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Fatal gastrointestinal histoplasmosis 15 years after orthotopic liver transplantation

World Journal of Gastroenterology 2017年第43期23卷 7807-7812页

作者： nikita Agrawal David EJ Jones Jessica K Dyson Tim Hoare Sharon A Melmore Stephanie Needham Nick P Thompson Department of Gastro-enterology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom Faculty of Medical Sciences Newcastle UniversityNewcastle Upon Tyne NE7 7DNUnited Kingdom Department of Radiology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom Department of Histopathology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom

We report a case of ileo-colonic Histoplasmosis without apparent respiratory involvement in a patient who had previously undergone an orthotopic liver transplant(OLT) for primary biliary cholangitis 15 years earlier. The recipient lived in the United Kingdom,a non-endemic region for Histoplasmosis. However,she had previously lived in rural southern Africa prior to her OLT. The patient presented with iron deficiency anaemia,diarrhoea,abdominal pain and progressive weight loss. She reported no previous foreign travel,however,it later became known that following her OLT she had been on holiday to rural southern Africa. On investigation,a mild granulomatous colitis primarily affecting the right colon was identified,that initially improved with mesalazine. Her symptoms worsened after 18 mo with progressive ulceration of her distal small bowel and right colon. Mycobacterial,Yersinia,cytomegalovirus and human immunodeficiency virus infections were excluded and the patient was treated with prednisolone for a working diagnosis of Crohn's disease. Despite some early symptom improvement following steroids,there was subsequent deterioration with the patient developing gram-negative sepsis and multi-organ failure,leading to her death. Post-mortem examination revealed that her ileo-colonic inflammation was caused by Histoplasmosis.

关键词： Histoplasmosis Orthotopic 肝移植主要胆汁的胆管炎主要胆汁的胆管炎

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Clinical characteristics of COVID-19 patients who underwent tracheostomy and its effect on outcome:A retrospective observational study

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World Journal of Virology 2022年第6期11卷 477-484页

作者： Yudhyavir Singh Kapil Dev Soni Abhishek Singh nikita Choudhary Fahina Perveen Richa Aggarwal Nishant Patel Shailendra Kumar Anjan Trikha Department of Anesthesiology Pain Medicine and Critical CareAll India Institute of Medical SciencesNew Delhi 110029India Department of Critical and Intensive Care Jai Prakash Narayan Apex Trauma CenterAll India Institute of Medical SciencesNew Delhi 110029India Department of Anesthesia All India Institute of Medical SciencesNew Delhi 110029India

BACKGROUND The exponential rise in Coronavirus disease 2019(COVID-19)cases has resulted in an increased number of patients requiring prolonged ventilatory support and subsequent *** the limited availability of literature regarding the outcomes of COVID-19 patients with tracheostomy,we attempted to study the clinical characteristics and multiple parameters affecting the outcomes in these *** To determine all-cause mortality following tracheostomy and its association with various risk factors in COVID-19 *** This retrospective study included 73 adult COVID-19 patients admitted to the ICU between 1 April,2020 and 30 September,2021 who underwent tracheostomy as a result of acute respiratory failure due to *** data collected included demographics(age,sex),comorbidities,type of oxygen support at admission,severity of COVID-19,complications,and other parameters such as admission to tracheostomy,intubation to tracheostomy,ICU stay,hospital stay,and *** This study included 73 adult patients with an average age of 52±16.67 years,of which 52%were *** average time for admission to tracheostomy was 18.12±12.98 days while intubation to tracheostomy was 11.97±9 *** mortality rate was 71.2%and 28.8%of patients were discharged *** mean duration of ICU and hospital stay was 25±11 days and 28.21±11.60 days,*** age,severe COVID-19,mechanical ventilation,shock and acute kidney injury were associated with poor prognosis;however,early tracheostomy in intubated patients resulted in better *** Patients with severe COVID-19 requiring mechanical ventilation have a poor prognosis but patients with early tracheostomy may benefit with no added *** recommend that the timing of tracheostomy be decided on a case-by-case basis and a well-designed randomised controlled trial should be performed to elucidate the potential benefit of early tracheostomy in such patients.

关键词： COVID-19 Intubation Mechanical ventilation ICU Tracheostomy Oxygen therapy

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Evaluation of cardiolipin nanodisks as lipid replacement therapy for Barth syndrome

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The Journal of Biomedical Research 2018年第2期32卷 107-112页

作者： nikita Ikon Fong-Fu Hsu Jennifer Shearer Trudy M.Forte Robert O.Ryan Children's Hospital Oakland Research Institute Oakland CA 94609 USA Department of Medicine School of Medicine Washington University St. Louis MO 63110 USA Department of Biochemistry University of Nevada Reno NV 89557 USA.

Barth syndrome（BTHS） is a mitochondrial disorder characterized by cardiomyopathy and skeletal muscle weakness. Disease results from mutations in the tafazzin（TAZ） gene, encoding a phospholipid transacylase. Defective tafazzin activity results in an aberrant cardiolipin（CL） profile. The feasibility of restoring the intracellular CL profile was tested by in vivo administration of exogenous CL in nanodisk（ND） delivery particles. Ninety mg/kg CL（as ND）was administered to doxycycline-inducible taz shRNA knockdown（KD） mice once a week. After 10 weeks of CLND treatment, the mice were sacrificed and tissues harvested. Liquid chromatography-mass spectrometry of extracted lipids revealed that CL-ND administration failed to alter the CL profile of taz KD or WT mice. Thus, although CL-ND were previously shown to be an effective means of delivering CL to cultured cells, this effect does not extend to an in vivo setting. We conclude that CL-ND administration is not a suitable therapy option for BTHS.

关键词： mitochondria cardiomyopathy nanoparticles drug delivery

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Whispering-gallery microlasers for cell tagging and barcoding:the prospects for in vivo biosensing

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Light(Science & Applications) 2021年第5期10卷 710-712页

作者： nikita Toropovo Frank Vollmer Department of Physics and Astronomy Living Systems InstituteUniversity of ExeterExeter EX44QDUK

Researchers in the field of whispering-gallery-mode(WGM)microresonators have proposed biointegrated low-threshold WGM lasers,to enable large-scale parallel single-cell tracking and *** the reported devices have so far been primarily investigated in model applications,most recent results represent important steps towards the development of in vivo tags and sensors that utilize the unique and narrow spectral features of miniature WGM lasers.

关键词： lasers vivo utilize

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Optical in vivo and ex vivo imaging of glioma cells migration via the cerebral vessels:Prospective clinical application of the beta2-adrenoreceptors blockade for glioma treatment

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 98-107页

作者： Olga Pavlova Alexander Shirokov Alexander Fomin nikita Navolokin Andrey Terskov Alexander Khorovodov Anton Namykin Alexey Pavlov Valery Tuchin Oxana Semyachkina-Glushkovskaya Interdisciplinary Center of Critical Technologies in Medicine Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences13 Entuziastov Ave.Saratov 410049Russia Saratov State Medical University 112 Bolshaya Kazachia Str. Saratov 410012Russia Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Yuri Gagarin State Technical University of Saratov 77 Politechnicheskaya Str. Saratov 410054Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control of RAS 24 Rabochaya Str.Saratov 410028Russia Laboratory of Biophotonics Tomsk State University 36 Lenin's Ave.Tomsk 634050Russia

Malignant gliomas are highly invasive tumors that 1use the cerebral vessels for invasion due to high vascular fragility of the blood--brain barrier(BBB).On one hand,glioma is characterized by the BBB disruption,on the other hand,drug brain delivery via the BBB is a big challenge in glioma *** limited information about vascular changes associated with glioma growth is a reason of slow progress in prevention of glioma ***,we present in vrivo and er vrivo study of the BBB disruption and glioma cells(GCs)migration in rats using fuorescence and confocal *** uncovered a local breach in the BBB in the main tumor mass but not within the border of normal and malignant cells,where the BBB was impermeable for high weight *** migr ation of GCs were observed via the cerebral vessels with the intact BBB that was associated with macrophages *** mechanisms underlying glioma progression remain umknown but there is an evidence that the sympathetic nervous system(SNS)via activation of vascular beta2-adrenoreceptors(B2-ADRs)can play an important role in tumor *** results clearly show an increase in the expression of vascular B2-ADRs and production of the beta arrestin-1-co-factor of B2-ADRs signaling pathway in rats with *** blockade of B2-ADRs reduces the BBB disruption,macrophages infiltration,GCs migration and increases survival *** data suggest that the blockade of B2-ADRs may be a novel adjuvant therapeutic strategy to reduce glioma progression and prevent metastasis。

关键词： Glioma macrophages blood-brain barrier beta-2 adrenoreceptors bet a arrestin-1

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主题模型在基于社交媒体的灾害分类中的应用及比较

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地球信息科学学报 2019年第8期21卷 1152-1160页

作者：苏凯程昌秀 nikita Murzintcev 张婷北京师范大学地理科学学部地理数据与应用分析中心北京100875 中国科学院地理科学与资源研究所北京100101

“一带一路”沿线为自然灾害高发地区,且多为经济欠发达、抗灾能力弱的发展中国家。灾害发生时,挖掘和分析相关推特数据有助于开展应急救援、灾情评估、减灾防灾等工作,为中国国际救援与救助工作提供重要支撑。主题模型能在没有经验语... 详细信息

“一带一路”沿线为自然灾害高发地区,且多为经济欠发达、抗灾能力弱的发展中国家。灾害发生时,挖掘和分析相关推特数据有助于开展应急救援、灾情评估、减灾防灾等工作,为中国国际救援与救助工作提供重要支撑。主题模型能在没有经验语料库的情况下,从海量灾害相关推文中快速聚合出对灾害救援、评估有价值的信息。本文采用BTM模型和LDA模型,对2013年海燕台风相关推文进行细粒度的主题聚类,分析2个模型的精度并测试它们对近似灾害主题的区分能力,并基于“需求相关”主题类的推文,通过地名匹配,分析了海燕台风发生过程中菲律宾物资、医疗等需求程度的空间分布。结果表明:①在区分主题近似的短文本时,BTM总体精度为***的总体精度仅为0.321,说明在海燕台风灾害推文的主题识别中,BTM模型的精度高于LDA模型;②BTM能够较好识别出“灾害地点相关”、“祈福相关”等较为精细的灾害主题;③经初步验证,基于“需求相关”主题文本生成的物资、医疗等需求的需求程度空间分布与实际需求情况基本相符。

关键词：主题模型 BTM LDA 推文主题分类自然灾害应急管理

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Corrigendum:Edible seaweed-derived constituents:an undisclosed source of neuroprotective compounds

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Neural Regeneration Research 2021年第12期16卷 2564-2568页

作者： Melissa Schepers nikita Martens Assia Tiane Kenneth Vanbrabant Hong-Bing Liu Dieter Lütjohann Monique Mulder Tim Vanmierlo Department of Neuroimmunology Biomedical Research InstituteHasselt UniversityEuropean Graduate School of Neuroscience(EURON)HasseltBelgium Department of Psychiatry&Neuropsychology Division of Translational NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityEuropean Graduate School of Neuroscience(EURON)MaastrichtThe Netherlands Department of Internal Medicine Laboratory of Vascular MedicineErasmus MC University Medical CenterRotterdamthe Netherlands Institue for Clinical Chemistry and Clinical Pharmacology BonnGermany Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong ProvinceChina

Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and *** the last decades,seaweedderived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological ***,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative *** particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory ***,the antiinflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more *** this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.

关键词： algae carotenoids neuro-active phenols phytosterols polysaccharides seaweed

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Dissociative disorder presenting as foreign accent syndrome

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World Journal of Psychiatry 2013年第4期3卷 103-106页

作者： nikita Rajpal Subho Chakrabarti Department of Psychiatry Postgraduate Institute of Medical Education and ResearchChandigarh 160012 India

The foreign accent syndrome(FAS) is a rare speech disorder, characterised by the appearance of a new accent, different from the speaker's native language and perceived as foreign by others. In the majority of patients, FAS is secondary to focal brain damage caused by stroke or other neurological disorders. Infrequently, FAS has been reported in association with psychiatric disorders, including dissociative or conversion disorders. The case of a young woman with recurrent episodes of speaking with a foreign accent is described. Repeated neurological examinations, imaging and electroencephalography did not reveal any brain abnormality. However, there was a history of a difficult childhood, alcohol dependence in the father, parental discord, alleged sexual abuse in the past, interpersonal difficulties and parental death. Episodes were precipitated by stressful life circumstances and resolved spontaneously, or with supportive treatment. She had additional "suspect" symptoms such as non-epileptic seizures, aphonia and motor paralysis. All these features indicated that a dissociative disorder was involved in the genesis of her FAS. The influence of external factors such as the media was unclear. Generally biological factors have been implicated in the onset of FAS, but the presentation in this young woman suggests that psychological factors such as personality, trauma, stressful life events and psychiatric disorder; familial factors such as parental discord and parental death and family conflicts; and, social factors such the possible influence of the media may also be involved in the production of foreign accents by patients.

关键词： Foreign accent syndrome Dissociative disorder Conversion disorder Psychosocial

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The influence on biotissue laser resection of a strongly absorbing layer at the optical fiber tip

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 15-21页

作者： Daria Kuznetsova Vadim Elagin Maria Karabut Maria Shakhova Vladimir Bredikhin Liudmila Snopova Andrei Shakhov Natalia Sapogova nikita Bityurin Victor Bagratashvili Vladislav Kamensky Institute of Biomedical Technologies Nizhny Novgorod State Medical Academy 10/1 Minin and Pozharsky Sq. Nizhny Novgorod 603005Russia Lobachevsky State University of Nizhni Novgorod 23 Gagarin Avenue BLDG 2 Nizhny Novgorod 603950Russia Nizhny Novgorod State Medical Academy 10/1 Minin and Pozharsky Sq. Nizhny Novgorod 603005Russia Institute of Applied Physics Russian Academy of Sciences 46 Ul'yanov StreetNizhny Novgorod 603950Russia Institute on Laser and Information Technologies Russian Academy of Sciences 2 Pionerskaya St. Troitsk 142092Russia

In this paper,we consider a method of laser resection using the silica glass core from which the cladding layer has been removed as the cutting part of a laser *** absorbing layer coating the silica fiber tip markedly alters its biotissue cutting character *** results of histological studies of skin after exposure to a laser scalpel with and without a strongly absorbing coating(SAC)at a wavelength of 097μm show that resection using a coated scalpel is more *** an uncoated scalpel was used,skin injury was more apparent in both its surface spread and the depth of structural damage,resulting in poorer tissue regeneration.

关键词： Laser surgery silica fibers strongly absorbing coating histology

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俄罗斯医疗器械市场的进入策略 ——以中国公司为例

俄罗斯医疗器械市场的进入策略 ——以中国公司为例

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作者： nikita Martov 北京外国语大学

学位级别：硕士

目前,俄罗斯的经济正处于下降的状态,被西方制裁和限制,然而市场仍然是最有利可图的,国际企业有新的机会。俄罗斯是不同组织的成员,比如金砖国家(BRICS),这意味着该国的稳定和它的潜力是巨大的,俄国也成为了一种政治力量,并开始影响其... 详细信息

目前,俄罗斯的经济正处于下降的状态,被西方制裁和限制,然而市场仍然是最有利可图的,国际企业有新的机会。俄罗斯是不同组织的成员,比如金砖国家(BRICS),这意味着该国的稳定和它的潜力是巨大的,俄国也成为了一种政治力量,并开始影响其他国家。这些行为导致与欧盟和美国的敌对关系。因此,西方公司可能会面临许多挑战和法规,政府已出台政策支持当地的产品,并邀请东方公司。所以,中国企业在俄罗斯市场潜力巨大,并且仍然可以受到官僚机构和立法的影响。本篇论文有几个目标。本篇论文有几个论点。首先,要了解俄罗斯市场是一个整体,这就是问题所在,什么进入策略可以在局势被应用。其次,要找到并讨论相应的退出策略,在俄罗斯市场的具体中国公司,找出存在的主要问题,以及如何避免它们。该市场被定义为医疗设备市场,这在医学上最大领域之一使用——"泌尿外科"使用。该项目还考察了医疗设备,定制,网络关系,官僚机构认证的重要性,并拒绝腐败。该方法是基于螺旋式中国公司的实际案例来研究的,该公司于20]6年底进入市场,主要经验来自数据收集和与中国方面的代表面谈。此外,为了了解医疗器械企业在俄罗斯的经营情况,还与这个领域最大的参与者进行了面谈。这些巨头在加入战略提出,将与境外企业建立与俄罗斯的合作伙伴关系。本文的考察对象主要是那些参与到卫生保健系统的中国医疗公司或相关企业,并期望为其进入俄罗斯市场带来帮助。这项研究需要了解、分析中俄两国的基本国情、医疗市场、企业运营等,并尝试分析俄罗斯医疗器械市场的介入、退出策略,和当下俄罗斯卫生部门的优势与竞争何在。特别是中国公司在全球视野下不断发展,其又将如何面对俄罗斯的医疗器械市场(特别是在泌尿外科领域),以及会有哪些发展趋势,本文都将给予解答。

关键词：进入策略市场分析俄罗斯的市场卫生保健医疗器械泌尿科

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