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The Reliability of Fibro-test in Staging Orthotopic Liver Transplant Recipients with Recurrent Hepatitis C

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Journal of Clinical and Translational Hepatology 2020年第1期8卷 9-12页

作者： Panagiotis Trilianos Adamantios Tsangaris Augustine Tawadros Vrushak Deshpande nikolaos Pyrsopoulos Division of Gastroenterology&Hepatology University HospitalRutgers-New Jersey Medical SchoolNJUSA

Background and Aims:Liver biopsy remains the gold stand-ard for staging of chronic liver disease following orthotopic liver *** assessment of fibrosis with Fibro-test(FT)is well-studied in immunocompetent populations with chronic hepatitis C virus *** aim of this study is to investigate the diagnostic value of FT in the assessment of hepatic fibrosis in the allografts of liver transplant recipients with evidence of recurrent hepatitis ***:We retro-spectively compared liver biopsies and FT performed within a median of 1 month of each other in orthotopic liver transplan-tation recipients with recurrent hepatitis ***:The study population comprised 22 patients,most of them male(19/22),and with median age of 62 *** all patients,there was at least a one-stage difference in fibrosis as assessed by liver biopsy compared to FT,while for the majority(16/22)there was at least a two-stage *** absence of correlation between the two modalities was statistically demonstrated(Mann-Whitney U test,p=0.01).In detecting significant fib-rosis(a METAVIR stage of F2 and above),an FT cut-off of 0.5 showed moderate sensitivity(77%)and negative predictive value(80%),but suboptimal specificity(61%)and positive predictive value(58%).Conclusions:In post-transplant pa-tients with recurrent hepatitis C,FT appears to be inaccurately assessing the degree of allograft fibrosis,therefore limiting its reliability as a staging tool.

关键词： Fibro-test Orthotopic liver transplantation Fibrosis Recurrent hepatitis C Hepatitis C virus

Update on the association of hepatitis B with intrahepatic cholangiocarcinoma:Is there new evidence?

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World Journal of Gastroenterology 2021年第27期27卷 4252-4275页

作者： nikolaos Fragkou Lazaros Sideras Panteleimon Panas Christos Emmanouilides Emmanouil Sinakos Fourth Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642Greece Department of Oncology Interbalkan Medical CenterThessaloniki 57001Greece

Intrahepatic cholangiocarcinoma(iCCA)is a subgroup of cholangiocarcinoma that accounts for about 10%-20%of the total *** with hepatitis B virus(HBV)is one of the most important predisposing factors leading to the formation of *** has been recently estimated based on abundant epidemiological data that the association between HBV infection and iCCA is strong with an odds ratio of about *** HBV-associated mechanisms that lead to iCCA are under intense *** diagnosis of iCCA in the context of chronic liver disease is challenging and often requires histological confirmation to distinguish from hepatocellular *** is currently unclear whether antiviral treatment for HBV can decrease the incidence of *** terms of management,surgical resection remains the mainstay of *** is a need for effective treatment modalities beyond resection in both first-and second-line *** this review,we summarize the epidemiological evidence that links the two entities,discuss the pathogenesis of HBV-associated iCCA,and present the available data on the diagnosis and management of this cancer.

关键词： Cholangiocarcinoma Hepatitis B Intrahepatic Hepatocellular carcinoma Resection Chemotherapy

Autoimmune Hepatitis Induced after Treatment of Syphilitic Hepatitis

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 174-177页

作者： Hasan Ali Taqi Rizvi Mumtaz Niazi Mark Galan nikolaos Pyrsopoulos Department of Internal Medicine Rutgers University New Jersey Medical SchoolNewarkNJUSA Edward Via College of Osteopathic Medicine SpartanburgSCUSA Division of Gastroenterology and Hepatology Rutgers University New Jersey Medical SchoolNewarkNJUSA Department of Pathology Immunology and Laboratory MedicineRutgers University New Jersey Medical SchoolNewarkNJUSA

We present a unique case of biopsy-proven syphilitic hepa-titis which presented as severe acute liver injury with sig-nificant elevation in aminotransferases and bilirubin,and improved with antibiotic ***,the patient re-turned weeks after initial presentation with new-onset acute liver injury and had developed hypergammaglobulinemia,positive autoantibody titers,and repeat liver biopsy dem-onstrating interface hepatitis,supporting a diagnosis of autoimmune *** had an otherwise unrevealing etiologic workup,and responded to glucocorticoid *** believe that syphilitic hepatitis and its treatment sub-sequently triggered an immunogenic response,leading to autoimmune *** hepatitis is a chronic liver disease thought to manifest as a result of predisposing genetic factors in combination with environmental insults,especially hepatotropic *** is a sexually transmitted disease caused by Treponema pallidum that has been associated with autoimmunity and the develop-ment of *** propose that in the setting of syphilitic hepatitis,a molecular mimicry event resulting from structural similarities between *** and liver antigens,as well as impaired regulatory T-cell function,led to the breakdown of immune tolerance and the onset of au-toimmune *** support this hypothesis,further mo-lecular analyses and case series are necessary to determine if syphilitic hepatitis and its treatment are risk factors for the onset of autoimmune *** hepatitis should be considered early as the cause of acute liver injury in susceptible patients with risk factors for the disease,as prompt recognition and appropriate treatment may prevent progression of liver injury and result in improved outcomes.

关键词： Autoimmune hepatitis Syphilis Molecular mimicry

Acute acalculous cholecystitis due to infectious causes

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World Journal of Clinical Cases 2021年第23期9卷 6674-6685页

作者： Ioulia Markaki Afroditi Konsoula Lamprini Markaki nikolaos Spernovasilis Marios Papadakis Department of Emergency General Hospital of Kythira“Trifyllio”Kythira 80200Greece Department of Emergency General Hospital of Mytilene"Vostaneio"Lesvos 81132Greece Department of Pediatrics "Agia Sofia"Children's HospitalAthens 11527Greece School of Medicine University of CreteHeraklion 71003Greece Department of Surgery II University of Witten-HerdeckeWuppertal 40235NRWGermany

Acute acalculous cholecystitis(AAC)is an inflammation of the gallbladder not associated with the presence of *** usually occurs in critically ill patients but it has also been implicated as a cause of cholecystitis in previously healthy *** this subgroup of patients,infectious causes comprise the primary ***,herein,discuss the pathophysiological mechanisms involved in AAC,focusing on the infectious *** associated with critical medical conditions is caused by bile stasis and gallbladder *** mechanisms are reported to be involved in AAC in patients without underlying critical illness including direct invasion of the gallbladder epithelial cells,gallbladder vasculitis,obstruction of the biliary tree,and *** emphasize that multiple pathogenic mechanisms may concurrently contribute to the development of AAC in varying *** of the implicated pathogens is essential since it will allow a more focused examination of the histopathological *** conclusion,additional research and a high degree of clinical suspicion are needed to clarify the complex spectrum of mechanisms that are involved in the pathogenesis of AAC.

关键词： Cholecystitis Infectious causes Vasculitis Sequestration Epstein-Barr virus

Yolk-sac larval development of the substrate-brooding cichlid Archocentrus nigrofasciatus in relation to temperature

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Integrative Zoology 2015年第5期10卷 497-504页

作者： nikolaos VLAHOS Michael VASILOPOULOS Eleni MENTE George HOTOS George KATSELIS Kosmas VIDALIS Department of Aquaculture and Fisheries Technological Educational Institution of Western GreeceMesollonghiGreece Department of Ichthyology and Aquatic Environment School of Agricultural SciencesUniversity of ThessalyVolosGreece

In order to conserve and culture the cichlid fish Archocentrus nigrofasciatus,more information about its reproductive biology and its larval behavior and morphogenesis is ***,temperatures ranging from 21 to 27°C are used in ornamental aquaculture *** temperatures are preferred to reduce the costs of water heating,and 23°C is usually the selected ***,there is limited information on culturing protocols for ornamental species and most of the information generated on this topic remains ***,the present study examines the morphological development of Archocentrus nigrofasciatus during the yolk-sac period up to the age of 100 h post-hatching in relation to 2 temperature regimes used in ornamental aquaculture:a temperature of 27°C(thermal optimum)and a decreased temperature of 23°C(thermal tolerance).The results of this study suggest that the 27°C temperature generates intense morphological changes in yolk-sac development in a shorter *** has advantages as it reduces the time of yolk-sac larval development,and,thus,minimizes the transition phase to exogenous feeding and maximizes the efficiency at which yolk is converted into body *** present paper provides necessary information to produce freshwater ornamental fish with better practices so as to increase larval survival and capitalize on time for growth.

关键词： Archocentrus nigrofasciatus convict cichlid growth yolk-sac development temperature

Synthesis of carbon nanotubes loaded hydroxyapatite: Potential for controlled drug release from bone implants

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Journal of Advanced Ceramics 2016年第3期5卷 232-243页

作者： Lisa COSTANTINI nikolaos BOUROPOULOS Dimitrios G.FATOUROS Ioanna KONTOPOULOU Marta ROLDO School of Pharmacy and Biomedical Science University of Portsmouth St Michael's BuildingWhite Swan Road Portsmouth UK Department of Materials Science University of Patras 26504 Rio Patras GreeceFoundation for Research and Technology Hellas-Institute of Chemical Engineering and High Temperature Chemical Processes—FORTH/ICEHT P.O.Box 1414 GR 26504 Patras Greece Department of Pharmaceutical Technology School of Pharmacy Aristotle University of ThessalonikiGR-54124 Thessaloniki Greece Department of Materials Science University of Patras 26504 Rio Patras Greece

Carbon nanotubes (CNTs) can support the building of flexible and porous scaffolds for bone regeneration. Various studies have looked at the mixing of CNTs with hydroxyapaptite for the formulation of bone implants. In the present work, we report the one step preparation and characterisation of chitosan/hydroxyapatite/CNTs composite materials obtained by wet precipitation of hydroxyapatite (HA) in the presence of chitosan or its amphiphilic derivative N-octyl-O-sulphate chitosan and CNTs. The in situ precipitation of HA assured inclusion of the polysaccharide and the CNTs in the HA structure and provided materials with the ability to control the release of different model drugs.

关键词： carbon nanotubes (CNTs) hydroxyapatite (HA) composites bone regeneration chitosan

Non-linear optimal control for multi-DOF electro-hydraulic robotic manipulators

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IET Cyber-Systems and Robotics 2020年第2期2卷 96-106页

作者： Gerasimos Rigatos nikolaos Zervos Masoud Abbaszadeh Jorge Pomares Patrice Wira Unit of Industrial Automation Industrial Systems Institute26504Rion PatrasGreece Unit of Digital Communications Industrial Systems Institute26504Rion PatrasGreece GE Global Research General Electric12309 New YorkUSA Department of Systems Engineering University of Alicante03690 AlicanteSpain IRIMAS Universitéd’Haute Alsace68093MulhouseFrance

A non-linear optimal(H-infinity)control approach is proposed for the dynamic model of multi-degree-of-freedom(DOF)electro-hydraulic robotic *** of electro-hydraulic manipulators is a non-trivial problem because of their non-linear and multi-variable *** this study,the considered robotic system consists of a multi-link robotic manipulator that receives actuation from rotary electro-hydraulic *** article's approach relies first on approximate linearisation of the state-space model of the electro-hydraulic manipulator,according to first-order Taylor series expansion and the computation of the related Jacobian *** the approximately linearised model of the manipulator,a stabilising H-infinity feedback controller is *** compute the controller's gains,an algebraic Riccati equation is solved at each time-step of the control *** global stability properties of the control scheme are proven through Lyapunov *** proposed control method retains the advantages of typical optimal control,*** and accurate tracking of the reference setpoints under moderate variations of the control inputs.

关键词： manipulators robotic optimal

Facing the challenge of venous thromboembolism prevention in patients undergoing major abdominal surgical procedures for gastrointestinal cancer

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World Journal of Gastrointestinal Oncology 2018年第10期10卷 328-335页

作者： Aikaterini Mastoraki Sotiria Mastoraki Dimitrios Schizas Raphael Patras nikolaos Krinos Ioannis S Papanikolaou Andreas Lazaris Theodore Liakakos nikolaos Arkadopoulos 4th Department of Surgery National and Kapodistrian University of AthensAttikon University HospitalAthens 12462Greece Department of Vascular Surgery National and Kapodistrian University of AthensAttikon University HospitalAthens 12462Greece 1st Department of Surgery National and Kapodistrian University of AthensLaikon HospitalAthens 11527Greece

Venous thromboembolism(VTE)refers to a hypercoa-gulable state that remains an important and preven-table factor in the surgical treatment of *** includes two identical entities with regards to deep vein thrombosis and pulmonary *** incidence of VTE after major abdominal interventions for gastro-intestinal,hepato-biliary and pancreatic neoplastic disor-ders is as high as 25%without *** use of classic or low-molecular-weight heparin,anti-Xa factors,antithrombotic stocking,intermittent pneumatic compression devices and early mobilization have been ***,thromboprophylaxis is often dis-continued after discharge,although a serious risk may persist long after the initial triggering event,as the coagu-lation system remains active for at least 14 d *** aim of this review is to evaluate the results of the current practice of VTE prevention in cancer patients undergoing major abdominal surgical operations,with special attention to adequately elucidated guidelinesand widely accepted *** addition,the recent literature is presented in order to provide an update on the current concepts concerning the surgical manage-ment of the disease.

关键词： Deep vein thrombosis Pulmonary embolism Gastro-intestinal cancer Thromboprophylaxis Venous thromboembolism

Beta-blocker treatment in heart failure patients with atrial fibrillation:challenges and perspectives

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Journal of Geriatric Cardiology 2021年第5期18卷 362-375页

作者： Emmanouil Chourdakis Ioanna Koniari Dimitrios Velissaris Grigorios Tsigkas nikolaos G Kounis Neriman Osman Krankenhaus der Barmherzigen Brüder Trier Germany Manchester Heart Institute Manchester University Foundation TrustManchesterUnited Kingdom Department of Internal Medicine University Hospital of PatrasPatrasGreece Cardiology Department University Hospital of PatrasPatrasGreece

Heart failure(HF)and atrial fibrillation(AF)are common conditions that share similar clinical phenotype and frequently *** classification of HF in patients with preserved ejection fraction(>50%,HFpEF),midrange reduced EF(40%−49%,HFmrEF)and reduced EF(<40%,HFrEF)are crucial for optimising the therapeutic approach,as each subgroup responds *** constitute an important component of our pharmacological regimen for chronic *** administration is reccomended in patients with HF with reduced ejection fraction in stable sinus rhythm,due to improvement of symptoms,the better long termoutcome and *** beneficial role of betablocker use in patients with preserved EF still remain unclear,as no treatment showed a positive impact,regarding morbidity or mortality *** presence of AF in HF patients increases as the disease severity evolves and is associated with a higher rate of cardiovascular morbidity and *** more question is the use of betablocker in HF patients irrespective of EF and concomitant *** are many conflicting data and publications,regarding the beta blocker benefit in this ***,it is supported an attenuation of betablockers beneficial effect in HF patients with AF.A design of more randomised trials/studies with HF patients and concomitant AF may improve our clinical approach of betablockers use and identify the patients with HF,who mostly profit from an invasive approach.

关键词： treatment evolve mostly