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急性B型主动脉夹层患者假腔部分血栓形成

世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 10-11页

作者： Tsai T.T. Evangelista A. nienaber c.a. 罗亮 University of Michigan Cardiovascular Center 1500 E. Medical Center Dr. Ann Arbor MI 48109- 5853 United States.Dr

背景:急性B型主动脉夹层假腔未闭合或血栓形成已被发现可以预测结果。假腔部分血栓形成的预后意义尚未阐明。方法:对1996—2003年间纳入急性主动脉夹层国际注册研究且出院时存活的201例急性B型主动脉夹层患者进行了分析。根据当次住院... 详细信息

背景:急性B型主动脉夹层假腔未闭合或血栓形成已被发现可以预测结果。假腔部分血栓形成的预后意义尚未阐明。方法:对1996—2003年间纳入急性主动脉夹层国际注册研究且出院时存活的201例急性B型主动脉夹层患者进行了分析。根据当次住院期间的假腔状态(未闭合、部分血栓形成或完全血栓形成)对Kaplan-Meier死亡率曲线进行分层。

关键词：假腔未闭住院期间主动脉夹层血栓形成血栓栓塞患者

利用Talent Thoracic支架型人工血管行血管内胸主动脉修补的效果:Talent Thoracic回顾性注册研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 61-62页

作者： Fattori R. nienaber c.a. Rousseau H. 张步升 cardiovascular Radiology University Hospital S. Orsola Bologna Italy Dr.

Background: Endovascular treatment of thoracic.a.rtic diseases demonstrated low perioperative morbidity and mortality when compared with conventional open repair. Long-term effectiveness of this minimally invasive technique remains to be proven. The Talent Thoracic Retrospective Registry was designed to evaluate the impact of this therapy on patients treated in 7 major European referral centers over an 8-year period. Methods: Data from 457 consecutive patients (113 emergency and 344 elective cases) who underwent endovascular thoracic.a.rtic repair with the Medtronic Talent Thoracic stent graft (Medtronic.a.E, Santa Rosa, calif) were collected. Follow-up analysis (24±19.4 months, range 1-85.1 months)was based on clinical and imaging findings, including all adverse events. To ensure consistency of data interpretation and event reporting, one physic.a. reviewed all adverse events and deaths for the whole cohort of patients. In the case of discrepancies, the treating physic.a.s were queried. Findings: Among 422 patients who survived the interventional procedure (in-hospital mortality 5%, 23 patients), mortality during follow-up was 8.5%(36 patients), and in 11 of them the death was related to the aortic disease. Persistent endoleak was reported at imaging follow-up in 64 cases: 44 were primary (9.6%) and 21 occurred during follow-up (4.9%). Seven patients with persistent endoleak had aortic rupture during follow-up, at a variable time from 40 days to 35 months, and all subsequently died. A minor incidence of migration of the stent graft (7 cases), graft fabric.a.teration (2 cases), and modular disconnection (3 cases) was observed at imaging. Kaplan-Meier overall survival estimate at 1 year was 90.97%, at 3 years was 85.36%, and at 5 years was 77.49%. At the same intervals, freedom from a second procedure (either open conversion or endovascular) was 92.45%, 81.3%, and 70.0%, respectively. conclusion: Endovascular treatment for thoracic.a.rtic disease with the Talent stent graft is assoc.a.ed with low early morbidity a

关键词：支架型人工血管胸主动脉 Talent 主动脉疾病随访分析影像学检查经治医师择期手术主动脉

Shielding AZ91D-1%ca from corrosion through ultrasound melt treatment:A study for stent design

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Journal of Magnesium and Alloys 2023年第8期11卷 2901-2915页

作者： I.V.Gomes M.Pacheco M.nienaber S.c.Neves D.Mei A.Barros R.L.Reis J.L.Alves H.Puga cMEMS–UMinho University of MinhoGuimarãesPortugal LABBELS–Assoc.a.e Laboratory BragaGuimarãesPortugal B's Research Group-Research Institute on Biomaterials Biodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAvepark-Parque de Ciência e TecnologiaBarco GuimarãesPortugal IcVS/3B's-PT Government Assoc.a.e Laboratory BragaGuimarãesPortugal Institute of Material and Process Design Helmholtz-Zentrum HereonGeesthacht 21502Germany School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy Zhengzhou UniversityZhengzhou 450001China

Magnesium-based materials show great potential for producing biodegradable stents,but their high corrosion rates are a roadblock.This study investigates whether ultrasound melt treatment can c.a.ge the corrosion response of an extruded AZ91D-1.0%ca(wt.%)in Earle's Balanced Salt Solution by tailoring the intermetallics'morphology in the as-extruded state.The results showed that the wires from ultrasound-treated ingots corroded faster than non-treated ones in immersion for up to 6 hours.This trend shifted for longer periods,and ultrasound-treated material showed lower corrosion rates and uniform corrosion,while the non-treated material displayed localized corrosion signs.Tensile testing of the wires demonstrated that immersion in EBSS lowered the tensile strength and elongation at fracture due to material degradation,regardless of the processing route.Nonetheless,this decline was sharper in the non-treated material.These findings suggest that ultrasound melt processing can be a promising method for improving the corrosion resistance of magnesium-based materials,paving the way for their use in manufacturing biodegradable stents.

关键词： Magnesium Ultrasound treatment Stent corrosion Mec.a.ical properties

Very late coronary aneurysm formation with subsequent stent thrombosis secondary to drug-eluting stent

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chinese Medical Journal 2011年第20期124卷 3427-3429页

作者： Ibrahim Akin Stephan Kische Tim c Rehders Henrik Schneider Gokmen R Turan Tilo Kleinfeldt Jasmin Ortak Huseyin Ince christoph A. nienaber Heart center Rostock Department of Internal Medicine I University Hospital Rostock Germany

Drug-eluting stents have c.a.ged the practice in interventional cardiology. With the widespread use of these stents important safety concerns regarding stent thrombosis and formation of coronary artery aneurysm have been expressed. While the majority of attention was focused on stent thrombosis, the formation of coronary aneurysm was only described in anecdotal reports. We report on a patient who suffered from very late stent thrombosis in assoc.a.ion with coronary artery aneurysm formation secondary to drug-eluting stent but not to bare-metal stent.

关键词： stent thrombosis coronary artery aneurysm drug-eluting stent

荟萃分析的结果支持血管内支架置入治疗降主动脉夹层

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心血管病学进展 2006年第5期27卷 680-680页

作者： Eggebrecht H nienaber c.a.Neuhauser M 蒋晖（摘译）蔡琳（校）不详成都市第三人民医院心内科

德国一项荟萃分析显示:对于夹层局限于降主动脉的患者,经血管逆行置入支架具有较高的成功率,2年生存率约90%。[第一段]

关键词：降主动脉夹层荟萃分析支架置入治疗血管内置入支架经血管生存率

A型急性主动脉夹层患者的长期生存情况:国际急性主动脉夹层注册研究的启示

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 26-26页

作者： Tsai T.T. Evangelista A. nienaber c.a.罗亮 University of Michigan cardiovascular center 24 Frank Lloyd Wright Drive Lobby A Ann ArborMI 48106-0384 United StatesDr

背景:较早的一些研究对A型急性主动脉夹层(TA-AAD)患者的长期生存情况进行了评价,但仅限于小样本单中心临床试验。作者利用当前多中心国际注册TA-AAD患者资料来进一步了解长期生存情况的相关因素。方法和结果:研究对象为1996—2003年间... 详细信息

背景:较早的一些研究对A型急性主动脉夹层(TA-AAD)患者的长期生存情况进行了评价,但仅限于小样本单中心临床试验。作者利用当前多中心国际注册TA-AAD患者资料来进一步了解长期生存情况的相关因素。方法和结果:研究对象为1996—2003年间国际急性主动脉夹层注册研究(IRAD)中的303例TA-AAD患者。

关键词：急性主动脉夹层国际注册生存情况临床试验单中心治疗经历临床随访资料生存曲线心脏外科并

激光心肌血运重建术在难治性冠心病治疗中的应用和评价

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德国医学 1999年第5期16卷 298-300页

作者： H.Ngele P.Kalmar c.a.nienaber W.Rdiger H.M.Stubbe 魏翔 Universittklinik Eppendorf Martinistrasse 52D-20246 HamburgGermany 同济医科大学附属同济医院

激光心肌血运重建术(TMR)是在不能接受介入治疗和冠状动脉搭桥手术的冠心病患者中采用的一种手术。目前,越来越多的心脏中心,尤其在德国,已开始应用激光在全世界进行了几千例TMR手术。然而自关于TMR手术满意疗效的报告发表后,人们已变... 详细信息

激光心肌血运重建术(TMR)是在不能接受介入治疗和冠状动脉搭桥手术的冠心病患者中采用的一种手术。目前,越来越多的心脏中心,尤其在德国,已开始应用激光在全世界进行了几千例TMR手术。然而自关于TMR手术满意疗效的报告发表后,人们已变得较为清醒,不少中心因适应证的选择越来越严格,TMR例数停滞不前。然而,在美国FDA进行了TMR的3期临床研究(药物疗法和TMR的随机对照),认为它是有利的措施。TMR能减轻心绞痛的严重程度,取得较好的疗效,目前已得到公认。但其作用机制和临床价值仍不清楚。

关键词：难治性冠心病激光疗法 TMR 心肌血运重建术

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对激光心肌钻孔术治疗顽固性冠心病的评价

德国医学 1998年第2期15卷 64-65页

作者： H.Ngele P.Kalmar c.a.nienaber W.Rdiger H.M.Stubbe 王琳 Herzchirurgische Klinik Universittsklinik EppendorfMartinistr.52D-20246 HambrugGermany 同济医科大学附属同济医院

当冠心病患者不适合介入和冠脉搭桥治疗时,激光心肌钻孔术(TMR)可作为一种对症治疗方法。术前检查在TMR术前应进行冠状动脉造影检查,首先确定是否还适合血管再通术。病人除做常规检查外,尽量做负荷心电图。术前还应继续观察,若内科治... 详细信息

当冠心病患者不适合介入和冠脉搭桥治疗时,激光心肌钻孔术(TMR)可作为一种对症治疗方法。术前检查在TMR术前应进行冠状动脉造影检查,首先确定是否还适合血管再通术。病人除做常规检查外,尽量做负荷心电图。术前还应继续观察,若内科治疗心绞痛,数周仍不见效者,再考虑TMR。为了判定心肌灌注障碍及冬眠心肌的部位和程度,可进行静息SPEcT和PET。

关键词：冠心病顽固性激光心肌钻孔术