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Phalloplasty following penectomy for penile cancer

Asian Journal of Urology 2022年第4期9卷 460-466页

作者： Wai Gin Lee A.nim Christopher David J.Ralph University College London Hospital LondonUnited Kingdom St Peter’s Andrology LondonUnited Kingdom

Objective:Penile reconstruction or phalloplasty following penectomy can be offered where the functional penile length is inadequate for a man to void while standing or to have sexual *** is usually staged due to the complex surgical techniques *** narrative review describes the technical concepts and summarises the contemporary outcomes following phalloplasty in this challenging ***:A retrospective review of the English literature was performed between January 1946 till November *** data were synthesised and complemented by the expert opinion of the authors with 20 years of experience in this *** flaps are ideally designed with an integrated urethra or alternatively,a further free flap urethroplasty can be ***-plasty is further complicated following penectomy by scarring from the previous surgery and the potential loss of structures that would normally be present at the recipient ***:There are limited published data with a total of 19 men recorded in the *** the radial artery forearm free flap and anterolateral thigh flap have been described in this cohort of *** outcomes including standing micturition,sensation in the neo-phallus,and the ability to orgasm are *** quality of life and satisfaction was also good despite the high risk for long-term complications of the neophallus and donor ***:Phalloplasty following penectomy requires microsurgical transfer of a free flap or a pedicled flap to reconstruct a *** erectile device is inserted at a later stage to facilitate sexual intercourse,if *** scarring from penectomy and the potential loss of vasculature that would normally be present at the recipient site may further complicate *** and functional outcomes are acceptable based on the limited published experience to date.

关键词： Humans Male Myocutaneous flap or transplantation Penis or surgery Phalloplasty Reconstructive surgical procedures Retrospective study Surgical flap Thigh or surgery Treatment outcome Urethra or surgery

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Impact of transport of fine and ultrafine particles from open biomass burning on air quality during 2019 Bangkok haze episode

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Journal of Environmental Sciences 2020年第11期32卷 149-161页

作者： Racha Dejchanchaiwong Perapong Tekasakul Surajit Tekasakul Worradorn Phairuang Nobchonnee nim Chaiyoth Sresawasd Kunchira Thongboon Thunyapat Thongyen Panwadee Suwattiga Air Pollution and Health Effect Research Center Prince of Songkla UniversityHat YaiSongkhla 90112Thailand Department of Chemical Engineering Faculty of EngineeringPrince of Songkla UniversityHat YaiSongkhla 90112Thailand Department of Mechanical Engineering Faculty of EngineeringPrince of Songkla UniversityHat YaiSongkhla 90112Thailand Department of Chemistry Faculty of SciencePrince of Songkla UniversityHat YaiSongkhla 90112Thailand Faculty of Environmental Management Prince of Songkla UniversityHat YaiSongkhla 90112Thailand Energy System Research Institute Prince of Songkla UniversityHat YaiSongkhla 90112Thailand Department of Environmental Engineering Faculty of EngineeringPrince of Songkla UniversityHat YaiSongkhla 90112Thailand Department of Technology and Environmental Management Faculty of environmentKasetsart UniversityBangkok 10900Thailand Department of Agro-Industrial Food and Environmental TechnologyFaculty of Applied ScienceKing Mongkut's University of Technology North BangkokBangkok 10900Thailand

Transboundary and domestic aerosol transport during 2018–2019 affecting Bangkok air quality has been *** characteristics of size-segregated ambient particles down to nano-particles collected during 2017 non-haze and 2018–2019 haze periods were *** average PM2.5 concentrations at KU and KMUTNB sites in Bangkok,Thailand during the haze periods were about 4 times higher than in non-haze *** highest average organic carbon and elemental carbon concentrations were 4.6±2.1μg/m3 and 1.0±0.4μg/m3,respectively,in PM0.5–1.0 range at KU *** values of OC/EC and charEC/soot-EC ratios in accumulation mode particles suggested the significant influence of biomass burning,while the nuclei and coarse mode particles were from mixed *** concentrations during 2018–2019 haze period at KU and KMUTNB were 3.4±0.9 ng/m3 and 1.8±0.2 ng/m3,*** PAH diagnostic ratio of PM2.5 also suggested the main contributions were from biomass *** is supported by the 48-hrs backward trajectory *** higher PM2.5 concentrations during 2018–2019 haze period are also associated with the meteorological conditions that induce thermal inversions and weak winds in the morning and *** values of benzo(a)pyrene toxic equivalency quotient during haze period were about 3–6 times higher than during non-haze *** should raise a concern of potential human health risk in Bangkok and vicinity exposing to fine and ultrafine particulate matters in addition to regular exposure to traffic emission.

关键词： Transboundary Domestic Carbonaceous aerosol PAHs Source apportionment

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Revascularization for Iliac-femoral Artery Pseudoaneurysm with Greater Saphenous Vein

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Chinese Medical Sciences Journal 2010年第1期25卷 57-60页

作者： Ji-dong Wu Yue-hong Zheng nim Choi Furtado Rui Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China Department of General Surgery Cir Gen/Vas Central Hospital Centre S. Januario Macao China

Objective To investigate the role of revascularization procedures with autologous greater saphenous vein in surgical management of iliac-femoral artery pseudoaneurysm in parenteral drug abusers. Methods Twenty-one patients with iliac-femoral artery pseudoaneurysm caused by parenteral drug abuse from 2004 to 2007 were enrolled. Among them,15 patients were male and 6 were female; their average age was 31.3 years. The size of pseudoaneurysms ranged from 3.0 cm to 7.5 cm. Common femoral artery and distal external iliac artery were often involved. We performed arterial reconstruction on these patients with autologous greater saphenous vein as a graft after excising iliac-femoral artery pseudoaneurysm through a single curved inguinal incision. All patients were followed up,and the complications were recorded. Results The surgical procedures were finished without intraoperative mortality or perioperative complications. All patients were free of claudication symptoms after the surgery except one case with preoperative popliteal artery stenosis. One case of infection and wound tissue fistula was found later. One case had inguinal incisional hematoma and another complained of numbness in thigh skin. Conclusions The use of autologous greater saphenous venous grafts for arterial reconstruction after pseudoaneurysm excision in drug abusers is safe and effective. This technique offers more advantages than arterial ligation alone without revascularization. An optimal greater saphenous venous graft is a prerequisite for revascularization.

关键词： pseudoaneurysm drug abuser bypass greater saphenous vein

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Fine and ultrafine particle- and gas-polycyclic aromatic hydrocarbons affecting southern Thailand air quality during transboundary haze and potential health effects

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Journal of Environmental Sciences 2023年第2期124卷 253-267页

作者： Napawan Mahasakpan Phatsarakorn Chaisongkaew Muanfun Inerb Nobchonnee nim Worradorn Phairuang Surajit Tekasakul Masami Furuuchi Mitsuhiko Hata Thaniya Kaosol Perapong Tekasakul Racha Dejchanchaiwong Air Pollution and Health Effect Research Center Prince of Songkla UniversityHat YaiSongkhla 90110Thailand Energy Technology Program Faculty of EngineeringPrince of Songkla UniversityHat YaiSongkhla 90110Thailand Faculty of Environmental Management Prince of Songkla UniversityHat YaiSongkhla 90110Thailand Department of Geography Faculty of Social SciencesChiang Mai UniversityMuangChiang Mai 50200Thailand Department of Chemistry Faculty of SciencePrince of Songkla UniversityHat YaiSongkhla 90110Thailand Faculty of Geoscience and Civil Engineering Institute of Science and EngineeringKanazawa UniversityKakuma-machiKanazawaIshikawa 920-1192Japan Department of Civil and Environmental Engineering Faculty of EngineeringPrince of Songkla UniversityHat YaiSongkhla 90110Thailand Department of Mechanical and Mechatronics Engineering Faculty of EngineeringPrince of Songkla UniversityHat YaiSongkhla 90110Thailand Department of Chemical Engineering Faculty of EngineeringPrince of Songkla UniversityHat YaiSongkhla 90110Thailand

Distribution of PM_(0.1),PM_(1) and PM_(2.5) particle-and gas-polycyclic aromatic hydrocarbons(PAHs)during the 2019 normal,partial and strong haze periods at a background location in southern Thailand were investigated to understand the behaviors and carcinogenic ***1 was the predominant component,during partial and strong haze periods,accounting for 45.1% and 52.9% of total suspended particulate matter,respectively,while during normal period the contribution was only 34.0%.PM_(0.1) concentrations,during the strong haze period,were approximately 2 times higher than those during the normal *** increased levels of particle-PAHs for PM_(0.1),PM_(1) and PM_(2.5) were observed during strong haze period,about 3,5 and 6 times higher than those during normal ***-PAH concentrations were 10 to 36 times higher than those of particle-PAHs for PM_(2.5).Average total Benzo[a]Pyrene Toxic Equivalency Quotients(BaP-TEQ)in PM_(0.1),PM_(1) and PM_(2.5) during haze periodswere about 2–6 times higher than in the normal *** total accumulated Incremental Lifetime Cancer Risks(ILCRs)in PM_(0.1),PM_(1) and PM_(2.5) for all the age-specific groups during the haze effected scenario were approximately 1.5 times higher than those in nonhaze scenario,indicating a higher potential carcinogenic *** observations suggest PM_(0.1),PM_(1) and PM_(2.5) were the significant sources of carcinogenic aerosols and were significantly affected by transboundary haze from peatland *** leads to an increase in the volume of smoke aerosol,exerting a significant impact on air quality in southern Thailand,as well as many other countries in lower southeast Asia.

关键词： Particle-PAH Gas-PAH Ultrafine particle Health risk Source identification

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Meta-analysis on randomized controlled trials for scalp acupuncture treatment of stroke：A systematic review

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Journal of Traditional Chinese Medicine 2018年第4期38卷 465-479页

作者： Young-nim You Min-Yeong Song Gwang-Cheon Park Chang-Su Na Jae-Young Han Myung-Rae Cho Jae-Hong Kim Clinical Research Center Dong-Shin University Gwangju Oriental Hospital Gwangju City 61619 Republic of Korea Department of Acupuncture and Moxibustion Medicine College of Korean Medicine Dong-Shin University Naju City 58245 Republic of Korea Department of Korean Rehabilitation Therapy College of Korean Medicine Dong-Shin University Naju City 58245 Republic of Korea Department of Meridians and Acupoints College of Korean Medicine Dong-Shin University Naju City 58245 Republic of Korea Department of Physical & Rehabilitation Therapy Chonnam National University Medical School & Hospital Gwangju City 61619 Republic of Korea

OBJECTIVE:To conduct a systematic review to assess the clinical effectiveness of scalp acupuncture(SA) for ***:Literature searches were performed in7 databases up to 16 August 2014,and all the randomized controlled trials(RCTs) in which SA therapy was administered to stroke patients were *** quality was assessed using the Jadad score,the Cochrane risk of bias assessment,and the Standards for Reporting Interventions in Clinical Trials of ***:Of a total of 2086 papers,21 RCTs were ***-analysis revealed significant differences in the total efficacy rates of the SA group and the body acupuncture(BA) group vs the medication group(P 0.002,P 0.000 001,respectively),the SA plus BA group vs the BA group(P 0.001);in the motor function of the SA plus BA group vs the BA group(P = 0.077);and in the nerve function of the SA group vs the SA plus BA group(P 0.0001).CONCLUSION:The results of our systematic review showed that SA therapy may exhibit effects in treatment efficacy and in the recovery of motor and nervous functions in patients with acute to chronic ***,because of the lack of methodological quality,the thoroughly planned clinical studies are still required.

关键词： Stroke Review ized controlled trial Scalprisk of bias Jadad scoreMeta-analysis Random-acupuncture Cochrane

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细针吸取细胞学的进展

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中华病理学杂志 2006年第5期35卷 306-309页

作者：王念黎澳门镜湖医院病理科

自从上世纪80年代开始,细针吸取活检(fine needle aspiration biopsy,FNAB),又称细针吸取细胞学(fine needle aspiration cytology,FNAC或称FNA)以其具有快捷、损伤少、经济及准确率高的优点,深受临床医生及患者的欢迎,使其应用非常广泛... 详细信息

自从上世纪80年代开始,细针吸取活检(fine needle aspiration biopsy,FNAB),又称细针吸取细胞学(fine needle aspiration cytology,FNAC或称FNA)以其具有快捷、损伤少、经济及准确率高的优点,深受临床医生及患者的欢迎,使其应用非常广泛,几乎涉及全身所有的器官.但是,也因其取材较少导致的取材不满意率和假阴性率高,造成对组织结构观察不满意,分型不够细致和确定等缺点而局限了其应用.此方法对操作人员的技术要求也较高。

关键词：细针吸取细胞学 aspiration needle biopsy 病理科医生 FNAC 细针吸取活检组织结构医疗纠纷细胞病理学

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Hybrid Endovascular Aorta Repair with Simultaneous Supra-aortic Branch or Iliac Branch Revascularization

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Chinese Medical Sciences Journal 2009年第3期24卷 182-185页

作者： Yue-hong Zheng nim Choi Hong-ru Deng CU Kouk Kun Yu Furtado Rui Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China Department of General Surgery Central Hospital Conde S. Januario of Macao Caixa Postal 3002 Macao

Objective To describe a hybrid endovascular procedure for aorta repair with different kinds of bypass followed by concomitant placement of stent graft in the aorta. Methods From June 2007 to May 2008, 5 consecutive patients who presented with aortic aneurysm or dissection were treated with a new hybrid aorta repair technique. Complete surgical rerouting of supra-aortic vessels was simultaneously created by endovascular repair of aortic arch aneurysm with stent graft. Hybrid left carotid-subclavian bypass with stent graft deployment covering the ostium of the left subclavian artery was performed in a Debakey type III aortic dissection case. The supra-aortic branch was revascularized in 2 cases from ascending aorta to bilateral common carotid arteries using a 16-8 mm bifurcated graft, then total aortic arch and descending artery was occluded with stent-graft. The left carotid artery to the left subclavian artery bypass was created in 1 case, followed by stent-graft deployment. Two cases of infrarenal abdominal aortic aneurysm underwent left external iliac artery to left internal iliac artery bypass by a retroperineal route, then hybrid procedure was performed with bifurcated stent-graft. All stent grafts were deployed via a retrograde femoral artery approach in 5 patients. Results Technical success with complete aneurysmal exclusion was achieved in all patients. There was no incidence of encloleak. During a follow-up period of 2 to 10 months, documented perioperative neurologic events did not occur in all patients. One patient suffered from adult respiratory distress syndrome. After received tracheostomy, he recovered later. There was one death resulting from a postoperative myocar- dial infarction. Conclusion Hybrid arch repair provides an alternative therapy to patients otherwise considered prohibitively high risk for traditional open arch and thoracoabdominal aorta repair.

关键词： aortic aneurysm dissection surgery hybrid

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免疫组织化学标记物在乳腺细针吸取细胞学鉴别诊断中的意义

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中华病理学杂志 2006年第12期35卷 738-743页

作者：狄方王念黎澳門镜湖医院病理科

目的探讨免疫标记物对鉴别乳腺细针吸取细胞学(FNAC)良性病变和癌的意义。方法收集135例有随访资料、活检和组织病理学诊断对照的乳腺FNAC资料:良性病变88例,包括非增生性病变43例和增生性病变45例;乳腺癌47例,对其FNAC涂片和相应的石... 详细信息

目的探讨免疫标记物对鉴别乳腺细针吸取细胞学(FNAC)良性病变和癌的意义。方法收集135例有随访资料、活检和组织病理学诊断对照的乳腺FNAC资料:良性病变88例,包括非增生性病变43例和增生性病变45例;乳腺癌47例,对其FNAC涂片和相应的石蜡切片作细胞周期蛋白(cyclin)D1、c-erbB-2、Ki-67、p21CIP1/WAF1(简称p21)和34βE12的免疫组织化学APAAP和ABC法检测。利用SPSS11·5软件进行分析。结果(1)以上各标记物在良性非增生性和增生性病变中的标记差异无统计学意义。(2)以上各标记物在良、恶性病变中的标记差异均有统计学意义(P0·001)。多因素的logistic回归分析显示最有意义的组合标记物为cyclinD1(P0·001)、34βE12(P0·001)和c-erbB-2(P=0·003).cyclinD1、c-erbB-2阳性和34βE12阴性提示为癌,其组合诊断的敏感性和特异性最高。组合标记物共同判断,cyclinD1和34βE12任一判断为癌,诊断的敏感性和特异性分别为95·7%和94·3%;这三个标记物任一判断为癌,诊断的敏感性进一步上升至97·9%,特异性下降至92·0%;这三个标记物任两个共同判断为癌,诊断的敏感性为72·3%,特异性为100·0%。(3)在癌组中,根据Robinson细胞学分级把癌分为3级,cyclinD1、34βE12和p21在各级癌中的表达差异不大,而c-erbB-2和Ki-67在1级癌的阳性表达率最低,仅为40·0%和33·3%,在3级癌中阳性表达率最高。组合cyclinD1和34βE12,cyclinD1和34βE12,任一判断为癌,1级和2级癌的检出率为93·3%和96·2%。结论所检测的免疫标记物对良、恶性病变的鉴别诊断价值较大,组合cyclinD1、34βE12和c-erbB-2可最有效地提高癌的诊断敏感性和特异性。对鉴别分化好的乳腺癌和乳腺良性病变,最有效的组合为cyclinD1和34βE12。

关键词：乳腺肿瘤细胞学细胞周期蛋白D1 角蛋白受体,erbB-2 诊断,鉴别

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软组织黏液性病变的细针吸取细胞学分析

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中华病理学杂志 2007年第9期36卷 619-624页

作者：王念黎狄方澳门特别行政区镜湖医院病理科

目的总结各软组织黏液性病变的细针吸取细胞学(FNAC)特点,确定鉴别良恶性病变和个别病变诊断的细胞学标准及其临床意义。方法总结1993-2006年澳门特别行政区镜湖医院24例软组织黏液性病变(良性病变14例,恶性病变10例)的针吸细胞学改变,... 详细信息

目的总结各软组织黏液性病变的细针吸取细胞学(FNAC)特点,确定鉴别良恶性病变和个别病变诊断的细胞学标准及其临床意义。方法总结1993-2006年澳门特别行政区镜湖医院24例软组织黏液性病变(良性病变14例,恶性病变10例)的针吸细胞学改变,结合临床资料经过及手术后结果进行综合分析。结果腱鞘囊肿(5例)、黏液瘤(5例)及黏液型结节性筋膜炎(3例)是最常见的良性软组织黏液性病变;共同的特点是涂片细胞较少,细胞无明显的不典型性。腱鞘囊肿的特点是吸出黏液后结节消失或明显缩小,涂片不见血管;黏液型结节性筋膜炎的特点是细胞多形性或有节细胞样细胞。黏液型脂肪肉瘤、骨外黏液型软骨肉瘤及黏液型纤维肉瘤是最常见的黏液型肉瘤,其共同的特点是涂片细胞丰富及细胞具有一定的不典型性。黏液型脂肪肉瘤的特点多有鸡爪样纤细的毛细血管或脂肪母细胞;黏液型纤维肉瘤的特点是细胞的多形性与异型性均非常明显。结论结合临床及辅助检查,FNAC 是诊断软组织黏液性病变的有效方法。在软组织病变中,FNAC可为软组织黏液性病变制订治疗计划提供了客观的根据,亦有助于避免某些不必要的切除手术。

关键词：软组织肿瘤活组织检查细针细胞学诊断鉴别

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应用细针吸取细胞技术诊断乳腺导管病变的细胞学指标

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中华病理学杂志 2010年第7期39卷 467-472页

作者：狄方王念黎澳门镜湖医院病理科

目的探讨采用细针吸取细胞学（FNAC）诊断乳腺导管病变的有效和联合的指标，以建立有效的乳腺导管病变FNAC诊断模式。方法收集澳门镜湖医院6年内400例有随访结果的乳腺FNAC病例作回顾性分析。按组织学诊断结果分为导管上皮非增生性病变... 详细信息

目的探讨采用细针吸取细胞学（FNAC）诊断乳腺导管病变的有效和联合的指标，以建立有效的乳腺导管病变FNAC诊断模式。方法收集澳门镜湖医院6年内400例有随访结果的乳腺FNAC病例作回顾性分析。按组织学诊断结果分为导管上皮非增生性病变（104例）和增生性病变（163例）及癌（133例）三组，对涂片进行60个细胞学指标分析，再根据各指标的程度或量采用半定量分级评估。以组织学诊断结果为金标准对病变分类，研究各指标对诊断导管病变的意义。采用Logistic多重回归模型和分类树模型进行统计学分析。结果（1）400例良、恶性病变组，上皮细胞团中掺杂肌上皮细胞（P〈0．05）、上皮细胞排列成大的细胞团（P〈0．05）、上皮细胞排列成小的细胞团（P〈0．05）、细胞质内空泡（P〈0．05）和细胞套细胞（P〈0．1）为有统计学意义的鉴别诊断指标。最重要的鉴别指标为上皮细胞团中有无掺杂有肌上皮细胞。良性病变的诊断指标为上皮细胞团中掺杂有肌上皮细胞，联合大量的上皮细胞排列成大的细胞团，94．4％为良性病变，中等至大量的上皮细胞排列成小的细胞团，倾向为增生性病变；癌的诊断指标为上皮细胞团中无掺杂肌上皮细胞，上皮细胞排列成小的细胞团，细胞质内空泡和细胞套细胞。上皮细胞团中无掺杂肌上皮细胞时，癌占81．3％。（2）267例非增生性和增生性良性导管上皮病变组，上皮细胞团中见不规则的细胞间腔隙（P：0．001）、上皮细胞团成松散排列（P〈0．05）和细胞核深染（P〈0．1）为诊断增生的有意义指标。两结构指标在涂片中出现的量越多，越提示为增生。单一上皮细胞团中见不规则的细胞间腔隙，增生性病变占70．1％；当中等至大量时增生占82．7％，若同时伴上皮细胞团成松散排列，诊断增生的阳性预测价值为87．5％。（3）伴不典型细胞学改变的35例中，组织学诊断26例增生，多为导管上皮增生性纤维腺瘤，极少数为不典型增生或癌。结论在乳腺病变FNAC诊断中，结构指标较细胞指标更重要，联合指标和对其量的评估可更有效地鉴别良恶性病变、非增生性和增生性良性病变；对伴不典型细胞学改变的病例应避免误诊为癌，均应组织活检。

关键词：乳腺疾病癌导管乳腺增生细胞学活组织检查细针诊断

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