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第十四届全国中药和天然药物学术研讨会

作者： nikles stefanie Zou Huiqin Liu Yong He Xiaojuan Bian Yanqin Lu Aiping Bauer Rudolf University of Graz Beijing University of Chinese Medicine China Academy of Chinese Medical Sciences Institute of Basic Research in Clinical Medicine SHong Kong Baptist University

＜正＞Yu Ping Feng San,a classical TCM formulation,has been used traditionally for chronic inflammatory diseases with immune dysfunction（allergies,asthma,Crohn’s disease and ulcerative colitis）.The formula is a mixture of three herbs consisting of 30g Saposhnikoviae radix（Fang Feng）,60g Astragali radix（Huang Qi）and 60g Atractylodes macrocephalae

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Effect of Saposhnikovia divaricata(Fangfeng) Ethylacetate Extract on the Production of IL-1β, IL-6 and NLRP3 in LPS-induced U937 Cells

Effect of Saposhnikovia divaricata(Fangfeng) Ethylacetate Ex...

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第十一届全国免疫学学术大会

作者： QIU Xue-mei FAN Dan-ping LIU Xue nikles stefanie Bauer Rudolf Lu Ai-ping HE Xiao-juan Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences School of Life Science and Engineering Southwest Jiaotong University Institute of Pharmaceutical Sciences Department of PharmacognosyUniversity of Graz School of Chinese Medicine Hong Kong Baptist University

Background: Saposhnikovia divaricate(Fangfeng), a traditional Chinese medicine, has been commonly used for some chronic inflammatory diseases such as arthritis. However, the underlying functional mechanism is still unknown. Objective: The aim of this study is to investigate the effect of Saposhnikovia divaricate ethylacetate extract(SDE) on the production of IL-1β, IL-6 and NLRP3 in LPS-induced U937 Cells. Methods: Saposhnikovia divaricate has been extracted with ethylacetate(Et OAc). U937 cells were pre-treated with different concentrations(0, 3.125, 6.25 12.5, 25, 50, 100, 200 μg/ml) of SDE after being induced with PMA(10 ng/ml) for 48 h into macrophages. The cell viability was determined by CCK-8 assay. Furthermore, U937 cells induced by PMA were stimulated with LPS(1 μg/ml) for 48 h with or without the indicated concentration(25 μg/ml) of SDE for 2 h, followed by ATP(5 m M) treatment for 45 min. The mRNA levels of IL-1β, IL-6 and NLRP3 in the cells and the protein levels of these factors in the supernatant were assessed by real-time PCR and ELISA, ***: Our results showed that SDE didn’t exhibit obvious cytotoxicity at the concentration of 3.125, 6.25 12.5 and 25 μg/ml. Subsequently, 25 μg/ml SDE was used for the further experiments. We found that IL-1β, IL-6 and NLRP3 mRNA levels in cells and protein levels in supernatant were all significantly increased in LPS combined with ATP-stimulated U937 cells compared to the control group. SDE could significantly downregulate the mRNA and protein levels of IL-1β, IL-6 and NLRP3 in SDE-treated groups compared to the LPS combined with ATP-stimulated group. Conclusion: These results showed that SDE could inhibit the production of IL-1β, IL-6 and NLRP3 in LPS combined with ATP-stimulated U937 cells.

关键词： Saposhnikovia divaricata ethylacetate NLRP3 cytokine U937

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Don’t burn the baby: Advice from Australian nurses recommending therapeutic sun exposure during infancy

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Open Journal of Preventive Medicine 2013年第2期3卷 212-218页

作者： Simone Lee Harrison Jane nikles Madeleine Nowak JCU Skin Cancer Research Group Anton Breinl Centre School of Public Health Tropical Medicine and Rehabilitation Sciences James Cook University Townsville Australia

Background: Previous studies have demonstrated inappropriate advice from health profes- sionals advocating therapeutic sun exposure during infancy and the post-partum period. This study examines the proportion of Australian midwives and related hospital nursing staff who recommend therapeutic sun exposure during this period. Methods: Questionnaires were completed by 363 Australian nurses (57.2% response) responsible for nursing post-partum women in 11 maternity hospitals in Queensland (QLD) and the Australian Capital Territory (ACT). Results: Many nurses believed sun exposure was beneficial in treating: cracked nipples (QLD 41.3%, ACT 65.8%;p specified exposure time limits. Nursing staff from public hospitals in QLD, but not the ACT, were more likely than nurses from private hospitals to hold one or more such beliefs (p = 0.008). Approximately 40% of respondents thought people generally looked healthier with a suntan;79% of this group also held one or more risky beliefs about therapeutic sun exposure (p = 0.043). Conclusion: A high proportion of these nurses held risky beliefs about the beneficial uses of sunlight for post-partum women and their infants and made recommendations consistent with their beliefs. Professional education is needed to change the beliefs and practices of nursing staff about intentional sun exposure of women and their babies to reduce their long- term skin cancer risk, particularly as Australia has such a high prevalence of skin cancer.

关键词： Therapeutic Sun Exposure Nursing Staff Midwives Beliefs Practices Skin Cancer Prevention

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