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Robotic-assisted microsurgery in andrology: a systematic review

Asian Journal of Andrology 2023年第4期25卷 454-461页

作者： Konstantinos Douroumis Eleftherios Spartalis Konstantinos Stravodimos Panagiotis K Levis Gerasimos Tsourouflis Dimitrios Dimitroulis nikolaos I nikiteas Hellenic Minimally Invasive and Robotic Surgery(MIRS)Study Group National and Kapodistrian University of AthensMedical SchoolAgiou Thoma 15bGoudiAthens 11527Greece First Department of Urology National and Kapodistrian University of AthensMedical SchoolAgiou Thoma 17GoudiAthens 11527Greece Second Department of Propaedeutic Surgery National and Kapodistrian University of AthensMedical SchoolAgiou Thoma 17GoudiAthens 11527Greece

Robot-assisted surgery is the gold standard of treatment in many fields of urology. In this systematic review, we aim to reportits usage in andrology and to evaluate any advantages. A systematic search of the PubMed and Cochrane Library databases wasconducted to identify articles referring to robotic-assisted microsurgery in andrology. The search strategy was in line with thePreferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Cochrane Handbook. Thearticles were then reviewed by two authors. A qualitative analysis of the articles that met the inclusion criteria was ***-one articles that met the inclusion criteria were reviewed. The first results for robot-assisted vasovasostomy (RAVV) areencouraging as excellent patency rates, short operative times, and learning curves were achieved. Interestingly, patency rates weregreater in some case series for RAVV than for microsurgical vasovasostomy, with a statistically significant difference. In addition,robot has been shown to be of great use in bypassing fibrotic changes in cases of iatrogenic vasal injuries, difficulties encounteredwith traditional microsurgery. In addition, the feasibility of robot-assisted microsurgery has been proven for varicocelectomy andmicrosurgical denervation of the spermatic cord, with acceptable improvement in sperm parameters and pain, respectively. Thecurrent evidence suggests that there are potential advantages of the use of robots in andrology. However, for robotic surgery tobecome incorporated into the daily use of the andrologists, large, multicenter randomized trials are needed. As robotics systemsare becoming standard in urology practice, it is reasonable for one to believe that they will also find their place in andrology.

关键词： andrology male infertility robotic surgical procedures varicocele vasovasostomy

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Comparison of cosmetic outcomes between remote-access and conventional thyroidectomy:A review of the current literature

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第1期9卷 1-8页

作者： Anna Kasouli Eleftherios Spartalis Alexios Giannakodimos Gerasimos Tsourouflis Dimitrios Dimitroulis nikolaos I.nikiteas Hellenic Minimally Invasive and Robotic Surgery(MIRS)Study Group Medical School AthensNational and Kapodistrian University of AthensAthensGreece 2nd Department of Propaedeutic Surgery Medical SchoolNational and Kapodistrian University of AthensAthensGreece

Objective:The pursuit of an esthetically pleasing scar following open thyroid surgery has led to the development of endoscopic thyroidectomy through remote incisions placed in several locations outside the *** objective of this study is to review the recent literature and compare the incision site appearance and patient satisfaction with the cosmetic outcome after extracervical and conventional ***:The English literature published since 2010 was searched through the PubMed/Medline database for studies comparing the cosmetic outcomes between remote-access endoscopic and conventional thyroidectomy using a form of scar assessment ***:A total of 9 relevant papers fulfilled the eligibility criteria including 1486 *** them,595 patients underwent endoscopic thyroidectomy through several remote-access approaches and 891 patients were assigned to the conventional *** one randomized-controlled trial was identified,whereas among the rest,four were prospective and four were retrospective nonrandomized *** the extracervical modifications performed in the endoscopic groups,the axillary approach was performed in three studies and the breast approach in four studies,while the retroauricular facelift technique and the transoral vestibular method were applied in one study,***:Evaluation of the wound appearance and patient satisfaction with the cosmetic outcome at various time points during the follow-up highlighted the superiority of the extracervical approaches over the conventional *** these findings,remote-access techniques could possibly be the ideal surgical method for patients with high esthetic requirements,providing an excellent appearance of the thoroughly exposed neck.

关键词： esthetic cosmesis cosmetic cosmetic results incision scar thyroidectomy

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Barrett's esophagus with high-grade dysplasia:Focus on current treatment options

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World Journal of Gastroenterology 2011年第37期17卷 4174-4183页

作者： Leonidas Lekakos nikolaos P Karidis Dimitrios Dimitroulis Christos Tsigris Gregory Kouraklis nikolaos nikiteas Second Propedeutic Department of Surgery Medical SchoolUniversity of AthensGeneral Hospital LaikoAthens 11527Greece Christos Tsigris First Department of SurgeryMedical SchoolUniversity of AthensGeneral Hospital LaikoAthens 11527Greece

High-grade dysplasia(HGD) in Barrett's esophagus(BE) is the critical step before invasive esophageal *** its natural history remains unclear,an aggressive therapeutic approach is usually *** represents the only treatment able to reliably eradicate the neoplastic *** healthy patients with reasonable life expectancy,vagal-sparing esophagectomy,with associated low mortality and low early and late postoperative morbidity,is considered the treatment of choice for BE with *** unfit for surgery should be managed in a less aggressive manner,using endoscopic ablation or endoscopic mucosal resection of the entire BE segment,followed by lifelong *** eligible for surgery who present with a long BE segment,multifocal dysplastic lesions,severe reflux symptoms,a large fixed hiatal hernia or dysphagia comprise a challenging group with regard to the appropriate treatment,either surgical or endoscopic.

关键词：治疗方案食管癌增生异型高档预期寿命迷走神经自然史

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Role of surgery in colorectal liver metastases:Too early or too late?

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World Journal of Gastroenterology 2010年第28期16卷 3484-3490页

作者： Dimitrios Dimitroulis nikolaos nikiteas Theodore Troupis Dimitrios Patsouras Panayiotis Skandalakis Gregory Kouraklis Second Department of Propaedeutic Surgery School of MedicineUniversity of Athens"LAIKON" University Hospital14 Ag.Thoma Street11527 AthensGreece Department of Surgery and Transplantation 4 Sakelariou Street17455 AlimosAthensGreece Department of Anatomy School of MedicineUniversity of Athens75 Mikras Asias Street11527 AthensGreece

As colorectal cancer and colorectal liver metastases become a serious public health problem,new treatment modalities are needed in order to achieve better results. In the last decade there has been very important progress in oncology,with new and more effective chemotherapeutic agents administered alone or in combination improving the resectability rate in up to 40%of patients with colorectal liver *** in interventional radiology,in particular,with the use of portal vein embolization and radiofrequency thermal ablation are new strategies allowing major liver resections and treatment of small liver metastases or early ***,however,remains the gold standard strategy with intention to *** this review article we will describe the advanced role of surgery in the multidisciplinary approach to colorectal liver metastases,and the clinical problems the liver surgeon has to deal with,such as theresectability of the metastases,the presence of bilobar liver lesions and extrahepatic disease,the impact of chemotherapy in already resectable liver metastases,the problem of vanishing metastases after chemotherapy and the dilemma of staged or combined liver and colon operations and which organ first in the clinical scenario of synchronous colorectal liver metastases.

关键词： Metastases Liver metastases Colorectal cancer Surgery

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Development of a quantum-dot-labelled magnetic immunoassay method for circulating colorectal cancer cell detection

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World Journal of Gastroenterology 2012年第32期18卷 4419-4426页

作者： Maria Gazouli Anna Lyberopoulou Pericles Pericleous Spyros Rizos Gerassimos Aravantinos nikolaos nikiteas Nicholas P Anagnou Efstathios P Efstathopoulos Department of Basic Medical Sciences Laboratory of BiologySchool of MedicineUniversity of Athens11527 AthensGreece First Department of Surgery "Tzaneion" General Hospital18536 PiraeusGreece Third Department of Internal Medicine Agii Anargyri Hospital14564 AthensGreece Second Department of Propedeutic Surgery University of Athens School of MedicineLaiko General Hospital11527 AthensGreece Department of Radiology Attikon University Hospital12462 AthensGreece

AIM:To detect of colorectal cancer(CRC) circulating tumour cells(CTCs) surface antigens,we present an assay incorporating cadmium selenide quantum dots(QDs) in these ***:The principle of the assay is the immunomagnetic separation of CTCs from body fluids in conjunction with QDs,using specific antibody biomarkers:epithelial cell adhesion molecule antibody,and monoclonal cytokeratin 19 *** detection signal was acquired from the fluorescence signal of *** the evaluation of the performance,the method under study was used to isolate the human colon adenocarcinoma cell line(DLD-1) and CTCs from CRC patients' peripheral ***:The minimum detection limit of the assay was defined to 10 DLD-1 CRC cells/mL as fluorescence was measured with a *** cell sorting analysis and Real Time RT-PCR,they both have also been used to evaluate the performance of the described *** conclusion,we developed a simple,sensitive,efficient and of lower cost(than the existing ones) method for the detection of CRC CTCs in human *** have accomplished these results by using magnetic bead isolation and subsequent QD fluorescence ***:The method described here can be easily adjusted for any other protein target of either the CTC or the host.

关键词：磁性分离检测信号测定方法结直肠癌量子点免疫学癌细胞循环

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Serum IL-6, TNFα and CRP levels in Greek colorectal cancer patients: Prognostic implications

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World Journal of Gastroenterology 2005年第11期11卷 1639-1643页

作者： nikolaos I. nikiteas nikolaos Tzanakis Maria Gazouli George Rallis Kessaris Daniilidis George Theodoropoulos Alkiviadis Kostakis George Peros 2nd Propedeutic Department of Surgery Department of Surgery Department of Biology s

AIM: The significance of preoperative serum IL-6, TNFαand CRP levels in the progression of colorectal cancer (CRC) has not been fully elucidated. Our intention was to investigate their role and identify their prognostic ***: The IL-6, TNFα and CRP levels were measured in 74 CRC patients and the relationships between their elevation s and both the clinicopathological factors and prognosis of patients were investigated. Serum concentrations of human IL-6 and TNFα were determined by enzyme-linked immunosorbent assay (ELISA). CRP was measured by an immunoturbinometric ***: Median IL-6, TNFα and CRP levels weresignificantly higher in CRC patients than in normal *** levels of serum IL-6, TNFα and CRP were correlated with larger tumor size. Furthermore, high IL-6 and high CRP levels were associated with reduced overall ***: Serum IL-6, TNFα and CRP levels definitely increase in CRC patients. Pre-operative serum elevation of IL-6 and CRP was thus found to be predictor of the prognosis of CRC patients. The clinical value of TNFα in CRC needs to be further investigated.

关键词： CRP IL-6 TNFα CRC ELISA

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Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?

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World Journal of Gastroenterology 2008年第17期14卷 2691-2701页

作者： Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis nikolaos I nikiteas Third Department of Surgery General Hospital of Athens "G.Gennimatas" Department of Immunology National Tissue Typing Center General Hospital of Athens "G.Gennimatas" Second Department of Surgery University of Athens Medical School Laikon General Hospital

Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies.

关键词： VEGF-C VEGF-D 胃肠疾病结直肠癌淋巴结转移

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Amyand's hernia: A case report

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World Journal of Gastroenterology 2006年第29期12卷 4761-4763页

作者： Sofia Anagnostopoulou Dimitrios Dimitroulis Theodore G Troupis Maria Allamani Alexandras Paraschos Antonios Mazarakis nikolaos I nikiteas Alkiviadis Kostakis Department of Anatomy School of Medicine University of Athens75 Mikras Asias streetAthens 11527Greece 2nd Department of Propedeutic Surgery School of Medicine "LAIKON" University Hospital14 Ag.Thoma StreetAthens 11527Greece

在腹股沟疝的蚓状的附录的存在是稀罕的并且作为 Amyand 的脱肠被知道。我们报导 Amyand 的脱肠，在附录 90 二年在一具男死尸在正确腹股沟疝被发现的地方。

关键词：疝气阑尾疾病治疗临床

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Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer

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World Journal of Gastroenterology 2006年第31期12卷 5037-5043页

作者： George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras nikolaos nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli 1st Propaideutic Surgical DepartmentHippocration University Hospital School of MedicineUniversity of AthensGreece 1st Surgical DepartmentLaikon University Hospital University of AthensGreece Department of PathologySchool of Medicine University of AthensGreece 2nd Propaideutic Surgical DepartmentLaikon University Hospital University of AthensGreece Department of CytopathologyUniversity General Hospital "Artikon" University of AthensGreece Department of BiologySchool of Medicine University of AthensGreece

瞄准：在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ，肿瘤坏死因素高山哈( TNFalpha )， peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma )，细胞间的粘附 m... 详细信息

瞄准：在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ，肿瘤坏死因素高山哈( TNFalpha )， peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma )，细胞间的粘附 molecule-1 ( ICAM-1 )和颜色的风险在一组希腊病人的表面的癌症( CRC )。方法：学习组由 222 个 CRC 病人和 200 健康控制组成了。Genotyping 用 PRC-RFLP 的等位基因特定的 PCR 被执行，结果被定序证实。我们在 IL-6 学习了 SNP 的协会(-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G 和 K469E ) ，和 PPARgamma (Pro12Ala ) 基因和 CRC 的风险。结果：ICAM-1 的 IL-6 -174G, R241 和 K469 等位基因与 CRC 的增加的风险被联系(或 = 1.77， 95% CI：1.34-2.34；或 = 1.83， 95% CI：1.23-2.72；并且或 = 1.35， 95% CI：1.03-1.77 分别地) 。IL-8 和 TNFalpha 多型性没有效果。而 PPARgamma Pro12 遗传型与疾病的增加的风险被联系(或 = 1.78， 95% CI：1.25-2.49 ) 。结论：在在免疫逻辑的普通 SNP 之间的协会反应相关的基因和 CRC 在现在的学习被报导。除了使恶意开始和前进的机制清楚些， SNP 可以改进在风险的为亚人口的适当屏蔽。

关键词：基因多态性炎症结肠癌直肠癌

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