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Journal of Chemistry and Chemical Engineering 2014年第8期8卷 778-785页

作者： Nashchokin Anton Malakho Artem Garadja nikita Rogozin Alexey Chemistry Department Moscow State University Moscow 119991 Russia Aleksin Chemical Plant Aleksin 301361 Russia

In the present work, novolac phenolic resin-based composites reinforced with short discrete carbon fibers were pyrolized at different temperatures from 400℃ to 900℃. Their physical and chemical properties were studied, linterfacial bonding between the matrix and carbon fiber and its influence on mechanical properties of analyzed composites were analyzed. Experimental results demonstrated strengthening of interfacial bonding with increase of pyrolysis temperature. Evolution of failure behavior was observed.

关键词： Carbon/carbon composite phenolic resin interfacial bonding pyrolysis carbonization.

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俄罗斯能源出口贸易研究

俄罗斯能源出口贸易研究

作者： Kazakov nikita（尼基塔）哈尔滨工业大学

学位级别：硕士

俄罗斯油气资源储量丰富,开发潜力巨大,不仅可以满足俄罗斯的基本生活和生产需要,还可以形成强大的出口能力。俄罗斯凭借强大的能源储备、大规模的油气资源出口实现了经济的稳定、复兴和增长。能源资源已经成为影响俄罗斯当前和未来发... 详细信息

俄罗斯油气资源储量丰富,开发潜力巨大,不仅可以满足俄罗斯的基本生活和生产需要,还可以形成强大的出口能力。俄罗斯凭借强大的能源储备、大规模的油气资源出口实现了经济的稳定、复兴和增长。能源资源已经成为影响俄罗斯当前和未来发展的关键性因素。随着亚太地区能源消费能力的快速增长以及俄罗斯东部大开发战略的实施,俄罗斯能源对外贸易的发展关系不仅影响到俄罗斯国内能源产业发展、国内宏观经济发展以及对整个世界能源体系产生深远的影响。俄罗斯能源出口贸易伙伴主要是欧盟、日本、美国和中国,从对俄欧、俄日、俄美、俄中能源贸易现状的分析中,可以发现俄罗斯能源出口贸易发展中存在着一系列问题。而导致这些问题出现的主要原因在于能源产品结构单一,其中石油天燃气在能源贸易中占主导地位、能源效率差异较大、能源利用率很低;管道等运输基础设施不足,能源开采与运输成本过高,导致能源发展潜力受限;加上俄罗斯能源领域相关法律制度不完善,能源管理体制落后及执行力差等能源法规与政府管理体制因素制约了俄罗斯能源合作的进一步发展。另外,国际政治经济形势的变动对俄罗斯能源出口也产生了重要的影响作用,由于国际能源价格波动,以及俄与欧美、与东北亚地地缘政治关系也对俄罗斯能源发展带来了挑战。针对俄罗斯能源对外贸易发展中面临的问题,必须制定合理的能源发展战略,发挥俄罗斯国内能源产业投资优势,积极开展俄罗斯与多方能源经贸合作,不断提高俄罗斯能源产业的国际竞争力,促进俄罗斯能源贸易的发展,以此发挥能源贸易对俄国内经济的带动作用。

关键词：能源产品能源出口贸易能源合作

Experimental Simulation of Red Sprites in a Laboratory

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Journal of Atmospheric Science Research 2022年第3期5卷 26-36页

作者： Victor Tarasenko nikita Vinogradov Evgenii Baksht Dmitry Sorokin Laboratory of Optical Radiations Institute of High Current Electronics SB RASTomsk634055Russia

Over the past three decades,research of high-altitude atmospheric discharges has received a lot of *** paper presents the results of experimental modeling of red sprites during a discharge in low-pressure *** initiate ionization waves in a quartz tube,an electrodeless pulse-periodic discharge fed by microsecond voltage pulses with an amplitude of a few kilovolts and a repetition rate of tens of kHz were *** this case ionization waves(streamers)have a length of tens of *** main plasma parameters were measured at various distances along the *** measurements confirm the fact that ionization waves propagate in opposite directions from the zone of the main electrodeless discharge,just as it happens during the formation of red sprites.

关键词： Red sprites Experimental modeling Streamer discharge in air Low pressures

Infertility Management in Men with Cystic Fibrosis

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Journal of Reproduction and Contraception 2009年第1期20卷 57-62页

作者： nikita Rawal Rafit Gazvani Roger Mountford Department of Obstetrics and Gynaecology Liverpool Women's Hospita Crown Street Liverpool L8 7SS UK Department of Molecular Genetics Liverpool Women’s Hospital Crown Street Liverpool L8 7SS UK

Cystic fibrosis （CF） is a multisystem autosomal recessive disorder. CF has a reported incidence of 1 in 2 500 and a carrier frequency of 1 in 25. It is caused by mutations in a gene located on the long arm of chromosome 7. With almost 50% of patients with CF now in the adult population, and a very high interest in future parenting （78% of men wanting children）, there is an increasing need to be proactive in terms of advice about reproductive health. Discussion on reproduction should start in early adolescence and be regularly updated by medical staff. The recent advances in reproductive techniques have allowed the development of sperm aspiration coupled with intra-cytoplasmic sperm injection （ICSI）. Spermatozoa can be retrieved from either the epididymis or the testes. Genetic counselling is strongly recommended for both partners when congenital bilateral aplasia of vas deferens （CBAVD） is diagnosed as there is the inevitability of transmitting a mutated CFTR gene, and an increased risk of producing an affected child with serious long-term implications. Most treatment centres, with the introduction of ICSI, routinely screen all males with azoospermia caused by obstruction （other than that caused by vasectomy） or germ cell failure. Protocols usually involve screening for 28 relatively common CFTR mutations. Further advanced testing may be necessary up to a final detection level of approximately 98.5%. Before considering any assisted reproduction treatment, it is pertinent that CF patients receive medical and psychological counselling.

关键词： systic fibrosis (CF) ICSI infertility

Liquid Metal Heat Transfer in an Inclined Tube Affected by a Longitudinal Magnetic Field

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Journal of Iron and Steel Research International 2012年第S1期19卷 487-490页

作者： BELYAEV Ivan A. LISTRATOV Yaroslav I. RAZUVANOV nikita G. Sviridov Valentin G. MPEI-Moscow Power Engineering Institute JIHT-Joint Institute of High Temperatures of the Russian Academy of Science

This paper presents results of hydrodynamic and heat transfer investigations in liquid metal flow affected by a longitudinal magnetic field in an inclined tube with respect to tokamak cooling *** study has been conducted for the tube with slope 1\5 to the horizon which corresponds to the conditions oflTER project in case the LM flow faced longitudinal *** results obtained in the regimes without the MF,may be interesting for the design of nuclear reactors cooled by LM and metallurgical processes.

关键词： heat transfer inclined tube probe measurements longitudinal magnetic field liquid metal

Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques

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World Journal of Gastroenterology 2015年第16期21卷 4894-4902页

作者： Thomas Karlas Joachim Berger nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim IFB Adiposity Diseases Leipzig University Medical Center Department of Medicine Neurology and DermatologyDivision of Gastroenterology and RheumatologyUniversity Hospital Leipzig Department of Diagnostic and Interventional Radiology University Hospital Leipzig Internistische Hausarzt- und Diabetologische Schwerpunktpraxis Dr. Relke Department of Medicine Neurology and DermatologyDivision of Endocrinology and NephrologyUniversity Hospital Leipzig

AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver ***:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and *** parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP ***:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the *** ASQ parameters showed differences between healthy controls and diabetic patients(P0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver *** estimation with ASQ should be further evaluated in biopsy-controlled studies.

关键词： Transient elastography Non-alcoholic fatty liver disease Liver stiffness Fibrosis score Controlled attenuation parameter

Electro Energetic Technological Control in Eastern Siberia Railway

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Journal of Energy and Power Engineering 2012年第2期6卷 293-298页

作者： Zakaryukin Vasiliy Panteleymonovich Kryukov Andrew Vasilievich Abramov nikita Andreevich Irkutsk State Transport University Irkutsk 664074 Russia

By system analysis and imitating modeling authors show the most effective modern techniques for railway electric systems control. Modem measure technologies PMU-WAMS and smart grid allow to solve real time tasks of centralizing control of railway electric systems. Quantity characteristics of control effectiveness are determined. According to computer modeling the situation approach is available for practical tasks of railway electric system control.

关键词： Electric supplying railway electric traction technological control.

血液透析患者血清成纤维细胞生长因子21与肌少症的关系及相关机制

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中华肾脏病杂志 2023年第3期39卷 188-199页

作者：李旻张培王彬张梦雨刘舒苏 CROMWELL nikita 杨敏苏州大学附属第三医院肾内科常州213003 东南大学附属中大医院肾内科南京210009 Department of Nephrology Georgetown Public Hospital CorporationGeorgetownGuyana

目的探讨血液透析(hemodialysis, HD)患者血清成纤维细胞生长因子21(fibroblast growth factor 21, FGF21)与肌少症的关系, 并在细胞水平初步探索尿毒症状态下FGF21与骨骼肌代谢相关信号通路的关系。方法该前瞻性观察性研究搜集2018—2... 详细信息

目的探讨血液透析(hemodialysis, HD)患者血清成纤维细胞生长因子21(fibroblast growth factor 21, FGF21)与肌少症的关系, 并在细胞水平初步探索尿毒症状态下FGF21与骨骼肌代谢相关信号通路的关系。方法该前瞻性观察性研究搜集2018—2019年苏州大学附属第三医院血液净化中心接受HD的患者资料。以ELISA法检测HD患者血清FGF21浓度, 同时根据第四胸椎(the fourth thoracic vertebra, T4)及第一腰椎(the first lumbar vertebra, L1)计算机断层扫描(computed tomography, CT)平面骨骼肌指数(skeletal muscle index, SMI)将患者分为肌少症组及非肌少症组, 分析FGF21与肌少症的关系。体外培养小鼠C2C12成肌细胞, 分别给予健康人血清、健康人血清+不同浓度FGF21、尿毒症血清、尿毒症血清+不同浓度FGF21干预细胞, 并采用Western印迹法检测各组肌肉环指蛋白-1(muscle ring finger protein-1, MURF1)、肌肉萎缩相关的F-box蛋白(muscle atrophy F-box, MAFbx/Atrogin-1)、成肌分化因子(myogenic differentiation, MyoD)、肌细胞生成素(myogenin, MyoG)的表达。结果共有118例HD患者被纳入此项研究, 其中男性64例(54.2%), 女性54例(45.8%), 年龄为(52.64±15.29)岁。118例HD患者有CT T4图像, 根据T4 SMI性别特异性最低四分位数(P25)为截点值分组(男性 < 59.92 cm^(2)/m^(2), 女性 < 46.75 cm^(2)/m^(2)), 肌少症组29例, 非肌少症组89例, 肌少症患者比例高达24.58%。82例患者有L1横断面图像, 根据L1 SMI性别特异性最低四分位数(P25)为截点值分组(男性 < 29.02 cm^(2)/m^(2), 女性 < 24.50 cm^(2)/m^(2)), 肌少症组20例, 非肌少症组62例, 肌少症患者比例高达24.39%。根据T4 SMI分组结果显示, 肌少症组患者血清FGF21水平高于非肌少症组, 但两组间差异无统计学意义[448.52(183.96, 1 684.08)ng/L比273.65(152.83, 535.54)ng/L, Z=-1.741, P=0.082]。根据L1 SMI分组结果显示, 肌少症组患者血清FGF21水平显著高于非肌少症组[460.95(188.91, 1 276.38)ng/L比239.10(133.25, 466.36)ng/L, Z=-2.170, P=0.030]。分别根据T4 SMI及L1 SMI进行分组, 二元Logistic回归分析结果均显示FGF21升高是HD患者发生肌少症的独立影响因素(根据T4 SMI分组:OR=4.085, 95%CI 1.778~9.388, P=0.001;根据L1 SMI分组:OR=7.327, 95%CI 1.841~29.160, P=0.005)。在T4和L1平面, FGF21预测HD患者发生肌少症的受试者工作特征曲线下面积分别为0.636(95%CI 0.494~0.779, P=0.036)和0.684(95%CI 0.535~0.833, P=0.018)。细胞实验结果显示, 在尿毒症血清中给予外源性FGF21干预后, 肌管细胞MURF1、Atrogin-1表达升高, 而MyoD、MyoG表达显著降低(均P < 0.05)。结论 HD患者血清FGF21升高与肌少症风险增加相关。FGF21在尿毒症状态下可能通过调节泛素蛋白酶体系统的表达, 减少骨骼肌细胞蛋白的合成及分化, 导致肌肉萎缩的发生。

关键词：肾透析成纤维细胞生长因子肌减少症尿毒症肌骨骼泛素蛋白酶体系统

Targeting the PI3K/AKT/mTOR pathway in epithelial ovarian cancer,therapeutic treatment options for platinum-resistant ovarian cancer

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Cancer Drug Resistance 2021年第3期4卷 573-595页

作者： Natasha Rinne Elizabeth LChristie Anastasia Ardasheva Chun Hei Kwok nikita Demchenko Caroline Low Catherine Tralau-Stewart Christina Fotopoulou Paula Cunnea Department of Surgery&Cancer Imperial College LondonHammersmith campusLondon W120NNUK Peter MacCallum Cancer Centre East MelbourneVictoria 3002Australia Department of Metabolism Digestion&Reproduction Imperial College LondonLondon W120NNUK Takeda Academic Innovation Center for External InnovationTakeda CaliforniaSan DiegoCA 92121USA

The survival rates for women with ovarian cancer have shown scant improvement in recent years,with a 5-year survival rate of less than 40%for women diagnosed with advanced ovarian ***-grade serous ovarian cancer(HGSOC)is the most lethal subtype where the majority of women develop recurrent disease and chemotherapy resistance,despite over 70%-80%of patients initially responding to platinum-based *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)signaling pathway regulates many vital processes such as cell growth,survival and ***,this pathway is frequently dysregulated in cancers including different subtypes of ovarian cancer,through amplification or somatic mutations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha(PIK3CA),amplification of AKT isoforms,or deletion or inactivation of *** evidence indicates a role for the PI3K/AKT/mTOR pathway in the development of chemotherapy resistance in ovarian ***,targeting key nodes of the PI3K/AKT/mTOR pathway is a potential therapeutic *** this review,we outline dysregulation of PI3K signaling in ovarian cancer,with a particular emphasis on HGSOC and platinum-resistant *** review pre-clinical evidence for inhibitors of the main components of the PI3K pathway and highlight past,current and upcoming trials in ovarian cancers for different inhibitors of the *** no inhibitors of the PI3K/AKT/mTOR pathway have thus far advanced to the clinic for the treatment of ovarian cancer,several promising compounds which have the potential to restore platinum sensitivity and improve clinical outcomes for patients are under evaluation and in various phases of clinical trials.

关键词： Ovarian cancer high-grade serous PI3K/AKT/mTOR pathway chemotherapy resistance inhibitors therapeutics

Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases

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World Journal of Gastroenterology 2016年第47期22卷 10275-10286页

作者： Hannah Ceuleers Hanne Van Spaendonk nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns Joris G De Man Ingrid De Meester Benedicte Y De Winter Laboratory of Experimental Medicine and Pediatrics Division of Gastroenterology University of Antwerp Laboratory of Medical Biochemistry University of Antwerp Laboratory of Medicinal Chemistry and Antwerp Drug Discovery Network University of Antwerp

Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein.

关键词： Proteases Proteinase-activated receptors Protease inhibitors Visceral hypersensitivity Visceral pain Irritable bowel syndrome Inflammatory bowel diseases