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Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds

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Neural Regeneration Research 2020年第5期15卷 790-795页

作者： Melissa Schepers nikita Martens Assia Tiane Kenneth Vanbrabant Hong-Bing Liu Dieter Lütjohann Monique Mulder Tim Vanmierlo Department of Neuroimmunology Biomedical Research InstituteHasselt UniversityEuropean Graduate School of Neuroscience (EURON)HasseltBelgium Department of Psychiatry & Neuropsychology Division of Translational NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityEuropean Graduate School of Neuroscience (EURON)MaastrichtThe Netherlands Department of Internal Medicine Laboratory of Vascular MedicineErasmus MC University Medical CenterRotterdamthe Netherlands Institue for Clinical Chemistry and Clinical Pharmacology BonnGermany Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong ProvinceChina

Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and *** the last decades,seaweed-derived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological ***,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative *** particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory ***,the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more *** this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.

关键词： algae carotenoids neuro-active phenols phytosterols polysaccharides seaweed

Effects of mineralogical composition on uniaxial compressive strengths of sedimentary rocks

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Petroleum Science 2023年第5期20卷 3062-3073页

作者： Zhen-Liang Chen Huai-Zhong Shi Chao Xiong Wen-Hao He Hai-Zhu Wang Bin Wang nikita Dubinya Kai-Qi Ge Beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of Petroleum-BeijingBeijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BeijingBeijing102249China Basic Research Center for Energy Interdisciplinary College of ScienceChina University of PetroleumBeijing102249China Schmidt Institute of Physics of the Earth of the Russian Academy of Sciences 123242MoscowRussia Science and Technology Center of Geophysics and Mineral Resources Moscow Institute of Physics and Technology141701DolgoprudnyRussia Shale Gas Exploration and Development Project Manager Department CNPC Chuanqing Drilling Engineering Co.Ltd.ChengduSichuan610051China

Figuring out rock strength plays essential roles in the sub ground mining activities,such as oil and gas well drilling and hydraulic fracturing,coal mining,tunneling,and other civil engineering *** help understand the effects of the mineralogical composition on evaluating the rock strength,this research tries to establish indirect prediction models of rock strength by specific input mineral contents for common sedimentary *** rock samples collected from the outcrops in the Sichuan Basin,uniaxial compression tests have been conducted to sandstone,carbonate,and shale *** with statistical analysis,the experimental data prove it true that the mineralogical composition can be utilized to predict the rock strength under specific conditions but the effects of mineralogical composition on the rock strength highly depend on the rock *** to the statistical analysis results,the predicted values of rock strengths by the mineral contents can get high accuracies in sandstone and carbonate rocks while no evidences can be found in shale *** best indicator for predicting rock strength should be the quartz content for the sandstone rocks and the dolomite content for the carbonate ***,to improve the evaluation accuracy,the rock strengths of sandstones can be obtained by substituting the mineral contents of quartz and clays,and those of carbonates can be calculated by the mineral contents of dolomite and ***,the research data point out a significant contrast of quartz content in evaluating the rock strength of the sandstone rocks and the carbonate *** quartz content helps increase the sandstone strength but decrease the carbonate *** for shale rocks,no relationship exists between the rock strength and the mineralogical composition(e.g.,the clay fractions).To provide more evidences,detailed discussion also provides the readers more glances into the framework of the rock matrix,which can

关键词： Uniaxial compressive strength Quartz content Clay Sandstone Carbonate Shale

Rational management of the plant microbiome for the Second Green Revolution

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Plant Communications 2024年第4期5卷 1-15页

作者： Xiaofang Li Xin Zheng nikita Yadav Shouvik Saha El-Sayed Salama Xiangkai Li Likun Wang Byong-Hun Jeon Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021China Department of Earth Resources and Environmental Engineering Hanyang UniversitySeoul 04763South Korea Natural Resources Research Institute University of Minnesota DuluthHermantownMN 55811USA Department of Biotechnology Brainware UniversityBarasatKolkata 700125West BengalIndia Department of Occupational and Environmental Health School of Public HealthLanzhou UniversityLanzhouGansu 730000China Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life ScienceLanzhou UniversityLanzhouGansu 730000China

The Green Revolution of the mid-20th century transformed agriculture worldwide and has resulted in envi-ronmental challenges.A new approach,the Second Green Revolution,seeks to enhance agricultural pro-ductivity while minimizing negative environmental *** microbiomes play critical roles in plant growth and stress responses,and understanding plant–microbiome interactions is essential for developing sustainable agricultural practices that meet food security and safety challenges,which are among the United Nations Sustainable Development *** review provides a comprehensive exploration of key deterministic processes crucial for developing microbiome management strategies,including the host effect,the facilitator effect,and microbe–microbe interactions.A hierarchical framework for plant mi-crobiome modulation is proposed to bridge the gap between basic research and agricultural *** framework emphasizes three levels of modulation:single-strain,synthetic community,and in situ mi-crobiome ***,rational management of plant microbiomes has wide-ranging applications in agriculture and can potentially be a core technology for the Second Green Revolution.

关键词： Second Green Revolution plant microbiome rational management host effect microbiome heritability

中国企业海外投资的政治风险及其管控——以“一带一路”沿线国家为例

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深圳大学学报（人文社会科学版） 2016年第1期33卷 93-100页

作者：黄河 Starostin nikita 复旦大学国际关系与公共事务学院上海200433

国际投资中的政治风险是指由政治因素引起的不连续性出现于商业环境中,导致一个国际投资的利润潜力或资产损失的任何类型的政治事件,如战争、恐怖活动、政府变化和第三国干预等。通常我们可以从常规、影响层次、风险来源、"传统"与"非传... 详细信息

国际投资中的政治风险是指由政治因素引起的不连续性出现于商业环境中,导致一个国际投资的利润潜力或资产损失的任何类型的政治事件,如战争、恐怖活动、政府变化和第三国干预等。通常我们可以从常规、影响层次、风险来源、"传统"与"非传统"等角度将政治风险加以分类。伴随着"一带一路"战略的推进,中国企业在沿线国家的国际直接投资领域、范围和规模还将不断扩大。与此同时,在地缘政治上,目前在欧亚大陆由东向西正在逐渐形成一个"社会政治动荡风险弧",包括中南半岛、南亚、中亚、西亚及北非,地缘上与我国"一带一路"战略及多个海外投资重点地区重合,推升了我国海外投资企业面临的政治风险。因此,对政治风险进行管控在中国企业"走出去"过程中的作用举足轻重,我国亟需制定有效的相关政策,对面临的政治风险提前做出详细评估,并及早制定风险防范措施。

关键词：中国企业海外投资政治风险 “一带一路”

Mechanism of the Initial Stage of Thermal Decomposition of Nitroguanidine

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火炸药学报 2023年第1期46卷 31-40页

作者： Boris E.Krisyuk Danila A.Markin Timofey M.Sypko Viktor V.Zakharov nikita V.Chukanov Boris L.Korsunskiy Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry Russian Academy of Sciences142432prosp.Academician Semenov1ChernogolovkaMoscow RegionRussia Plekhanov Russian University of Economics Department of Chemistry and Physics36 Stremyanny laneMoscow 117997Russia Lomonosov Moscow State University Faculty of Fundamental Physical and Chemical engineeringGSP-11 Leninskie Goryp.51Moscow 119991Russia N.N.Semenov Federal Research Center for Chemical Physics Russian Academy of Science 4 Kosygina StreetBuilding 1Moscow 119991Russia

A theoretical and experimental study of the thermal decomposition of nitroguanidine(NQ) has been carried out. Various thermolysis channels were studied by quantum chemistry methods at the CCSD(or DLPNO-CCSD) level using the aug-cc-pVDZ basis set. It is shown that the lowest activation enthalpies(170-180kJ/mol) are characteristic of the reactions of NO2abstraction from the initial NQ and the reaction channel with the transfer of oxygen from the nitro group to carbon in the limiting stage. Additionally, the thermolysis of NQ was studied experimentally in a nonisothermal mode with heating rates from 1 to 10K/min. In these experiments, the weight loss of the sample, thermal effects, and mass spectra of the products were recorded. An analysis of the experimental data confirmed the results of a theoretical study of the mechanism of thermal decomposition of NQ. The main thermolysis products are N2O, HNCO, NH3, and NO2, which fully corresponds to quantum chemical calculations.

关键词： primary thermolysis steps quantum-chemical calculation mass spectrometry DSC TG

Strain improvement, optimization and purification studies for enhanced production of streptokinase from Streptococcus uberis TNA-M1

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Frontiers in Biology 2017年第5期12卷 376-384页

作者： Teetam Ghosal nikita Augustine Ashwini Siddapur Vaishnavi Babu Merlyn Keziah Samuel Subathra Devi Chandrasekaran School of Biosciences and Technology VIT University Vellore-632014 TN India

BACKGROUND： Screening of isolates for their potency to produce streptokinase was an important criterion of this research. The current study emphasizes the strain improvement, optimization and purification studies for enhanced production of streptokinase from Streptococcus uberis TNA-M1 isolated from bovine milk. METHODS： The study was carried out on samples collected from milk sample. Primary screening and characterization is used as an excellent source for the isolation of 13-hemolytic organisms. Strain improvement was done by both physical ＆ chemical mutagenesis. The enzyme activity was checked by clot lysis assay and confirmed by fibrin plate method. The partially purified and crude enzyme were analysed by high-performance liquid chromatography. Molecular weight ＆ enzyme purity was checked by SDS -PAGE, further confirmed by fibrin zymography. RESULTS： Out of the 3 isolated strains, only one isolate expressed 13-haemolysis with streptokinase （SK） activity. Based on the results of radial caseinolytic assay and blood clot dissolving assay, isolate TNA-M1 demonstrated the highest streptokinase activity. Based on morphological, biochemical and molecular characterization, it was identified as Streptococcus uberis and the strain was named as Streptococcus uberis TNA-M1. The results indicated that ultra-violet （UV） and ethyl methane sulfonate （EMS） were effective mutagenic agents for strain improvement of Streptococcus uberis TNA-M1 and enhanced SK productivity. HPLC analysis was performed in order to confirm the presence of streptokinase with the similar retention time （0.875 min） with its standard （0.854） min. SDS-PAGE of the enzyme showed protein band of approximately 47 kDa and confirmed by fibrin zymography. It exhibited fibrinolytic activity, which was more potent than other fibrinolytic enzymes. Glucose and peptone were recorded to be the optimum carbon and nitrogen sources respectively. CONCLUSION： Thus this study presents its novelty by highlighting the potentia

关键词： Streptokinase Streptococcus uberis clot busters mutagenesis optimization

Fatal gastrointestinal histoplasmosis 15 years after orthotopic liver transplantation

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World Journal of Gastroenterology 2017年第43期23卷 7807-7812页

作者： nikita Agrawal David EJ Jones Jessica K Dyson Tim Hoare Sharon A Melmore Stephanie Needham Nick P Thompson Department of Gastro-enterology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom Faculty of Medical Sciences Newcastle UniversityNewcastle Upon Tyne NE7 7DNUnited Kingdom Department of Radiology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom Department of Histopathology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom

We report a case of ileo-colonic Histoplasmosis without apparent respiratory involvement in a patient who had previously undergone an orthotopic liver transplant(OLT) for primary biliary cholangitis 15 years earlier. The recipient lived in the United Kingdom,a non-endemic region for Histoplasmosis. However,she had previously lived in rural southern Africa prior to her OLT. The patient presented with iron deficiency anaemia,diarrhoea,abdominal pain and progressive weight loss. She reported no previous foreign travel,however,it later became known that following her OLT she had been on holiday to rural southern Africa. On investigation,a mild granulomatous colitis primarily affecting the right colon was identified,that initially improved with mesalazine. Her symptoms worsened after 18 mo with progressive ulceration of her distal small bowel and right colon. Mycobacterial,Yersinia,cytomegalovirus and human immunodeficiency virus infections were excluded and the patient was treated with prednisolone for a working diagnosis of Crohn's disease. Despite some early symptom improvement following steroids,there was subsequent deterioration with the patient developing gram-negative sepsis and multi-organ failure,leading to her death. Post-mortem examination revealed that her ileo-colonic inflammation was caused by Histoplasmosis.

关键词： Histoplasmosis Orthotopic liver transplant Primary biliary cholangitis Primary biliary cholangitis

Blockchain-based prosumer incentivization for peak mitigation through temporal aggregation and contextual clustering

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Blockchain(Research and Applications) 2021年第2期2卷 82-96页

作者： nikita Karandikar Rockey Abhishek Nishant Saurabh Zhiming Zhao Alexander Lercher Ninoslav Marina Radu Prodan Chunming Rong Antorweep Chakravorty Department of Electrical Engineering and Computer Science University of StavangerStavanger86004036Norway Department of Energy and Petroleum Engineering University of StavangerStavanger86004036Norway Institute of Information Technology University of KlagenfurtKlagenfurt am Worthersee9020Austria Multiscale Networked Systems University of AmsterdamAmsterdam 1012 WXNetherlands University of Information Science and Technology OhridNorth Macedonia

Peak mitigation is of interest to power companies as peak periods may require the operator to over provision supply in order to meet the peak *** the usage curve can result in cost savings,both for the power companies and the end *** of renewable energy into the energy infrastructure presents an opportunity to use excess renewable generation to supplement supply and alleviate *** addition,demand side management can shift the usage from peak to off-peak times and reduce the magnitude of *** this work,we present a data driven approach for incentive-based peak *** user energy profiles is an essential step in this *** begin by analysing a popular energy research dataset published by the Ausgrid *** aggregated user energy behavior in temporal contexts and semantic linking and contextual clustering give us insight into consumption and rooftop solar generation *** implement,and performance test a blockchain-based prosumer incentivization *** smart contract logic is based on our analysis of the Ausgrid *** implementation is capable of supporting 792,540 customers with a reasonably low infrastructure footprint.

关键词： Peak shaving Aggregation analysis Contextual clustering Blockchain Incentivization

Evaluation of cardiolipin nanodisks as lipid replacement therapy for Barth syndrome

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The Journal of Biomedical Research 2018年第2期32卷 107-112页

作者： nikita Ikon Fong-Fu Hsu Jennifer Shearer Trudy M.Forte Robert O.Ryan Children's Hospital Oakland Research Institute Oakland CA 94609 USA Department of Medicine School of Medicine Washington University St. Louis MO 63110 USA Department of Biochemistry University of Nevada Reno NV 89557 USA.

Barth syndrome（BTHS） is a mitochondrial disorder characterized by cardiomyopathy and skeletal muscle weakness. Disease results from mutations in the tafazzin（TAZ） gene, encoding a phospholipid transacylase. Defective tafazzin activity results in an aberrant cardiolipin（CL） profile. The feasibility of restoring the intracellular CL profile was tested by in vivo administration of exogenous CL in nanodisk（ND） delivery particles. Ninety mg/kg CL（as ND）was administered to doxycycline-inducible taz shRNA knockdown（KD） mice once a week. After 10 weeks of CLND treatment, the mice were sacrificed and tissues harvested. Liquid chromatography-mass spectrometry of extracted lipids revealed that CL-ND administration failed to alter the CL profile of taz KD or WT mice. Thus, although CL-ND were previously shown to be an effective means of delivering CL to cultured cells, this effect does not extend to an in vivo setting. We conclude that CL-ND administration is not a suitable therapy option for BTHS.

关键词： mitochondria cardiomyopathy nanoparticles drug delivery