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Chronic administration of sildenafil improves erectile function in a rat model of chronic renal failure

Asian Journal of Andrology 2015年第5期17卷 797-801,I0008-I0009页

作者： nilgun gurbuz Arif Kol Tumay Ipekci Erhan Ates Asli Baykal Mustafa F Usta Department of Biochemistry Akdeniz University School of Medicine Antalya Turkey Department of Urology Section of Andrology Akdeniz University School of Medicine Antalya Turkey

The relationship between erectile dysfunction （ED） and chronic renal failure （CRF） has been reported in several studies. This study aimed to investigate whether the chronic use of sildenafil could enhance the erectile capacity in CRF-induced rats. In addition, we assessed the effect of that treatment on certain molecules, which have been suggested to play crucial roles in erectile physiology and CRF-related ED as well. Three groups of animals were utilized：（1） age-matched control rats, （2） CRF-induced rats, （3） CRF-induced rats treated with chronic administration of sildenafil （5 mg kg^-1 p.o. for 6 weeks [treatment started after 6 weeks of CRF induction]）. At 3 months, all animals underwent cavernosal nerve stimulation （CNS） to assess erectile function. Penile tissue advanced glycation end products （AGE＇s）/5-hydroxymethyl-2-furaldehyde, malondialdehyde （MDA）, cGMP （ELISA）, inducible nitric oxide synthase （iNOS） and neuronal NOS （nNOS）（Western blot） analyses were performed in all rat groups. CRF-induced rats had a significant decrease in erectile function when compared to control rats （P 〈 0.05）. The increase in both intracavernosal pressure （ICP） and area under the curve of CRF-induced rats treated with sildenafil （Group 3） was greater than CRF-induced rats （Group 2）. Additionally, sildenafil treatment decreased AGE, MDA and iNOS levels, while it preserved nNOS and cGMP contents in CRF-induced penile tissue. Decreased AGE, MDA, iNOS and increased nNOS, cGMP levels at the sildenafil-treated group increased both ICP and Total ICP to CNS, which led to improve erectile function in CRF-induced rats. The results of the present study revealed the therapeutic effect of chronic sildenafil administration on erectile function in CRF-induced rats.

关键词： chronic renal failure erectile function sildenafil

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Hypogonadism and erectile dysfunction： an overview

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Asian Journal of Andrology 2008年第1期10卷 36-43页

作者： nilgun gurbuz Elnur Mammadov Mustafa Faruk Usta Section of Andrology Department of Urology Akdeniz University School of Medicine Antalya 07070 Turkey

In humans androgen decline is presented as a clinical picture which includes decreased sexual interest, diminished erectile capasity, delayed or absent orgasms and reduced sexual pleasure. Additionally, changes in mood, diminished well being, fatigue, depression and irritability are also associated with androgen insufficiency. The critical role of androgens on the development, growth, and maintanence of the penis has been widely accepted. Although, the exact effect of androgens on erectile physiology still remains undetermined, recent experimental studies have broaden our understanding about the relationship between androgens and erectile function. Preclinical studies showed that androgen deprivation leads to penile tissue atrophy and alterations in the nerve structures of the penis. Furthermore, androgen deprivation caused to accumulation of fat containing cells and decreased protein expression of endothelial and neuronal nitric oxide synthases （eNOS and nNOS）, and phosphodiesterase type-5 （PDE-5）, which play crucial role in normal erectile physiology. On the light of the recent literature, we aimed to present the direct effect of androgens on the structures, development and maintanence of penile tissue and erectile physiology as well. Furhermore, according to the clinical studies we conclude the aetiology, pathophysiology, prevalance, diagnosis and treatment options of hypogonadism in aging men.

关键词： testosterone erectile physiology symptomatic late onset hypogonadism

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