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Critical role of SDF-1/CXCR4 signaling pathway in stem cell homing in the deafened rat cochlea after acoustic trauma

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Neural Regeneration Research 2018年第1期13卷 154-160页

作者： Ali Asghar Peyvandi Navid Ahmady Roozbahany Hassan Peyvandi Hojjat-Allah Abbaszadeh niloofar majdinasab Mohammad Faridan Somayeh Niknazar Hearing Disorders Research Center Loghman Hakim Medical Center Shahid Beheshti University of Medical Sciences Tehran Iran G. Raymond Chang School Ryerson University Toronto Canada Yale University New Haven CT USA Department of Biology and Anatomical Sciences School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran Department of Occupational Health Engineering School of Health Loorestan University of Medical Sciences Khorramabad Iran

Previous animal studies have shown that stromal cell-derived factor-1 （SDF-1）/CXC chemokine receptor-4 （CXCR4） signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells （BMSCs） to the injured area. In the present study, we aimed to investigate the potential role of chemotactic SDF-1/CXCR4 signaling pathway in the homing of transplanted BMSCs to the injured cochlea after noise-induced hearing loss （NIHL） in a rat model. White noise exposure （110 dB） paradigm was used for hearing loss induction in male rats for 6 hours in 5 days. Distortion-product otoacoustic emission （DPOAE） responses were recorded before the experiment and post noise *** 33342-labeled BMSCs and CXCR4 antagonist （AMD3100）-treated BMSCs were injected into the rat cochlea through the round window. SDF-1 protein expression in the cochlear tissue was assayed using western blot assay. The number of labeled BMSCs reaching the endolymph was determined after 24 ***-1 was significantly increased in the cochlear tissue of rats in the noise exposure group than in the control group. The number of Hoechst 33342-labeled BMSCs reaching the endolymph of the cochlea was significantly smaller in the AMD3100-treated BMSCs group than in the normal BMSCs group. Our present findings suggest that the SDF-1/CXCR4 signaling pathway has a critical role in BMSCs migration to the injured cochlea in a rat model of noise-induced hearing loss.

关键词： nerve regeneration stem cells migration SDF-1/ CXCR4 axis noise-induced hearing loss neural regeneration

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