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Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study

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Neural Regeneration Research 2020年第7期15卷 1300-1307页

作者： Kamini Rakkar Othman Othman nikola Sprigg Philip Bath Ulvi Bayraktutan Stroke Division of Clinical Neuroscience University of Nottingham Clinical Sciences Building City Hospital

Ischemic stroke is a devastating,life altering event which can severely reduce patient quality of *** years of research there have been minimal therapeutic *** progenitor cells(EPCs),stem cells involved in both vasculogenesis and angiogenesis,may be a potential therapeutic *** a stroke,EPCs migrate to the site of ischemic injury to repair cerebrovascular damage,and their numbers and functional capacity may determine patients'*** study aims to determine whether the number of circulating EPCs and their functional aspects may be used as biomarkers to identify the type(cortical or lacunar)and/or severity of ischemic *** study will also investigate if there are any differences in these characteristics between healthy volunteers over and under 65 years of age.100 stroke patients(50 lacunar and 50 cortical strokes)will be recruited in this prospective,observational case-controlled *** samples will be taken from stroke patients at baseline(within 48 hours of stroke)and days 7,30 *** will be counted with flow *** plasma levels of pro-and anti-angiogenic factors and inflammatory cytokines will also be *** endothelial cells will be cultured to be used in tube formation,migration and proliferation functional *** outcome is disability or dependence on day 90 after stroke,assessed by the modified Rankin *** outcomes are changes in circulating EPC numbers and/or functional capacity between patient and healthy volunteers,between patient subgroups and between elderly and young healthy *** started in February 2017,167 participants have been *** will end in November *** Midlands-Coventry&Warwickshire Research Ethics Committee approved this study(REC number:16/WM/0304)on September8,*** version:*** Bayraktutan Dunhill Medical Trust EPC Study was registered in ***(NCT02980354)on November 15,*** st

关键词： ageing biomarkers cortical stroke endothelial progenitor cells ischemic stroke lacunar stroke observational study stem cells

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Blood pressure management in acute stroke

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Stroke & Vascular Neurology 2016年第2期1卷 72-82页

作者： Jason P Appleton nikola Sprigg Philip M Bath Stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK

Blood pressure(BP)is elevated in 75%or more of patients with acute stroke and is associated with poor *** to modulate BP in acute stroke has long been *** the loss of normal cerebral autoregulation,theoretical concerns are twofold:high BP can lead to cerebral oedema,haematoma expansion or haemorrhagic transformation;and low BP can lead to increased cerebral infarction or perihaematomal *** evidence from multiple large,high-quality,randomised trials is increasing our understanding of this challenging area,such that BP lowering is recommended in acute intracerebral haemorrhage and is safe in ischaemic *** we review the evidence for BP modulation in acute stroke,discuss the issues raised and look to on-going and future research to identify patient subgroups who are most likely to benefit.

关键词： Blood acute cerebral

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Cerebral misery perfusion due to carotid occlusive disease

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Stroke & Vascular Neurology 2017年第2期2卷 88-93页

作者： Mohana Maddula nikola Sprigg Philip M Bath Sunil Munshi Acute Stroke Unit Tauranga HospitalTaurangaNew Zealand Division of Clinical Neuroscience University of NottinghamNottinghamUK Department of Stroke Nottingham University Hospitals NHS TrustNottinghamUK

Purpose Cerebral misery perfusion(CMP)is a condition where cerebral autoregulatory capacity is exhausted,and cerebral blood supply in insufficient to meet metabolic *** present an educational review of this important condition,which has a range of clinical *** A non-systematic review of published literature was undertaken on CMP and major cerebral artery occlusive disease,using Pubmed and *** Patients with CMP may present with strokes in watershed territories,collapses and transient ischaemic attacks or episodic movements associated with an orthostatic *** positron emission tomography is the gold standard investigation for misery perfusion,advanced MRI is being increasingly used as an alternative investigation *** presence of CMP increases the risk of *** addition to the devastating effect of stroke,there is accumulating evidence of impaired cognition and quality of life with carotid occlusive disease(COD)and misery *** evidence for revascularisation in the setting of complete carotid occlusion is *** management constitutes careful blood pressure management while addressing other vascular risk *** The evidence for the management of patients with COD and CMP is discussed,together with recommendations based on our local *** this review,we focus on misery perfusion due to *** Patients with CMP and COD may present with a wide-ranging clinical phenotype and therefore to many *** identification of patients with misery perfusion may allow appropriate management and focus on strategies to maintain or improve cerebral blood flow,while avoiding potentially harmful treatment.

关键词： perfusion carotid impaired

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NSVS 2569022:a peculiar binary among W UMa stars with extremely small mass ratios

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Research in Astronomy and Astrophysics 2018年第10期18卷 123-130页

作者： Diana P.Kjurkchieva Velimir A.Popov nikola I.Petrov Department of Physics and Astronomy Shumen University Institute of Astronomy and NAO Bulgarian Academy of Sciences

Photometric observations of the W UMa binary NSVS 2569022 are presented. The light curve solution reveals that both components are of F spectral type （temperatures T1 = T2 = 6100 K）. NSVS 2569022 undergoes a total eclipse of W subtype and the mass ratio is well-determined. Its extremely small value of only 0.077 implies that the target will probably experience instability and a possible merger. This value ranks NSVS 2569022 in sixth place among binaries with the smallest mass ratio. Based on an empirical relation of ＂period - total mass＂ for low mass-ratio binaries, we estimate the global parameters of NSVS 2569022： masses M1 = 1.17 M⊙ and M2 = 0.09 M⊙; radii R1 = 1.19 R⊙ and R2 = 0.38 R⊙; luminosities L1 = 1.73 L⊙ and L2 = 0.17L⊙. An analysis of the characteristics of binaries with extremely low-mass ratios is made. NSVS 2569022 turns out to be a peculiar binary among W UMa stars with extremely small mass ratios due to its unexpectedly small fill-out factor of only 0.014 （slightly overcontact configuration）.

关键词： binaries eclipsing - binaries close - stars fundamental parameters - stars individual(NSVS 2569022)

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New observations and transit solutions of the inflated exoplanets HAT-P-40b and HAT-P-51b

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Research in Astronomy and Astrophysics 2021年第2期21卷 157-160页

作者： Diana P.Kjurkchieva nikola I.Petrov Velimir A.Popov Department of Physics and Astronomy Shumen University115 Universitetska str.9700 ShumenBulgaria Institute of Astronomy and NAO Bulgarian Academy of SciencesTsarigradsko shossee 721784 SofiaBulgaria

We present high-precision photometric observations of the transiting exoplanets HAT-P-40 b and HAT-P-51 b by the Rozhen 2-m *** newly-observed transit of HAT-P-40 b is the first one with a complete *** orbital periods of the two targets were *** modeled the observed transits and found bigger stellar radii than those derived from the stellar *** planet radii of HATP-40 b and HAT-P-51 b obtained from our transit solutions are bigger than the values calculated by the empirical relations for Jupiter-mass and Saturn-mass planets *** values reveal the highlyinflated nature of the two targets,especially that of HAT-P-51 *** established that the best transit solutions correspond to a quadratic limb-darkening *** fitted limb-darkening coefficients of HAT-P-40 are close to the theoretical ones while those of HAT-P-51 are a little *** precise astrometric Gaia distances of the two targets are smaller by 6%–7%than the calculated values from the stellar *** propose the Gaia distances to be used for improvement of the stellar models as well as for more reliable calculation of the parameters of the known exoplanets.

关键词： (Stars )planetary systems-techniques photometric-Stars individual(HAT-P-40 and HAT-P-51)

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ON CRITERIA FOR STARLIKENESS AND CONVEXITY OF ANALYTIC FUNCTIONS

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Acta Mathematica Scientia 2004年第4期24卷 597-602页

作者： Vikramaditya Singh nikola Tuneski Faculty of Mechanical Engineering Karpos Ⅱ b.b. 1000 Skopje Republic of MacedoniaFaculty of Mechanical Engineering Karpos Ⅱ b.b. 1000 Skopje Republic of Macedonia

In this paper the authors study (1-γ+zf(?)(z)/f'(z))/(zf'(z)/f(z)) as a criteria for starlikeness and convexity. Sharp upper bound of |α2| and of the Fekete-Szego functional |α3-μα22| is given for a class of anal... 详细信息

关键词： Starlike convex criteria Fekete-Szego

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Biobased Aromatic-Aliphatic Polyols from Cardanol by Thermal Thiol-Ene Reaction

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Journal of Renewable Materials 2018年第1期6卷 87-101页

作者： Maha LShrestha Mihail Ionescu Xianmei Wan nikola Bilic′ Zoran SPetrovic′ Tom Upshaw Pittsburg State University Kansas Polymer Research Center1701 South BroadwayPittsburgKansas66762USA Chevron Phillips Chemical Company LP Bartlesville Technology CenterBartlesvilleOklahoma74003-6670USA

Cardanol is a natural phenol which is obtained from high vacuum distillation of cashew nut shell *** contains a hydrocarbon chain of 15 carbon atoms in the meta position,either with one,two or three nonconjugated double *** article describes thermal thiol-ene reaction to synthesize new cardanol-based polyols for polyurethanes with aromatic-aliphatic *** hydroxyl group was blocked by alkoxylation and 2-mercaptoethanol was added to the double bonds of propoxylated *** resultant product is a mixture of polyols that may contain one,two,three or four hydroxyl groups,as a function of the number of double bonds reacted with *** polyols,but with much higher functionality,were also synthesized from condensation of cardanol-based novolacs with *** cardanolbased polyols were further utilized to prepare rigid polyurethane foams(PUs)with excellent physical and mechanical properties,useful for various applications in chemical and food industries.

关键词： Thiol-ene mercaptans cashew nut shell liquid polyurethanes

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Observations and light curve solutions of a selection of middle-contact W UMa binaries

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Research in Astronomy and Astrophysics 2018年第4期18卷 105-114页

作者： Diana Petrova Kjurkchieva Velimir Angelov Popov Doroteya Lyubenova Vasileva nikola Ivanov Petrov Department of Physics Shumen University IRIDA Observatory Rozhen NAO Institute of Astronomy and NAO Bulgarian Academy of Sciences

Photometric observations in Sloan g′and i′ bands of W UMa binaries NSVS 4340949,T-Dra0–00959,GSC 03950–00707,NSVS 4665041,NSVS 4803568,MM Peg,MM Com and NSVS4751449 are *** light curve solutions revealed that the components of each target are of G and K spectral *** binaries of the sample have middle-contact configurations whose fillout factors are within the range 0.2–*** only exception is NSVS 4751449 which is in deeper contact（fillout factor of 0.55）.It precisely obeys the relation between mass ratio and fillout factor for deep,low mass ratio overcontact *** of the eclipses of almost all targets（except MM Peg）is an occultation and their photometric mass ratios and solutions could be accepted with *** found that the target components have almost equal temperatures but differ considerably in size and *** components of the partially-eclipsed MM Peg have close *** solutions reveal that NSVS 4340949,T-Dra0–00959,NSVS 4803568 and MM Com are of W subtype while GSC 03950–00707,NSVS 4665041,MM Peg and NSVS 4751449 are of A *** subclassification is well-determined for all totallyeclipsed *** targets confirm the trends in which W-subtype systems have smaller periods and lower temperatures than A subtype binaries.

关键词： binaries close — binaries eclipsing — stars fundamental parameters — stars late-type

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Photometric observations and light curve solutions of the W UMa stars NSVS 2244206,NSVS 908513,CSS J004004.7+385531 and VSX J062624.4+570907

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Research in Astronomy and Astrophysics 2016年第9期16卷 15-22页

作者： Diana Petrova Kiurkchieva Velimir Angelov Popov Doroteya Lyubenova Vasileva nikola Ivanov Petrov Department of Physics Shumen University115Universitetska Str.1712 ShumenBulgaria IRIDA Observatory 17A Prof.Asen Zlatarov Str.SofiaBulgaria Institute of Astronomy and National Astronomical Observatory Bulgarian Academy of Sciences72Tsarigradsko Shose Blvd.1784 SofiaBulgaria

Photometric observations in Sloan 9＇ and i＇ bands of four W UMa stars, NSVS 2244206, NSVS 908513, CSS J004004.7＋385531 and VSX J062624.4＋570907, are presented. The light curve solutions reveal that all targets have overcontact configurations with fillout factors within 0.15-0.26. Their components are G-K spectral types and are almost in thermal contact. They are also relatively close in size and luminosity： the radius ratios r2/r1 are within 0.75-0.90; the luminosity ratios 12/11 are within 0.53-0.63. The results of the light curve solution of CSS J004004.7＋385531 imply the weak limb-darkening effect of its primary component and possible presence of additional absorbing features in the system.

关键词： methods data analysis -- stars fundamental parameters -- stars binaries eclipsing individ-ual (NSVS 2244206, NSVS 908513, CSS J004004.7+385531, VSX J062624.4+570907)

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Erythrocytic transglutaminase inhibition hemolysis at presentation of celiac disease

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World Journal of Gastroenterology 2010年第44期16卷 5647-5650页

作者： Petar Ivanovski Dimitrije Nikoli nikola Dimitrijevi Ivan Ivanovski Vojislav Perii Pediatric Clinic of the University Children's Hospital Medical Faculty University of Belgrade Department of Medical Student Research Medical Faculty University of Belgrade

Celiac disease (CD) is a common autoimmune *** it was considered to be a rare childhood disorder,but is actually considered a relatively common condition,present at any age,which may have multiple complications and *** disorders of the disease are not *** these disorders,the most frequently reported are anemias as a result of iron deficiency,often associated with folate and/or B12 *** caused by hemolysis are very rarely reported in celiac *** 11-year-old girl with a previous uneventful medical history presented with severe hemolytic *** was Coombs negative,accompanied by inappropriate low reticulocyte count,despite exaggerated bone marrow hyperplasia of the erythroid precursors which showed normal *** for recent infections,including EpsteinBarr virus,parvovirus B19,cytomegalovirus and mycoplasma,were all *** of serum IgA,IgG and IgM,were all within normal ranges for *** anti-DNA,antinuclear,antineutrophil cytoplasmic,antimicrosomal,antithyroglobulin,and antimitochondrial antibodies and lupus anticoagulants,was *** was also negative for human immunodeficiency *** therapy with corticosteroids and intravenous immunoglobulin *** was serendipitously discovered upon screening for anti-tissue transglutaminase *** disease was confirmed by biopsy of the small intestine *** patient recovered with gluten-free diet.A unique case of CD is *** should be serologically screened in each patient with Coombs negative "immune"hemolytic anemia,particularly if accompanied by "reticulocytopenia".A new hemolytic mechanism and very speculative explanation for "reticulocytopenia"are discussed.

关键词： Celiac disease Tissue transglutaminase Antibodies Hemolytic anemia Gluten free diet

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