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Clinical associations of corneal neuromas with ocular surface diseases

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Neural Regeneration Research 2024年第1期19卷 140-147页

作者： Charmaine Jan Li Toh Chang liu Isabelle Xin Yu Lee Molly tzu Yu Lin Louis Tong Yu-Chi liu Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore Singapore Eye Research Institute Singapore Department of Cornea and External Eye Disease Singapore National Eye CentreSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Corneal neuromas,also termed microneuromas,refer to microscopic,irregula rly-shaped enlargements of terminal subbasal nerve endings at sites of nerve damage or *** formation of corneal neuromas results from damage to corneal nerves,such as following corneal pathology or corneal or intraocular surge ***,denervated areas of sensory nerve fibers become invaded by sprouts of intact sensory nerve fibers,and later injured axons regenerate and new sprouts called neuromas *** recent years,analysis of corneal nerve abnormalities including corneal neuromas which can be identified using in vivo confocal microscopy,a non-invasive imaging technique with microscopic resolution,has been used to evaluate corneal neuropathy and ocular surface *** neuromas have been shown to be associated with clinical symptoms of discomfort and dryness of eyes,and are a promising surrogate biomarker for ocular surface diseases,such as neuropathic corneal pain,dry eye disease,diabetic corneal neuropathy,neurotrophic keratopathy,Sjogren's syndrome,bullous keratopathy,post-refra ctive surgery,and *** this review,we have summarized the current literature on the association between these ocular surface diseases and the presentation of corneal microneuromas,as well as elaborated on their pathogenesis,visualization via in vivo confocal microscopy,and utility in monitoring treatment *** current quantitative analysis on neuromas mainly relies on manual annotation and quantification,which is user-dependent and labor-intensive,future direction includes the development of artificial intelligence software to identify and quantify these potential imaging biomarkers in a more automated and sensitive manner,allowing it to be applied in clinical settings more *** imaging and molecular biomarkers may also help elucidate the associations between corneal neuromas and ocular surface diseases.

关键词： cornea corneal diseases corneal nerve corneal neuropathy in vivo confocal microscopy microneuroma neuroma ocular surface diseases

Modified stapled hemorrhoidopexy for lower postoperative stenosis: A five-year experience

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2787-2795页

作者： Yu-Hong liu tzu-Chiao Lin Chao-Yang Chen Ta-Wei Pu Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Stapled hemorrhoidopexy(SH)is currently a widely accepted method for treating the prolapse of internal *** anal stenosis is a critical complication of SH.A remedy for this involves the removal of the circumferential staples of the anastomosis,followed by the creation of a hand-sewn *** studies have reported modified SH procedures to improve *** hypothesized that our modified SH technique may help reduce complications of anal stenosis after *** To compare outcomes of staple removal at the 3-and 9-o’clock positions during modified SH in patients with mixed *** This was a single-center,retrospective,observational *** with grade III or IV hemorrhoids who underwent standard or modified SH at our colorectal center between January 1,2015,and January 1,2020,were *** operation time,blood loss,length of hospital stay,and incidence of minor or major complic-ations were *** Patients with grade III or IV hemorrhoids who underwent standard or modified SH at our colorectal center between January 1,2015 and January 1,2020,were *** time,blood loss,length of hospital stay,and incidence of minor or major complications were *** investigated 187 patients(mean age,50.9 years)who had undergone our modified SH and 313 patients(mean age,53.0 years)who had undergone standard *** the modified SH group,54%of patients had previously undergone surgical intervention for hemorrhoids,compared with the 40.3%of patients in the standard SH *** modified SH group included five(2.7%)patients with anal stenosis,while 21(6.7%)patients in the standard SH group had complications of anal *** was a significant relationship between the rate of postoperative anal stenosis and the modified SH:0.251(0.085-0.741)and 0.211(0.069-0.641)in multiple regression *** modified SH technique is a safe surgical method for advanced grade hemorrhoids and might result in

关键词： Anal canal Hemorrhoids Prolapse Stapled hemorrhoidopexy Postoperative anal stenosis Modified stapled hemorrhoidopexy

Unraveling autophagy-related pathogenesis in active ulcerative colitis:A bioinformatics approach

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World Journal of Clinical Cases 2024年第30期12卷 6335-6338页

作者： Wen-Rui Hao Chun-Yao Cheng Ju-Chi liu tzu-Hurng Cheng Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei City 11002Taiwan Department of Medical Education National Taiwan University HospitalTaipei 100225Taiwan Department of Ophthalmology Cathay General HospitalTaipei 10633Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404333Taiwan

In this editorial,we provide commentary on the study by Gong et *** this original research article,Gong et al employed a bioinformatics approach to investigate the involvement of autophagy in active ulcerative colitis(UC).Through differential gene expression analysis,they identified 58 differentially expressed autophagy-related genes in UC patients compared to healthy ***,HSPA5,CASP1,SERPINA1,CX3CL1,and BAG3,were found to be upregulated in active UC patients,suggesting their significance as core autophagyrelated *** analysis unveiled associations with crucial signaling pathways and diseases such as middle cerebral artery occlusion and ***,immune cell infiltration analysis revealed notable differences in immune cell composition between UC patients and healthy *** findings offer valuable insights into the role of autophagy in UC pathogenesis and potential therapeutic targets.

关键词： Ulcerative colitis Autophagy Bioinformatics Pathogenesis Therapeutic targets

Patient-centered care in diabetes care-concepts,relationships and practice

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World Journal of Diabetes 2024年第7期15卷 1417-1429页

作者： Tsung-Tai Chen Wei-Chih Su Mei-I liu Department of Public Health College of MedicineFu Jen Catholic UniversityNew Taipei 24205Taiwan Department of Gastroenterology Taipei Tzu-Chi HospitalNew Taipei 23142Taiwan Department of Pediatric Endocrinology Mackay Children's HospitalTaipei 10449Taiwan

We still do not have comprehensive knowledge of which framework of patientcentered care(PCC)is appropriate for diabetes care,which elements of PCC are evidence-based,and the mechanism by which PCC elements are associated with outcomes through *** this review,we elaborate on these *** found that for diabetes care,PCC elements such as autonomy support(patient individuality),cooperation and collaboration(system-level approach),communication and education(behavior change techniques),emotional support(biopsychosocial approach),and family/other involvement and support are critically *** of these factors are directly associated with different patient outcomes and indirectly associated with outcomes through patient *** present the practical implications of these PCC elements.

关键词： Diabetes mellitus Patient-centered care Autonomy support Patient activation Patient adherence

Analysis of corneal nerve plexus in corneal confocal microscopy images

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Neural Regeneration Research 2021年第4期16卷 690-691页

作者： Yu-Chi liu Molly tzu-Yu Lin Jodhbir S.Mehta Tissue Engineering and Cell Therapy Group Singapore Eye Research InstituteSingapore Department of Cornea and External Eye Disease Singapore National Eye CentreOphthalmology and Visual Sciences Academic Clinical ProgramDuke-NUS Medical SchoolSingapore

Small Aδand C nerve fibers of the sensory and autonomic nervous systems constitute 70–90%of peripheral nerve fibers including corneal nerves(Muller et al.,2003).Corneal nerves originate from the ophthalmic branch of the trigeminal nerve and enter the cornea at the limbus radially from all directions toward the central cornea at the level of anterior and middle *** subepithelial nerve plexus lies at the interface between the Bowman layer and anterior *** then divide into smaller branches and turn 90°toward Bowman’s layer(Muller et al.,2003),travelling between Bowman’s layer and the basal epithelial layer and forming the sub-basal nerve plexus(Muller et al.,2003).

关键词： Bowman layer travelling

The study of using infrared thermal image to assist surgery of coronary artery bypass

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红外与毫米波学报 2018年第1期37卷 1-7页

作者： CHANG Chia-Jui TSAI Chien-Sung TANG Shiang-Feng YANG Chi-Shih LIN Wen-Jen liu Chiang-Lung CHEN tzu-Chiang Defense Science Chung Cheng Institute of Technology National Defense University National Defense Medical Center Department of Surgery Materials & Electro-Optics Research Division National Chung Shun Institute of Technology Lee-Ming Institute of Technology Department of Mechanical Engineering

Digital infrared thermography is suitable for monitoring the planar two-dimensional temperature distribution of curved surfaces of objects by sensing their infrared radiation. Cardiac infrared thermography also has a thermal coronary angiography alias. This study proposes a digital image processing methodology for locating blood clot blockage. This methodology contains four consequent processes. The two-dimensional gray scale infrared thermograph pixels are first binarized and classified as background or coronary arteries using multi-thresh adaptive *** coronary artery contours are extracted from segmented raw pixels using continuous pepper-like pixel removal,erosion,subtraction,recursive neighborhood visiting,contour point-list construction and short edge *** the third process one coronary artery branch is selected by physicians for calculating the longest curved central axis using morphological thinning and neighborhood analysis. In the last process the nearest left and right distances from each pixel along the directional central axis to its corresponding boundary contour are added as the coronary artery variable diameter at the current pixel's position. A variable diameter versus straighten length diagram along this axial curved path is plotted to provide useful physiological information to the physician. An obstruction rate equation is then defined to calculate the possible vascular blockage positions with the local minimal rates. Finally,preoperative cases are tested to prove the predictive positions are correct in comparison to individual patient myocardial perfusion imaging.

关键词：红外技术毫米波光源仪器

One step synthesis of efficient red emissive carbon dots and their bovine serum albumin composites with enhanced multi-photon fluorescence for in vivo bioimaging

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Light(Science & Applications) 2022年第5期11卷 955-968页

作者： Huiqi Zhang Gang Wang Zhiming Zhang Josh Haipeng Lei tzu-Ming liu Guichuan Xing Chu-Xia Deng Zikang Tang Songnan Qu Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoMacao 999078China Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao 999078China MoE Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China Cancer Center Faculty of Health SciencesUniversity of MacaoMacao 999078China

Efficient red emissive carbon dots(CDs)in aqueous solutions are very scarce for high performance bioimaging *** this work,we report a one-step solvothermal treatment to synthesize pure red emissive CDs(FA-CDs)from citric acid and urea in formic acid without complicated purification *** quantum yield(PLQY)of 43.4%was observed in their dimethyl sulfoxide *** PLQY up to 21.9%in aqueous solutions was achieved in their bovine serum albumin(BSA)composites(FA-CDs@BSA)with significantly enhanced multiphoton *** strong surface electron-withdrawing structure of FA-CDs caused by the high content of C=O groups contributes for their pure red *** to the significantly enhanced single and multi-photon red fluorescence and enlarged particle sizes after composing with BSA,in vivo tumor imaging and two-photon fluorescence imaging of blood vessels in mouse ear have been realized via intravenous injection of FA-CDs@BSA aqueous solutions.

关键词： photon pure synthesis

Antioxidant and antiglycation properties of different solvent extracts from Chinese olive(Canarium album L.) fruit

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Asian Pacific Journal of Tropical Medicine 2015年第12期8卷 987-995页

作者： Chiung-Tsun Kuo tzu-Hao liu Tai-Hao Hsu Fang-Yi Lin Hui-Yin Chen Department of Food Science and Technology Central Taiwan University of Science and Technology Department of Bioindustry Technology Da-Yeh University

Objective:To evaluate the antioxidant activity,antiglycation property,and bioactivc components content of different solvent extracts from Chinese olive(Canarium album L.) ***:The dry powder of Chinese olive fruit was extracted with different solvents,i.e.,water,water/ethanol(1/1,v/v),ethanol,methanol,acetone and ethyl *** total phenolic,total flavonoids and total triterpenoids contents of various extracts were determined by spectrophotometric *** compounds were identified by high performance liquid *** assayed antioxidant activity was determined in vitro models such as antioxidant capacity by radical scavenging activity using 2,2'-azino-bLs(3-ethylbenzthiazoline-6-sulfonic acid)(ABTS),l,l-diphenyl-2-picryl- hydrazyl(DPPH) and nitrite oxide methods,chelating activity on metal ions,lipid and protein peroxidation *** vitro glucosebovine serum albumin assay was used to evaluate the antiglycation of various ***:The water/ethanol extracts of Chinese olive fruit exerted significant scavenging effects on free radicals and strong inhibitory effects on advanced glycation end products *** Chinese olive fruit extracts were rich in phenolic compounds and *** acid,ferulic acid and rutin were identified from the water/ethanol *** analysis indicated that there was a linear relationship between the antioxidant potency,free radical scavenging ability and phenolic compounds content of the Chinese olive fruit ***:Chinese olive fruit could be a natural candidate for studies of dietary complement to diabetes treatment since it combines antioxidant and antiglycation activities.

关键词： Chincsc olivc Antioxidant Antiglycation Phenolic c

GIS-based Evaluation on the Fault Motion-Induced Coseismic Landslides

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Journal of Mountain Science 2012年第5期9卷 601-612页

作者： Ming-Wey HUANG Chien-Yuan CHEN tzu-Hsiu WU Chi-Ling CHANG Sheu-Yien liu Ching-Yun KAO Taiwan Science & Technology Center for Disaster Reduction Sindian City Taipei County 231 Chinese Taipei Taiwan Chiayi University Department of Civil & Water Resources Engineering Chiayi City 60004 Chinese Taipei Chia Nan University of Pharmacy and Science Institute of Industrial Safety & Disaster Prevention Tainan City 71710 Chinese Taipei

Earthquake-induced potential landslides are commonly estimated using landslide susceptibility maps. Nevertheless, the fault location is not identified and the ground motion caused by it is unavailable in the map. Thus, potential coseismic landslides for a specific fault motion-induced earthquake could not be predicted using the map. It is meaningful to incorporate the fault location and ground motion characteristics into the landslide predication model. A new method for a specific fault motion-induced coseismic landslide prediction model using GIS （Geographic Information System） is proposed herein. Location of mountain ridges, slope gradients over 45~, PVGA （Peak Vertical Ground Accelerations） exceeded o.15 g, and PHGA （Peak Horizontal Ground Accelerations） exceeded o.25 g of slope units were representing locations that initiated landslides during the 1999 Chi-Chi earthquake in Taiwan. These coseismic landslide characteristics were used to identify areas where landslides occurred during Meishan fault motion-induced strong ground motions in Chiayi County in Taiwan. The strong ground motion （over 8 Gal in the database, 1 Gal = 0.0l m/s2, and 1 g = 981 GaD characteristics were evaluated by the fault length, site distance to the fault, and topography, and their attenuation relations are presented in GIS. The results of the analysis show that coseismic landslide areas could be identified promptly using GIS. The earthquake intensity and focus depthhave visible effects on ground motion. The shallower the focus depth, the larger the magnitude increase of the landslides. The GIS-based landslide predication method is valuable combining the geomorphic characteristics and ground motion attenuation relationships for a potential region landslide hazard assessment and in disaster mitigation planning.

关键词： Coseismic landslide GIS Chi-Chiearthquake