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Prevalence of pseudoexfoliation syndrome and its association with ocular and systemic diseases in Eskisehir,Turkey

International Journal of Ophthalmology(English edition) 2017年第1期10卷 128-134页

作者： nilgun yildirim Erdogan Yasar Huseyin Gursoy Ertugrul Colak Department of Ophthalmology Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey Department of Biostatistics Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey

AIM： To investigate the prevalence of pseudoexfoliation syndrome （PEX） and its associations with ocular and systemic diseases in a population sample aged over 40y. METHODS： A total of 2356 subjects were randomly chosen for the sample population based on the database of the Turkish Statistical Agency in Eskisehir. Of the invited 2356 subjects, 2017 subjects participated, out of which 2009 were eligible for the study. Systemic diseases, drug use, smoking and body mass index were assessed using questionnaires. Measurements of central corneal thickness （CCT）, anterior chamber depth （ACD） and intraocular pressure （IOP） were performed during June to December, 2015. After pupillary dilation, the anterior segment and lenses were evaluated using a slit ***： Prevalence of PEX in this sample was 5.0% （n=100）. Of patients with PEX, 26% also had glaucoma. Incidence of cataracts, and using drugs for hypertension, cardiac and psychiatric conditions was higher in patients with PEX compared to normal cases （P〈0.05）. Hearing loss was more common in PEX cases （34.0% vs 5.4%; P〈0.001）. The mean CCT, ACD and IOP were not significantly different between PEX and non-PEX ***： This study is the first population-based, randomized trial in Turkey. Prevalence of PEX in patients over 40 years old was found to be 5.0%. Besides glaucoma and cataract, hypertension, hearing loss, using drugs for cardiac and psychiatric diseases were associated with PEX.

关键词： pseudoexfoliation syndrome pseudoexfoliation glaucoma prevalence of pseudoexfoliation systemic disease Turkey

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Effect of vasoactive intestinal peptide on the wound healing of alkali-burned corneas

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 204-210页

作者： Nese Tuncel nilgun yildirim Firdevs Gurer Hikmet Basmak Kubilay Uzuner Varol Sahinturk Huseyin Gursoy Department of Physiology Eskisehir Osmangazi University Medical Faculty Eskisehir 26480 Turkey Department of Ophthalmology Eskisehir Osmangazi University Medical Faculty Eskisehir 26480 Turkey Department of Histology Eskisehir Osmangazi University Medical Faculty Eskisehir 26480 Turkey

AIM： To study the effect of vasoactive intestinal peptide （VIP） on wound healing in experimental alkali burns of the cornea. METHODS： Twenty-seven albino rabbits, weighing 3.2 -0.75 kg were used. Alkali burns were induced on corneas by applying 10 mm Whatman paper No：50 soaked in 1 mol/L NaOH. They have further classified into 5 groups as follows： 1） control group given no treatment （n=5）; 2） VIP given subconjunctivally （n=6）; 3） VIP injected into anterior chamber （n=6）; 4） NaCI 0.9% given subconjunctivally （n=5）; 5） NaCI 0.9% given into the anterior chamber （n=5）. All treatment protocols except control group were followed by topical eye drops composed of VIP at two hourly intervals for one week from 8 *** to 6 p.m, RESULTS： VIP treated groups of rabbits with alkali burns were found to have better wound healing findings histo-pathologically when compared to those of control group who have received no treatment on day 30. No differences were observed between groups in respect to degree of polymorphonuclear leukocytes （PMNL） infiltration and degree of loss of amorphous substrate on day 15. However, PMNL infiltration and degree of loss of amorphous substrate were lower in Groups 2 and 3 when compared to that of control group on day 30 （P〈0.05）. CONCLUSION： We have shown that VIP has positive effects on alkali induced corneal burns. VIP may inhibit PMNL migration to cornea through an immunomodulatory effect. Inhibition of PMNL migration might reduce the release of collagenaees and this might prevent the extracellular amorphous substance loss.

关键词： vasoactive intestinal peptide alkali-burnedcornea wound healing alkali burn rabbit

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Vasoactive intestinal peptide,a promising agent for myopia?

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 211-216页

作者： Ayse Idil Cakmak Hikmet Basmak Huseyin Gursoy Mete Ozkurt nilgun yildirim Nilufer Erkasap Mustafa Deger Bilgec Nese Tuncel Ertugrul Colak Department of Ophthalmology Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey Department of Physiology Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey Department of Biostatistics Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey

AIM： To investigate the role of vasoactive intestinal peptide（VIP） in form-deprivation myopia（FDM）.METHODS： FDM was created in three groups of eight chicks by placing a translucent diffuser on their right *** injections of saline and VIP were applied once a day into the occluded eyes of groups 2 and 3,*** and axial length（AL） measurements were performed on the first and 8^th days of diffuser *** retina mR NA levels of the VIP receptors and the ZENK protein in right eyes of the three groups and left eyes of the first group on day 8 were determined using real time polymerase chain reaction（PCR）.RESULTS： The median final refraction（D） in right eyes were-13.75（-16.00,-12.00）,-11.50（-12.50,-7.50）,and-1.50（-4.75,-0.75） in groups 1,2,and 3,respectively（P〈0.001）.The median AL（mm） in right eyes were 10.65（10.00,11.10）,9.90（9.70,10.00）,and 9.20（9.15,9.25） in groups 1,2,and 3,respectively（P〈0.001）.The median delta-delta cycle threshold（CT） values for the VIP2 receptors were 1.07（0.82,1.43）,1.22（0.98,1.65）,0.29（0.22,0.45） in right eyes of groups 1,2,and 3,and 1.18（0.90,1.37） in left eyes of group 1,respectively（P=0.001）.The median delta-delta CT values for the ZENK protein were 1.07（0.63,5.03）,3.55（2.20,5.55）,undetectable in right eyes of groups 1,2,and 3 and 1.89（0.21,4.73） in left eyes of group 1,respectively（P=0.001）.CONCLUSION： VIP has potential inhibitory effects in the development of FDM.

关键词： vasoactive intestinal peptide form-deprivation myopia myopia chicks ZENK protein vasoactive intestinal peptide receptor

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COVID-19 vaccine candidates and vaccine development platforms available worldwide

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Journal of Pharmaceutical Analysis 2021年第6期11卷 675-682页

作者： nilgun Duman Zahraa ALzaidi Busra Aynekin Duygu Taskin Busra Demirors Abdulbaki yildirim Izem Olcay Sahin Faik Bilgili Eda Tahir Turanli Tommaso Beccari Matteo Bertelli Munis Dundar Department of Medical Genetics Dragos Hospital IstanbulBezmialem Vakif UniversityIstanbul34854Turkey Department of Biotechnology Faculty of Applied ScienceCukurova UniversityAdana01380Turkey Department of Medical Genetics Medical FacultyErciyes UniversityKayseri38030Turkey Department of Economics Faculty of Economics and Administrative SciencesErciyes UniversityKayseri38030Turkey Department of Molecular Biology and Genetics Faculty of ScienceAcibadem University34684IstanbulTurkey Department of Pharmaceutical Sciences University of PerugiaPerugia06123Italy MAGI'S LAB Trentino38068Italy

The pandemic caused by the worldwide spread of the coronavirus,which first appeared in 2019,has been named coronavirus disease 19(COVID-19).More than 4.5 million deaths have been recorded due to the pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),according to the World Health ***-19 Dashboard in September *** from the wildtype,other variations have been successfully transmitted early in the outbreak although they were not discovered until March *** in the SARS-CoV-2 genetic material,such as mutation and recombination,have the ability to modify the viral life span,along with transitivity,cellular tropism,and symptom *** processes are involved in introducing novel vaccines to the population,including vaccine manufacturing,preclinical studies,Food and Drug Administration permission or certification,processing,and ***-19 vaccine candidates have been developed by a number of public and private groups employing a variety of strategies,such as RNA,DNA,protein,and viral vectored *** comprehensive review,which included the most subsequent evidence on unique features of SARS-CoV-2 and the associated morbidity and mortality,was carried out using a systematic search of recent online databases in order to generate useful knowledge about the COVID-19 updated versions and their consequences on the disease symptoms and vaccine development.

关键词： COVID-19 vaccine Vaccine development platform Coronavirus outbreak SARS-CoV-2 variants Treatment

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