a decrease of "Nm-Sa","Nm-Ez" circulation groups are responsible for the precipitation change in the two time periods(1959-1980 and 1981-2014).

关键词： Altai Mountains Precipitation Atmospheric circulation

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Thyrotoxicity of the Chlorides of Cadmium and Mercury in Rabbit

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Biomedical and Environmental Sciences 1992年第3期5卷 236-240页

作者： nina GHOSH SHELLEY BHATTACARYA Environmental Toxicology Laboratory Department of Zoology Visva-Bharati UniversityEnvironmental Toxicology Laboratory Department of Zoology Visva-Bharati University Santiniketan-731235 IndiaSantiniketan-731235 India

Exposure to heavy metals such as cadmium and mercury is of immediate environmental concern. The present study was aimed at establishing a direct relationship between heavy metal poisoning and thyroid dysfunction. Cadmium and mercury treatment at LD50 levels resulted in severe thyrotoxicosis in the rabbit. Within 24 h of intramuscular administration of cadmium chloride 15 mg-kg-1 body weight (bw) and mercury chloride 20 ***-1 bw, thyroid peroxidase activity increased significantly over the control with a concomitant rise in the triiodothyronine (T3) titre. On the other hand, there was a remarkable fall in the thyroxine (T4) level, and the T3/T4 ratio was high as compared with the control. Evidence indicates that acute heavy metal lethality will induce unmediate hyperthyroidism. It is suggested that T3-toxicosis may be produced by a preferential synthesis of T3 and/or preferential deiodination of T4 to T3. Measurement of T3 and T4 levels may thus be utilized as a reliable indicator of heavy metal lethality.

关键词： Exposure to heavy metals such as cadmium and mercury is of immediate environmental concern. The present study was aimed at establishing a direct relationship between heavy metal poisoning and thyroid dysfunction. Cadmium and mercury treatment at LD50 levels resulted in severe thyrotoxicosis in the rabbit. Within 24 h of intramuscular administration of cadmium chloride 15 mg·kg-1 body weight (bw) and mercury chloride 20 mg·kg-1 bw, thyroid peroxidase activity increased significantly over the control with a concomitant rise in the triiodothyronine (T3) titre. On the other hand, there was a remarkable fall in the thyroxine (T4) level, and the T3/T4 ratio was high as compared with the control. Evidence indicates that acute heavy metal lethality will induce immediate hyperthyroidism. It is suggested that T3-toxicosis may be produced by a preferential synthesis of T3 and/or preferential deiodinafion of T4 to T3. Measurement of T3 and T4 levels may thus be utilized as a reliable indicator of heavy metal lethality.

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Catheters coated with Zn-doped CuO nanoparticles delay the onset of catheter-associated urinary tract infections

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Nano Research 2017年第2期10卷 520-533页

作者： Yakov Shalom Ilana Perelshtein nina Perkas Aharon Gedanken Ehud Banin The Mina and Everard Goodman faculty of Life Sciences and Institute for Advanced Materials and Nanotechnology Bar-Ilan University Ramat-Gan 52900 Israel The Department of Chemistry and Institute for Advanced Materials and Nanotechnology Bar-Ilan University Ramat-Gan 52900 Israel

Catheter-associated urinary tract infections （CAUTIs） are among the most common bacterial infections associated with medical devices. In the current study, the synthesis, coating, antibiofilm properties, and biocompatibility of urinary catheters coated with Zn-doped CuO （Zn0.12Cu0.880） nanoparticles （NPs） were examined. The doped NPs were synthesized and subsequently deposited on the catheter by the sonochemical method. The coated catheters displayed high antibiofilm activity and promising biocompatibility, as indicated by low in vitro cytotoxicity, negligible associated cytokine secretion, and absence of detectable irritation. The biocompatibility and ability of the Zn-doped CuO coating to inhibit biofilm formation were also evaluated in vivo using a rabbit model. Rabbits catheterized with uncoated catheters scored positive for CAUTI by day 4 of the experiment. In contrast, rabbits catheterized with Zn-doped CuO-coated catheters did not exhibit CAUTI until day 7 or remained completely uninfected for the whole duration of the 7-day experiment. furthermore, the in vivo biocompatibility assays and examinations supported the biosafety of Zn-doped CuO-coated catheters. Taken together, these data highlight the potential of Zn-doped CuO nanocomposite as effective antibiofilm compound.

关键词： antibiofilm urinary tract infection catheter nanoparticle coating metal oxide

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