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Frontiers of Architectural Research 2024年第3期13卷 561-574页

作者： Kim Hamers nienke moor Masi Mohammadi Research Group Architecture in Health HAN University of Applied SciencesArnhemthe Netherlands Chair Smart Architectural Technologies Eindhoven University of TechnologyEindhoventhe Netherlands

Dutch housing associations are dealing with a growing number of tenants who are ageing in ***,there is a lack of suitable housing that meets the(social)needs of this target *** housing,which offers a socio-spatial context that facilitates encounters between residents,is considered a promising housing concept to(partly)fill this ***,clustered housing is a broad concept consisting of a variety of housing types that differ from each other in the extent to which people“live together”.Still little is known about which types of clustered housing can be distinguished in relation to the potential for social ***,in this article we distinguish between types of clustered housing based on social,organizational,and spatial building *** have mapped these characteristics by combining real estate data of housing association Woonzorg Nederland with survey data collected among their building *** on this dataset,an explorative cluster analysis was performed,resulting in four types of clustered ***,further exploration of the data shows that,from the perspective of building managers,residents of certain types of clustered housing interact more often and feel more connected with each other than residents of non-clustered housing types.

关键词： Clustered housing Typology Seniors Social housing

Fire up the pyre:inosine thermogenic signaling for obesity therapy

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Signal Transduction and Targeted Therapy 2022年第12期7卷 4255-4256页

作者： nienke Willemsen Stefan Kotschi Alexander Bartelt Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-UniversityMunichGermany Institute for Diabetes and Cancer(IDC) Helmholtz Center MunichGerman Research Center for Environmental HealthNeuherbergGermany German Center for Cardiovascular Research Partner Site Munich Heart AllianceLMU HospitalMunichGermany Department of Molecular Metabolism&SabriÜlker Center for Metabolic Research Harvard T.H.Chan School of Public HealthBostonMAUSA

In a recent study published in Nature,Niemann et *** have discovered a metabolite signaling pathway that could pave the way to new weight loss drugs1(Fig.1).Obesity and its comorbidities are a major threat to public h... 详细信息

关键词： sine weight drugs

Clinical efficacy of the Ankle Spacer for the treatment of multiple secondary osteochondral lesions of the talus

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World Journal of Orthopedics 2022年第2期13卷 178-192页

作者： Jari Dahmen J nienke Altink Gwendolyn Vuurberg Coen A Wijdicks Sjoerd AS Stufkens Gino MMJ Kerkhoffs Department of Orthopedic Surgery Amsterdam UMCLocation AMCAmsterdam 1105AZNetherlands Department of Orthopedic Research ArthrexNaplesFL 34108United States

BACKGROUND The Ankle Spacer was developed as a joint-sparing alternative to invasive endstage ***,there are no clinical studies on the Ankle *** To describe the operative technique and the clinical efficacy of the Ankle Spacer for the treatment of multiple,cystic osteochondral lesions of the talus in patients with failed prior operative *** This is a prospective study during which patients were assessed preoperatively,at 2-and 6 wk,and at 3,6,12 and 24 mo *** with multiple,cystic or large(≥15 mm)osteochondral lesions of the talus after failed prior surgery were *** primary outcome measure was the numeric rating scale(NRS)for pain during walking at 2 years *** outcome measures included the NRS in rest and during stair climbing,the American Orthopaedic Foot and Ankle Society Hindfoot Score,the Foot and Ankle Outcome Score,the Short-Form 36 physical and mental component scale,and the Range of Motion(ROM).Radiographic evaluations were conducted to evaluate prosthetic loosening and *** rates and complications were also *** Two patients underwent an Ankle Spacer implantation on the *** NRS during walking improved from 6 and 7 preoperatively to 2 and 2 points postoperatively at 2 years,in patient 1 and 2,*** other patient-reported outcome measures also improved *** were no re-operations nor *** imaging showed no loosening of the implant and no change of implant *** The Ankle Spacer showed clinically relevant pain reduction during walking,improvement in clinical outcomes as assessed with PROMs,and no complications or *** treatment option may evolve as a joint-sparing alternative to invasive end-stage surgeries.

关键词： Hemi-arthroplasty Ankle Spacer Talar surface implant Osteochondral lesions of the talus Endstage

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数字印花技术在缝制产品加工中的应用

纺织导报 2009年第4期 83-85页

作者： Kerry Maguire King Genevieve Garland Lujuanna Pagan Jack nienke ^2公司

纺织品数字印花技术和系统的进步使其成为日益增长的产品和市场的一种可行性工艺选择。当前数字印花技术主要用于独一无二的高端产品开发，满足个性化、小众市场的需求。图像行业将数字印花技术用于软标识领域，而对于T恤印花市场，服... 详细信息

纺织品数字印花技术和系统的进步使其成为日益增长的产品和市场的一种可行性工艺选择。当前数字印花技术主要用于独一无二的高端产品开发，满足个性化、小众市场的需求。图像行业将数字印花技术用于软标识领域，而对于T恤印花市场，服装印花技术的开发和应用备受关注。数字印花技术与缝纫工艺的链接是完全加入缝制产品供应链的第二步。

关键词：数字印花技术产品加工应用缝制产品开发缝纫工艺市场纺织品

Perception of the Psychosocial Aspects of Subfertility by Parents Following Successful Medically Assisted Conception: A Qualitative Study

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Open Journal of Obstetrics and Gynecology 2016年第13期6卷 830-845页

作者： J. Catja Warmelink Janiek M. Meijer nienke Mulder Sybren Mulder Mirjam T. van Lohuizen Department of Midwifery Science AVAG and the EMGO Institute for Health and Care Research VU University Medical Centre Amsterdam The Netherlands Midwifery Academy Amsterdam Groningen Groningen The Netherlands

Nearly 5% of new-borns in the Netherlands are now born following Medically Assisted Conception (MAC), a steadily increasing number. Our qualitative study explored the subjective impact of subfertility and fertility treatment for parents who successfully achieve pregnancy following MAC and make health professionals more aware of the psychological needs of those clients. The study was based on the constructive/interpretative paradigm using a constant comparison/grounded theory design. Two men and nine women in the Netherlands who conceived as a result of MAC were interviewed in 2011. Our findings show that MAC-parents were exposed to a range of emotions such as disappointment, hope and uncertainty during the subfertile period, and these feelings were even felt after successful fertility treatment. The relationship and social support from friends and others in the same position were very important. Regarding the relationship with the partner during the subfertile period, the main thing the couple have to do is to keep talking with one another. Although they did not always agree on all issues, it was found that maintaining the communication strengthened the links between them by the end of the process. We concluded that the feelings and emotions during fertility treatment play a big role during the subfertile period and remain important during pregnancy and even after childbirth. Subfertile clients want maternity care providers to ask those who successfully achieve pregnancy following MAC about their experiences during fertility treatment, check that they still are receiving adequate social support, and involve the partner in prenatal checks.

关键词： Subfertility Fertility Treatment Maternity Care Perception Qualitative Research

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“植物朋克”咖啡馆

现代装饰 2018年第4期 76-81页

作者： Klunderbie Wiglius De bie nienke Klunder 彭佳 Studio C102 The Stella Collective

墨尔本室内设计事务所The Stella Collective与伦敦工作室Studio C102近日为英国布莱顿最古老的咖啡馆——Red Roaster,设计了一间以＂植物朋克＂为主题的充满复古风情的全新概念咖啡馆。

关键词：咖啡馆植物 Stella 室内设计事务所墨尔本工作室 Red

Phase Ⅱ study of docetaxel,cisplatin and capecitabine as preoperative chemotherapy in resectable gastric cancer

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World Journal of Gastrointestinal Surgery 2016年第10期8卷 706-712页

作者： Anneriet E Dassen nienke Bernards Valery EPP Lemmens Yes AJ van de Wouw Koop Bosscha Geert-Jan Creemers Hans JFM Pruijt Department of Gastro-intestinal Surgery and Surgical Oncology Jeroen Bosch Hospital Department of Oncology Catharina Hospital Comprehensive Cancer South (IKZ) Eindhoven Cancer Registry Department of Public Health Erasmus MC University Department of Oncology Vie Curi Hospital Department of Oncology Jeroen Bosch Hospital

AIM To investigate the feasibility of preoperative docetaxel,cisplatin and capecitabine(DCC) in patients with resectable gastric *** Patients with resectable gastric cancer fulfilling the inclusion criteria,were treated with 4 cycles of docetaxel(60 mg/m2),cisplatin(60 mg/m2) and capecitabine(1.875 mg/m2 orally on day 1-14,two daily doses) repeated every three weeks,followed by *** end point was the feasibility and toxicity/safety profile of DCC,secondary endpoints were pathological complete resection rate and pathological complete response(p CR) *** All of the patients(51) were assessable for the feasibility and safety of the *** entire preoperative regimen was completed by 68.6% of the *** Ⅲ/Ⅳ febrile neutropenia occurred in 10% of all *** patients died due to treatment related toxicity(5.9%),one of them(also) because of refusing further treatment for *** the 45 patients who were evaluable for secondary endpoints,four developed metastatic disease and 76.5% received a curative *** 3 patients a p CR was seen(5.9%),two patients underwent a R1 resection(3.9%).CONCLUSION Four courses of DCC as a preoperative regimen for patients with primarily resectable gastric cancer is highly *** high occurrence of febrile neutropenia is of *** decrease the occurrence of febrile neutropenia the prophylactic use of granulocyte colonystimulating factor(G-CSF) should be explored.A curative resection rate of 76.5% is *** use of DCC without G-CSF support as preoperative regimen in resectable gastric cancer is debatable.

关键词： Gastric cancer Preoperative chemotherapy Docetaxel Capecitabine

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儿童注意缺陷多动障碍

英国医学杂志中文版 2017年第11期20卷 650-659页

作者： nienke Verkuijl Marian Perkins Mina Fazel 牛曼曼韩颖 Department ofPsychiatry University of OxfoudOxford OX3 7JX UK Child and Adolescent Neuropsychiatry Service Oxfond Health NHS Foundation TrustOxfordUK Childre's Psychological Medicine The Children's HospilalOxford UniversityHospitals NHS Trust Oxford UK 北京大学第一医院儿科

注意缺陷多动障碍（ADHD）是儿童时期第二大最常见的精神障碍。2010年全球性疾病研究表明，儿童ADHD在全世界范围内的点患病率为男性2．2％、女性0．7％。但是，对于ADHD的诊断和治疗，不同的国家和地区各不相同，这种不确定性成为ADHD... 详细信息

注意缺陷多动障碍（ADHD）是儿童时期第二大最常见的精神障碍。2010年全球性疾病研究表明，儿童ADHD在全世界范围内的点患病率为男性2．2％、女性0．7％。但是，对于ADHD的诊断和治疗，不同的国家和地区各不相同，这种不确定性成为ADHD管理的一大特点。

关键词：儿童缺陷多动障碍精神障碍治疗方法

Neurodevelopmental Outcome After Fetoscopic Laser Surgery for Twin-twin Transfusion Syndrome:A Systematic Review of Follow-up Studies from the Last Decade

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Maternal-Fetal Medicine 2020年第3期2卷 154-161页

作者： Knijnenburg Patricia J.C. Lopriore Enrico Oepkes Dick Vreeken nienke Tan Ratna N.G.B. Rijken Monique van Klink Jeanine M.M. Department of Pediatrics Division of NeonatologyLeiden University Medical CenterLeiden 2333 ZAThe Netherlands Department of Obstetrics Division of Fetal MedicineLeiden University Medical CenterLeiden 2333 ZAThe Netherlands Department of Pediatrics Division of Child and Adolescent PsychologyLeiden University Medical CenterLeiden 2333 ZAThe Netherlands

Objective:To review the literature on long-term neurodevelopmental outcome after fetoscopic laser surgery for twin-twin transfusion syndrome(TTTS).Methods:A literature search in PubMed,Embase,Emcare,Web of Science,Cochrane library,and Academic Search Premier was *** criteria were studies between 2009 and 2019 in TTTS-survivors treated with fetoscopic laser surgery and followed-up after the neonatal period with cognitive developmental tests and neurologic *** criteria were non-English articles and reviews,case reports,letters,and ***:Nineteen articles were ***-term severe neurodevelopmental impairment(NDI)was reported by seven and ranged from 4.0%to 18.0%with a mean of 9.7%(95%confidence interval(CI):7.8-11.5).The prevalence of cerebral palsy ranged from 1.6%to 18.2%,with a mean of 5.1%(95%CI:4.1-6.2).The mean prevalence of minor impairment was 13.7%(95%CI:11.4-16.0).However,only 78.9%(15/19)studies used a validated neurodevelopmental *** studies lack uniform definitions of primary outcome,timing of follow-up,inclusion criteria,and methods,adequate comparison is ***:The prevalence of severe NDI and cerebral palsy after fetoscopic laser surgery for TTTS in the last decade remains stable around 9.7%and 5.1%,*** agreements on primary outcomes,methods,and follow-up are necessary to improve the knowledge of NDI in TTTS-survivors.

关键词： Cerebral palsy Fetofetal transfusion Fetoscopic laser surgery Neurodevelopmental impairment Neurodevelopmental outcome

2018伦敦设计周Dutch Stuff展览

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现代装饰 2018年第8期 92-101页

作者： alissa+nienke Bart Joachim Borisde Beijer Christian Heikoop Earnest Studio Lennartlauren Maria Tyakina Studio Studio Johan Viladrich Studio Thier&vanDaalen VANTOT REM Atelier 范嘉苑

2018年9月20-23日,Dutch Stuff展览将再次回归伦敦设计周,这也是Dutch Stuff继2017年后的第二届展览,该展览旨在展示荷兰的当代设计作品。去年的Dutch Stuff向观众展现了60多个荷兰设计工作室及独立设计师的作品,今年会向观众呈现更多... 详细信息

2018年9月20-23日,Dutch Stuff展览将再次回归伦敦设计周,这也是Dutch Stuff继2017年后的第二届展览,该展览旨在展示荷兰的当代设计作品。去年的Dutch Stuff向观众展现了60多个荷兰设计工作室及独立设计师的作品,今年会向观众呈现更多优质的设计作品。此外,展场的布局也经过了改善,观众会有更多的机会去挖掘和发现设计师们的设计理念,了解当代荷兰设计的风采与魅力。

关键词：设计作品展览伦敦设计工作室设计理念设计师荷兰展场