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PERIODIC SYSTEMS WITH TIME DEPENDENT MAXIMAL MONOTONE OPERATORS

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Acta Mathematica Scientia 2024年第4期44卷 1280-1300页

作者： Zhenhai LIU nikolaos S.PAPAGEORGIOU Center for Applied Mathematics of Guangri Yulin Normal UniversityYulin 537000China Guangri Key Laboratory of Universities Optimization Control and Engineering Calculation College of Mathematics and PhysicsGuangri Minzu UniversityNanning 530006China Department of Mathematics National Technical UniversityZografou Campus15780 AthensGreece

We consider a first order periodic system in R^(N),involving a time dependent maximal monotone operator which need not have a full domain and a multivalued *** prove the existence theorems for both the convex and nonconvex *** also show the existence of extremal periodic solutions and provide a strong relaxation ***,we provide an application to nonlinear periodic control systems.

关键词： periodic boundary condition time-dependent maximal monotone operator convex and nonconvex problems extremal solutions strong relaxation

Role of exosomal circular RNAs as microRNA sponges and potential targeting for suppressing hepatocellular carcinoma growth and progression

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World Journal of Gastroenterology 2024年第9期30卷 994-998页

作者： nikolaos Papadopoulos Eleni-Myrto Trifylli The Second Department of Internal Medicine 401 General Army Hospital of AthensAthens 11525Greece The First Department of Internal Medicine 417 Share Army Fund HospitalAthens 11521Greece

In this editorial,we comment on the article by Lyu et al published in the recent issue of the World Journal of Gastroenterology(2023;2219-2840).Hepatocellular carcinoma(HCC)is a frequently encountered and highly aggressive primary liver cancer,which remains the third-commonest cause of cancer-related death despite the current therapeutic *** is urgency in developing novel thera-peutic approaches,such as by manipulating extracellular vesicles,which con-stitute a highly heterogeneous nanoparticle population that contains various *** cargoes have a pivotal role in cell-to-cell communication and can modify the functional level of the recipient cells via their uptake by other recipient *** non-coding RNAs have particular evolving significance in HCC,such as circular RNAs,which have been found differentially expressed in normal hepatic and HCC *** aberrations in their expression levels have a key role in the HCC development and progression and the overall *** this editorial,we will shed light on the emerging role of exosomal circular RNAs in HCC development and progression,focusing on the oncogenic or potentially tumor suppressive effect of mesenchymal stem cells-derived exosomal non-coding RNAs.

关键词： circular sponge progression

Multifunctional HDPE/Cu biocidal nanocomposites for MEX additive manufactured parts: Perspectives for the defense industry

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Defence Technology（防务技术） 2024年第8期38卷 16-32页

作者： Nectarios Vidakis nikolaos Michailidis Markos Petousis Nektarios K.Nasikas Vassilios Saltas Vassilis Papadakis nikolaos Mountakis Apostolos Argyros Mariza Spiridaki Ioannis Valsamos Department of Mechanical Engineering Hellenic Mediterranean UniversityHeraklion 71410Greece Physical Metallurgy Laboratory Mechanical Engineering DepartmentSchool of EngineeringAristotle University of ThessalonikiThessaloniki 54124Greece Centre for Research&Development of Advanced Materials(CERDAM) Center for Interdisciplinary Research and InnovationBalkan CentreThessaloniki 57001Greece Division of Mathematics and Engineering Sciences Department of Military SciencesHellenic Army AcademyVari GR16673AtticaGreece Department of Electronic Engineering Hellenic Mediterranean UniversityChania 73133Greece Department of Industrial Design and Production Engineering University of West AtticaAthens 12244Greece Institute of Electronic Structure and Laser Foundation for Research and Technology-HellasHeraklion 70013Greece

In this study, we investigated the performance improvement caused by the addition of copper(Cu)nanoparticles to high-density polyethylene(HDPE) matrix material. Composite materials, with filler percentages of 0.0, 2.0, 4.0, 6.0, 8.0, and 10.0 wt% were synthesized through the material extrusion(MEX)3D printing technique. The synthesized nanocomposite filaments were utilized for the manufacturing of specimens suitable for the experimental procedure that followed. Hence, we were able to systematically investigate their tensile, flexural, impact, and microhardness properties through various mechanical tests that were conducted according to the corresponding standards. Broadband Dielectric Spectroscopy was used to investigate the electrical/dielectric properties of the composites. Moreover, by employing means of Raman spectroscopy and thermogravimetric analysis(TGA) we were also able to further investigate their vibrational, structural, and thermal properties. Concomitantly, means of scanning electron microscopy(SEM), as well as atomic force microscopy(AFM), were used for the examination of the morphological and structural characteristics of the synthesized specimens, while energy-dispersive Xray spectroscopy(EDS) was also performed in order to receive a more detailed picture on the structural characteristics of the various synthesized composites. The corresponding nanomaterials were also assessed for their antibacterial properties regarding Staphylococcus aureus(S. aureus) and Escherichia coli(E. coli) with the assistance of a method named screening agar well diffusion. The results showed that the mechanical properties of HDPE benefited from the utilization of Cu as a filler, as they showed a notable improvement. The specimen of HDPE/Cu 4.0 wt% was the one that presented the highest levels of reinforcement in four out of the seven tested mechanical properties(for example, it exhibited a 36.7%improvement in the flexural strength, compared to the pure matrix). At the same

关键词： High-density polyethylene(HDPE) Copper(Cu) Material extrusion(MEX) Mechanical performance Electrical properties Antibacterial Defense and security

Downstaging strategies for unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第20期30卷 2731-2733页

作者： Georgia Sofia Karachaliou nikolaos Dimitrokallis Dimitrios P Moris Division of Gastroenterology Department of MedicineDuke University Medical CenterDurhamNC 27710United States First Department of Surgery&Organ Transplant Unit Evangelismos General HospitalAthens 10676Greece Department of Surgery Duke University Medical CenterDurhamNC 27710United States

A significant number of patients with hepatocellular carcinoma(HCC)are usually diagnosed in advanced stages,that leads to inability to achieve *** options are focusing on downstaging a locally advanced *** is wellsupported in the literature that patients with HCC who undergo successful conversion therapy followed by curative-intent surgery may achieve a significant survival benefit compared to those who receive chemotherapy alone or those who are successfully downstaged with conversion therapy but not treated with *** artery infusion chemotherapy can be a potential downstaging strategy,since recent studies have demonstrated excellent outcomes in patients with colorectal liver metastatic disease as well as primary liver malignancies.

关键词： Unresectable hepatocellular carcinoma Hepatic arterial infusion chemotherapy Downstaging Hepatocellular carcinoma

Beamline design for multipurpose muon beams at CSNS EMuS

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Nuclear Science and Techniques 2024年第5期35卷 1-12页

作者： Yang Hong Ying-Peng Song Lu-Ping Zhou Jing-Yu Tang Zhi-Hao Zhou nikolaos Vassilopoulos Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China Radiotherapy Physics and Technology Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Xi’an Jiaotong University Health Science Center Xi’an 710049China Department of Radiation Oncology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

A new muon beam facility,called the Experimental Muon Source(EMuS),was proposed for construction at the China Spallation Neutron Source(CSNS).The design of the complex muon beamlines for the EMuS baseline scheme,which is based on superconducting solenoids,superferric dipoles and room-temperature magnets,is presented *** muon beams,including surface muons,decay muons and low energy muons,have been developed for multipurpose *** optics design and simulation results of the trunk beamline and branch beamlines are *** a proton beam power of 25 kW at a standalone target station that consists of a conical graphite target and high-field superconducting solenoids,the muon beam intensity in the trunk beamline varies from 10^(7)/s for surface muons to 10^(10)/s for high-momentum decay *** at the endstations,these values vary from 10^(5)/s for surface muons to 10^(8)/s for decay muons.

关键词： Surface muons Decay muons Muon beamline Superconducting solenoids Multi-channel electrostatic separator

Slope stability of reclaimed coal mines through a new water filling index

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 828-839页

作者： Antonios Mikroutsikos Alexandros I.Theocharis nikolaos C.Koukouzas Ioannis E.Zevgolis Chemical Process&Energy Resources Institute Centre for Research&Technology HellasAthensGreece School of Mining and Metallurgical Engineering National Technical University of AthensAthensGreece

A common reclamation practice for closed coal surface mines is filling them with water to form pit *** creation and sustainability of these lakes are significantly affected by the stability of the corresponding *** present study provides a general framework for analyzing the water filling’s effect on slope stability based on a new water filling index,which can indirectly consider the factors affecting the process and efficiently quantify the filling speed’s *** assumptions of the proposed approach are thoroughly discussed,and the range of the water filling index is ***,the safety factor is calculated using the finite element method with the shear strength reduction technique during the filling process for various conditions(soil properties,slope geometry,hydraulic conditions,and water filling speed).Results are presented as normalized stability charts for practical *** the water filling,the stability gradually decreases until the reservoir reaches a critical level of 10%e40%of the total height;it then increases to even more stable conditions than the initial ***,the present analysis allows for the preliminary stability evaluation of a coal mine during the formation of a pit lake and the appropriate quantification of the water filling’s effect.

关键词： Post-coal era Open-pit flooding Stability charts Critical level

Drawing lines in the sand: The growing threat of obesity in type 1 diabetes

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World Journal of Diabetes 2024年第5期15卷 823-827页

作者： Theocharis Koufakis Dimitrios Patoulias Ioanna Zografou nikolaos Papanas Djordje S Popovic Second Propedeutic Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642Greece Diabetes Centre Second Department of Internal MedicineDemocritus University of ThraceAlexandroupolis 68100Greece Clinic for Endocrinology Diabetes and Metabolic DisordersClinical Center of VojvodinaMedical FacultyUniversity of Novi SadNovi Sad 21000Serbia

In this editorial,we comment on the article by Zeng et al published in the recent issue of the World Journal of Diabetes in *** focus on the epidemiological,pathophysiological,and clinical interplay between obesity and type 1 diabetes mellitus(T1DM).Overweight and obesity represent a growing threat for modern societies and people with T1DM could not be an exception to this *** exogenous insulin administration,genetic and epigenetic factors,and psy-chosocial and behavioral parameters,along with the modern way of life that incorporates unhealthy eating patterns and physical inactivity,set the stage for the increasing obesity rates in *** our knowledge of the underlying mechanisms that lead to the development of obesity and hyperglycemia expands,it becomes clear that there are overlap zones in the pathophysiology of the two main types of *** regarding strict dividing lines between“autoimmune”and“metabolic”phenotypes increase the risk of trapping physicians into ineffective therapeutic approaches,instead of individualized diabetes *** this context,the use of adjuncts to insulin therapy that have the potential to alleviate cardiorenal risk and decrease body weight can reduce the burden of obesity in patients with T1DM.

关键词： Obesity Overweight Type 1 diabetes Metabolic syndrome

Stochastic PDEs for large portfolios with general mean-reverting volatility processes

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Probability, Uncertainty and Quantitative Risk 2024年第3期9卷 263-300页

作者： Ben Hambly nikolaos Kolliopoulos Mathematical Institute University of OafordRadcliff Observatory QuarterWoodstock RoadOrfordOX26GGUK Department of Mathematics University of Michigan2074 East Hall530 Church StreetAnn ArborMI 48109-1043USA

We consider a structural stochastic volatility model for the loss from a large portfolio of credit risky *** the asset value and the volatility processes are correlated through systemic Brownian motions,with default determined by the asset value reaching a lower *** prove that if our volatility models are picked from a class of mean-reverting diffusions,the system converges as the portfolio becomes large and,when the vol-of-vol function satisfies certain regularity and boundedness conditions,the limit of the empirical measure process has a density given in terms of a solution to a stochastic initial-boundary value problem on a *** problem is defined in a special weighted Sobolev *** results are established for solutions to this problem,and then we show that there exists a unique *** contrast to the CIR volatility setting covered by the existing literature,our results hold even when the systemic Brownian motions are taken to be correlated.

关键词： Stochastic PDEs Large portfolios General mean-reverting volatility processes Stochastic volatility model Credit risk

Antifungal pipeline:Is there light at the end of the tunnel?

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World Journal of Clinical Cases 2024年第16期12卷 2686-2691页

作者： Georgios Schinas nikolaos Spernovasilis Karolina Akinosoglou Department of Medicine University of PatrasPatras 26504Greece Department of Infectious Diseases German Oncology CenterLimassol 4108Cyprus

The misuse and overuse of classic antifungals have accelerated the development of resistance mechanisms,diminishing the efficacy of established therapeutic pathways and necessitating a shift towards alternative *** this pressing need for new treatments,the antifungal drug pipeline has been largely stagnant for the past three decades,primarily due to the high risks and costs associated with antifungal drug development,compounded by uncertain market *** research durations,special patient populations and rigorous regulatory demands pose significant barriers to bringing novel antifungal agents to *** response,the“push-pull”incentive model has emerged as a vital strategy to invigorate the pipeline and encourage *** editorial critically examines the current clinical landscape and spotlights emerging antifungal agents,such as Fosmanogepix,Ibrexafungerp,and Olorofim,while also unraveling the multifaceted challenges faced in new antifungal drug *** generation of novel antifungals offers a beacon of hope in the battle against antimicrobial resistance,but it is premature to declare them as definitive *** future role hinges on thorough clinical validation,costeffectiveness assessments,and continuous post-marketing *** through strategic implementation and integration with market strategies we can transform the landscape of antifungal development,addressing both the resistance crisis and the treatment challenges.

关键词： Antifungals Resistance Fosmanogepix Ibrexafungerp Olorofim