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Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy

Light(Science & Applications) 2023年第11期12卷 2335-2349页

作者： Hailong He nikolina-alexia fasoula Angelos Karlas Murad Omar Juan Aguirre Jessica Lutz Michael Kallmayer Martin Fuchtenbusch Hans-Henning Eckstein Annette Ziegler Vasilis Ntziachristos Institute of Biological and Medical Imaging Helmholtz Zentrum MunchenNeuherbergGermany Chair of Biological Imaging at the Central Institute for Translational Cancer Research(TranslaTUM) School of MedicineTechnical University of MunichMunichGermany Department for Vascular and Endovascular Surgery Klinikum rechts der IsarTechnical University of Munich(TUM)MunichGermany DZHK(German Centre for Cardiovascular Research) partner site Munich Heart AllianceMunichGermany Diabetes Center at Marienplatz MunichGermany Forschergruppe Diabetes e.V. Helmholtz Zentrum MunchenNeuherbergGermany Institute of Diabetes Research Helmholtz Zentrum MunchenNeuherbergGermany

Being the largest and most accessible organ of the human body,the skin could offer a window to diabetes-related complications on the ***,skin microvasculature is typically assessed by histological analysis,which is not suited for applications to large populations or longitudinal *** introduce ultra-wideband rasterscan optoacoustic mesoscopy(RSOM)for precise,non-invasive assessment of diabetes-related changes in the dermal microvasculature and skin micro-anatomy,resolved with unprecedented sensitivity and detail without the need for contrast *** unique imaging contrast,we explored a possible role for RSOM as an investigational tool in diabetes healthcare and offer the first comprehensive study investigating the relationship between different diabetes complications and microvascular features in *** applied RSOM to scan the pretibial area of 95 participants with diabetes mellitus and 48 age-matched volunteers without diabetes,grouped according to disease complications,and extracted six label-free optoacoustic biomarkers of human skin,including dermal microvasculature density and epidermal parameters,based on a novel image-processing *** then correlated these biomarkers to disease severity and found statistically significant effects on microvasculature parameters as a function of diabetes *** discuss how label-free RSOM biomarkers can lead to a quantitative assessment of the systemic effects of diabetes and its complications,complementing the qualitative assessment allowed by current clinical metrics,possibly leading to a precise scoring system that captures the gradual evolution of the disease.

关键词： diabetes anatomy precise

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Improving the phenotypic expression of rice genotypes:Rethinking “intensification” for production systems and selection practices for rice breeding

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The Crop Journal 2015年第3期3卷 174-189页

作者： Norman Uphoff Vasilia fasoula Anas Iswandi Amir Kassam Amod K.Thakur SRI-Rice 624 Bradfield Hall Cornell University Institute of Plant Breeding Genetics and Genomics University of Georgia Soil Biotechnology Laboratory Deptof Soil Science and Land Resources Faculty of Agriculture Institut Pertanian Bogor (IPB) Bogor West Java 16680 Indonesia School of Agriculture Policy and Development University of Reading Reading RG6 6AR UK ICAR-Directorate of Water Management Bhubaneswar 751023 India

Intensification in rice crop production is generally understood as requiring increased use of material inputs: water, inorganic fertilizers, and agrochemicals. However, this is not the only kind of intensification available. More productive crop phenotypes, with traits such as more resistance to biotic and abiotic stresses and shorter crop cycles, are possible through modifications in the management of rice plants, soil, water, and nutrients, reducing rather than increasing material inputs. Greater factor productivity can be achieved through the application of new knowledge and more skill, and(initially) more labor, as seen from the System of Rice Intensification(SRI), whose practices are used in various combinations by as many as 10 million farmers on about 4 million hectares in over 50 countries. The highest yields achieved with these management methods have come from hybrids and improved rice varieties, confirming the importance of making genetic improvements. However,unimproved varieties are also responsive to these changes, which induce better growth and functioning of rice root systems and more abundance, diversity, and activity of beneficial soil organisms. Some of these organisms as symbiotic endophytes can affect and enhance the expression of rice plants' genetic potential as well as their phenotypic resilience to multiple stresses, including those of climate change. SRI experience and data suggest that decades of plant breeding have been selecting for the best crop genetic endowments under suboptimal growing conditions, with crowding of plants that impedes their photosynthesis and growth, flooding of rice paddies that causes roots to degenerate and forgoes benefits derived from aerobic soil organisms, and overuse of agrochemicals that adversely affect these organisms as well as soil and human health. This review paper reports evidence from research in India and Indonesia that changes in crop and water management can improve the expression of rice plants' g

关键词： Expression of genetic potential Rice phenotypes Selection criteria for plant breeding Selection efficiency System of Rice Intensification

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自体、异体和无竞争间的相关及其在植物育种中的意义

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国外农学（麦类作物） 1991年第3期 1-3页

作者： Dionysia A.fasoula 汪自强

引言在特定基因型产量上竞争的可能条件可评估为:(1)同种个体间的竞争,即自体竞争,遗传学一致的基因型同等地利用环境资源且其产量受到均等的限制;(2)与遗传学不同的基因型间的竞争,即异体竞争,不同基因型不均等的利用有效资源且其产量... 详细信息

引言在特定基因型产量上竞争的可能条件可评估为:(1)同种个体间的竞争,即自体竞争,遗传学一致的基因型同等地利用环境资源且其产量受到均等的限制;(2)与遗传学不同的基因型间的竞争,即异体竞争,不同基因型不均等的利用有效资源且其产量非均等地受到限制;(3)完全缺乏竞争,即无竞争,各植株依其遗传潜能利用环境资源而不受其它植株影响。

关键词：植物育种自体竞争异体竞争

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控制芽疫病抗性的一个大豆基因的鉴定、图谱研究和证实

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国外作物育种 2004年第1期23卷 63-64页

作者： VasiliaA．fasoula 向平

由烟草环斑病毒(TRSV)引起的芽疫病能显著降低大豆籽粒产量和籽粒品质。抗性基因的鉴定和抗性品种的培育构成了一个阻止产量损失的有效策略。本研究旨在鉴定和绘制赋予芽疫病抗性的数量性状位点(QTLs)图谱，并在“Young’(抗性)×P14169... 详细信息

由烟草环斑病毒(TRSV)引起的芽疫病能显著降低大豆籽粒产量和籽粒品质。抗性基因的鉴定和抗性品种的培育构成了一个阻止产量损失的有效策略。本研究旨在鉴定和绘制赋予芽疫病抗性的数量性状位点(QTLs)图谱，并在“Young’(抗性)×P1416937(感病)杂交所获得的两个群体中证实它们的基因组位点。

关键词：芽疫病大豆抗性基因鉴定遗传图谱烟草环斑病毒抗病育种

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