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Antiviral adsorption activity of porous silicon nanoparticles against different pathogenic human viruses

Bioactive Materials 2022年第1期7卷 39-46页

作者： Liubov A.Osminkina Svetlana N.Agafilushkina Ekaterina A.Kropotkina nikolay yu saushkin Ivan V.Bozhev Sergei S.Abramchuk Jeanne V.Samsonova Alexandra S.Gambaryan Lomonosov Moscow State University Physics DepartmentLeninskie Gory 1119991MoscowRussian Federation Institute for Biological Instrumentation of Russian Academy of Sciences 142290PushchinoMoscow RegionRussian Federation Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products Russian Academy of Sciences108819MoscowRussian Federation Lomonosov Moscow State University Faculty of ChemistryLeninskie Gory 1119991MoscowRussian Federation Quantum Technology Center Lomonosov Moscow State UniversityPhysics DepartmentLeninskie Gory 1119991MoscowRussian Federation A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences Vavilova 28119991MoscowRussian Federation

New viral infections,due to their rapid spread,lack of effective antiviral drugs and vaccines,kill millions of people every *** global pandemic SARS-CoV-2 in 2019-2021 has shown that new strains of viruses can widespread very quickly,causing disease and death,with significant socio-economic ***,the search for new methods of combating different pathogenic viruses is an urgent task,and strategies based on nanoparticles are of significant *** work demonstrates the antiviral adsorption(virucidal)efficacy of nanoparticles of porous silicon(PSi NPs)against various enveloped and non-enveloped pathogenic human viruses,such as Influenza A virus,Poliovirus,Human immunodeficiency virus,West Nile virus,and Hepatitis *** NPs sized 60 nm with the average pore diameter of 2 nm and specific surface area of 200 m^(2)/g were obtained by ball-milling of electrochemically-etched microporous silicon *** interaction with PSi NPs,a strong suppression of the infectious activity of the virus-contaminated fluid was observed,which was manifested in a decrease in the infectious titer of all studied types of viruses by approximately 104 times,and corresponded to an inactivation of 99.99%viruses in *** sorption capacity of PSi NPs is possible due to their microporous structure and huge specific surface area,which ensures efficient capture of virions,as confirmed by ELISA analysis,dynamic light scattering measurements and transmission electron microscopy *** results obtained indicate the great potential of using PSi NPs as universal viral sorbents and disinfectants for the detection and treatment of viral diseases.

关键词： Pathogenic human viruses Porous silicon nanoparticles Virus Antiviral activity Virucide

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Effects of Substrate Pulse Bias Duty Cycle on the Microstructure and Mechanical Properties of Ti–Cu–N Films Deposited by Magnetic Field-Enhanced Arc Ion Plating

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Acta Metallurgica Sinica(English Letters) 2017年第2期30卷 176-184页

作者： Sheng-Sheng Zhao Yan-Hui Zhao Lv-Sha Cheng Vladimir Viktorovich Denisov nikolay Nikolaevich Koval Bao-Hai yu Hai-Juan Mei School of Mechanical and Electrical Engineering Shenzhen Polytechnic Institute of Metal Research Chinese Academy of Sciences Institute of High Current Electronics Siberian BranchRussian Academy of Sciences

Ti–Cu–N films were deposited on 316 L stainless steel substrates by magnetic field-enhanced arc ion *** effect of substrate pulse bias duty cycle on the chemical composition,microstructure,surface morphology,mechanical and tribological properties of the films was systemically *** results showed that,with increasing the duty cycle,Cu content decreases from 3.3 to 0.58 at.%.XRD results showed that only Ti N phase is observed for all the deposited films and the preferred orientation transformed from Ti N（200） to Ti N（111） plane with the increase in duty *** surface roughness and deposition rate showed monotonous decrease with increasing the duty *** residual stress and hardness firstly increase and then decrease afterwards with the increase in duty cycle,while the variation of critical load shows reverse *** for the film with duty cycle of 10%,others perform the better wear resistance.

关键词： Magnetic field Arc ion plating Ti-Cu-N film Residual stress Hardness

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Discovery of Japalura chapaensis Bourret,1937(Reptilia:Squamata:Agamidae)from Southeast yunnan Province,China

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Zoological Research 2018年第2期39卷 105-113页

作者： Kai Wang Ke Jiang yu-Fan Wang nikolay A.Poyarkov Jr. Jing Che Cameron D.Siler Sam Noble Oklahoma Museum of Natural History & Department of Biology University of Oklahoma Kunming Institute of Zoology Chinese Academy of Sciences Southeast Asia Biodiversity Research Institute Chinese Academy of Sciences Zhejiang Forest Resource Monitoring Center Department of Vertebrate Zoology Biological Faculty Lomonosov Moscow State University

Due to a paucity of surveys in northern Indochina and lack of international collaborations among neighboring countries, recognized distributional ranges for many amphibian and reptile species end at the political borders for some countries, despite seemingly continuous suitable habitat spanning the region. Combining both morphological and genetic data, we report the first discovery of Japalura chapaensis, a rare agamid lizard believed previously to be endemic to northern Vietnam only, along the border region of southeastern yunnan Province,China. To facilitate future research on the genus Japalura sensu lato in Indochina, we provide detailed descriptions of additional specimens of this rare species, including the first description of coloration in life and an expanded diagnosis, and discuss the species boundary of J. chapaensis with respect to its congeners.

关键词： Draconinae Indochina Morphological Variation New record Range extension Systematics Taxonomy

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Diagnostic value ultrasound signs of stones less than or equal to 10 mm and clinicoradiological variants of ureteric colic

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Asian Journal of Urology 2023年第1期10卷 39-49页

作者： Denis V.Krakhotkin Volodymyr A.Chernylovskyi Kemal Sarica Arman Tsaturyan Evangelos Liatsikos Jurijus Makevicius nikolay yu Iglovikov Dmitry N.Pikhovkin Central District Hospital Outpatient ClinicSadovaya Lane 23KamenolomniRostov RegionRussia Private Urological Practice DniproUkraine Department of Urology Biruni University HospitalInstanbulTurkey Department of Urology University Hospital of PatrasPatrasGreece Department of Urology Medical University of ViennaViennaAustria Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Institute of Clinical Medicine Faculty of MedicineVilnius UniversityVilniusLithuania Department and Clinic of Urology S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian FederationSt.PetersburgRussia Central District Hospital Department of SurgeryLenina Avenue 28AksayRostov RegionRussia

Objective:To determine the diagnostic value of ultrasound signs of urinary stones less than or equal to 10 mm and to determine clinico-radiological variants of ureteric ***:A total of 455 ultrasound investigations were performed in patients referring to emergency department with urolithiasis and symptoms suspected of ureteric colic between January 2021 and May *** addition to microscopic evaluation of urine sediment to detect different crystals and non-contrast spiral computed tomography to detect stones,B-mode and color Doppler sonography was performed to assess the presence of acoustic shadow(AS)and twinkle artifacts(TA)as possible signs of stone(s)in ***:While the sensitivity and specificity of AS and TA were higher than 90%in patients with stones greater than 5 mm;positive prognostic values of these parameters were found to be extremely low for stones with sizes of 1-3 mm with specificity and sensitivity values not exceeding 53%.The sensitivity and specificity of AS and TA in the upper and lower ureters were higher for stones greater than or equal to 5 than for compared to those less than 5 *** the same time,the diagnostic values of TA and AS for middle ureter stones were very *** most prevalent clinico-radiological variants of ureteric colic were types I,III,and V being observed in 39%,28% and 21% cases,***:Our results demonstrate that TA and AS parameters seem to have a very low sensitivity and specificity in the diagnosis of urinary stones less than 5 *** diagnostic value of TA and AS increase significantly in stones greater than or equal to 5 ***,clinicians need to be very careful for overestimating the diagnostic values of TA and AS for stones less than 5 mm and non-contrast spiral computed tomography must be the method of choice for patients presenting to emergency department with ureteric colic.

关键词： Ureteric colic Urolithiasis Ultrasound Twinkle artifact Non-contrast computed tomography

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Investigation of the pin-roller metering device and tube effect for wheat seeds and granular fertilizers based on DEM

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International Journal of Agricultural and Biological Engineering 2023年第2期16卷 103-114页

作者： Sugirbay Adilet Kaiyuan Zhao Guangyao Liu Nukeshev Sayakhat Jun Chen Guangrui Hu Lingxin Bu yu Chen Hongling Jin Shuo Zhang Zagainov nikolay Muratkhan Marat College of Mechanical and Electronic Engineering Northwest A&F UniversityXianyang 712100ShaanxiChina College of Water Resources and Architectural Engineering Northwest A&F UniversityXianyang 712100ShaanxiChina Technical Faculty S.Seifullin Kazakh Agrotechnical UniversityAstana 010000Kazakhstan College of Mechatronic Engineering North Minzu UniversityYinchuan 750021China

The metering device is the central part of the seeder discharging granular fertilizers or seeds from the hopper to the colter passing through the *** on the metering device design,the batches of particles are discharged or discharged *** research analyzes existing metering devices,and a new pin-roller metering device is recommended to discharge evenly high doses of granular fertilizers and wheat seeds at low rotation *** objective was to adapt the metering device to precision agriculture so that a little electric motor containing gearbox drives every metering ***,the pin-roller metering device parameters were investigated to apply high doses of granular fertilizers and wheat seeds *** optimal pin positions were determined according to response surface methods(RSM)by simulating the granular fertilizers and wheat seeds'behavior on *** coefficient of variation(CV)and the slip rate(SR)of the particles between the pins were chosen as indicators for evaluating the *** shape of the pin was specified,and then the number of lines,the number of pins in a line,and the pin height were chosen to *** analysis of the simulation results shows the optimal parameters:the number of pins in a line is four,and the number of lines is *** SR of granular fertilizers and wheat seeds were 8%and 2%,*** pin-roller metering device is compared with the six-grooved and twelve-grooved metering *** comparison results show that the pin-roller metering device distributes twice more uniformly than other metering *** CV of the granular fertilizer distribution for six-grooved,twelve-grooved,and pin-roller metering devices was 111.13%,80.74%,and 37%,*** CV of the wheat seed distribution for twelve-grooved and pin-roller metering devices was 96%,and 37%,*** long as the particles interact with the tube,leaving the metering device,the effect of tube type and position is investi

关键词： pin-roller metering device DEM coefficient of variation slippage rate tube

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Application of quantum-statistical methods to studies of thermodynamic and radiative processes in hot dense plasmas

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Matter and Radiation at Extremes 2019年第5期4卷 17-27页

作者： nikolay yu.Orlov Maxim A.Kadatskiy Oleg B.Denisov Konstantin V.Khishchenko Joint Institute for High Temperatures of the Russian Academy of Sciences Izhorskaya 13 Bldg 2Moscow 125412Russia Moscow Institute of Physics and Technology Institutskiy Pereulok 9DolgoprudnyMoscow Region 141701Russia

Calculations of thermodynamic and radiative characteristics of hot dense plasmas within different quantum-statistical approaches,such as the use of the Hartree–Fock–Slater model and the ion model,are *** equations of state of different substances are used to investigate findings from absolute and relative measurements of the compressibility of solid aluminum samples in strong shock *** is shown that our calculated Hugoniot adiabat of aluminum is in a good agreement with experimental data and other theoretical results from first *** present a review of the most important applications of the quantum-statistical approach to the study of radiative properties of hot dense *** includes the optimization problem of hohlraum wall materials for laser inertial fusion,calculations of the radiative efficiency of complex materials for optically thin plasma in X-pinch,modeling of radiative and gas-dynamic processes in plasma for experiments,where both intense laser and heavy ion beams are used,and temperature diagnostics for X-and Z-pinch plasmas.

关键词： radiative quantum thermodynamic

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Afterpulse measurement of JUNO 20‑inch PMTs

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Nuclear Science and Techniques 2023年第1期34卷 136-145页

作者： Rong Zhao nikolay Anfimov yu Chen Hang Hu Jun Hu Xiao‑Lu Ji Denis Korablev Min Li Alexander Olshevskiy Zhao‑yuan Peng Arseny Rybnikov Zhong‑Hua Qin Jun Wang Wei Wang Zhi‑Min Wang Björn Wonsak School of Physics Sun Yat-sen UniversityGuangzhou 510275China Joint Institute for Nuclear Research Dubna 141980Russia Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Particle Detection and Electronics Beijing 100049China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China State Key Laboratory of Particle Detection and Electronic Beijing 100049China Institut für Experimentalphysik Universität HamburgHamburg 20148Germany

In this study,we present the large photomultiplier tube(PMT)afterpulse measurement results obtained from the Jiangmen underground neutrino observatory(JUNO)experiment.A total of 11 dynode-PMTs(R12860)from the Hamamatsu company(Hamamatsu Photonics K.K.(HPK))and 150 micro-channel plate PMTs(MCP-PMTs,GDB-6201)from the NNVT company(North Night Vision Technology Co.,Ltd.(NNVT))were ***,an afterpulse model was built according to the afterpulse time distribution and the probability of occurrence for these two types of *** average ratio of the total afterpulse charge with a delay between 0.5μs and 20μs to the primary pulse charge is∼5.7%(13.2%)for the tested MCPPMTs(dynode-PMTs).The JUNO experiment will deploy 20,01220-inch PMTs;this study will benefit detector simulation,event reconstruction,and data analysis regarding the JUNO experiment.

关键词： Afterpulse MCP-PMT JUNO Dynode-PMT 20-inch PMT

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Database system for managing 20,00020-inch PMTs at JUNO

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Nuclear Science and Techniques 2022年第3期33卷 10-21页

作者： Jun Wang nikolay Anfimov Jing-yuan Guo yu Gu Hang Hu Min Li Qiu-Mei Ma Alexander Olshevskiy Zhao-yuan Peng Zhong-Hua Qin Alexander Tietzsch Bjorn Wonsak Wei Wang Zhi-Min Wang Mei-Hang Xu Wan Xie Zheng-yun You Hai-Qiong Zhang Rong Zhao School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Joint Institute for Nuclear Research Dubna 141980Russia College of Science and Engineering Ji Nan UniversityGuangzhou 510632China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Particle Detection and Electronics Beijing 100049China Physikalisches Institut Eberhard Karls Universitat Tubingen72074 TubingenGermany Institut fur Experimentalphysik Universitat Hamburg20148 HamburgGermany Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China

A database system,known as the large PMT characterization and instrumentation database system(LPMT-CIDS),was designed and implemented for the Jiangmen Underground Neutrino Observatory(JUNO).The system is based on a Linux+Apache+MySQL+PHP(LAMP)server and focuses on modularization and architecture *** covers all the testing stages for the 20-inch photomultiplier tubes(PMTs)at JUNO and provides its users with data storage,analysis,and visualization *** on the successful use of the system in the 20-inch PMT testing program,its design approach and construction elements can be extended to other projects.

关键词： LAMP Photomultiplier tubes Jiangmen underground neutrino observatory Data visualization

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东方山羊豆GoGID基因表达载体构建及紫花苜蓿转化

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草地学报 2015年第1期23卷 167-172页

作者：李俊温红雨高洪文 Dzyubenko nikolay Chapurin Vladimir 王学敏中国农业科学院北京畜牧兽医研究所北京100193 俄罗斯瓦维洛夫全俄植物栽培研究所圣彼得堡190000

根据已经克隆得到的东方山羊豆赤霉素受体(GoGID)基因,扩增编码区cDNA。以pBI121为基础载体,采用酶切连接法,构建植物超表达载体pBI121-GoGID。酶切鉴定表明:目的基因已经正确插入载体中,超表达载体构建成功。采用CaCl_2冻融法将重组载... 详细信息

根据已经克隆得到的东方山羊豆赤霉素受体(GoGID)基因,扩增编码区cDNA。以pBI121为基础载体,采用酶切连接法,构建植物超表达载体pBI121-GoGID。酶切鉴定表明:目的基因已经正确插入载体中,超表达载体构建成功。采用CaCl_2冻融法将重组载体转入农杆菌菌株中。以叶片为外植体,采用农杆菌介导的愈伤组织培养法,转化紫花苜蓿(Medicage sativa),得到抗性苗。对载体携带的nptⅡ基因、GUS基因进行PCR检测均成阳性,表明目的基因已成功导入紫花苜蓿基因组中。同时对转基因植株进行Southern-blot及RT-PCR检测,并均得到目的条带。本研究为进一步分析GoGID基因对紫花苜蓿生物量影响奠定了基础。

关键词：东方山羊豆赤霉素受体紫花苜蓿遗传转化

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基于GPS观测研究中国东北地区现今地壳形变特征

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地震 2019年第3期39卷 11-27页

作者：于吉鹏孟国杰苏小宁 nikolay Shestakov Mikhail Gerasimenko Hiroaki Takahashi Mako Ohzono 刘泰李承涛中国地震局地震预测重点实验室(地震预测研究所) 北京100036 Far Eastern FederalUniversity Vladivostok690068Russia Institute of Applied Mathematics Far EasternBranch of Russian Academy of SciencesVladivostok690091Russia Institute ofSeismology and Volcanology Hokkaido UniversitySapporo0600810Japan

基于中国东北和俄罗斯远东东南部2012—2017年的GPS观测数据,利用包含年周期、半年周期、线性项和阶跃项的函数模型拟合GPS站坐标时间序列,得到ITRF2014下的速度场,并进一步转换到欧亚参考框架下得到相对欧亚板块的速度场。基于多尺度... 详细信息

基于中国东北和俄罗斯远东东南部2012—2017年的GPS观测数据,利用包含年周期、半年周期、线性项和阶跃项的函数模型拟合GPS站坐标时间序列,得到ITRF2014下的速度场,并进一步转换到欧亚参考框架下得到相对欧亚板块的速度场。基于多尺度球面小波方法解算应变率场,并分析了其空间分布特征,同时研究了各GPS站对2011年日本东北M_W9.0大地震的震后松弛响应特征和背景形变场特征。结果表明:①若不扣除日本东北大地震的松弛效应,相对欧亚板块中国东北主体上表现为东南方向运动,在依兰—伊通断裂和嫩江断裂带之间,地壳表现为逆时针旋转,其他区域向东南方向运动,方向一致性较好,在敦化—密山断裂东侧速度大小明显增加。敦化—密山断裂和依兰—伊通断裂两侧拉张量分别为3.96±0.04 mm/a和0.71±0.05 mm/a,两条断裂的剪切运动不明显。总体上,面应变率显示出NW—SE向的拉张和NE—SW向的挤压,面应变率显示出依兰—伊通断裂南端、嫩江断裂带北端和俄罗斯远东东南部呈挤压状态。在依兰—伊通断裂、敦化—密山断裂南侧以及俄罗斯远东东南部最大剪应变率相对较大。②各GPS测站对2011年日本东北M_W9.0大地震震后松弛的响应整体上表现为东南向运动,松弛形变量随震中距增加而减小。松弛效应的面应变率总体上表现为NW—SE向的拉张和NE—SW向的挤压,面应变率显示出依兰—伊通、敦化—密山断裂南端、嫩江断裂带北端以及俄罗斯远东地区具有挤压特征,其他地区表现为拉张特征。中国与俄罗斯远东边界南端存在一个明显的最大剪应变率高值区。③扣除日本东北M_W9.0大地震引起的松弛变形后,总体上面应变率仍然表现为NW—SE向的拉张和NE—SW向的挤压,面应变率最大值仍然位于依兰—伊通断裂和敦化—密山断裂南端、第二松花江断裂带以及俄罗斯远东和中国边界最南段。在依兰—伊通断裂、敦化—密山断裂南端,中国与俄罗斯远东边界南端的最大剪应变率高值区仍然存在,表明这些地区应变积累较快,并且一直在持续。

关键词：应变率场多尺度球面小波日本东北M_W9.0大地震震后粘弹性松弛中国东北地区

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