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Chinese Journal of Traumatology 2022年第5期25卷 272-276页

作者： nils muhlenfeld.philipp stormann Ingo Marzi Felix Rosenow Adam Strzelczyk Rene D.Verboket Laurent M.Willems Department of Traurma Hand and Reconstructive SurgeryGoethe University FrankfurtFrankfurt Am MainGermany Epilepsy Center Frankfurt Rhine-Main Department of NeurologyGoethe University FrankfurlFrankfurt Am MainGermany LOEWE Center for Personalized Translational Epilepsy Research(CePTER) Goethe-Universitat FrankfurtFrankfurt Am MainGermany Department of Neurology and Epilepsy Center Hessen Philipps-University MarburgMarburg(Lahn)Germany

Purpose: Epileptic seizures frequently result in distinct physical injuries, fractures, traumatic brain injuries and minor trauma. The aim of this study was to retrospectively determine the frequent injury patterns due to seizure episode and to analyze consecutive acute medical care. Methods: This retrospective mono-center study was conducted at Frankfurt University Hospital, Frankfurt am Main, Germany between January 2007 and December 2017. Epilepsy patients with seizure-related fractures admitted to the emergency department were identified via a retrospective systematic query in the hospital information system using the ICD-10 German modification codes G40.0—G40.9. Patients with an unclear diagnosis of epilepsy were excluded. Sociodemographic as well as disease specific aspects were analyzed. Descriptive and Kruskal—Wallis one-way analysis of variance were used for statistical analysis. Results: A total number of 62 epilepsy patients were included. The mean age was 58.1 years. Fractures concerned the upper extremity most frequently (43.5%,n= 20), and 70.0% (14/20) were humerus fractures. Admission to intensive care unit for acute trauma care was necessary in 29.0% patients (n = 18), and surgery in 45.2% patients (n = 28). Twenty-five patients (26.6%) showed clinical or radiological signs of traumatic brain injury. Provoking factors were identified in 20 patients (32.3%), i.e., acute withdrawal or excess of alcohol (n = 15), relevant sleep deprivation (n = 2), and intoxication or withdrawal of other illegal drugs or trivial infect (n = 1 for each) and non-compliance with anti-seizure drugs (n = 1). A decreased T-score (-1.04 ± 1.15) and Z-score (-0.84 ± 0.75) compared to healthy subjects were found. Conclusion: Fractures in upper extremities, trunk and craniocerebral trauma occur frequently as seizure-induced injuries. Alcohol excess and withdrawal are important provoking factors and should be targeted with preventive measurements to avoid seizure related injuries and accidents.

关键词： Epilepsy Wounds and injuries Falls Quality of life

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Heterotopic bone formation in the musculus latissimus dorsi of sheep usingβ-tricalcium phosphate scaffolds:evaluation of different seeding techniques

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Regenerative Biomaterials 2018年第2期5卷 77-84页

作者： Simon Spalthoff Rudiger Zimmerer Jan Dittmann Horst Kokemuller Marco Tiede Laura Flohr philippe Korn nils-Claudius Gellrich philipp Jehn Department of Oral and Maxillofacial Surgery Hannover Medical SchoolCarl-Neuberg-Str.1Hannover 30625Germany Department of Conservative Dentistry Periodontology and Preventive DentistryHannover Medical SchoolCarl-Neuberg-Str.1Hannover 30625Germany

Osseous reconstruction of large bone defects remains a challenge in oral and maxillofacial surgery.In addition to autogenous bone grafts,which despite potential donor-site mobility still represent the gold standard in reconstructive surgery,many studies have investigated less invasive alternatives such as in vitro cultivation techniques.This study compared different types of seeding techniques on pureβ-tricalcium phosphate scaffolds in terms of bone formation and ceramic resorption in vivo.Cylindrical scaffolds loaded with autologous cancellous bone,venous blood,bone marrow aspirate concentrate or extracorporeal in vitro cultivated bone marrow stromal cells were cultured in sheep on a perforator vessel of the musculus latissimus dorsi over a 6-month period.Histological and histomorphometric analyses revealed that scaffolds loaded with cancellous bone were superior at promoting heterotopic bone formation and ceramic degradation,with autogenous bone and bone marrow aspirate concentrate inducing in vivo formation of vital bone tissue.These results confirm that autologous bone constitutes the preferred source of osteoinductive and osteogenic material that can reliably induce heterotopic bone formation in vivo.

关键词： heterotopic bone formation β-tricalcium phosphate bone marrow stromal cells bone marrow aspirate concentrate prevascularization ceramic degradation

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