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Exercise training improves long-term memory in obese mice

Life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey L.Egan Tina L.robinson nimna per.r. Heidy K.Latchman Lauren V.Terry Emma D.McLennan Carolina Chavez Emma L.Burrows John W.Scott robyn M.Murphy Henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

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Genetic associations of inflammatory bowel disease in a South Asian population

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World Journal of Clinical Cases 2018年第15期6卷 908-915页

作者： Madunil Anuk Niriella Isurujith Kongala Liyanage Senerath Kuleesha Kodisinghe Arjuna Priyadarsin De Silva nimna rajapakshe Sunali D Nanayakkara Dunya Luke Thilakshi Silva Metthananda Nawarathne ranjith K Peiris Udaya P Kalubovila Sujeewa r Kumarasena Vajira Harshadeva Weerabaddana Dissanayake rohan W Jayasekara Hithanadura Janaka de Silva Faculty of Medicine University of Kelaniya Faculty of Medical Sciences University of Sri Jayewardenepura University Medical Unit Colombo North Teaching Hospital Gastroenterology Unit National Hospital of Sri Lanka Gastroenterology Unit Colombo South Teaching Hospital Gastroenterology Unit Teaching Hospital Kandy Gastroenterology Unit Teaching Hospital Karapitiya Human Genetics Unit Faculty of Medicine University of Colombo

AIM To estimate prevalence and phenotypic associations of selected inflammatory bowel disease(IBD)-associated genetic variants among Sri Lankan patients. METHODS A case study of histologically confirmed ulcerative colitis(UC) or Crohn's disease(CD) patients with ≥ 1 year disease duration, who were compared to unrelated, gender-matched, healthy individuals as controls, was conducted at four major centers in Sri Lanka. Phenotypic data of the cases were obtained and all participants were genotyped for 16 selected genetic variants: IL12 B :rs1045431, IL23 r :rs11805303, ArPC2 :rs12612347, IrGM :rs13361189, IL26/IL22 :rs1558744, CDH1 :rs1728785, IL10 :rs3024505, FCGr2 A :rs3737240, PTGEr4 :rs4613763, IL17 rEL/PIM3 :rs5771069, HNF4 a :rs6017342, STAT3 :rs744166, SMUrF1 :rs7809799, LAMB1 :rs886774, HLA-DrB5, DQA1, DrB1, DrA :rs9268853, MST1, UBA7, and APEH :rs9822268. The genotypes of all variants were in Hardy-Weinberg Equilibrium(P > 10^(-3)). To account for multiple hypothesis testing, P-values re considered *** A total of 415 patients and 465 controls were recruited. Out of the single nucleotide polymorphisms(SNPs) tested, the majority were not associated with IBD in Sri Lankans. Significant positive associations were noted between rs886774(LAMB1-gene) and UC(odds ratio(Or) = 1.42, P = 0.001). UC patients with rs886774 had mild disease(Or = 1.66, P remained in remission(Or = 1.48, P rs10045431(IL 12 B gene) and upper gastrointestinal involvement in CD(Or = 4.76, P = 0.002). CONCLUSION This confirms the heterogeneity of allelic mutations in South Asians compared to Caucasians. Most SNPs and disease associations reported here have not been described in South Asians.

关键词： Inflammatory bowel disease Genetics of inflammatory bowel disease Ulcerative colitis Crohn’s disease LAMB1 gene mutation IL-12B gene mutation

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