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On the winter enhancement of adaptive humoral immunity: hypothesis testing in desert hamsters (Phodopus roborovskii: Cricetidae, Rodentia) kept under long-day and short-day photoperiod

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Integrative Zoology 2020年第3期15卷 232-247页

作者： nina yu.vasilieva Anastasiya M.KHRUSHCHOVA Alexander V.KUPTSOV Olga N.SHEKAROVA Olga V.SOKOLOVA Dehua WANG Konstantin A.ROGOVIN Severtsov Institute of Ecology and Evolution RAS MoscowRussia Institute of Zoology Chinese Academy of Science Chaoyang DistrictBeijingChina

We tested the winter immunity enhancement hypothesis(WIEH)on male desert hamsters(Phodopus roborovskii)kept under long-day(LD)and short-day(SD)*** assumed that under SD in a laboratory,the adaptive humoral immune responsiveness to the antigenic challenge would be enhanced due to the lack of winter physical stressors and food shortages and/or because of the action of an endogenous winter bolstering mechanism,while under LD the immune responsiveness would be suppressed by the activity of the reproductive *** results support the WIEH in *** did not find a difference in antibody production in response to sheep erythrocytes between SD and LD hamsters,but SD males had the lower number of granulocytes and the higher number of lymphocytes in white blood cell *** activity was lower in SD *** males demonstrated an increase in their mass-specific resting metabolic rate,their mass-specific maximal metabolic rate and their level of *** result of a generalized linear model analysis indicates the negative effect on secondary immunoresponsiveness to sheep erythrocytes of mid-ventral gland size,the organ characterizing individual reproductive quality,and designates a tradeoff between antibody production and reproductive *** mass-independent maximal metabolic rate also negatively affected antibody production,indicating a tradeoff between maximal aerobic performance and the adaptive immune *** higher stress in SD males seems to be the most likely reason for the lack of the effect of daylight duration on antibody production.

关键词： adaptive humoral immunity desert hamster photoperiodicity winter immunoenhancement

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Permutation orbifolds of vertex operator superalgebras and associative algebras

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Science China Mathematics 2025年第1期 19-38页

作者： Chongying Dong Feng Xu nina yu Department of Mathematics University of California at Santa Cruz Department of Mathematics Huzhou University Department of Mathematics University of California at Riverside School of Mathematical Sciences Xiamen University

Let V be a vertex operator superalgebra and g =（1 2 ···k） be a k-cycle which is viewed as an automorphism of the tensor product vertex operator superalgebra V■*** this paper,we construct an explicit isomorphism from Ag(V■k) to A（V） if k is odd and to Aσ（V） if k is even where σ is the canonical automorphism of V of order 2 determined by the superspace structure of *** recover previous results by Barron（2016）and Barron and Vander Werf（2014） that there is a one-to-one correspondence between irreducible g-twisted V■k-modules and irreducible V-modules（*** σ-twisted V-modules） when k is odd（***）.This explicit isomorphism is expected to be useful in our further study on the Zhu algebra of the fixed point subalgebra.

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Females choose gentle, but not healthy or macho males in Campbell dwarf hamsters （Phodopus campbelli Thomas 1905）

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Current Zoology 2017年第5期63卷 545-554页

作者： Konstantin A. ROGOVIN Anastasiya M. KHRUSHCHOVA Olga N. SHEKAROVA nina A. VASlLIEVA nina yu.vasilieva A.N. Severtsov Institute of Ecology and EvoLution RAS Leninskii prospect 33 Moscow 119071 Russia

Androgen-dependent male sexual traits （STs） as well as immunocompetence are theoreticallyassumed to be key indicators of a male＇s quality for the mate-choosing female. We studied matechoice by sexually motivated （SM） females of Campbell＇s dwarf hamsters. Females chose between2 tethered male siblings that differed in expression of STs. Males were unrelated to the female andable to contact and copulate with her. In both males, we measured sex-related morphology ofbody mass, mid-ventral specific skin gland, ano-genital distance, and external testicular *** also estimated levels of blood testosterone and cortisol, specific T- and B-cell immune re-sponses to antigens, as well as aggressive and sexual dominance in sibling males through add-itional encounter experiments with another SM female （male sibs could freely compete for thefemale）. We found that SM females chose a partner among 2 male sibs and spent over 80% of theirtime on average with the preferred male compared with the non-preferred one. Her choice was notassociated with the first visit of the chosen male, with a higher expression of sex-related traits,higher levels of blood testosterone, or with aggressive dominance. The choice was not associatedwith the intensity of T-cell immune response to phitohemagglutinin （PHA）. Instead there was a ten-dency for a negative relationship with the expression of STs and B-cell response to the antigenchallenge. The only character that unambiguously influenced female choice was the non-aggressive male to female grooming during sexual contact. There was no difference in breedingsuccess between preferred and non-preferred males paired with virgin females.

关键词： Campbell's dwarf hamsters, female mate choice, immunocompetence handicap, male-male aggression, sexual traits,testosterone.

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Permutation orbifolds and associative algebras

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Science China Mathematics 2022年第2期65卷 259-268页

作者： Chongying Dong Feng Xu nina yu Department of Mathematics University of California at Santa CruzSanta CruzCA 95064USA Department of Mathematics Huzhou UniversityHuzhou 313000China Department of Mathematics University of California at RiversideRiversideCA 92521USA School of Mathematical Sciences Xiamen UniversityXiamen 361005China

Let V be a vertex operator algebra and g =(1 2 ··· k) be a k-cycle which is viewed as an automorphism of the vertex operator algebra V?k. It is proved that Dong-Li-Mason’s associated associative algebra Ag(V?k) is isomorphic to Zhu’s algebra A(V) explicitly. This result recovers a previous result that there is a one-to-one correspondence between irreducible g-twisted V?k-modules and irreducible V-modules.

关键词： vertex operator algebra permutation orbifold Zhu algebra

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Exploring changes of precipitation extremes under climate change through global variable-resolution modeling

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Science Bulletin 2024年第2期69卷 237-247页

作者： Wei Sun Jian Li Rucong yu nina Li Yi Zhang State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Institute of Tibetan Plateau Meteorology China Meteorological AdministrationChengdu 610072China Department of Atmospheric Science Yunnan UniversityKunming 650091China National Meteorological Center China Meteorological AdministrationBeijing 100081China 2035 Future Laboratory PIESAT Information Technology Co.Ltd.Beijing 100105China

Understanding the responses of precipitation extremes to global climate change remains limited owing to their poor representations in models and complicated interactions with multi-scale *** we take the record-breaking precipitation over China in 2021 as an example,and study its changes under three different climate scenarios through a developed pseudo-global-warming(PGW)experimental framework with 60-3 km variable-resolution global ensemble *** to the present climate,the precipitation extreme under a warmer(cooler)climate increased(decreased)in intensity,coverage,and total amount at a range of 24.3%-37.8%(18.7%-56.1%).With the help of the proposed PGW experimental framework,we further reveal the impacts of the multi-scale system interactions in climate change on the precipitation *** the warmer climate,large-scale water vapor transport converged from double typhoons and the subtropical high marched into central China,enhancing the convective energy and instability on the leading edge of the transport *** a result,the mesoscale convective system(Mcs)that directly contributed to the precipitation extreme became stronger than that in the present *** the contrary,the cooler climate displayed opposite changing characteristics relative to the warmer climate,ranging from the large-scale systems to local environments and to the *** summary,our study provides a promising approach to scientifically assess the response of precipitation extremes to climate change,making it feasible to perform ensemble simulations while investigating the multi-scale system interactions over the globe.

关键词： Precipitation extreme Climate change Pseudo-global-warming experiment Variable-resolution modeling Multi-scale system interaction

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高密度种群的社会条件对大沙鼠幼年雄鼠形态生理特征的影响:一个实例研究(英文)

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动物学报 2006年第3期52卷 454-461页

作者： Konstantin ROGOVIN Jan A. RANDALL Irina KOLOSOVA nina yu. vasilieva Mikhail MOSHKIN A.N.Severtzov Institute of Ecology and Evolution RAS Leninskii Prospect 33 119071 Moscow Russia Department of Biology San Francisco State University 1600 Holloway Avenue San Francisco CA 94132 USA Institute of Systematic and Ecology of Animals RAS Frunze st. 11 630091 Novosibirsk Russia

在非繁殖期高密度大沙鼠(RhombomysopimusLicht)种群中,我们研究了胁迫以及幼年雄鼠的性激素浓度、腹中腺大小和体重对社群中成体(≥1年龄)存在的依赖性。用无损伤放射免疫方法,测定了于1999年秋天在野外采集的幼年雄鼠粪便样品的皮质... 详细信息

在非繁殖期高密度大沙鼠(RhombomysopimusLicht)种群中,我们研究了胁迫以及幼年雄鼠的性激素浓度、腹中腺大小和体重对社群中成体(≥1年龄)存在的依赖性。用无损伤放射免疫方法,测定了于1999年秋天在野外采集的幼年雄鼠粪便样品的皮质酮和睾酮。有成体社群中的个体大于无成体社群的个体。因此,成体对幼体的影响不能独立于社群大小本身。成体的存在促进粪便睾酮的浓度和抑制了幼年雄鼠的性成熟(由雄激素依赖的较小的腹中腺来估计),但是同时促进了其生长。因此,自然存在的社群环境能影响幼年雄鼠的形态生理特征发育。

关键词：沙漠鼠大沙鼠啮齿动物目哺乳动物胁迫粪便皮质酮粪便睾酮性成熟

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Rational design, synthesis, and biological evaluation of novel C6-modified geldanamycin derivatives as potent Hsp90 inhibitors and anti-tumor agents

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Chinese Chemical Letters 2023年第2期34卷 434-439页

作者： Ruxuan Wang Rentao Zhang Haoran Yang nina Xue Xiaoguang Chen Xiaoming yu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Heat shock protein 90(Hsp90) is an appealing anticancer drug target that provoked a tremendous wave of investigations. Geldanamycin(GA) is the first identified Hsp90 inhibitor that exhibited potent anticancer activity, but the off-target toxicity associated with the benzoquinone moiety hampered its clinical application. Until now, structure optimization of GA is still in need to fully exploit the therapeutic value of Hsp90. Due to the structural complexity and synthetic challenge of this compound family, conventional optimization is bound to be costly but high efficiency is expected to be reachable by combining the art of rational design and total synthesis. Described in this paper is our first attempt at this approach aiming at rational modification of the C6-position of GA. The binding affinities towards Hsp90 of compound 1(C6-ethyl) and 2(C6-methyl) were designed and predicted by using Discovery Studio. These compounds were synthesized and further subjected to a thorough in vitro biological evaluation. We found that compounds1 and 2 bind to Hsp90 protein with the IC_(50) of 34.26 nmol/L and 163.7 nmol/L, respectively. Both compounds showed broad-spectrum antitumor effects. Replacing by ethyl, compound 1 exhibited more potent bioactivity than positive control GA, such as in G2/M cell cycle arrest, cell apoptosis and client proteins degradations. The results firstly indicated that the docking study is able to provide a precise prediction of Hsp90 affinities of GA analogues, and the C6 substituent of GA is not erasable without affecting its biological activity.

关键词： Hsp90 inhibitors Geldanamycin derivatives Total synthesis Structure-activity relationship Anticancer

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Dispersive Shallow Water Wave *** II:Numerical Simulation on a Globally Flat Space

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Communications in Computational Physics 2018年第1期23卷 30-92页

作者： Gayaz Khakimzyanov Denys Dutykh Oleg Gusev nina yu.Shokina Institute of Computational Technologies Siberian Branch of the Russian Academy of SciencesNovosibirsk 630090Russia LAMA UMR 5127 CNRSUniversitéSavoie Mont BlancCampus Scientifique73376 Le Bourget-du-Lac CedexFrance

In this paper we describe a numerical method to solve numerically the weakly dispersive fully nonlinear SERRE-GREEN-NAGHDI(SGN)celebrated ***,our scheme is based on reliable finite volume methods,proven to be very efficient for the hyperbolic part of *** particularity of our study is that we develop an adaptive numerical model using moving ***,we use a special form of the SGN equations where non-hydrostatic part of pressure is found by solving a linear elliptic ***,this form of governing equations allows to determine the natural form of boundary conditions to obtain a well-posed(numerical)problem.

关键词： Nonlinear dispersive waves non-hydrostatic pressure moving adaptive grids finite volumes conservative finite differences

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The Inhibitory Effects of PSS-Loaded Nanoparticles on the Dysfunction of Cardiac Microvascular Endothelia in Rats with Diabetic Cardiomyopathy

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Journal of Ocean University of China 2019年第1期18卷 253-259页

作者： AN nina yu Luyan HU Yi FENG Wenjing SHI Shujuan CHEN Honghua MAO Yongjun Department of Geriatrics the Affiliated Hospital of Qingdao University

Propylene glycol alginate sodium sulfate-loaded nanoparticles(PSS-NP) has been shown potential to prevent the microvascular endothelial injuries caused by diabetic cardiomyopathy(DCM). In this study, we aimed to investigate the effects of PSS-NP on the dysfunction of cardiac microvascular endothelia in streptozotocin(STZ)-induced DCM rat model. Echocardiographic measurements showed a significant improvement of cardiac function in the PSS-NP-treated group. Our results revealed that the abnormalities of cardiac systolic and diastolic functions were suppressed by the treatments of prostaglandin E1(PGE1), low molecular weight heparin(LMWH), PSS and PSS-NP. Our comparison analysis indicated that PSS-NP showed the strongest inhibitory effects on microvascular endothelial injuries. Transmission electron microscopy analysis demonstrated that PSS-NP protected the cardiac microvascular endothelium and further improved endothelium dysfunction in DCM rats. ELISA and Western blot assays further showed a high efficiency of improving cardiac microvascular endothelial dysfunction with PSS-NP. Our results demonstrated that PSS-NP increased the protein expression of phosphatidylinositol 3-kinase(PI3K)-p85 and vascular endothelial growth factor(VEGF)-A, and the phosphorylation of protein kinase B(Akt) and endothelial nitric oxide synthase(eNOS), which were involved in the amelioration of cardiac microvascular endothelial dysfunction. These data suggest that PSS-NP may be a novel approach to the treatment the coronary microcirculation disorder diseases such as DCM.

关键词： PSS-loaded nanoparticles marine drug DCM microvascular endothelial dysfunction

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Pole placement approach to coherent passive reservoir engineering for storing quantum information

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Control Theory and Technology 2017年第3期15卷 193-205页

作者： Thien NGUYEN Zibo MIAO yu PAN nina AMINI Valery UGRINOVSKII Matthew R. JAMES ARC Centre for Quantum Computation and Communication Technology Research School of Engineering The Australian National University Canberra ACT 2601 Australia QUANTIC lab INRIA Paris 2 rue Simone Iff 75012 Paris France Institute of Cyber-Systems and Control Zhejiang University Hangzhou Zhejiang 310027 China CNRS Laboratoire des signaux et systèmes (L25) CentraleSupélec 3 rue Joliot Curie 91192 Gif-Sur-Yvette France School of Engineering and Information Technology University of New South Wales at the Australian Defence Force Academy Canberra ACT 2600 Australia

Reservoir engineering is the term used in quantum control and information technologies to describe manipulating the environment within which an open quantum system operates. Reservoir engineering is essential in applications where storing quantum information is required. From the control theory perspective, a quantum system is capable of storing quantum information if it possesses a so-called decoherence free subsystem （DFS）. This paper explores pole placement techniques to facilitate synthesis of decoherence free subsystems via coherent quantum feedback control. We discuss limitations of the conventional ＇open loop＇ approach and propose a constructive feedback design methodology for decoherence free subsystem engineering. It captures a quite general dynamic coherent feedback structure which allows systems with decoherence free modes to be synthesized from components which do not have such modes.

关键词： Open quantum system decoherence free subsystem reservoir engineering coherent feedback control quantum control

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