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Hepatitis E in immunocompromised individuals

World Journal of Hepatology 2022年第3期14卷 482-494页

作者： Konstantinos Damiris Mohamad Aghaie Meybodi Mumtaz Niazi nikolaos Pyrsopoulos Department of Medicine Rutgers-New Jersey Medical SchoolNewarkNJ 07103United States Department of Medicine-Gastroenterology and Hepatology Rutgers-New Jersey Medical SchoolNewarkNJ 07103United States

Hepatitis E virus(HEV)originally identified as a cause of acute icteric hepatitis in developing countries has grown to be a cause of zoonotic viral hepatitis in developed countries such as the United *** there are eight identified genotypes to date,genotype 1(HEV1),HEV2,HEV3,HEV4 are the most common to infect ***1 and HEV2 are most common in developing countries including Latina America,Africa and Asia,and are commonly transmitted through contaminated water supplies leading to regional *** contrast HEV3 and HEV4 circulate freely in many mammalian animals and can lead to occasional transmission to humans through fecal contamination or consumption of undercooked *** incidence and prevalence of HEV in the United States is undetermined given the absence of FDA approved serological assays and the lack of commercially available *** majority of cases,HEV infection is a selflimiting hepatitis requiring only symptomatic ***,this is not the case in immunocompromised individuals,including those that have undergone solid organ or stem cell *** this subset of patients,chronic infection can be life threatening as hepatic insult can lead to inflammation and fibrosis with subsequent cirrhosis and *** need for re-transplantation as a result of post-transplant hepatitis is of great *** addition,there have been many reported incidents of extrahepatic manifestations,for which the exact mechanisms remain to be *** cornerstone of treatment in immunocompromised solid organ transplant recipients is reduction of immunosuppressive therapies,while attempting to minimize the risk of organ *** treatment options include ribavirin,and pegylated interferon alpha in those who have demonstrated ribavirin *** investigation assessing safety and efficacy of anti-viral therapy is imperative given the rising global health *** this concern,vaccination has been approved in Chin

关键词： Hepatitis E Hepatitis E virus Chronic hepatitis Acute hepatitis Immunocompromised Liver transplant

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Prognostic value of ΔSYNTAX% score in octogenarians undergoing percutaneous coronary intervention

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Journal of Geriatric Cardiology 2023年第7期20卷 509-515页

作者： Joanna Abramik Nestoras Kontogiannis Roberto Scarsini Giovanni Luigi De Maria Tushar Raina nikolaos Fragakis George Kassimis Department of Cardiology Cheltenham General HospitalGloucestershire Hospitals NHS Foundation TrustCheltenhamUnited Kingdom Department of Cardiology Oxford University Hospitals NHS Foundation TrustOxfordUnited Kingdom Division of Cardiology Department of MedicineUniversity of VeronaVeronaItaly Second Department of Cardiology Hippokration HospitalMedical SchoolAristotleUniversity of ThessalonikiThessalonikiGreece

OBJECTIVES To verify whether incomplete revascularisation(IR),quantified using the rSYNTAX(Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery)score andΔSYNTAX%score,could predict short-(in-hospital mortality)and long-term outcomes(12-month mortality)in octogenarians undergoing percutaneous coronary intervention(PCI).METHODS&RESULTS A retrospective analysis of 665 consecutive octogenarian patients presenting for PCI to a UK centre was *** baseline SYNTAX and rSYNTAX scores were assessed from angiographic images.ΔSYNTAX%score was calculated(ΔSYNTAX%=((SYNTAX-rSYNTAX)/SYNTAX)×100%))to measure the relative completeness of ***-Meier analysis assessed survival at 12 months by tertiles of rSYNTAX andΔSYNTAX%***ΔSYNTAX%score was associated with reduced in-hospital mortality(P=0.017),and improved survival benefit(log rank 14.8,P=0.001)at 12 *** Enhancing the completeness of revascularisation in octogenarians selected to undergo PCI is associated with a lower in-hospital mortality and a survival benefit at 12 months.

关键词： SYNTAX mortality coronary

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Uniform Convergence of Translation Operators

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Advances in Pure Mathematics 2022年第12期12卷 715-723页

作者： nikolaos Tsirivas Department of Mathematics University of Thessaly Lamia Greece

We denote N, R, C the sets of natural, real and complex numbers respectively. Let (λn), n ∈ N be an unbounded sequence of complex numbers. Costakis has proved the following result. There exists an entire function f with the following property: for every x, y ∈ R with 0 , every θ ∈(0,1) and every a ∈ C there is a subsequence of natural numbers (mn), n ∈ N such that, for every compact subset L ⊆C , In the present paper we show that the constant function a cannot be replaced by any non-constant entire function G. This is so even if one demands the convergence in (*) only for a single radius r and a single positive number θ. This result is related with the problem of existence of common universal vectors for an uncountable family of sequences of translation operators.

关键词： Hypercyclic Operator Common Hypercyclic Vectors Translation Operator

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Second Order Nonlinear Evolution Inclusions Ⅱ： Structure of the Solution Set

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Acta Mathematica Sinica,English Series 2006年第1期22卷 195-206页

作者： nikolaos S. PAPAGEORGIOU nikolaos YANNAKAKIS National Technical University Department of Mathematics Zografou Campus Athens 157 80 Greece

We contimle the work initiated in [1] （Second order nonlinear evolution inclusions I： Existence and relaxation results. Acta Mathematics Science, English Series, 21（5）, 977-996 （2005）） and study the structural properties of the solution set of second order evolution inclusions which are defined in the analytic framework of the evolution triple. For the convex problem we show that the solution set is compact Rs, while for the nonconvex problem we show that it is path connected, Also we show that the solution set is closed only if the multivalued nonlinearity is convex valued. Finally we illustrate the results by considering a nonlinear hyperbolic problem with discontinuities.

关键词： Evolution triple Compact embedding Second order evolution Compact Rs Pathconnected Connected Continuum Hyperbolic problem

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The habitation Model Trend Calculation(MTC):A new effective tool for predictive modeling in archaeology

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Geo-Spatial Information Science 2019年第4期22卷 314-331,I0008页

作者： George Malaperdas nikolaos Zacharias Department of History Archaeology and Cultural Resources ManagementUniversity of PeloponneseKalamataGreece

The aim of this paper is to create and present a new archaeological predictive model via GIS,incorporating what archaeologists consider the most important criterion absent of similar past models,that of critical *** new model suggested in this paper is named habitation Model Trend Calculation(MTC)and is not only integrates the archaeological questions with a critical view,but it can be easily adjusted,according to the conditions or the questions concerning the archaeological ***,it uses new topographical and geomorphological indexes such as Topographical Index(TPI),Hillslope and Landform Classification that give a new sense of the topographical and geomorphological characteristics of the examined area;therefore this model is a more powerful tool compared to older models that did not use new topographical and geomorphological *** success of the created model is checked as a case study in the region of Messenia,Greece during the Mycenaean *** region of Messenia is considered as one of the most important Mycenaean regions of Greece due to the great number and the importance of Mycenaean sites *** the present paper,140 habitation sites were divided into four hierarchical categories(centers,large villages,villages,and farms)based on the extent and the plurality of the tholos tombs that exist in the broader region and according to the hierarchical categorization used by the archaeologists who have studied the *** new predictive model presented in this work can assist in solving a series of criticisms that have been expressed in the previous studies regarding such ***,in the case of Mycenaean Messenia,the model shows excellent results in relation to the habitats of the time.

关键词： GIS Mycenaean Messenia predictive model archaeology habitation Model Trend Calculation(MTC) analytical hierarchy process(AHP) spatial analysis

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Packed Bed Thermocline Thermal Energy Storage for Medium-Temperature Concentrating Solar Systems: Numerical and Experimental Study

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Journal of Power and Energy Engineering 2023年第5期11卷 1-23页

作者： nikolaos Stathopoulos nikolaos Papadimitriou Vassilis Belessiotis Elias Papanicolaou Solar and Other Energy Systems Laboratory Demokritos National Center for Scientific Research Attiki Athens Greece

Thermal Energy Storage is becoming a necessary component of sustainable energy production systems as it helps alleviate intrinsic limitations of Renewable Energy Sources, such as intermittent use and mismatch between power demand and supply. This paper discusses a packed bed thermocline tank as a thermal energy storage solution. Firstly, this paper presents the development of a numerical model calculating heat transfers within the tank, based on a discretization over several nodes and the nodal formulation of the heat balance equation. The model considers a filler material and a heat transferring fluid and uses the finite difference method to calculate the temperature evolution of the two media across the tank. The model was validated with two different packed bed systems from the literature during a discharging process, presenting a good fit with the experimental results. Secondly, the experimental packed bed is presented and characterized for a charging cycle from ambient temperature to approximately 180?C. The charging experiment was accurately reproduced with the numerical model requiring minimal computational time. Two additional charging modes were simulated with different inlet HTF conditions: constant temperature and varying temperature following the profile produced by a thermal solar collector field. The temperature profiles obtained from the three charging modes were analysed and compared to each other. The proposed numerical and experimental tools will be used in future studies for a better understanding of the design and operating conditions of packed bed thermal energy storage systems.

关键词： Thermal Energy Storage Packed Bed Numerical Model Experimental

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Pulmonary involvement and allergic disorders in inflammatory bowel disease

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World Journal of Gastroenterology 2010年第3期16卷 299-305页

作者： nikolaos E Tzanakis Ioanna G Tsiligianni nikolaos M Siafakas Department of Social Medicine & Thoracic Medicine Medical School University of Crete General Practitioner Agia Barvara Health Care Center Department of Thoracic Medicine Medical School University of Crete

Inflammatory bowel disease (IBD) has been associated with either clinical or subclinical airway and parenchymal lung involvement and interstitial lung complications. Several studies have reported that atopy has a high prevalence in IBD patients. Overlapping allergic disorders seem to be present in both the respiratory and gastrointestinal systems. The purpose of this review is to update clinicians on recent available literature and to discuss the need for a highly suspicious approach by clinicians.

关键词： Atopy Inflammatory bowel disease Pulmonary involvement

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Indications for the surgical management of pancreatic trauma: An update

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World Journal of Gastrointestinal Surgery 2022年第6期14卷 538-543页

作者： Efstathios Theodoros Pavlidis Kyriakos Psarras nikolaos G Symeonidis Georgios Geropoulos Theodoros Efstathios Pavlidis 2^(nd) Propedeutic Department of Surgery School of MedicineAristotle UniversityThessaloniki 54642Greece Department of General Surgery University College London HospitalsLondon NW12BUUnited Kingdom

Pancreatic trauma is rare compared to other abdominal solid organ injuries,accounting for 0.2%-0.3% of all trauma patients. Moreover, this type of injury may frequently be overlooked or not readily appreciated on initial clinical examinations and investigations. The organ injury scale determines the severity of the trauma. Nonetheless, there are conflicting recommendations for the best strategy in severe cases. Overall, conservative management of induced severe traumatic pancreatitis is adequate. Modern imaging modalities such as ultrasound scanning and computed tomography scanning can detect injuries in fewer than 60% of patients. However, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography(ERCP) have diagnostic accuracies approaching 90%-100%. Thus, management options include ERCP and stent placement or distal pancreatectomy in cases of complete gland transection and wide drainage only for damage control surgery, which can prevent mortality but increases the risk of morbidity. In the majority of cases, surgical intervention is not required and should be reserved for only severe grade Ⅲ to grade Ⅴ injuries.

关键词： Pancreas Acute pancreatitis Abdominal trauma Pancreatic traumatic injury Emergency surgery Damage control surgery

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Forecasting wind speed using a reinforcement learning hybrid ensemble model:a high-speed railways strong wind signal prediction study in Xinjiang,China

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Transportation Safety and Environment 2023年第4期5卷 17-28页

作者： Bin Liu Xinmin Pan Rui Yang Zhu Duan Ye Li Shi Yin nikolaos Nikitas Hui Liu Research Institute of Science and Technology of China Railway Urumqi Group Co. Ltd.Urumqi 830011XinjiangChina Xinjiang Uygur Autonomous Region Meteorological Service Urumqi 830002XinjiangChina School of Traffic and Transportation Engineering Central South UniversityChangsha 410075HunanChina School of Civil Engineering University of LeedsLS29JTLeedsUK

Considering the application of wind-forecasting technology along the railway,it becomes an effective means to reduce the risk of tain more reliable wind-speed prediction results,this study proposes an intelligent ensemble forecasting method for strong winds train derailment and *** prediction of crosswinds can provide scientific guidance for safe train *** obalong the high-speed *** method consists of three parts:the data preprocessing module,the hybrid prediction module and original wind speed ***,Broyden-Fletcher-Goldfarb-Shanno(BFGS)method,non-linear autoregressive network with exoge-the reinforcement learing ensemble ***,fast ensemble empirical model decomposition(FEEMD)is used to process the prediction models for all the sublayers of ***,Q-learning is utilized to iteratively calculate the combined weights nous inputs(NARX)and deep belief network(DBN),three benchmark predictors with different characteristics are employed to build of the three models,and the prediction results of each sublayer are superimposed to obtain the model *** real wind speed data of two railway stations in Xinjiang are used for experimental *** show that compared with the single benchmark model,the hybrid ensemble model has better accumacy and robustness for wind speed prediction along the *** 1-step forecasting results mean absolute error(MAE),mean absolute percentage error(MAPE)and root mean square error(RMSE)of Q-leaming-FEEMD-BFGS-NARX-DBN in site #1 and site #2 are 0.0894 m/s,0.6509%,0.1146 m/s,and 0.0458 m/s.0.2709%,0.0616 m/*** proposed ensemble model is a promising method for railway wind speed prediction.

关键词： wind speed forecasting high-speed railways signal decomposition reinforcement learning ensemble model

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Multi-period Power System State Estimation with PMUs Under GPS Spoofing Attacks

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Journal of Modern Power Systems and Clean Energy 2020年第4期8卷 597-606页

作者： Paresh Risbud nikolaos Gatsis Ahmad Taha Department of Electrical and Computer Engineering University of Texas at San AntonioSan AntonioUSA IEEE

This paper introduces a dynamic network model together with a phasor measurement unit(PMU)measurement model suitable for power system state estimation under spoofing attacks on the global positioning system(GPS)receivers of *** spoofing attacks may introduce time-varying phase offsets in the affected PMU *** algorithm is developed to jointly estimate the state of the network,which amounts to the nodal voltages in rectangular coordinates,as well as the time-varying *** algorithm features closedform *** effectiveness of the algorithm is verified on the standard IEEE transmission *** is numerically shown that the estimation performance is improved when the dynamic network model is accounted for compared with a previously reported static approach.

关键词： Dynamic state equation global positioning system(GPS)spoofing phasor measurement unit(PMU) state estimation time synchronization weighted least squares

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