检索结果-南通市图书馆

Gene set enrichment analysis of alpha-glucosidase inhibitors from Ficus benghalensis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical biomedicine 2019年第6期9卷 263-270页

作者： Pukar Khanal b.M.patil Department of Pharmacology and Toxicology KLE College of Pharmacy Belagavi KLE Academy of Higher Education and Research (KAHER)

Objective:To identify alpha-glucosidase inhibitors from Ficus benghalensis and analyze gene set enrichment of regulated protein ***:The phytoconstituents of Ficu.s *** were queried for inhibitors of alphaglucosidase,also identified as aldose reductase *** score,absorption,distribution,metabolism,excretion and toxicity profile,biological spectrum,and gene expression were predicated for each *** study was performed to predict the binding affinity with alpha-glucosidase and aldose reductase and compared with clinically proven *** Encyclopedia of Genes and Genomes pathway analysis was performed for the regulated genes to identify the modulated ***:Apigenin,3,4’,5,7-tetrahydroxy-3’-methoxyflavone,and kaempferol were identified as inhibitors of alpha-glucosidase and aldose *** was predicted to possess the highest binding affinity with both *** p53 signaling pathway was predicted to modulate the majority of protein molecules in diabetes *** the alpha-glucosidase inhibitors were also predicted as membrane integrity agonist and anti-mutagenic ***:The current study indicates alpha-glucosidase inhibitors from Ficus benghale,nsis can act as aldose reductase inhibitors after absorption from the intestinal ***,these phytoconstituents are involved in the regulation of numerous protein molecules and ***,the anti-diabetic efficacies of these compounds are due to their action on multiple protein molecules and synergistic effects which should be confirmed by future investigations.

关键词： Ficus benghalensis Gene set enrichment Kaempferol Network pharmacology Type 2 diabetes mellitus

Un-catalyzed tandem Knoevenagel-Michael reaction for the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols)in aqueous medium

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2011年第12期22卷 1415-1418页

作者： nilesh P.Tale Girdharilal b.Tiwari Nandkishor N.Karade Department of Chemistry Rashtrasant Tukadoji Maharaj Nagpur UniversityNagpurMaharashtra 440 033India

An environmentally benign un-catalyzed one-pot synthesis of 4,4＇-（arylmethylene）bis（1H-pyrazol-5-ols） has been reported via tandem Knoevenagel-Michael reaction of aldehydes with two equivalents of 3-methyl-1-phen... 详细信息

关键词： Knoevenagel reaction Michael addition Aldehydes 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one Aqueous medium

Fluorimetric study of the interaction between ATP and ciprofloxacin-Y^(3+) complex and its application

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2010年第3期28卷 329-332页

作者： Shailaja R.patil Umesh S.Mote Shivajirao R.patil Sang-Hak Lee Govind b.Kolekar Fluorescence Spectroscopy Research Laboratory Department of ChemistryShivaji UniversityKolhapur-416 004MaharashtraIndia Department of Chemistry Kyungpook National UniversityDaeguS.Korea 133-791)

A simple spectrofluorimetric method was developed for determination of trace amount of adenosine disodium triphosphate(ATP).Under the optimum conditions,we studied the interaction between CIP-Y3+-ATP complex by using absorption and fluorescence *** was observed that ATP remarkably enhanced the fluorescence intensity of the CIP-Y3+ complex at λem=415 nm and the enhanced fluorescence intensity of Y3+ ion remained proportional to the concentration of *** developed method was successfully applied for...

关键词： adenosine disodium triphosphate(ATP) ciprofloxacin(CIP) yttrium(Y3+) spectrofluorimetric method rare earths

Progeny evaluation of Jatropha curcas and Pongamia pinnata with comparison to bioproductivity and biodiesel parameters

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2015年第1期26卷 137-142页

作者： Vinod Kumar patil Prithviraj bhandare Pramod b. Kulkarni G.R.Naik Department of biotechnology Gulbarga University

Progeny studies of Jatropha curcas and Pongamia pinnata were carried with respect to bioproductivity,pod and seed characters which is one of the selection methods in tree improvement programmes. Variations in bioproductivity and biodiesel parameters of both the plants were compared every 6 months for 4 years of investigation and analyzed by analysis of variance and correlation coefficient by Pearson＇s method using software Graphpad instat 3.06（for Windows and Mac）. P. pinnata has better germination rate（71.4 %）, 100 pod weight（PW）（311.59 g） and 100 seed weight（SW）（173.46 g） as compared to J. curcas for germination rate（43.2 %）, 100 PW（111.29 g） and 100 SW（67.46 g）. P. pinnata has strong correlation for plant height to canopy growth（CG）（0.948）, collar diameter（CD）（0.994）, number of branches per plant（NbP）（0.995） and to number of leaves per branch（NLb）（0.862） as compared to *** which showed good correlation among plant height to CG（0.976）, CD（0.970）, NbP（0.988）, NLb（0.920） and to number of pods per branch（0.657）. However, J. curcas depicted negative correlation for pod breadth to seed length（SL）（-0.447）, seed breadth（-0.248） and to seed thickness（ST）（-0.364） and among the 100 PW to SL（-0.199）, ST（-0.220） and to 100 SW（-0.704）. About 4 kg of P. pinnata seeds were required for each liter of crude oil which yields896 ml of biodiesel on transesterification as compared to5.66 kg of J. curcas seeds for a liter of crude oil, producing about 663 ml of biodiesel. The quality of biodiesel meets the major specification of American Society for Testing and Materials（ASTM） standards for biodiesel. The crude glycerin and seed cake obtained as byproduct during biodiesel production were also measured which can be purified and used in composting, animal feeds, pharmaceuticals and cosmetic industries.

关键词： biodiesel biofuel plants bioproductivity Jatropha curcas Pongamia pinnata

Impact of La^(3+)substitution on electrical,magnetic,dielectric and optical properties of Ni_(0.7)Cu_(0.1)Zn_(0.2)LaxFe_(2-x)O_(4)(0

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2023年第5期41卷 740-746,I0004页

作者： b.b.patil A.D.Pawar S.S.barate J.S.Ghodake J.b.Thorat T.J.Shinde P.G.Department of Physics Smt.KRP Kanya MahavidyalayaIslampurMS415409India Department of Physics Shivaji UniversityKolhapurMS416004India Departments of Physics PDVP MahavidyalayaMahavidyalayaTasgaonMS416312India Department of Physics Sadguru Gadage Maharaj CollegeKaradMS415110

The oxalate co-precipitation method was used to synthesize the La3+substituted Ni-Cu-Zn(La-NCZ)nanoferrites having chemical composition Ni_(0.7)Cu_(0.1)Zn_(0.2)LaxFe_(2-x)O_(4)(x=0.015,0.025 and 0.035).DC resistivity study of nanoferrites shows both the conducting and semiconducting *** room temperature DC electrical resistivity of Ni-Cu-Zn(NCZ)nanoferrites decreases,whereas Curie temperature increases with increasing La^(3+)*** the temperature range of 30-170℃nanoferrites show p-type semiconducting behavior except x=0.015;thereafter,they show n-type *** frequency dispersive initial permeability(μi)associated with its real and imaginary(μ’andμ")parts are attributed to the domain wall movement and magnetic spin ***μi,u’andμ"of La-NCZ nanoferrites are higher than those of pure NCZ *** constant(ε’),dielectric loss(ε")and AC resistivity(ρAC)of La-NCZ nanoferrites show normal dielectric *** is found thatε’of NCZ nanoferrites decreases with the increasing content of La3+*** bandgap energy of La-NCZ nanoferrites is achieved in the range 1.36-1.70 eV confirming the semiconducting nature of materials.

关键词： Ni-Cu-La-Zn nanoferrites DC electrical Resistivity Permeability Dielectric properties bandgap energy Rare earths

在线全文

学校读者我要写书评

暂无评论

155例男性尿道狭窄处理手术术式

宁夏医科大学学报 1981年第Z1期 87-91页

作者： Umesh b.patil 马成义纽约州北部医学中心泌尿科

本文叙述了155例男性尿道狭窄治疗时手术方式的选择,介绍了手术要点,术后病人随访2—4年。在现代工业社会里,经常发生外伤。在各种意外事故中,泌尿系损伤占3%;骨盆骨折病人泌尿系损伤占5—15%。外伤发生尿道狭窄日益增多,加上淋病和手... 详细信息

本文叙述了155例男性尿道狭窄治疗时手术方式的选择,介绍了手术要点,术后病人随访2—4年。在现代工业社会里,经常发生外伤。在各种意外事故中,泌尿系损伤占3%;骨盆骨折病人泌尿系损伤占5—15%。外伤发生尿道狭窄日益增多,加上淋病和手术损伤导致的尿道

关键词：男性尿道狭窄全厚皮片排泄性外伤性全层皮片尿道成形术尿道球部前列腺手术尿道扩张尿道造影内侧韧带三角韧带

Natural and artificial small RNAs:a promising avenue of nucleic acid therapeutics for cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cancer biology & Medicine 2017年第3期14卷 242-253页

作者： Sunny Yadav Mamta Shekhawat Devashree Jahagirdar nilesh Kumar Sharma Cancer and Translational Research Lab Dr.D.Y Patil Biotechnology&Bioinformatics InstituteDr.D.Y.Patil VidyapeethPune 411033MaharashtraIndia

Since the failure of traditional therapy, gene therapy using functional DNA sequence and small RNA/DNA molecules(oligonucleotide) has become a promising avenue for cancer treatment. The discovery of RNA molecules has impelled researchers to investigate small regulatory RNA from various natural and artificial sources and determine a cogent target for controlling tumor progression. Small regulatory RNAs are used for therapeutic silencing of oncogenes and aberrant DNA repair response *** their advantages, therapies based on small RNAs exhibit limitations in terms of stability of therapeutic drugs, precisionbased delivery in tissues, precision-based intercellular and intracellular targeting, and tumor heterogeneity-based responses. In this study, we summarize the potential and drawbacks of small RNAs in nucleic acid therapeutics for cancer.

关键词： Cancer drug targeting gene intracellular therapeutics tumor heterogeneity

Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats:Role of gastric mucosal glycoproteins and antioxidants

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 610-615页

作者： b.P.Pimple P.V.Kadam M.J.patil P.E.Society's Modern College of Pharmacy NigdiPuneMaharashtraIndia.411044 and Jawaharlal Nehru Technological UniversityHyderabadAndhra PradeshIndia Marathwada Mitra Mandal's College of Pharmacy ThergaonPuneMaharashtraIndia 411033

Objective:To study the comparative gastroprotective effect of Luffa acutangula methanolic extract(LAM) and aqueous extract(LAW) on typeⅡdiabetes ***:Streptozotocin(65 mg/kg,Lp.) along with nicotinamide(120 mg/kg,Lp.) was used to induce non insulin dependent diabetes mellitus(NIDDM) in rats.A daily oral dose of aspirin(200 mg/kg,Lp.) was administered for initial seven days to induce gastric ulcerations in the diabetic *** and LAW were administered orally in the doses of 100,200 and 400 mg/kg once daily for 21 *** and ranitidine were used as standards for comparing the antidiabetic and antiulcer effect ***:LAM significantly(Pbetic rats than LAW(P betic rats close to the normal *** exhibited better ulcer healing effect than glibenclamide and LAW,because of its both antihyperglycemic and mucosal defensive ***:Thus,LAM is proved to be a better alternative for treating gastric ulcers co-occurring with diabetes.

关键词： Aspirin Clibenclamide Nicotinamide Ranitidine Streptozotocin

Integration of network and experimental pharmacology to decipher the antidiabetic action of Duranta repens L.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2021年第1期19卷 66-77页

作者： Pukar Khanal basanagouda M.patil Department of Pharmacology and Toxicology KLE College of Pharmacy BelagaviKLE Academy of Higher Education and ResearchBelagavi 590010India

Objective:Duranta repens is reported to contain a wide array of secondary metabolites,including aamylase and a-glucosidase inhibitors,and-has potent antioxidant *** present study evaluated the network pharmacology of ***(whole plant)with targets related to diabetes mellitus and assessed its outcome by evaluating the effects of the hydroalcoholic extract of *** in streptozotocin-nicotinamide-induced diabetes mellitus in ***:Phytoconstituents of *** were retrieved from an open-source database and published literature,and their targets were predicted for diabetes mellitus using binding Db and the therapeutic target ***-protein interaction was predicted using STRING,and pathways involved in diabetes mellitus were identified using the Kyoto Encyclopedia of Genes and Genomes pathway ***,ADMET profile(absorption,distribution,metabolism,excretion and toxicity)and cytotoxicity of compounds modulating proteins involved in diabetes were predicted using Mol Soft,admet SAR2.0 and CLC-Pred,*** interaction network among phytoconstituents,proteins and pathways was constructed using Cytoscape,and the docking study was performed using Auto *** hydroalcoholic extract of *** was evaluated using streptozotocin-nicotinamide-induced diabetes mellitus animal model for 28 d,followed by an oral glucose tolerance *** the end of the study,biochemical parameters like glycogen content,hepatic enzymes,antioxidant biomarkers and lipid profiles were ***,the liver and pancreas were collected for a histopathology ***:Thirty-six different secondary metabolites from *** were identified to regulate thirty-one targets involved in diabetes mellitus,in which protein-tyrosine phosphatase 1 b(PTP1 b)was primarily *** analysis of modulated proteins identified 12 different pathways in diabetic pathogenesis in which the phosphatidylinositol 3-kinase-protein kinase b(PI3 K-Ak

关键词： Diabetes mellitus Duranta repens DurantaninⅠ Network pharmacology Phosphatidylinositol 3-kinase-protein kinase b signaling pathway Protein-tyrosine phosphatase 1b