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A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

Oncology Research 2024年第5期32卷 849-875页

作者： nilam BHUSARE MAUSHMI KUMAR Somaiya Institute for Research&Consultancy Somaiya Vidyavihar UniversityVidyavihar(East)Mumbai400077India

Glioblastoma,the most aggressive form of brain tumor,poses significant challenges in terms of treatment success and patient *** treatment modalities for glioblastoma include radiation therapy,surgical intervention,and ***,the median survival rate remains dishearteningly low at 12–15 *** of the major obstacles in treating glioblastoma is the recurrence of tumors,making chemotherapy the primary approach for secondary glioma ***,the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance ***,considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing targeted *** tackle glioma,numerous studies have examined kinase-downstream signaling pathways such as *** targeting specific signaling pathways,heterocyclic compounds have demonstrated efficacy in glioma ***,key kinases including phosphatidylinositol 3-kinase(PI3K),serine/threonine kinase,cytoplasmic tyrosine kinase(CTK),receptor tyrosine kinase(RTK)and lipid kinase(LK)have been considered for *** pathways play crucial roles in drug effectiveness in glioma *** compounds,encompassing pyrimidine,thiazole,quinazoline,imidazole,indole,acridone,triazine,and other derivatives,have shown promising results in targeting these *** part of this review,we propose exploring novel structures with low toxicity and high potency for glioma *** development of these compounds should strive to overcome multidrug resistance mechanisms and efficiently penetrate the blood-brain *** optimizing the chemical properties and designing compounds with enhanced drug-like characteristics,we can maximize their therapeutic value and minimize adverse *** the complex nature of glioblastoma,these novel structures should be rigorously tested and e

关键词： Glioblastoma Kinase pathway Pyrimidine Quinazoline Heterocycles

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Improvement of Plasma Performance with Lithium Wall Conditioning in Aditya Tokamak

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Plasma Science and Technology 2013年第2期15卷 123-128页

作者： M. B. CHOWDHURI R. MANCHANDA J. GHOSH S. B. BHATT Ajai KUMAR B. K. DAS K. A. JADEJA P. A. RAIJADA Manoj KUMAR S. BANERJEE nilam ramaiya Aniruddh MALI Ketan M. PATEL Vinay KUMAR P. VASU R. BHATTACHARYAY R. L. TANNA Y. Shankara JOISA P. K. ATREY C. V. S. RAO D. Chenna REDDY P. K. CHATTOPADHYAY R. JHA Y. C. SAXENA Aditya team Institute for Plasma Research Bhat Gandhinagar 382 428 India

Lithiumization of the vacuum vessel wall of the Aditya tokamak using a lithium rod exposed to glow discharge cleaning plasma has been done to understand its effect on plasma performance. After the Li-coating, an increment of ~100 eV in plasma electron temperature has been observed in most of the discharges compared to discharges without Li coating, and the shot reproducibility is considerably improved. Detailed studies of impurity behaviour and hydrogen recycling are made in the Li coated discharges by observing spectral lines of hydrogen, carbon, and oxygen in the visible region using optical fiber, an interference filter, and PMT based systems. A large reduction in O I signal （up to ~40% to 50%） and a 20% to 30% decrease of Ha signal indicate significant reduction of wall recycling. Furthermore, VUV emissions from O V and Fe XV monitored by a grazing incidence monochromator also show the reduction. Lower Fe XV emission indicates the declined impurity penetration to the core plasma in the Li coated discharges. Significant increase of the particle and energy confinement times and the reduction of Zeff of the plasma certainly indicate the improved plasma parameters in the Aditya tokamak after lithium wall conditioning.

关键词： lithiumization wall conditioning impurity Aditya tokamak

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Effects of Nonmonotonic Functional Responses on a Disease Transmission Model:Modeling and Simulation

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Communications in Mathematics and Statistics 2022年第2期10卷 195-214页

作者： Abhishek Kumar nilam Department of Applied Mathematics Delhi Technological UniversityDelhi 110042India

In this article,a novel susceptible-infected-recovered epidemic model with nonmonotonic incidence and treatment rates is proposed and analyzed *** Monod-Haldane functional response is considered for nonmonotonic behavior of both incidence rate and treatment *** model analysis shows that the model has two equilibria which are named as disease-free equilibrium(DFE)and endemic equilibrium(EE).The stability analysis has been performed for the local and global behavior of the DFE and *** the help of the basic reproduction number(R_(0)),we investigate that DFE is locally asymptotically stable when R_(0)*** local stability of DFE at R_(0)=1 has been analyzed,and it is obtained that DFE exhibits a forward transcritical ***,we identify conditions for the existence of EE and show the local stability of EE under certain ***,the global stability behavior of DFE and EE has been ***,numerical simulations have been done in the support of our theoretical findings.

关键词： Monod-Haldane functional Basic reproduction number Local and global stability Bifurcation

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A review article based on composite graphene@tungsten oxide thin films for various applications

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Tungsten 2023年第4期5卷 391-418页

作者： Ayesha Khan B.nilam C.Rukhsar G.Sayali B.Mandlekar Anamika Kadam The Institute of Science Dr.Homi Bhabha State University15Madam Cama RoadFortMumbai400032India Indian Institute of Geomagnetism Mumbai Headquarter(Panvel Campus)Plot 5Sector 18Near KalamboliHighway New Panvel NaviMumbai410218India

Graphene and its derivatives are the hot topics of research during this decade due to their excellent thermal conductivities,mechanical strength,current densities,electron motilities,and large surface *** review article explores the outstanding applicability and features of graphene *** transition metal oxides(TMOs)have also gained considerable research attention due to their unique physicochemical properties in photocatalytic,self-cleaning,and gas sensing *** TMOs,tungsten metal oxides have received a tremendous response as they are naturally abundant,low in cost,less toxic,environmental friendly,and can be manufactured using various physical and chemical *** exhibits a cubic perovskite-like structure based on the corner-sharing of regular octahedra with the oxygen atoms at the corner and the tungsten atoms at the centre of each *** also shows structural polymorphism and sub stoichiometric phase transitions,which attracted the attention of researchers over the past few years to explore their potential in various *** graphene and its derivatives with tungsten oxide(WO_(3))to create heterojunction could be an auspicious tool to improve photocatalysis,energy storage,medical,electrochromism,and energy efficiency *** addition,composite exhibits significantly higher efficiency than either individual material due to their well-matched band edge positions,efficient charge separation,and light-harvesting *** morphology and heterojunction were found to be quite beneficial in improving the overall performance of the *** this review article,the noteworthy endeavors and turning points are accomplished utilizing heterojunction between WO_(3)and graphene derivatives for different *** review article will also provide the research gap and excite new ideas for further improvement of graphene-based tungsten oxide ***,the scope of future research work t

关键词： Tungsten oxide Reduced graphene oxide Composite Photocatalytic Gas sensor Electrochromism

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Study of the Effects of FFA and Obesity on Diabetes Through Numerical Simulation of the Mathematical Model

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Journal of Mathematics and System Science 2015年第6期5卷 252-261页

作者： Saloni Rathee, nilam Department of Applied Mathematics Delhi Technological University Main Bawana Road Shahbad Daulatpur Delhi-110042 lndia.

Aim of the study is to analyze the effect of FFA together with the obesity on the glucose - insulin dynamics of NIDD people through a mathematical model. An attempt has been made to capture the glucose and insulin concentration levels for NIDD people having raised level of FFA and obesity through numerical simulation of the model. It has been observed fi＇om the simulation of the model that elevated level of plasma FFA inhibit glucose uptake, glucose utilization, decrease insulin sensitivity and increase insulin resistance in NIDD people in comparison to the normal people.

关键词： Diabetes NIDD obesity FFA modeling simulation.

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Tamper Detection and Localization for Quranic Text Watermarking Scheme Based on Hybrid Technique

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Computers, Materials & Continua 2021年第7期68卷 77-102页

作者： Ali A.R.Alkhafaji nilam Nur Amir Sjarif M.A.Shahidan Nurulhuda Firdaus Mohd Azmi Haslina Md Sarkan Suriayati Chuprat Razak Faculty of Technology and Informatics University Teknologi MalaysiaKuala Lumpur54000Malaysia

The text of the Quran is principally dependent on the Arabic ***,improving the security and reliability of the Quran’s text when it is exchanged via internet networks has become one of the most difcult challenges that researchers face ***,the diacritical marks in the Holy Quran which represent Arabic vowels(i,j.s)known as the kashida(or“extended letters”)must be protected from *** cover text of the Quran and its watermarked text are different due to the low values of the Peak Signal to Noise Ratio(PSNR),and Normalized Cross-Correlation(NCC);thus,the location for tamper detection accuracy is *** gap addressed in this paper to improve the security of Arabic text in the Holy Quran by using vowels with *** enhance the watermarking scheme of the text of the Quran based on hybrid techniques(XOR and queuing techniques)of the purposed *** methodology propose scheme consists of four phases:The rst phase is *** is followed by the second phase where an embedding process takes place to hide the data after the vowel letters wherein if the secret bit is“1”,it inserts the kashida but does not insert the kashida if the bit is“0”.The third phase is an extraction process and the last phase is to evaluate the performance of the proposed scheme by using PSNR(for the imperceptibility),and NCC(for the security of the watermarking).Experiments were performed on three datasets of varying lengths under multiple random locations of insertion,reorder and deletion *** experimental results were revealed the improvement of the NCC by 1.76%,PSNR by 9.6%compared to available current schemes.

关键词： Text watermarking tamper detection authentication quranic text exclusive-or operation queuing technique

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Payload Capacity Scheme for Quran Text Watermarking Based on Vowels with Kashida

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Computers, Materials & Continua 2021年第6期67卷 3865-3885页

作者： Ali A.R.Alkhafaji nilam Nur Amir Sjarif M.A Shahidan Nurulhuda Firdaus Mohd Azmi Haslina Md Sarkan Suriayati Chuprat Osamah Ibrahim Khalaf Ehab Nabiel Al-Khanak Razak Faculty of Technology and Informatics University Teknologi MalaysiaKuala Lumpur54000Malaysia Al-Nahrain University Al-Nahrain Nanorenewable Energy Research CentreBaghdadIraq Department of Transport and Planning Faculty of Civil Engineering and Geosciences(CiTG)Delft University of TechnologyDelftNetherlands

The most sensitive Arabic text available online is the digital Holy *** sacred Islamic religious book is recited by all Muslims worldwide including non-Arabs as part of their worship ***,it should be protected from any kind of tampering to keep its invaluable meaning *** characteristics of Arabic letters like the vowels(),Kashida(extended letters),and other symbols in the Holy Quran must be secured from *** cover text of the Quran and its watermarked text are different due to the low values of the Peak Signal to Noise Ratio(PSNR)and Embedding Ratio(ER).A watermarking technique with enhanced attributes must,therefore,be designed for the Quran’s text using Arabic vowels with *** gap addressed by this paper is to improve the security of Arabic text in the Holy Quran by using vowels with *** purpose of this paper is to enhance the Quran text watermarking scheme based on a reversing *** methodology consists of four phases:The first phase is a pre-processing followed by the second phase-the embedding process phase—which will hide the data after the *** is,if the secret bit is“1”,then the kashida is inserted;however,the kashida is not inserted if the bit is“0”.The third phase is the extraction process and the last phase is to evaluate the performance of the proposed scheme by using PSNR(for the imperceptibility)and ER(for the capacity).The experimental results show that the proposed method of imperceptibility insertion is also optimized with the help of a reversing *** proposed strategy obtains a 90.5%***,the proposed algorithm attained 66.1%which is referred to as imperceptibility.

关键词： Quran text watermarking Arabic text capacity imperceptibility Kashida vowels reversing technique

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Anthropogenic disturbance of aquatic biodiversity and water quality of an urban river in Penang, Malaysia

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Water Science and Engineering 2023年第3期16卷 234-242页

作者： Nur Azalina Suzianti Feisal Noor Haziqah Kamaludin Muhammad Firdaus Abdullah Sani Dayang Khairulnisa Awang Ahmad Mohd Azwan Ahmad Nur Faiza Abdul Razak Tengku nilam Baizura Tengku Ibrahim Department of Environmental Health Faculty of Health SciencesMAHSA UniversityBandar Saujana Putra42610 JenjaromMalaysia Center of Environmental Health&Safety Faculty of Health SciencesUniversiti Teknologi MARA42300 Puncak AlamMalaysia NaturePRO Services Port Dickson71000 Negeri SembilanMalaysia Department of Environmental Health Faculty of Health SciencesUniversiti Teknologi MARACawangan Pulau PinangKampus Bertam13200 Pulau PinangMalaysia

Malaysia's rapid economic and demographic development have placed negative pressure on its water supplies and the quality of the Juru River, which is close to the nation's capital and its major source of water. Healthy aquatic ecosystems are supported by physicochemical properties and biological diversity. This study evaluated the anthropogenic impacts on aquatic biodiversity, especially plankton, fish, and macrobenthos, as well as the water quality of the Juru River in the Penang area. Aquatic biodiversity and river water parameters were collected from ten sampling stations along the Juru River. Seven variables were used to assess the physicochemical environment: pH, temperature, total suspended solids (TSS), salinity, dissolved oxygen (DO), biochemical oxygen demand (BOD), and chemical oxygen demand. At each sampling station, the total number of plankton, fish, and macrobenthic taxa were counted and analyzed. The relationships between the physicochemical parameters and aquatic biodiversity were investigated with biotypological analysis, principal component analysis, hierarchical cluster analysis, and linear regression analysis. These analyses showed that the richness and diversity indices were generally influenced by salinity, temperature, TSS, BOD, and pH. The data obtained in this study supported the bioindicator concept. The findings, as they related to scientifically informed conservation, could serve as a model for Juru River management, as well as for river management throughout Malaysia and other tropical Asian countries.

关键词： Anthropogenic disturbance Aquatic biodiversity River water quality Urban river Hierarchical cluster analysis

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Transfer out Patients Receiving Antiretroviral Therapy from Programme Clinic: A Potential “Leak” in the HIV Treatment Cascade

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World Journal of AIDS 2014年第4期4卷 382-386页

作者： Manisha Ghate Sunil Zirpe nilam Gurav Ramesh Paranjape Bharat Rewari Raman Gangakhedkar National AIDS Research Institute Pune India National AIDS Control Organization New Delhi India

Background: India has scaled up ART programme very rapidly. Though there are reports on retention of patients in the national programme, data on transfer out patients within the ART centers are scanty in India. Methods: This is a retrospective study of patients receiving antiretroviral treatment between January 2006 and July 2013. The patients who were transferred out from the ART center at National AIDS Research Institute in Pune were included in the study. The data on whether they reached the respective ART centers were collected either by making telephonic calls to the patients and/or to the respective ART centers. Results: Of the total 3015 patients ever started on treatment from the ART center, 158 (5.24%) were transferred out to other ART centers. Of these, 123 (77.8%) patients reached other centres and they were “transferred in”. However, 15 (9.5%) did not reach to respective ART centers and information could not be obtained for 20 (12.7%) transferred out patients. The analysis showed that those who were not living with their partners were 4.53 times more likely to not to reach the preferred ART centre after taking transfer [OR, 95% CI: (1.24 - 16.51), p = 0.022]. Conclusion: Our data suggest that significant number of transfer out patients is lost in HIV treatment cascade. Considering the total PLHIV on treatment in the country, this group adds significantly to the burden of lost to follow up patients. It is important to strengthen the system of tracking the transfer out patients in the programme which will help in patching an important leak in the cascade of HIV care.

关键词： HIV AIDS Transfer out ART Centre

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可客制化系统级芯片降低嵌入式系统故障率

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中国电子商情 2013年第5期 42-46页

作者： nilam Reparelia 美高森美SoC部门

减缓故障主要有两种方式——避免故障和容忍故障。避免故障即是确保系统在参数范围内运作，永远不出现故障状况，不过，故障必然会发生，因而这是一个无法达到的保证，并只会在如小型消费产品这一类故障无关重要的系统中有效。对需要较... 详细信息

减缓故障主要有两种方式——避免故障和容忍故障。避免故障即是确保系统在参数范围内运作，永远不出现故障状况，不过，故障必然会发生，因而这是一个无法达到的保证，并只会在如小型消费产品这一类故障无关重要的系统中有效。对需要较高运作保障水平的设计，如十分重视安全的网络系统，容忍故障就是解决方法。

关键词：嵌入式系统故障率系统级芯片客制化参数范围消费产品网络系统容忍

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