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Efficacy of gabapentin for low back pain at a tertiary hospital: A prospective observational study

Journal of Acute Disease 2022年第3期11卷 101-106页

作者： navaneetha Krishnan Subramanian VV.Ramesh Chandra Karthikeyan Elumalai narahari n Palei Tiruveedi Kusuma Vadlamuri Venkata Prasad Yellanti Bala Venkata Bhargav Phani Mungara Yeshwanth sai Pradeep Battula Anna Balaji Department of Pharmacology Dr.Kalam College of PharmacyPeriyanayagipuram 614623India Department of neurosurgery Sri Venkateswara Institute of Medical SciencesTirupati 517102India Faculty of Pharmacy Bharath Institute of Higher Education and ResearchSelaiyur 600073India School of Pharmacy the Neotia UniversitySarisha 743368India Department of Pharmacy Practice Sree Vidyanikethan College of PharmacyTirupati 517102India Departments of Pharmacy Practice Santhiram College of PharmacyNandyal 518501India Departments of Pharmaceutics Sree Vidyanikethan College of PharmacyTirupati 517102India

Objective:To assess the efficacy of gabapentin in the treatment of low back pain ***:This prospective observational study was conducted over 6 months to assess the efficacy of gabapentin in patients suffering from low back *** medical history,pain severity by Visual Analogue scale(VAS)and sleep quality by Pittsburgh Sleep Quality Index(PQSI)were *** scores and PQSI scores before and after gabapentin treatment were compared,and gabapentin satisfaction post treatment were ***:This study included 100 low back pain patients with 65 males and 35 females,and the mean age was(39.0±10.5)*** commonest presentation was non-radiating low back pain(40%).The mean VAS score and the mean PQSI score in the study before treatment were 7.70±1.91 and 10.95±5.02,*** treatment with gabapentin,the mean VAS score and the mean PQSI score decreased to 2.75±1.79 and 4.90±2.20,respectively,and the differences before and after the treatment were significantly different(both P=0.001).Overall,62%of the patients were extremely satisfied with gabapentin because they reported no adverse drug ***,31%of the patients were satisfied and 7%were strongly dissatisfied with the ***:Gabapentin can improve sleep quality and reduce lower back pain as measured by the VAS and *** efficacy of this drug is relatively good,but further improvement is required.

关键词： Gabapentin Low back pain Sleep Pittsburgh Sleep Quality Index Visual Analogue Scale

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n-乙基-9′-溴丁氧基螺噁嗪的合成及其化学改性PMMA的结构与光致变色性能

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影像科学与光化学 2016年第6期34卷 526-533页

作者：雷元张赛高峻四川大学高分子科学与工程学院四川成都610065 四川大学化学工程学院四川成都610065

合成了分子结构中含活性C—Br键的n-乙基-9′-正溴丁氧基螺噁嗪(Br-SO),利用Br-SO分子结构中的化学基团C—Br与部分水解的聚甲基丙烯酸甲酯(hPMMA)反应制备含SO的PMMA高分子化合物(SO-hPMMA)。采用1 HnMR和IR对Br-SO结构进行了表征,研究... 详细信息

合成了分子结构中含活性C—Br键的n-乙基-9′-正溴丁氧基螺噁嗪(Br-SO),利用Br-SO分子结构中的化学基团C—Br与部分水解的聚甲基丙烯酸甲酯(hPMMA)反应制备含SO的PMMA高分子化合物(SO-hPMMA)。采用1 HnMR和IR对Br-SO结构进行了表征,研究了Br-SO、SO-hPMMA的光致变色性能及其影响因素。研究表明:Br-SO、SO-hPMMA均具有良好的光致变色性能,且SO-hPMMA的热稳定性明显高于Br-SO。

关键词：螺噁嗪光致变色化合物合成 PMMA

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荧光光谱法考察七、八元瓜环与甲基吲哚的相互作用

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光谱学与光谱分析 2011年第6期31卷 1585-1590页

作者：侯华丽薛赛凤牟兰陶朱贵州省大环化学及超分子化学重点实验室贵州大学应用化学研究所贵州贵阳550025

利用荧光光谱法考察了七、八元瓜环（Cucurbit[n=7,8]urils,Q[7],Q[8]）与客体2-甲基吲哚（2-methylindol,Me）和3-甲基吲哚（3-methylindol,Sk）的相互作用;同时研究了体系pH以及温度对Q[7]和Q[8]与客体相互作用的影响;并计算了相应的... 详细信息

利用荧光光谱法考察了七、八元瓜环（Cucurbit[n=7,8]urils,Q[7],Q[8]）与客体2-甲基吲哚（2-methylindol,Me）和3-甲基吲哚（3-methylindol,Sk）的相互作用;同时研究了体系pH以及温度对Q[7]和Q[8]与客体相互作用的影响;并计算了相应的稳定常数及热力学参数等。实验结果表明：除Q[8]与Sk作用比为1：2外,其余主客体的作用比均为1：1;在pH值为1~11,温度为298~313 K的范围内上述体系的作用比不变;在pH 1和室温条件下,作用体系的稳定常数较大;通过热力学参数的测定可知上述主客体的相互作用均是自发进行。

关键词：瓜环甲基吲哚荧光光谱法稳定常数热力学稳定性

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Better Than You Think—Appropriate Use of Implantable Cardioverter-Defi brillators at a Single Academic Center:A Retrospective Review

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Cardiovascular Innovations and Applications 2021年第2期5卷 235-243页

作者： nikhil H.Shah Steven J.Ross Steve A.noutong njapo Justin Merritt Andrew Kolarich Michael Kaufmann William M.Miles David E.Winchester Thomas A.Burkart Matthew McKillop UF Division of Cardiovascular Medicine 1600 SW Archer RdPO Box 100277GainesvilleFL 32610USA UVA Division of Cardiovascular Medicine PO Box *** Lee St.CharlottesvilleVA 22908-0158USA The Johns Hopkins Hospital Department of Radiology 601 N Caroline StBaltimore 21287USA The Heart Center 930 Franklin Street SEHuntsvilleAL358015USA Intermountain Medical Center 1380 E Medical Center DrSte 1500St.GeorgeUT 847906USA Carolina Cardiology Consultants Prisma Health1005 Grove RoadGreenvilleSC 29605USA

Background:Implantable cardioverter-defi brillators(ICDs)can be life-saving devices,although they are expensive and may cause *** 2013,several professional societies published joint appropriate use criteria(AUC)assessing indications for ICD *** evaluating the clinical application of AUC are *** registry-based studies estimated that 22.5%of primary prevention ICD implantations were“non-evidence-based”*** the basis of AUC,we aimed to determine the prevalence of“rarely appropriate”ICD implantation at our institution for comparison with previous ***:We reviewed 286 patients who underwent ICD implantation between 2013 and *** of each ICD implantation was assessed by independent review and rated on the basis of ***:Of 286 ICD implantations,two independent reviewers found that 89.5%and 89.2%,respectively,were appropriate,5.6%and 7.3%may be appropriate,and 1.8%and 2.1%were rarely *** AUC indication was found for 3.5%and 3.4%of ICD implantations,*** prevention ICD implantations were more likely rarely appropriate(2.6%vs.1.2%and 3.6%vs.1.1%)or unrated(6.0%vs.1.2%and 2.7%vs.0.6%).The reviewers found 3.5%and 3.4%of ICD implantations,respectively,were non-evidence-based *** difference in rates between reviewers was not statistically signifi ***:Compared with prior reports,our prevalence of rarely appropriate ICD implantation was very *** high appropriate use rate could be explained by the fact that AUC are based on current clinical *** AUC could benefi t from additional secondary prevention *** importantly,clinical judgement and individualized care should determine which patients receive ICDs irrespective of guidelines or criteria.

关键词： Appropriate use appropriate use criteria implantable cardioverter-defi brillator

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Small interfering RnA for cancer treatment:overcoming hurdles in delivery

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2075-2109页

作者： nitin Bharat Charbe nikhil D.Amnerkar B.Ramesh Murtaza M.Tambuwala Hamid A.Bakshi Alaa A.A.Aljabali Saurabh C.Khadse Rajendran Satheeshkumar Saurabh Satija Meenu Metha Dinesh Kumar Chellappan Garima Shrivastava Gaurav Gupta Poonam negi Kamal Dua Flavia C.Zacconin Departamento de Quimica Orgánica Facultad de Química y de FarmaciaPontificia Universidad Católica de ChileSantiago 7820436Chile Sri Adichunchunagiri College of Pharmacy Sri Adichunchunagiri UniversityBG NagarKarnataka 571418India Adv V.R.Manohar Institute of Diploma in Pharmacy NagpurMaharashtra 441110India School of Pharmacy and Pharmaceutical Science Ulster UniversityColeraineNorthern Ireland BT521SAUK Faculty of Pharmacy Department of Pharmaceutics and Pharmaceutical TechnologyYarmouk UniversityIrbid 21163Jordan Department of Pharmaceutical Chemistry R.C.Patel Institute of Pharmaceutical Education and ResearchDist.DhuleMaharashtra 425405India Discipline of Pharmacy Graduate School of HealthUniversity of Technology SydneyNSW 2007Australia School of Pharmaceutical Sciences Lovely Professional UniversityPhagwara 144411 PunjabIndia Department of Life Sciences School of PharmacyInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia Department of Biochemical Engineering and Biotechnology Indian Institute of TechnologyDelhiNew Delhi 110016India School of Pharmacy Suresh Gyan Vihar UniversityJagatpuraJaipur 302017India School of Pharmaceutical Sciences Shoolini University of Biotechnology and Management SciencesSolan 173229India Priority Research Centre for Healthy Lungs Hunter Medical Research Institute(HMRI)and School of Biomedical Sciences and PharmacyUniversity of NewcastleNSW 2308Australia Institute for Biological and Medical Engineering Schools of EngineeringMedicine and Biological SciencesPontificia Universidad Católica de ChileSantiago 4860Chile

In many ways,cancer cells are different from healthy cells.A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy ***,nanotechnology-based delivery systems are the most promising tool to deliver DnA-based products to cancer *** review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRnA delivery to the cancer *** also provides the necessary information about siRnA development and its mechanism of ***,this review gives us a clear picture of lipid and polymer-based drug delivery systems,which in the future could form the base to translate the basic siRnA biology into siRnA-based cancer therapies.

关键词： Small interfering RnA(siRnA) nanomedicine Liposomes Micelles Cancer Polymer

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农垦对草甸草原生态系统温室气体(CH_4和n_2O)的影响

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中国环境科学 2015年第4期35卷 1047-1055页

作者：路则栋杜睿杜鹏瑞梁宗敏李梓铭秦赛赛中国科学院大学资源与环境学院北京100049

2012～2013年在呼伦贝尔谢尔塔拉牧场对天然草甸草地和草地开垦农田后,不同农作物种植和管理措施下甲烷（CH4）和氧化亚氮（n2O）排放进行了野外实地观测.结果表明,天然草甸草地和农田均为大气CH4的吸收汇、n2O的排放源.在生长季,天然... 详细信息

2012～2013年在呼伦贝尔谢尔塔拉牧场对天然草甸草地和草地开垦农田后,不同农作物种植和管理措施下甲烷（CH4）和氧化亚氮（n2O）排放进行了野外实地观测.结果表明,天然草甸草地和农田均为大气CH4的吸收汇、n2O的排放源.在生长季,天然草甸草地开垦增强了土壤的n2O排放量,但是对土壤CH4通量的影响却存在较大的不确定性.在相同的气象条件下,作物类型对生长季农田CH4和n2O排放通量都没有影响.在生长季,灌溉对干旱农田的CH4平均吸收通量没有显著影响,但降低了干旱农田n2O的平均排放通量.2012年和2013年农田CH4和n2O的差异主要是因为降雨量不同导致的年际差异.回归分析表明,n2O排放通量与土壤湿度呈线性相关,与土壤温度没有相关性,CH4的吸收通量与土壤温度呈线性相关,与土壤湿度呈线性负相关.土壤湿度是影响土壤CH4吸收和n2O排放的主要因素。

关键词：天然草甸草地农田开垦甲烷氧化亚氮

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瓜环类超分子药物载体的研究进展

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高等学校化学学报 2011年第9期32卷 2022-2031页

作者：黄英陶朱薛赛凤祝黔江贵州大学贵州省大环化学及超分子化学重点实验室西南药用生物资源教育部工程研究中心贵阳550025

瓜环具有"内疏水、外亲水"的特殊分子结构,可与多种有机物发生主-客体相互作用而形成自组装分子胶囊或超分子实体,使其在环境、医药、化学分离和材料改性等方面具有广泛的应用前景.本文结合本组工作,并参考国内外文献,综述了瓜环在药物... 详细信息

瓜环具有"内疏水、外亲水"的特殊分子结构,可与多种有机物发生主-客体相互作用而形成自组装分子胶囊或超分子实体,使其在环境、医药、化学分离和材料改性等方面具有广泛的应用前景.本文结合本组工作,并参考国内外文献,综述了瓜环在药物载体及药物传输方面的研究进展,并对瓜环在药物领域的发展进行了展望.

关键词：瓜环药物载体药物传输

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Fecal microbiota transplantation induces remission of infantile allergic colitis through gut microbiota re-establishment

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World Journal of Gastroenterology 2017年第48期23卷 8570-8581页

作者： Sheng-Xuan Liu Yin-Hu Li Wen-Kui Dai Xue-Song Li Chuang-Zhao Qiu Meng-Ling Ruan Biao Zou Chen Dong Yan-Hong Liu Jia-Yi He Zhi-Hua Huang sai-nan Shu Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Microbial Research We Health Gene InstituteShenzhen 518000Guangdong ProvinceChina Department of Computer Science College of Science and EngineeringCity University of Hong KongHong KongChina

AIM To investigate the impact of fecal microbiota transplantation(FMT) treatment on allergic colitis(AC) and gut microbiota(GM).METHODS We selected a total of 19 AC infants,who suffered from severe diarrhea/hematochezia,did not relieve completely after routine therapy or cannot adhere to the therapy,and were free from organ congenital malformations and other contraindications for FMT. Qualified donor-derived stools were collected and injected to the AC infants via a rectal tube. Clinical outcomes and follow-up observations were noted. Stools were collected from ten AC infants before and after FMT,and GM composition was assessed for infants and donors using 16 S r DnA sequencing *** After FMT treatment,AC symptoms in 17 infants were relieved within 2 d,and no relapse was observed in the next 15 mo. Clinical improvement was also detected in the other two AC infants who were lost to followup. During follow-up,one AC infant suffered from mild eczema and recovered shortly after hormone therapy. Based on the 16 S r DnA analysis in ten AC infants,most of them(n = 6) had greater GM diversity after FMT. As a result,Proteobacteria decreased(n = 6) and Firmicutes increased(n = 10) in post-FMT AC infants. Moreover,Firmicutes accounted for the greatest proportion of GM in the patients. At the genus level,Bacteroides(n = 6),Escherichia(n = 8),and Lactobacillus(n = 4) were enriched in some AC infants after FMT treatment,but the relative abundances of Clostridium(n = 5),Veillonella(n = 7),Streptococcus(n = 6),and Klebsiella(n = 8) decreased *** FMT is a safe and effective method for treating pediatric patients with AC and restoring GM balance.

关键词： Pediatric Infantile allergic colitis Fecal microbiota transplantation Gut microbiota Immune reaction

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Horizontal gene transfer contributes to pathogenicity and niche adaptation in Ilyonectria mors-panacis

Horizontal gene transfer contributes to pathogenicity and ni...

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2017年浙江省微生物学会青年论坛——微生物与健康专题研讨会

作者： Bo Zhu sai Wang Chunyi Mi Ruihuan Yang Xiufang Hu

Horizontal gene transfer(HGT) is a process of genetic material exchange between unrelated organisms through a mechanism other than *** process has now been widely accepted to be the major driving force in bacterial evolution,such as the acquisition of antibiotic resistance,resistance to heavy metal,and pesticide ***,HGT involving eukaryotes appears to be much less frequent and their impact on eukaryotes such as fungi is still largely *** mors-panacis is an important disease hampering the Panax notoginseng,an important Chinese medicinal herb,which is widely used in anti-inflammatory,anti-fatigue and hepato-protection effects,and coronary heart disease ***-panacis was first grouped in the genus "Cylindrocarpon",which were commonly associated with rot and decay of woody and herbaceous plants and recently Cabral et *** the nectria/neonectria radicicola(including ***) complex as Hyonectria radicicola complex,and reclassified the fungi in this complex into 15 species under the genus Hyonectria..Due to the frequently changed taxonomy classification of ***-panacis,we hypothesize that HGT may play some role in this fungal *** test this,whole genome sequencing and comprehensive analysis was carried out based on the model strain G3 *** assembly,this genome contained 145 contigs with n50 of 1,010,205 *** total size of the genome is 61,489,751 bp and has a GC content of 48.72%.A total of 18,321 CDSs were *** comprehensive search,8 genes were found to be transferred from *** these,6 genes encode *** on literature searching,these genes may play some roles in basic biological functions and niche ***2 encodes AidA,a transporter that has been proved to be important in adhesin,which is crucial first step for pathogen infection including bacteria and *** together,these results suggest that HGT drives the pathogenicity and adaptive evolution of

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小脑发育过程中Atoh1时空表达模式

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解剖学报 2023年第2期54卷 134-141页

作者：薛赛赛陈丽萍李莹吴燕吴海涛青岛大学基础医学院生理学与病理生理学系青岛266071 军事科学院军事医学研究院军事认知与脑科学研究所北京100850 首都医科大学基础医学院神经生物学系北京100069

目的探究小脑发育过程中转录因子Atoh1 mRnA及其蛋白的时空表达模式。方法取不同发育阶段的小鼠小脑冷冻切片,RnA scope技术分析Atoh1 mRnA在小脑中的时空表达模式,每组n=3。同时,使用Atoh1转基因和基因敲入两种不同遗传学策略的报告小... 详细信息

目的探究小脑发育过程中转录因子Atoh1 mRnA及其蛋白的时空表达模式。方法取不同发育阶段的小鼠小脑冷冻切片,RnA scope技术分析Atoh1 mRnA在小脑中的时空表达模式,每组n=3。同时,使用Atoh1转基因和基因敲入两种不同遗传学策略的报告小鼠,采用免疫荧光染色技术分析Atoh1在蛋白水平的时空表达,每组n=3。结果Atoh1 mRnA在胚胎小脑菱唇和外颗粒细胞层中呈高表达;Atoh1-3*V5-P2A-tdTomato/+基因敲入小鼠染色结果显示,Atoh1主要表达在菱唇和有增殖能力的外颗粒细胞层的外层;Atoh1-Cre;tdTomato/+转基因小鼠显示,Atoh1阳性细胞在菱唇和整个颗粒细胞发育过程中包括外颗粒细胞层和内颗粒细胞层中均呈高表达。结论小脑发育过程中,Atoh1 mRnA和蛋白在胚胎期的菱唇和出生后的外颗粒细胞层中高丰度表达;但在蛋白水平上,基因敲入小鼠和转基因小鼠Atoh1在菱唇和外颗粒细胞层中的表达略有不同。

关键词：小脑发育 Atoh1 颗粒前体细胞 RnAscope 小鼠

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