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Toward nanoscale molecular mass spectrometry imaging via physically constrained machine learning on co-registered multimodal data

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npj Computational Materials 2020年第1期6卷 956-963页

作者： nikolay Borodinov Matthias Lorenz Steven T.King Anton v.Ievlev Olga S.Ovchinnikova Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA University of Tennessee KnoxvilleTNUSA

Mass spectrometry imaging(MSI)plays a pivotal role in investigating the chemical nature of complex systems that underly our understanding in biology and *** fields of life science such as proteomics,lipidomics and metabolomics benefit from the ability to simultaneously identify molecules and pinpoint their distribution across a ***,achieving the necessary submicron spatial resolution to distinguish chemical differences between individual cells and generating intact molecular spectra is still a challenge with any single imaging ***,we developed an approach that combines two MSI techniques,matrix-assisted laser desorption/ionization(MALDI)and time-of-flight secondary ion mass spectrometry(ToF-SIMS),one with low spatial resolution but intact molecular spectra and the other with nanometer spatial resolution but fragmented molecular signatures,to predict molecular MSI spectra with submicron spatial resolution.

关键词： modal mass constrained

How the adoption of industry 4.0 technologies is related to participation in global and domestic value chains: Evidence from Russia

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International Journal of Innovation Studies 2024年第2期8卷 93-108页

作者： Anna A.Fedyunina nikolay A.Gorodnyi Yuri v.Simachev Centre for Industrial Policy Studies National Research University Higher School of EconomicMoscow11Pokrovsky BoulevardZip Code:101000Russia

This study explores the relationships among Industry 4.0 technologies, their application areas,and the involvement of Russian manufacturing firms in global and domestic value chains. Weapply logit and multinomial logit regressions using an original survey dataset of approximately1700 Russian manufacturing firms. We make a novel contribution to the literature by uncoveringan asymmetry in adopting Industry 4.0 technologies among Russian industrial firms in domesticvalue chains (DvCs) and global value chains (GvCs). This asymmetry has the potential to impedeGvC localization and DvC internationalization. Based on our results, software automation solu-tions are the only ones demonstrating statistical significance for firms participating simulta-neously in GvCs, DvCs, and both GvCs and DvCs. Companies in DvCs demonstrate a broaderutilization of Industry 4.0 technologies across various application areas. We also identify evidenceof reshoring in DvCs, indicating that Industry 4.0 adoption encourages firms to establish enduringrelationships with domestic suppliers. Highlighting that differences in technology adoption areinfluenced by external factors, including adherence to international standards and regulatoryprinciples, we propose policy implications for developing countries. Recommendations encom-pass reducing entry barriers to DvCs, improving procurement transparency, and promotingcompetition in the digital solutions market to empower firms for seamless GvC integration.

关键词： Industry 4.0 Global value chains Domestic value chains Forward linkages Backward linkages

GSC 4560–02157: a new long-period eclipsing cataclysmic variable star

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Research in Astronomy and Astrophysics 2015年第7期15卷 1005-1011页

作者： Anton v.Khruslov Anatoly v.Kusakin Elena A.Barsukova vitaly P.Goranskij Azamat F.valeev nikolay N.Samus Institute of Astronomy Russian Academy of Sciences Fesenkov Astrophysical Institute Special Astrophysical Observatory Russian Academy of Sciences Sternberg Astronomical Institute Lomonosov Moscow State University

We study the newly discovered variable star GSC 4560-02157. CCD photometry was performed in 2013-2014 at the Tien Shan Astronomical Observatory,and a spectrum was obtained with the 6-m telescope of the Special Astrophysical Observatory in June, 2014. GSC 4560-02157 is demonstrated to be an eclipsing variable star（P = 0.265359d）. All its flat-bottom primary minima are approximately at the same brightness level, but the star＇s out-of-eclipse brightness and brightness at secondary minima vary considerably（by up to 0.6m） from cycle to cycle. Moreover,there are short-term（time scale of 0.03-0.04 days） small-amplitude brightness variations out of eclipse. This behavior suggests a cataclysmic nature for the star, which is confirmed with a spectrum taken on 2014 June 5. The spectrum shows numerous emissions of the hydrogen Balmer series, He Ⅰ and He Ⅱ.

关键词： stars: dwarf novae -- binaries: eclipsing -- stars: individual: GSC 4560-02157

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Autoimmunity in acute ischemic stroke and the role of bloodbrain barrier: the dark side or the light one?

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Frontiers of Medicine 2019年第4期13卷 420-426页

作者： nikolay v. Tsygan Alexandr P. Trashkov Igor v. Litvinenko viktoriya A. Yakovleva Alexandr v. Ryabtsev Andrey G. vasiliev Leonid P. Churilov Department of Molecular and Radiation Biophysics B.P. Konstantinov Petersburg Nuclear Physics Institute Gatchina Leningrad Region 188300 Russian Federation Department of Nervous Diseases S.M. Kirov Military Medical Academy Saint Petersburg 194044 Russian Federation Department of Experimental Pharmacology I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry Saint Petersburg 194223 Russian Federation Department of Pathological Physiology with the Course of Immunopathology Saint Petersburg State Pediatric Medical University Saint Petersburg Russian Federation Department of Pathology Laboratory of the Mosaic of Autoimmunity Saint Petersburg State University Saint Petersburg 199034 Russian Federation

This article presents a synopsis of the current data on the mechanisms of blood-brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia-reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising.

关键词： stroke blood-brain barrier autoimmunity innate immunity inflammation cell death

Catalytic co-combustion of biomass and brown coal in a fluidized bed:Economic and environmental benefits

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Journal of Environmental Sciences 2024年第6期140卷 24-36页

作者： Yury v.Dubinin nikolay A.Yazykov Petr M.Yeletsky Roman B.Tabakaev Aleksandra I.Belyanovskaya vadim A.Yakovlev Federal Research Center Boreskov Institute of Catalysis SB RAS Lavrentiev Ave.5Novosibirsk630090Russia University of Tyumen Volodarskogo str.6Tyumen625003Russia

The work is devoted to the study of combustion of brown coal,pine sawdust,and their mixtures in a fluidized bed of catalyst at 600-750℃.It is shown that an increase in the content of sawdust in a mixture with brown coal leads to an increase in the burnout degree of solid fuel from 94.4%to 99.9%,while the emission of greenhouse gases in the form of CO_(2)CO and NOxis reduced(CO_(2)from the biomass is not included in the balance).The high content of alkaline earth metal oxides(CaO and MgO)in the mineral part of brown coal,sawdust,and their mixtures eliminates the emission of sulfur oxides and the slagging of heat-exchange surfaces during the combustion in a fluidized bed of *** optimal temperature,when the highest burnout degree of the above fuels is achieved in the combustion is 750℃.It is also shown that the increase in temperature and the content of sawdust in the composition of the fuel mixtures has a positive effect on the economic and environmental process indicators.

关键词： Co-combustion Fluidized catalyst bed Biomass Coal Economic effect Environmental impact

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Deep carbon cycling during subduction revealed by coexisting diamond-methane-magnesite in peridotite

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National Science Review 2023年第10期10卷 15-17页

作者： Xiaoxia Wang Yilin Xiao Hans-Peter Schertl nikolay v.Sobolev Yang-Yang Wang He Sun Deshi Jin Dong-Bo Tan CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of China CAS Center for Excellence in Comparative Planetology Ruhr-University Bochum Faculty of Geosciences Institute of GeologyMineralogy and Geophysics v.S.Sobolev Institute of Geology and Mineralogy Siberian Branch of Russian Academy of Sciences School of Resources and Environmental Engineering Hefei University of Technology

Subduction is an important process for transferring materials from the surface into the deep *** subduction,recycled carbon can be released from the subducting slab to the mantle wedge through various decarbonation *** oxidized(CO2/CO32-) and reduced(CH4) carbon-bearing species have been discovered in(ultra)high-pressure(HP-UHP) subduction zones worldwide [1-3].Diamond is a typical index mineral for UHP metamorphism.

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A new genus and three new species of miniaturized microhylid frogs from Indochina(Amphibia: Anura:Microhylidae: Asterophryinae)

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Zoological Research 2018年第3期39卷 130-157页

作者： nikolay A.Poyarkov Chatmongkon Suwannapoom Parinya Pawangkhanant Akrachai Aksornneam Tang van Duong Dmitriy v.Korost Jing Che Department of vertebrate Zoology Biological Faculty Lomonosov Moscow State University Joint Russian-vietnamese Tropical Research and Technological Center 3. Division of Fishery School of Agriculture and Natural Resources University of Phayao 4. Department of Zoology Faculty of Science Kasetsart University vietnam National Museum of Nature Vietnam Academy of Science and Technology Petroleum Geology Department Geological Faculty Lomonosov Moscow State University 7. State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Southeast Asia Biodiversity Research Institute Chinese Academy of Sciences

We report on the discovery of a new genus of microhylid subfamily Asterophryinae from northern and eastern Indochina, containing three new *** Gen. nov. are secretive miniaturized frogs(SvLvince in central vietnam, Cao Bang Province in northern vietnam, and Chiang Rai Province in northern Thailand proved to be separate species, different both in morphology and genetics(genetic divergence 3.1%≤P≤5.1%). Our work provides further evidence for the "out of Indo-Eurasia"scenario for Asterophryinae, indicating that the initial cladogenesis and differentiation of this group of frogs occurred in the Indochina Peninsula. To date, each of the three new species of vietnamophryne Gen. nov. is known only from a single specimen; thus,their distribution, life history, and conservation status require further study.

关键词： vietnamophryne Gen. nov. vietnamophryne inexpectata sp. nov. vietnamophryne orlovi sp. nov. vietnamophryne occidentalis sp. nov. Siamophryne Gastrophrynoides mtDNA micro-CT scanning vietnam Thailand Herpetofauna Amphibia Biogeography Taxonomy Indochina

Deep neural networks for understanding noisy data applied to physical property extraction in scanning probe microscopy

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npj Computational Materials 2019年第1期5卷 932-939页

作者： nikolay Borodinov Sabine Neumayer Sergei v.Kalinin Olga S.Ovchinnikova Rama K.vasudevan Stephen Jesse Center for Nanophase Materials Science Oak Ridge National LaboratoryOak RidgeTN 37831USA

The rapid development of spectral-imaging methods in scanning probe,electron,and optical microscopy in the last decade have given rise for large multidimensional *** many cases,the reduction of hyperspectral data to the lower-dimension materialsspecific parameters is based on functional fitting,where an approximate form of the fitting function is known,but the parameters of the function need to be ***,functional fits of noisy data realized via iterative methods,such as least-square gradient descent,often yield spurious results and are very sensitive to initial ***,we demonstrate an approach for the reduction of the hyperspectral data using a deep neural network approach.A combined deep neural network/least-square approach is shown to improve the effective signal-to-noise ratio of band-excitation piezoresponse force microscopy by more than an order of magnitude,allowing characterization when very small driving signals are used or when a material’s response is weak.

关键词： neural networks property

Kinetics and mechanism of the low-energy β-a phase transition of the second kind in 2,4-dinitroanisole

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Defence Technology（防务技术） 2024年第10期40卷 210-224页

作者： Aleksandr v.Stankevich nikolay A.Rasputin Anisa KhRudina Gennady L.Rusinov vera I.Filyakova valery N.Charushin I.Ya. Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciencesekaterinburg 620108russia Russian Federal Nuclear Center-Zababakhin All-Russia Research Institute of Technical Physics snezhinsk 456770russia Kazan National Research Technological University kazan 420015russia

In this work, comprehensive studies of 2,4-dinitroanisole(2,4DNAN) were carried out using powder thermorentgenography of the internal standard. The time of the complete polymorphic transition in the solid phase β→a in 2,4DNAN under various combinations of conditions has been determined. It has been established that, regardless of the season of manufacture of the substance, when it is stored for 8-9months, with a change in ambient temperature from minus 30℃ to plus 30℃, a complete polymorphic transition β→a occurs. When stored in conditions below minus 5℃, polymorphic transition does not occur. When stored in conditions above plus 30℃ in a closed container, polymorphic transition occurs within 3 weeks. The polymorphic transition is accompanied by a decrease in density by 1.3%-1.5% and an increase in melting temperature by 10-12℃, depending on the degree of purity of the starting substance. The activation energy of the molecular rearrangement was 68-70 k J/mol(16.5 ± 3 kcal/mol). The mechanism of polymorphic transition has been evaluated, which is presumably based on internal homodiffusion and energy transfer to the surface of the mass of powder particles and the product. The average activation energy of the polymorphic transition process was 110 ± 6.2 k J/mol(26.2 kcal/mol). In an open container, reactions proceed by a homogeneous mechanism, and in a closed container by a heterogeneous mechanism involving the gas phase.

关键词： Energetic materials Melt-castable 2,4-Dinitroanisole Polymorphic transition Kinetics Mechanism Homodiffusion Sublimation

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