检索结果-南通市图书馆

Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion

Science China Chemistry 2018年第1期61卷 54-63页

作者： Haolan Zhang Danyu Wang Xue Lin nikolaos politakos Jimena S. Tuninetti Sergio Enrique Moya Changyou Gao Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhej iang University Hangzhou 310027 China Centre for Cooperative Research in Biomaterials San Sebastian 20009 Gipuzkoa Spain Dr. Li Dak Sum & Iqp Chin Center for Stem Cell and Regenerative Medicine Zhejiang University Hangzhou 310058 China

Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer(LbL) self-assembly are much attractive due to their advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate(PA) was synthesized, and was copolymerized with acrylic acid(AA) to obtain the amphiphilic and photodegradable P(PA-co-AA)polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride(PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549, HepG2 and endothelial cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected significantly until 5 d.

关键词： biomaterials multilayers surfaces photo-responsive cell adhesion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：