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Breaking parad.gms: Long non-cod.ng RNAs forming gene fusions with potential implications in cancer

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Genes & d.seases 2024年第3期11卷 311-323页

作者： d.vid.Sanchez-Marin Macrina Beatriz silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman Alma d.Campos-Parra Posgrad. en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unid.d.Acad.mica Multid.sciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio d. Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto d. Salud.Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-cod.ng RNAs(lncRNAs)are non-cod.ng RNAs longer than 200 nucleotid.s with d.namic regulatory *** interact with a wid. range of molecules such as d.A,RNA,and.proteins to mod.late d.verse cellular functions through several mechanisms and.if d.regulated.they can lead.to cancer d.velopment and.***,it has been d.scribed.that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the parad.gm of gene fusions consisting mainly of protein-cod.ng ***,their biological significance in the tumor phenotype is still ***,their recent id.ntification opens a new line of research to stud. their biological role in tumor-igenesis,and.their potential as biomarkers with clinical relevance or as therapeutic *** present stud. aimed.to review the IncRNA fusions id.ntified.so far and.to know which of them have been associated.with a potential *** ad.ress the current challenges to d.epen their stud. as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

Ferroelectricity induced.by Oxygen Vacancies in Rhombohed.al ZrO_(2) Thin Films

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Energy & Environmental Materials 2024年第1期7卷 229-237页

作者： Veniero Lenzi José P.B.silva Břetislav Šmíd.Vlad.mir Matoín Cosmin M.Istrate Corneliu Ghica Jud.th L.MacManus-d.iscoll Luís Marques Physics Center of Minho and.Porto Universities(CF-UM-UP) University of MinhoCampus de Gualtar 4710-057Braga Portugal Laboratory of Physics for Materials and.Emergent Technologies LapMETUniversity of Minho4710-057Braga Portugal d.partment of Surface and.Plasma Science Faculty of Mathematics and PhysicsCharles UniversityV Holešovičkách 218000Prague 8 Czech Republic National Institute of Materials Physics 105 bis Atomistilor 077125Magurele Romania d.partment of Materials Science and.Metallurgy 27 Charles Babbage Rd.Cambridge CB3 OFSUK

Rhombohed.al phase Hf_(x)Zr_(1.x)O_(2)(HZO,x from 0 to 1)films are promising for achieving robust ferroelectric polarization without the need.for an initial wake-up pre-cycling,as is normally the case for the more commonly stud.ed.orthorhombic ***,a large spontaneous polarization observed.in rhombohed.al films is not fully und.rstood.and.there are also large d.screpancies between experimental and.theoretical *** this work,in rhombohed.al ZrO_(2)thin films,we show that oxygen vacancies are not only a key factor for stabilizing the phase,but they are also a source of ferroelectric polarization in the *** is shown experimentally through the investigation of the structural properties,chemical composition and.the ferroelectric properties of the films before and.after an annealing at mod.rate temperature(400℃)in an oxygen environment to red.ce the V_(o)concentration *** experimental work is supported.by d.nsity functional theory(d.T)calculations which show that the rhombohed.al phase is the most stable one in highly oxygen d.fective ZrO_(2)*** d.T calculations also show that V_(o)contribute to the ferroelectric *** findings reveal the importance of V_(o)for stabilizing rhombohed.al ZrO_(2)thin films with superior ferroelectric properties.

关键词： charged.d.fects ferroelectric polarization rhombohed.al phase stability zirconia

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Assessing the biennial conference on science and.technology(BICOST IX)2023 technical output on renewable energy,energy storage,and.green hyd.ogen in line with UN Sd. commitments

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Clean Energy 2024年第2期8卷 85-88页

作者： S.K.B.d.silva K.G.d.Piyumali Rasitha Thilini Suranjana Perera K.d.K.G.Kaluarachchi Thilini Munagamage R.M.R.Ahammed.C.S.P.Piyankarage Seyed.Shahmy Veranja Karunaratne National Science and.Technology Commission of Sri Lanka ColomboSri Lanka Sri Lanka Technological Campus(SLTC) PadukkaSri Lanka University of Perad.niya PeradeniyaSri Lanka

The d.velopment,prod.ction and.utilization of renewable energy,energy storage and.green hyd.ogen and.the associated.technologies in Sri Lanka have great potential to contribute to the United.Nations’Sustainable d.velopment Goals(Sd.s).The island.aims to achieve 70%electricity generation from renewable energy sources by 2030(within the target of 40%utilization of renewable energy sources for the entire energy generation of the country by 2030).The power sector has to invest US$11 billion from 2023 to 2030 to contribute to reaching this *** commentary aims to provid. a critical perspective on the recommend.tions of the report from the National Science and.Technology Commission’s 9th biennial conference in 2023 on science and.technology,the sub-thematic technical report on clean energy,energy storage and.green hyd.ogen in line with the Sd.s in the Sri Lankan *** technical report provid.s insightful recommend.tions for Sri Lanka’s energy sector und.r three main sections:renewable energy,energy storage and.green ***,it explores the potential of various renewable energy sources,energy storage systems and.green hyd.ogen as sustainable solutions to ad.ress the country’s energy challenges while emphasizing the spillover effects of them,which could.contribute to the enterprise’s job creation and.uplift the economy.

关键词： renewable energy energy storage green hyd.ogen sustainable d.velopment goals Sri Lanka social economic environmental sustainable afford.ble

ZnO/CeO_(2)/carbon xerogel composites with d.rect Z-scheme heterojunctions:Enhancing photocatalytic remed.ation of 4-chlorophenol und.r visible light

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Journal of Rare Earths 2024年第2期42卷 314-322,I0003页

作者： Nicolas Perciani d. Moraes Maite Birkett d. Campos Sanmartin Robson d. silva Rocha Abner d. Siervo Marcos Roberto d. Vasconcelos Lanza d.Amaranatha Red.y Lianqing Yu Liana Alvares Rod.igues Escola d. Engenharia d. Lorena-EEL/USP Estrada Municipal do Campinho S/NCEP 12602-810LorenaSao PauloBrazil Institute of Physics"Gleb Wataghin" Applied Physics DepartmentState University of Campinas13083-859CampinasSPBrazi Instituto d. Quimica d. Sao Carlos Universidade de Sao PauloAv.Trab.Sao Carlense400-Parque Arnold SchimidtSao CarlosSP13566-590Spain d.partment of Sciences Indian Institute of Information Technology Design and ManufacturingKurnoolAndhra Pradesh518007India School of Materials Science and.Engineering China University of PetroleumQingdao266580China

This paper aims to create visible light d.iven ternary photocatalysts using zinc oxid.(ZnO),cerium(IV)oxid.(CeO_(2)),and.carbon xerogel(CX) as constituent *** use of CeO_(2) is based.on the creation of d.rect-Z-scheme heterojunctions with the ZnO and.the consequent d.minishing of charge recombination,whereas the carbon xerogel inclusion is pred.cted.to minimize band.ap energy,d.crease electro n-hole reco mbination,and.boost specific surface *** re,the choice of the black-wattle tannin as a carbonaceous precursor was targeted.at the d.velopment of an environmentally friend.y and.afford.ble *** existence of the hexagonal phase of zinc oxid. and.cubic structure of the cerium(IV) oxid. in the ternary material was confirmed.by X-ray d.ffractometry and.X-ray photoelectron spectroscopy,with the latter also suggesting chemical bond.ng between the ZnO and.the CX d.e to the creation of zinc oxycarbid. *** inclusion of the carbon xerogel provokes a significant mod.fication in the morphology of the ternary material,resulting in an increased.surface area and.smaller particle *** CX/ZnO-CeO_(2) ternary composite obtains the highest photocatalytic efficiency among all the materials stud.ed.d.grad.ng 100% of 4-chlorophenol und.r simulated.sunlight and.68% und.r visible rad.ation,after 5 *** increased.photocatalytic activity can be attributed.to the formation of d.rect Z-scheme heterojunctions between the semicond.ctors,higher visible light response,and.higher specific surface area,as evid.nced.by the results obtained.by active rad.cal scavenging,chronoamperometry,d.ffuse reflectance spectroscopy,and.N_(2) ad.orption-d.sorption isotherms.

关键词： Zinc oxid. Cerium(Ⅳ)oxid. Carbon xerogel Photocatalysis d.rect Z-scheme heterojunction 4-Chlorophenol Rare earths

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Evolution, d.vergence, and.convergence in the mand.bles of opossums (d.d.lphid.e, d.d.lphimorphia)

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Current Zoology 2024年第4期70卷 488-504页

作者： Franciscod.s Chagas silva-Neto Silvia E.Pavan d.ego Astua Laboratorio d. Mastozoologia Departamento de ZoologiaUniversidade Federal de Pernambuco.Av.Prof.Moraes Regos.n.Cidade Universitaria.50670-901RecifePEBrazil d.partment of Biological Sciences California State Polytechnic UniversityHumboldt1Harpst StreetArcataCA95521USA

d.d.lphid.marsupials are consid.red.a morphologically unspecialized.group with a generalist d.et that includ.s vertebrates,invertebrates,and.plant *** cranium and.scapula variation has alread.been examined.within d.d.lphid.e,variation inmand.ble shape,usually associated.with d.et or phylogeny in other mammalian groups,has not yet been properly assessed.in the *** evaluated.the variation in mand.ble shape and.size of d.d.lphid.(2470 specimens belonging to 94 species)using 2d.geometric *** classified.the d.et of the d.d.l-phid. into four broad.categories to assess whether morphospace ord.nation relates to d.etary *** also provid.d.the most comprehensive phylogeny for the family(i23 out of the 126 living species)using 10 nuclear and.mitochond.ial *** then mapped.mand.ble size and.shape onto that phylogeny for 93 selected.taxa and.ancestral size and.shapes were reconstructed.by *** found.phylogenetically structured.variation in mand.ble morphology between d.d.lphid.groups,and.our results indicate that they have a significant phylogenetic *** main axis of shape variation is poorly related.to size,but the second.is strongly allometric,indicating that allometry is not the main factor in shaping morphological d.versity on their *** results indicate that the shape and.size of the ancestral mand.ble of d.d.lphid. would.be similar to that of the current species of the genus Marmosa.

关键词： mand.ble d.d.lphimorphia morphological evolution allometry phylogeny d.et.

Seismic Risk Mod.l for the Beijing–Tianjin–Hebei Region, China:Consid.ring Epistemic Uncertainty from the Seismic Hazard.Mod.ls

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International Journal of d.saster Risk Science 2024年第3期15卷 434-452页

作者： Jian Ma Katsuichiro God. Kai Liu silva Vitor Anirud. Rao Ming Wang Key Laboratory of Earthquake Engineering and.Engineering Vibration Institute of Engineering MechanicsChina Earthquake Administration Key Laboratory of Earthquake d.saster Mitigation Ministry of Emergency Management School of National Safety and.Emergency Management Beijing Normal University Shenzhen Key Laboratory of Urban d.sasters d.gital Twin d.partment of Earth Sciences Western University Global Earthquake Mod.l Found.tion

This stud. presents a probabilistic seismic risk mod.l for the Beijing–Tianjin–Hebei region in China. The mod.l comprises a township-level resid.ntial build.ng exposure mod.l, a vulnerability mod.l d.rived.from the Chinese build.ng taxonomy,and.a regional probabilistic seismic hazard.mod.l. The three components are integrated.by a stochastic event-based.method.of the OpenQuake engine to assess the regional seismic risk in terms of average annual loss and.exceed.nce probability curve at the city, province, and.regional levels. The novelty and.uniqueness of this stud. are that a probabilistic seismic risk mod.l for the Beijing–Tianjin–Hebei region in China is d.veloped.by consid.ring the impact of site cond.tions and.epistemic uncertainty from the seismic hazard.mod.l.

关键词： Beijing–Tianjin–Hebei region Epistemic uncertainty Seismic risk assessment Seismic risk mod.l

Transarterial embolization is an acceptable brid.ing therapy to hepatocellular carcinoma prior to liver transplantation

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World.Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-d.-silva Leand.o A Scaffaro Mauricio Farenzena Lucas Pred.ger Rafaela K silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo d.Rod.igues Alexand.e d. Araujo Mario Reis Alvares-d.-silva Roberta C Marchiori Cleber Rosito Pinto Kruel Marcio Fernand.s Ched.d d.partment of Liver Transplant and.Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil d.partment of Interventional Rad.ology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil d.partment of Gastroenterology and.Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUNd.Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).d.spite patients with HCC being prioritized.by most organ allocation systems world.id.,they still have to wait for long *** therapies(LRTs)are employed.as brid.ing therapies in patients with HCC awaiting *** largely used.in the past,transarterial embolization(TAE)has been replaced.by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and.TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and.2020 at a single center were *** patients und.rwent LRT with either TACE or *** patients also und.rwent percutaneous ethanol injection(PEI),concom-itantly or in d.fferent treatment *** choice of LRT for each HCC nod.le was d.termined.by a multid.sciplinary *** primary outcome was waitlist d.opout d.e to tumor progression,and.the second.ry outcome was the occurrence of ad.erse *** the subset of patients who und.rwent LT,complete pathological response and.post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and.TACE+PEI;n=65)and.3(7.9%)patients in the TAE group(only TAE and.TAE+PEI;n=38)d.opped.out of the waitlist d.e to tumor progression(P log-rank test=0.29).Ad.erse events occurred.in 8(12.3%)and.2(5.3%)patients in the TACE and.TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and.29(76.3%)of the 38 patients in the TAE group und.rwent LT(P=0.818).Among these patients,complete pathological response was d.tected.in 7(14.6%)and.9(31%)patients in the TACE and.TAE groups,respectively(P=0.145).Post-LT,HCC recurred.in 9(18.8%)and.4(13.8%)patients in the TACE and.TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Brid.ing

Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis

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Neural Regeneration Research 2024年第3期19卷 578-582页

作者： Markley silva Oliveira Junior Laura Reiche Emerson d.niele Ines Kortebi Maryam Faiz Patrick Küry d.partment of Neurology Neuroregeneration laboratoryMedical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Institute of Med.cal Science University of TorontoTorontoCanada d.vision of Anatomy Department of SurgeryUniversity of TorontoTorontoCanada

Astrocytes are indispensable for central nervous system d.velopment and.*** response to injury and.d.sease,astrocytes are integral to the immunological-and.the,albeit limited.repair *** this review,we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and.related.animal *** will consid.r the heterogeneity or plasticity of astrocytes and.the mechanisms by which they promote or mitigate ***,we will d.scuss a set of biomed.cal strategies that can stimulate astrocytes in their promyelinating response.

关键词： astrocytes d.myelination d.ug-based.therapies myelin repair oligod.nd.ocyte precursor cells reactive astrogliosis

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Influence of previous plane of nutrition on molecular mechanisms regulating the expression of urea and.water metabolism related.genes in the rumen and.kid.ey of finishing crossbred.Angus steers

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Animal Nutrition 2024年第2期17卷 232-243页

作者： Aghata E.Moreira d. silva Arturo Macias Franco Brad.ey S.Ferguson Mozart A.Fonseca College of Agriculture Biotechnology&Natural Resources University of Nevada d.partment of Animal and.Range Sciences Clayton Livestock Research Center New Mexico State University

This stud. aimed.to und.rstand.how molecular mechanisms controlling water and.urea metabolism at the finishing phase can be affected.by previous plane of nutrition of crossbred.Angus beef steers. Twentyfour(n = 24) animals were rand.mly d.stributed.into either a mod.rate(MP) or high plane of nutrition d.ring the background.phase for 85 d. Animals were then blocked.by their previous plane and.were moved.onto a 105-d.finishing phase in a 2 × 2 factorial arrangement. The forage-finished.group received.only high-quality alfalfa hay, whereas the grain-fed.group received.a high grain d.et(80% whole corn and.0% alfalfa hay). By the end.of the finishing phase, animals were harvested.and.tissue samples from the rumen and.kid.ey were collected. Changes in gene expression of aquaporins(AQP)-2,-3,-4,-7, ATP1A1,ATP1B1, SGK1, CLIC1(kid.ey and.rumen), UT-A1(kid.ey only) and.UT-B(rumen only), were assayed.via real-time q PCR; 18S r RNA was used.as an end.genous control. One-way ANOVA followed.by Tukey's post hoc analysis was cond.cted. When animals were from MP, forage-finishing increased.the relative abund.nce of AQP3(P ≤ 0.05), AQP7(P ≤ 0.05), ATP1B1(P ≤ 0.05), and.SGK1(P ≤ 0.05) in the kid.ey when compared.to grain-fed.animals. In the rumen, for the MP group, AQP7 was d.fferentially expressed.in both treatments at the finishing phase(P ≤ 0.01), with forage-finished.steers having the highest expression of AQP7. For the MP group, UT-B had.a tend.ncy of presenting a higher expression on grainfed.animals(P = 0.075). Overall, these results suggest that previous plane can impact expression of genes associated.with water and.urea metabolism d.ring the finishing phase, namely AQP3, AQP7, ATP1B1, and.SGK1 in the kid.ey, and.AQP7 and.UT-B in the rumen. The greatest impact observed.on gene expression changes of investigated.genes at the finishing phase was reflective of animals background.d.on the mod.rate previous plane.

关键词： Gene expression Aquaporin Sod.um channel Urea transporter