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Performance analysis of combined cycle power plant

Frontiers in Energy 2015年第4期9卷 371-386页

作者： nikhil dev rajesh attri Department of Mechanical Engineering YMCA University of Science and Technology Faridabad 121006 India

Combined cycle power plants （CCPPs） are in operation with diverse thermodynamic cycle configura- tions. Assortment of thermodynamic cycle for scrupulous locality is dependent on the type of fuel available and different utilities obtained from the plant. In the present paper, seven of the practically applicable configurations of CCPP are taken into consideration. Exergetic and energetic analysis of each component of the seven configurations is conducted with the help of computer programming tool, i.e., engineering equation solver （EES） at different pressure ratios. For Case 7, the effects of pressure ratio, turbine inlet temperature and ambient relative humidity on the first and second law is studied. The thermodynamics analysis indicates that the exergy destruction in various components of the combined cycle is significantly affected by the overall pressure ratio, turbine inlet temperature and pressure loss in air filter and less affected by the ambient relative humidity.

关键词： first-law second-law exergy destruction,components

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Perspectives and challenges of tropical medicinal herbs and modern drug discovery in the current scenario

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Asian Pacific Journal of Tropical Medicine 2019年第1期12卷 1-7页

作者： rajesh Kumar Kesharwani Krishna Misra dev Bukhsh Singh Department of Advanced Science & Technology NIET Nims University Rajasthan Department of Applied Science Indian Institute of Information Technology Allahabad Department of Biotechnology Institute of Biosciences and Biotechnology Chhatrapati Shahu Ji Maharaj University

Tropical diseases such as malaria, tuberculosis, trypanosomiasis, and leishmaniasis, account for a large number of deaths annually. Herbs are an excellent source of tropical medicines. Many advancements and discoveries have taken place in the field of drug discovery but still, a major population of tropical diseases relies on herbal traditional medicine. There are some challenges related to policy implementation, efficacy, resistance and toxicity of tropical medicines. There are many tropical diseases such as such as schistosomiasis, leishmaniasis, African sleeping sickness, filariasis and chagas disease which are neglected because very few pharmaceutical companies have shown their interest in developing therapeutics against these diseases of poor people. There are many benefits associated with herbal medicine such as the cost of production, patient tolerance, large scale availability, efficacy, safety, potency, recyclability, and environment friendly. A large number of natural extracts such as curcumin, artemisinin, morphine, reserpine, and hypericin, are in use for treatment of different tropical diseases for a long time. The current review is to discuss the overview of tropical medicinal herbs, its scope and limitations in the modern drug discovery process.

关键词： Herbs Natural sources Lead compounds Drug discovery Computational approaches

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Dust Acoustic Compressive Waves in a Warm Dusty Plasma Having Non-Thermal Ions and Non-Isothermal Electrons

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Plasma Science and Technology 2015年第9期17卷 721-727页

作者： Apul N.dev Manoj K.DEKA rajesh SUBEDI Jnanjyoti SARMA Department of Science and Humanities College of Science and Technology Department of Applied Sciences Institute of Science and TechnologyGauhati University Department of Mathematics R.G.Baruah College

In this article an investigation is presented on the properties of dust acoustic（DA）compressive solitary wave propagation in an adiabatic dusty plasma,including the effect of nonthermal positive and negative ions and non-isothermal *** reductive perturbation method has been employed to derive the lower degree modified Kadomtsev-Petviashivili（mK-P）,3D Schamel-Korteweg-de-Vries equation or modified Kadomtsev-Petviashivili（mK-P） equations for dust acoustic solitary waves in a homogeneous,unmagnetized and collisionless plasma whose constituents are non-isothermal electrons,singly charged positive and negative non-thermal ions and massive charged dust *** stationary analytical solutions of the lower degree mK-P and mK-P equations are numerically analyzed,where the effect of various dusty plasma constituents on DA solitary wave propagation is taken into *** is observed that both the ions in dusty plasma play a key role in the formation of DA compressive solitary waves,and also the ion concentration and non-isothermal electrons control the transformation of the compressive potentials of the waves.

关键词： dusty plasma reductive perturbation method non-isothermal ions compressive solitary wave

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Outcome of bone marrow instillation at fracture site in intracapsular fracture of femoral neck treated by head preserving surgery

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Chinese Journal of Traumatology 2017年第4期20卷 222-225页

作者： nikhil Verma M.P. Singh Rehan UI-Haq rajesh K. Rajnish Rahul Anshuman Department of Orthopaedics. UCMS and Ass. GTBH Delhi. India

Purpose： The aim of present study is to evaluate the outcome of bone marrow instillation at the fracture site in fracture of intracapsular neck femur treated by head preserving surgery. Methods： This study included 32 patients of age group 18e50 years with closed fracture of intracapsular neck femur. Patients were randomized into two groups as per the plan generated via ***. The two groups were Group A （control）, in which the fracture of intracapsular neck femur was treated by closed reduction and cannulated cancellous screw fixation, and Group B （intervention）, in which additional percutaneous autologous bone marrow aspirate instillation at fracture site was done along with cannulated cancellous screw fixation. Postoperatively the union at fracture site and avascular necrosis of the femoral head were assessed on serial plain radiographs at final follow-up. Functional outcome was evaluated by Harris hip score. Results： The average follow-up was 19.6 months. Twelve patients in each group had union and 4 patients had signs of nonunion. One patient from each group had avascular necrosis of the femoral head. The average Harris hip score at final follow-up in Group A was 80.50 and in Group B was 75.73, which was found to be not significant. Conclusion： There is no significant role of adding on bone marrow aspirate instillation at the fracture site in cases of fresh fracture of intracapsular neck femur treated by head preserving surgery in terms of accelerating the bone healing and reducing the incidence of femoral head necrosis.

关键词： Femoral neck fractures Bone marrow Cannulated cancellous screw

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Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation

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BIOCELL 2022年第12期46卷 2645-2657页

作者： POOJA JAISWAL VERSHA TRIPATHI ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY ANAMIKA SINGH JANESH KUMAR HEM CHANDRA JHA rajesh SHARMA AMIT KUMAR DIXIT HAMENDRA SINGH PARMAR School of Biotechnology Devi Ahilya UniversityIndore452001India Laboratory of Membrane Protein Biology National Centre for Cell SciencePune411007India Department of Biosciences and Biomedical Engineering Indian Institute of TechnologyIndore452020India Department of Biotechnology IPS AcademyIndore452012India School of Pharmacy Devi Ahilya UniversityIndore452001India Central Council for Research in Ayurvedic Sciences Kolkata263645India

Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in *** the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis,but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell *** have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase(AMPK),which activates the downstream transcription factors PGC-1α,PGC-1β,or FOXO1 for mitochondrial biogenesis;above-mentioned incretin-based therapies are also known to activate *** study evaluated the effects of sitagliptin,vildagliptin,and exendin-4 on MDA-MB-231 cells and the underlying changes in mitochondrial biogenesis,were *** with sitagliptin(100μM),vildagliptin(100μM),and exendin-4(10 nM)for 72 h to MDA-MB-231 cells led to a decrease in viability indicated by MTT assay,cell migration by scratch,and transwell migration assays,accompanied with marginal reduction in cell numbers along with the apoptotic appearance,the rate of apoptosis,and decreased lactate content in conditioned *** changes in the cancer phenotype were accompanied by an increase in the mitochondrial DNA to nuclear DNA ratio,increased MitoTracker green and red staining,and increased expression of transcription factors PGC-1α,NRF-1,NRF-2,TFAM,and ***-treatment of cells with these incretin-based drugs followed by 48 h treatment with 1μM doxorubicin increased doxorubicin sensitivity as observed by a decrease in viability by MTT ***,sitagliptin,vildagliptin,and exendin-4 exert their beneficial effects on TNBC cells via an increase in mitochondrial biogenesis that helps to switch Warburg metabolism into anti-Warburg *** response was in the order of:sitagliptin>vildagliptin>ex

关键词： Sitagliptin Vildagliptin Exendin-4 Apoptosis Migration Viability Chemo-sensitivity Mitochondrial biogenesis

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Fungal diversity notes 1387-1511:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2021年第6期111卷 1-335页

作者： Saranyaphat Boonmee Dhanushka N.Wanasinghe Mark S.Calabon Naruemon Huanraluek Sajini K.U.Chandrasiri Gareth E.B.Jones Walter Rossi Marco Leonardi Sanjay K.Singh Shiwali Rana Paras N.Singh Deepak K.Maurya Ajay C.Lagashetti Deepika Choudhary Yu-Cheng Dai Chang-Lin Zhao Yan-Hong Mu Hai-Sheng Yuan Shuang-Hui He Rungtiwa Phookamsak Hong-Bo Jiang María P.Martín Margarita Dueñas MTeresa Telleria Izabela L.Kałucka Andrzej M.Jagodziński Kare Liimatainen Diana S.Pereira Alan J.L.Phillips Nakarin Suwannarach Jaturong Kumla Surapong Khuna Saisamorn Lumyong Tarynn B.Potter Roger G.Shivas Adam H.Sparks Niloofar Vaghefi Mohamed A.Abdel-Wahab Faten A.Abdel-Aziz Guo-Jie Li Wen-Fei Lin Upendra Singh Rajendra P.Bhatt Hyang Burm Lee Thuong T.T.Nguyen Paul M.Kirk Arun Kumar Dutta Krishnendu Acharya VVenkateswara Sarma M.Niranjan Kunhiraman C.rajeshkumar nikhil Ashtekar Sneha Lad Nalin N.Wijayawardene Darbe J.Bhat Rong-Ju Xu Subodini N.Wijesinghe Hong-Wei Shen Zong-Long Luo Jing-Yi Zhang Phongeun Sysouphanthong Naritsada Thongklang Dan-Feng Bao Janith V.S.Aluthmuhandiram Jafar Abdollahzadeh Alireza Javadi Francesco Dovana Muhammad Usman Abdul Nasir Khalid Asha J.Dissanayake Anusha Telagathoti Maraike Probst Ursula Peintner Isaac Garrido-Benavent Lilla Bóna Zsolt Merényi Lajos Boros Bratek Zoltán JBenjamin Stielow Ning Jiang Cheng-Ming Tian Esmaeil Shams Farzaneh Dehghanizadeh Adel Pordel Mohammad Javan-Nikkhah Teodor T.Denchev Cvetomir M.Denchev Martin Kemler Dominik Begerow Chun-Ying Deng Emma Harrower Tohir Bozorov Tutigul Kholmuradova Yusufjon Gafforov Aziz Abdurazakov Jian-Chu Xu Peter E.Mortimer Guang-Cong Ren rajesh Jeewon Sajeewa S.N.Maharachchikumbura Chayanard Phukhamsakda Ausana Mapook Kevin D.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand CAS Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China CIFOR-ICRAF China Program World Agroforestry(ICRAF)Kunming 650201YunnanPeople’s Republic of China Honghe Center for Mountain Futures Kunming Institute of BotanyHonghe CountyKunming 654400YunnanPeople’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Section Environmental Sciences Department MeSVAUniversity of L’Aquila67100 CoppitoAQItaly National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.Agarkar RoadPune 411004India Institute of Microbiology School of Ecology and Nature ConservationBeijing Forestry UniversityBeijing 100083People’s Republic of China College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224People’s Republic of China CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110164People’s Republic of China University of the Chinese Academy of Sciences Beijing 100049People’s Republic of China Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanPeople’s Republic of China Department of Mycology Real Jardín Botánico-CSICPlaza de Murillo 228014 MadridSpain Department of Algology and Mycology Faculty of Biology and Environmental ProtectionUniversity of LodzBanacha 12/1690-237ŁódźPoland Institute of Dendrology Polish Academy of SciencesParkowa 562-035 KórnikPoland Jodrell Laboratory Royal Botanic GardensKewRichmond TW93DSSurreyUK Faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal Dep

This article is the 13th contribution in the Fungal Diversity Notes series,wherein 125 taxa from four phyla,ten classes,31 orders,69 families,92 genera and three genera incertae sedis are treated,demonstrating worldwide and geographic *** taxa described and illustrated in the present study include three new genera,69 new species,one new com-bination,one reference specimen and 51 new records on new hosts and new geographical *** new genera,Cylindrotorula(Torulaceae),Scolecoleotia(Leotiales genus incertae sedis)and Xenovaginatispora(Lindomycetaceae)are introduced based on distinct phylogenetic lineages and unique *** described species are Aspergillus lan-naensis,Cercophora dulciaquae,Cladophialophora aquatica,Coprinellus punjabensis,Cortinarius alutarius,***-latus,***,Coryneum fagi,Cruentomycena uttarakhandina,Cryptocoryneum rosae,Cyathus uniperidiolus,Cylindrotorula indica,Diaporthe chamaeropicola,Didymella azollae,Diplodia alanphillipsii,Dothiora coronicola,Efibula rodriguezarmasiae,Erysiphe salicicola,Fusarium queenslandicum,Geastrum gorgonicum,***,Helicosporium sexualis,Helminthosporium chiangraiensis,Hongkongmyces kokensis,Hydrophilomyces hydraenae,Hygrocybe boertmannii,Hyphoderma australosetigerum,Hyphodontia yunnanensis,Khaleijomyces umikazeana,Laboulbenia divisa,Laboulbenia triarthronis,Laccaria populina,Lactarius pallidozonarius,Lepidosphaeria strobelii,Longipedicellata megafusiformis,Lophiotrema lincangensis,Marasmius benghalensis,***,***,Mariannaea camelliae,Mel-anographium smilaxii,Microbotryum polycnemoides,Mimeomyces digitatus,Minutisphaera thailandensis,Mortierella solitaria,Mucor harpali,Nigrograna jinghongensis,Odontia huanrenensis,***,Paraconiothyrium ajrekarii,Par-afuscosporella niloticus,Phaeocytostroma yomensis,Phaeoisaria synnematicus,Phanerochaete hainanensis,Pleopunctum thailandicum,Pleurotheciella dimorphospora,Pseudochaetosphaeronema

关键词： 72 new taxa One new combination One reference specimen 51 new records Agaricomycetes Ascomycota Bartheletiomycetes Basidiomycota Dothideomycetes Eurotiomycetes Exobasidiomycetes Laboulbeniomycetes Leotiomycetes Mortierellomycetes Mortierellomycota Mucoromycetes Mucoromycota Phylogeny Sordariomycetes Taxonomy

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