检索结果-南通市图书馆

In vitro angiogenesis in response to biomaterial properties for bone tissue engineering:a review of the state of the art

引用

Regenerative Biomaterials 2023年第1期10卷 744-783页

作者： Else Ellermann nima Meyer Ruth E.Cameron Serena M.Best Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK

Bone tissue engineering(BTE)aims to improve the healing of bone fractures using scaffolds that mimic the native extracellular *** successful bone regeneration,scaffolds should promote simultaneous bone tissue formation and blood vessel growth for nutrient and waste ***,a significant challenge in regenerative medicine remains the development of grafts that can be vascularized *** other things,optimization of physicochemical conditions of scaffolds is key to achieving appropriate angiogenesis in the period immediately following *** phosphates and collagen scaffolds are two of the most widely studied biomaterials for BTE,due to their close resemblance to inorganic and organic components of bone,respectively,and their bioactivity,tunable biodegradability and the ability to produce tailored *** various strategies exist to enhance vascularization of these scaffolds in vivo,further in vitro assessment is crucial to understand the relation between physicochemical properties of a biomaterial and its ability to induce *** mono-culture studies can provide evidence regarding cell-material interaction of a single cell type,a co-culture procedure is crucial for assessing the complex mechanisms involved in angiogenesis.A co-culture more closely resembles the natural tissue both physically and biologically by stimulating natural intercellular interactions and mimicking the organization of the in vivo ***,a co-culture is a complex system requiring optimization of various parameters including cell types,cell ratio,culture medium and seeding *** fundamental knowledge of the mechanism behind the bioactivity of biomaterials and understanding the contribution of surface and architectural features to the vascularization of scaffolds,and the biological response in general,can provide an invaluable basis for future optimization *** review gives an overview of the

关键词： angiogenesis collagen scaffolds hydroxyapatite co-culture architectural features physicochemical properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adenoviral gene therapy in gastric cancer: A review

引用

World Journal of Gastroenterology 2008年第2期14卷 180-184页

作者： nima Khalighinejad Hesammodin Hariri Omid Behnamfar Arash Yousefi Amir Momeni Isfahan University of Medical Sciences Khalighinejad Nima Number 111 5th street Mardavij Street Isfahan Iran

Gastric cancer is one of the most common malignancies worldwide. With current therapeutic approaches the prognosis of gastric cancer is very poor, as gastric cancer accounts for the second most common cause of death in cancer related deaths. Gastric cancer like almost all other cancers has a molecular genetic basis which relies on disruption in normal cellular regulatory mechanisms regarding cell growth, apoptosis and cell division. Thus novel therapeutic approaches such as gene therapy promise to become the alternative choice of treatment in gastric cancer. In gene therapy, suicide genes, tumor suppressor genes and anti-angiogenesis genes among many others are introduced to cancer cells via vectors. Some of the vectors widely used in gene therapy are Adenoviral vectors. This review provides an update of the new developments in adenoviral cancer gene therapy including strategies for inducing apoptosis, inhibiting metastasis and targeting the cancer cells.

关键词： Gastric cancer Adenovirus Gene therapy Vector Apoptosis Metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Seismic Liquefaction Resistance Based on Strain Energy Concept Considering Fine Content Value Effect and Performance Parametric Sensitivity Analysis

引用

Computer Modeling in Engineering & Sciences 2023年第4期135卷 733-754页

作者： nima Pirhadi Xusheng Wan Jianguo Lu Jilei Hu Mahmood Ahmad Farzaneh Tahmoorian School of Civil Engineering and Geomatics Southwest Petroleum UniversityChengdu610500China Key Laboratory of Geological Hazards on ThreeGorges ReservoirArea Ministry of EducationChina Three Gorges UniversityYichang443002China College of Civil Engineering&Architecture China Three Gorges UniversityYichang443002China Department of Civil Engineering Faculty of EngineeringInternational Islamic University MalaysiaJalan GombakSelangor50728Malaysia Department of Civil Engineering University of Engineering and Technology Peshawar(Bannu Campus)Bannu28100Pakistan Central Queensland University Queensland4740Australia

Liquefaction is one of the most destructive phenomena caused by earthquakes,which has been studied in the issues of potential,triggering and hazard *** strain energy approach is a common method to investigate liquefaction *** this study,two Artificial Neural Network(ANN)models were developed to estimate the liquefaction resistance of sandy soil based on the capacity strain energy concept(W)by using laboratory test data.A large database was collected from the *** group of the dataset was utilized for validating the process in order to prevent overtraining the presented *** investigate the complex influence of fine content(FC)on liquefaction resistance,according to previous studies,the second database was arranged by samples with FC of less than 28%and was used to train the second ANN ***,two presented ANN models in this study,in addition to four extra available models,were applied to an additional 20 new samples for comparing their results to show the capability and accuracy of the presented models ***,a parametric sensitivity analysis was performed through Monte Carlo Simulation(MCS)to evaluate the effects of parameters and their uncertainties on the liquefaction resistance of *** to the results,the developed models provide a higher accuracy prediction performance than the previously *** sensitivity analysis illustrated that the uncertainties of grading parameters significantly affect the liquefaction resistance of soils.

关键词： Liquefaction resistance capacity strain energy artificial neural network sensitivity analysis Monte Carlo Simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lossless multi-scale constitutive elastic relations with artificial intelligence

引用

npj Computational Materials 2022年第1期8卷 638-649页

作者： Jaber Rezaei Mianroodi Shahed Rezaei nima H.Siboni Bai-Xiang Xu Dierk Raabe Microstructure Physics and Alloy Design Max-Planck-Institut für EisenforschungDüsseldorfGermany Ergodic Labs Lohmühlenstraße 6512435BerlinGermany Mechanics of Functional Materials Division Institute of Materials ScienceTechnische Universität DarmstadtDarmstadtGermany

A seamless and lossless transition of the constitutive description of the elastic response of materials between atomic and continuum scales has been so far *** we show how this problem can be overcome by using artificial intelligence(AI).A convolutional neural network(CNN)model is trained,by taking the structure image of a nanoporous material as input and the corresponding elasticity tensor,calculated from molecular statics(MS),as *** with the atomistic data,the CNN model captures the size-and pore-dependency of the material’s elastic properties which,on the physics side,derive from its intrinsic stiffness as well as from surface relaxation and non-local *** demonstrate the accuracy and the efficiency of the trained CNN model,a finite element method(FEM)-based result of an elastically deformed nanoporous beam equipped with the CNN as constitutive law is compared with that obtained by a full atomistic *** trained CNN model predicts the elasticity tensor in the test dataset with a root-mean-square error of 2.4 GPa(3.0%of the bulk modulus)when compared to atomistic *** the other hand,the CNN model is about 230 times faster than the MS calculation and does not require changing simulation methods between different *** efficiency of the CNN evaluation together with the preservation of important atomistic effects makes the trained model an effective atomistically informed constitutive model for macroscopic simulations of nanoporous materials,optimization of nanostructures,and the solution of inverse problems.

关键词： constitutive artificial elasticity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A deep learned nanowire segmentation model using synthetic data augmentation

引用

npj Computational Materials 2022年第1期8卷 845-856页

作者： Binbin Lin nima Emami David A.Santos Yuting Luo Sarbajit Banerjee Bai-Xiang Xu Mechanics of Functional Materials Division Institute of Materials ScienceTechnische Universität Darmstadt64287DarmstadtGermany Department of Chemistry Texas A&M UniversityCollege StationTX77843USA

Automated particle segmentation and feature analysis of experimental image data are indispensable for data-driven material *** learning-based image segmentation algorithms are promising techniques to achieve this goal but are challenging to use due to the acquisition of a large number of training *** the present work,synthetic images are applied,resembling the experimental images in terms of geometrical and visual features,to train the state-of-art Mask region-based convolutional neural networks to segment vanadium pentoxide nanowires,a cathode material within optical density-based images acquired using *** results demonstrate the instance segmentation power in real optical intensity-based spectromicroscopy images of complex nanowires in overlapped networks and provide reliable statistical *** model can further be used to segment nanowires in scanning electron microscopy images,which are fundamentally different from the training dataset known to the *** proposed methodology can be extended to any optical intensity-based images of variable particle morphology,material class,and beyond.

关键词： nanowires networks particle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Personalized clinical managements through exploring circulating neural cells and electroencephalography

引用

World Journal of Experimental Medicine 2023年第4期13卷 75-94页

作者： Parvin Mehdipour nima Fathi Masoud Nosratabadi Department of Medical Genetics Tehran University of Medical SciencesTehran 14176-1315Iran Neuro-Science Paarand Specialized Center for Human EnhancementTehran 157699304Iran Department of Research Paarand Specialized Center for Human EnhancementTehran 157699304Iran

BACKGROUND Since an initial diagnosis of Alzheimer disease(AD)in 1907,early detection,was unavailable through 116 ***-regulation of V-Ets erythroblastosis virus E26 oncogene homolog 2(Ets2)is capable to enhance neuronal susceptibility and *** expression(PE)of Ets2 has functional impact on AD and Down’s syndrome,with diverse *** of Ets2 has an influential pathogenic impact on *** aspects of neurological disorders directly interact with psychological ***,deterioration requires an early management including programmed based *** To include cell biology in neuro-genetics;personalized,prognostics,predictive,preventive,predisposing(5xP)platform,accompanied by stratifying brain channels behavior pre-and post-intervention by light music in the *** Include exploration of PE assay and electroencephalography of brain *** processes are applied according to:(1)Triangle style,by application of cellular network;and(2)PE assay of Ets2 in the peripheral blood of the patients with AD,by Manual single cell based analysis,and Flow-cytometry.(1)Applying the Genetic counselling and pedigree analysis;(2)considering the psychological status of the referral cases;(3)considering the macro-and/or micro-environmental factors;(4)performing the required Genetics’analysis;and(5)applying the required complementary test(s).RESULTS PE of Ets2 has pathogenic role in *** unmasked the nature of heterogeneity/diversity/course of evolution by exploring Ets2,D1853N polymorphism in Ataxia Telangiectasia mutated gene(ATM),vascular endothelial growth factor(VEGF),epidermal growth factor(EGF)and course of evolution at the single cell level of the ***2 revealed different cellular behavior in the blood and suggested the strategy as‘Gene Product-Based Therapy’and the personalized managements for the *** reflected weak expression of ATM,mosaic pattern of Ets2;remarkable expression of VEGF and EGF by highlighting

关键词： Alzheimer Protein expression Brain channels Predictive/early detection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The influence of microwave irradiation on rocks for microwaveassisted underground excavation

引用

Journal of Rock Mechanics and Geotechnical Engineering 2016年第1期8卷 1-15页

作者： Ferri Hassani Pejman M.Nekoovaght nima Gharib Department of Mining and Material Engineering McGill University

Demand is growing for explosive-free rock breakage systems for civil and mining engineering, and space industry applications. This paper highlights the work being undertaken in the Geomechanics Laboratory of Mc Gill University to make a real application of microwave-assisted mechanical rock breakage to fullface tunneling machines and drilling. Comprehensive laboratory tests investigated the effect of microwave radiation on temperature profiles and strength reduction in hard rocks(norite, granite, and basalt)for a range of exposure times and microwave power levels. The heating rate on the surface of the rock specimens linearly decreased with distance between the sample and the microwave antenna, regardless of microwave power level and exposure time. Tensile and uniaxial compressive strengths were reduced with increasing exposure time and power level. Scanning electron micrographs(SEMs) highlighted fracture development in treated basalt. It was concluded that the microwave power level has a strong positive influence on the amount of heat damage induced to the rock surface. Numerical simulations of electric field intensity and wave propagation conducted with COMSOL Multiphysics~ software generated temperature profiles that were in close agreement with experimental results.

关键词： Microwaves Crack density Microwave-assisted tunnel boring Rock breakage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The feasible application ofmicrofluidic tissue/organ-on-a-chip as an impersonator of oral tissues and organs:a direction for future research

引用

Bio-Design and Manufacturing 2023年第4期6卷 478-506页

作者： nima Farshidfar Sahar Assar Mohammad Amin Amiri Sarina Sahmeddini Shahram Hamedani Moein Zarei Lobat Tayebi Orthodontic Research Center School of DentistryShiraz University of Medical SciencesShirazIran Section for Oral Ecology and Caries Control Department of Dentistry and Oral HealthAarhus UniversityAarhusDenmark Student Research Committee Shiraz University of Medical SciencesShirazIran Oral and Dental Disease Research Center School of DentistryShiraz University of Medical SciencesShirazIran Department of Polymer and Biomaterials Science Faculty of Chemical Technology and EngineeringWest Pomeranian University of TechnologySzczecinAl.Piastow 4571-311 SzczecinPoland Marquette University School of Dentistry MilwaukeeWI 53233USA

Currently,cell culture models play a key role in determining cell behavior under various ***,the accurate simulation of cellular behavior that imitates the body’s conditions remains a ***,to overcome this obstacle,three-dimensional cell culture models have been *** tissues/organs-on-chips(TOOCs)are new devices that have provided the opportunity to culture cells in a medium that is almost similar to the physiological conditions of the *** can be designed in simple or complex models,which are mostly fabricated by soft *** novel structures have been developed to mimic the conditions of various tissues and organs;however,microfluidic models for oral and dental tissues have not yet been widely *** application of TOOCs for oral tissues/organs can provide the opportunity to study cell interactions with biomaterials used in ***,TOOCs can provide the opportunity to study the cellular interactions and developmental stages of oral tissues/organs more *** review of the current advances in the field of TOOC development for oral tissues provides a comprehensive understanding of this burgeoning concept,shows the progress and applications of these novel models in the imitation of oral tissues/organs thus far,and reveals the limitations that TOOCs ***,it suggests further perspectives for future applications.

关键词： Microfluidics Tissue-on-a-chip Organ-on-a-chip Tooth-on-a-chip Oral mucosa-on-a-chip Salivary gland-on-a-chip

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biomechanical assessment of new surgical method instead of kyphoplasty to improve the mechanical behavior of the vertebra:Micro finite element study

引用

World Journal of Orthopedics 2017年第11期8卷 829-835页

作者： Seyed Aref Hosseini Faradonbeh nima Jamshidi Department of Biomedical Engineering Faculty of Engineering University of Isfahan

AIM To reduce post treatments of kyphoplasty, as a common treatment for osteoporotic *** This study suggests a new method for treating vertebrae by setting the hexagonal porous structure instead of the rigid bone cement mass in the kyphoplasty(KP). The KP procedure was performed on the fresh ovine vertebra of the level L1. Micro finite element modeling was performed based on micro computed tomography of ovine trabecular cube. The hexagonal porous structure was set on one cube instead of the bone cement mass. For the implant designing, two geometrical parameters were considered: Spacing diameter and *** The results of micro finite element analyses indicated the improvement in the mechanical behavior of the vertebra treated by the hexagonal porous structures, as compared to those treated by vertebroplasty(VP) and KP under static loading. The improvement in the mechanical behavior of the vertebra, was observed as 54% decrease in the amount of maximum Von Misses stress(improvement of stress distribution), in trabecular cube with embedded hexagonal structure, as compared to VP and KP. This is comparable to the results of the experimental study already performed; it was shown that the improvement of mechanical behavior of the vertebra was observed as: 83% increase in the range of displacements before getting to the ultimate strength(increasing the toughness) after setting hexagonal pearls inside vertebrae. Both the material and geometry of implant influenced the amount of Von Mises stress in the *** The new proposed method can be offered as a substitute for the KP. The implant geometry had a more obvious effect on the amount of Von Mises stress, as compared to the implant material.

关键词： Vertebroplasty Kyphoplasty Micro finite element modeling Hexagonal porous structure Von mises stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-to micro-pore characterization by synchrotron radiation SAXS and nano-CT for bituminous coals

引用

Frontiers of Earth Science 2021年第2期15卷 189-201页

作者： Yixin ZHAO Chujian HAN Yingfeng SUN nima Noraei DANESH Tong LIU Yirui GAO Beijing Key Laboratory for Precise Mining of Intergrown Energy and Resources China University of Mining and Technology(Beijing)Beijing 100083China School of Energy and Mining Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory of Deep Earth Science and Engineering(Ministry of Education) Sichuan UniversityChengdu 610065China

Considering the complementarity of synchrotron radiation SAXS and nano-CT in the pore structure detection range,synchrotron radiation SAXS and nano-CT methods were combined to characterize the nano-to micropore structure of two bituminous coal *** mesopores,the pore size distribution curves exhibit unimodal distribution and the average pore diameters are similar due to the affinity of metamorphic grades of the two *** macropores,the sample with higher mineral matter content,especially clay mineral content,has a much higher number of *** fractal dimensions representing the pore surface irregularity and the pore structure heterogeneity were also characterized by synchrotron radiation SAXS and *** fractal dimensions estimated by both methods for different pore sizes show consistency and the sample with smaller average pore diameters has a more complex pore structure within the full tested range.

关键词： synchrotron radiation SAXS nano-CT pore size distribution fractal coal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：