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Science China(Technological Sciences) 2009年第11期52卷 3335-3347页

作者： KRONVANG brian WINDOLF JФrgen GRANT Ruth ANDERSEN Hans E THODSEN Hans ovesen niels b LARSEN SФren E National Environmental Research Institute Aarhus University VejlsФvej 25 DK-8600 Silkeborg Denmark

Nationwide monitoring of the aquatic environment was initiated in 1988 in Denmark as a means to follow the outcome of the Action Plans for nutrient pollution of the aquatic environment. Five Action Plans have been adopted by the Danish Parliament since 1985 and the nationwide monitoring programme can be used to quantify the outcome as shown by reductions in nutrient discharges from both point and non-point sources. Moreover, the empirical experience gathered from nearly 20 years of monitoring is assisting the development and calibration of models for simulation of nitrogen leaching, nitrogen removal in groundwater and surface waters and the establishment of a P-index all covering the entire land area of Denmark.

关键词： nitrogen phosphorus monitoring data point sources non-point sources models Action Plans Danish experience

Plethysmograph training:A refinement for collection of respiration data in mice

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动物模型与实验医学(英文) 2023年第4期6卷 369-374页

作者： Jorid b.Sørli Karin S.Hougaard niels Hadrup Chemical Work Environment The National Research Centre for the Working EnvironmentCopenhagenDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Research Group for Risk-benefit National Food InstituteTechnical University of DenmarkLyngbyDenmark

Inhaled chemicals can harm the *** effects can result in distinct changes in respiratory patterns;the type of change indicates where and how the respiratory system is ***,changes in respiratory patterns may be detected at much lower substance concentrations than those that cause more serious effects,such as histopathological *** in respiratory patterns can be studied experimentally by monitoring the breathing of mice placed in plethysmographs and exposing head-out to the test *** method is well established;however,it is not known if training mice in being restrained in the plethysmograph could increase the quality of data *** we report the results of training mice to be restrained in plethysmographs for 5 consecutive days,with respect to body weight,respiratory parameters,and time spent in the plethysmograph,before they are removed because of unstable breathing *** mice tolerated the procedure better(measured by time in the plethysmograph)on the second day of training than the first *** did not change the breathing parameters between *** parameters stabilized within 5 min after the mice were placed in the plethysmographs on all *** was an average of 3%weight loss between the first and last days of the training,indicating that the training procedure placed some strain on the *** reduces the number of mice attempting to escape from the plethysmograph.

关键词： Alarie assay refinement sensory irritation

Measurement of the electronic structure of a type-Ⅱ topological Dirac semimetal candidate VAI_(3) using angle-resolved photoelectron spectroscopy

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钨科技(英文) 2023年第3期5卷 332-338页

作者： Hong-Wei Fang Ai-Ji Liang niels b.M.Schroter Sheng-Tao Cui Zhong-Kai Liu Yu-Lin Chen School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Max Planck Institute of Microstructure Physics Halle 06120Germany National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Department of Physics University of OxfordOxford OX13PUUnited Kingdom

Type-Ⅱ topological Dirac semimetals are topological quantum materials hosting Lorentz-symmetry breaking type-Ⅱ Dirac fermions,which are tilted Dirac cones with various exotic physical properties,such as anisotropic chiral anomalies and novel quantum *** now,only limited material systems have been confirmed by theory and experiments with the type-Ⅱ Dirac ***,we investigated the electronic structure of a new type-Ⅱ Dirac semimetal VA1_(3) with angle-resolved photoelectron *** measured band dispersions are consistent with the theoretical prediction,which suggests the Dirac points are located close to(at about 100 meV above) the Fermi *** work demonstrates a new type-Ⅱ Dirac semimetal candidate system with different Dirac node configurations and application potentials.

关键词： Dirac semimetal.Electronic structure Angle-resolved photoelectron spectroscopy K evaporation

Organic geochemical and petrographic characteristics of the Cambrian-Ordovician organic-rich marine shales in Scandinavia

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Petroleum Science 2023年第5期20卷 2637-2647页

作者： Xiao-Wei Zheng niels-HSchovsbo Lei-bo bian Arka Rudra Hamed Sanei Lithospheric Organic Carbon(LOC)Group Department of GeoscienceAarhus University8000Denmark Department of Reservoir Geology Geological Survey of Denmark and Greenland(GEUS)Oster Voldgade 10Dk-1350Copenhagen KDenmark Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China

This work used organic geochemistry and organic petrology to study the depositional environment,organic matter characteristics,and thermal maturity of the Cambrian-Ordovician organic-rich marine shales in the baltic *** main macerals in Cambrian samples include alginite,bituminite and solid bitumen,while zooclastic macerals become the major proportion of organic matter in the Ordovician *** the maturity increase,solid bitumen becomes abundant and ***-like maceral was observed only in Furongian of well DbH15/73,which probably indicates the local intrusion of Permo-Carboniferous dolerite *** programmed pyrolysis results show that immature,early mature,and over-mature samples are ***,the data of high-uranium Furongian samples were greatly altered by igneous intrusives from local *** calculation model is simulated based on pyrolysis data and fitted according to the least-square fitting *** simulated fitting HIo:400mg HC/g TOC(369.5 mg HC/g TOC,430.5 mg HC/g TOC as 95%confidence bounds)is within the worldwide marine shale HI_(o)and indicates a marine anoxia and transgressive sea with shallow water column(organofacies b).

关键词： Lower paleozoic Organic petrology Initial hydrogen index Original geochemical properties

From oral formulations to drug-eluting implants:using 3D and 4D printing to develop drug delivery systems and personalized medicine

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bio-Design and Manufacturing 2022年第1期5卷 85-106页

作者： niels G.A.Willemen Margaretha A.J.Morsink Devin Veerman Classius F.da Silva Juliana C.Cardoso Eliana b.Souto Patrícia Severino Center for biomedical Engineering Department of MedicineBrigham and Women&HospitalHarvard Medical School65 Landsdowne StreetMA 02139 CambridgeUSA Department of Developmental bioEngineering Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteEnschedeThe Netherlands Translational Liver Research Department of Medical Cell BioPhysicsTechnical Medical CentreFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands Targeted Therapeutics Department of Biomaterials Science and TechnologyFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands Department of Chemical Engineering Institute of EnvironmentalChemical and Pharmaceutical SciencesFederal University of São PauloRua São Nicolau210Diadema 09913‑030Brazil University of Tiradentes(Unit) and Institute of Technology and Research(ITP)Av.Murilo Dantas300Aracaju 49010‑390Brazil Faculty of Pharmacy University of CoimbraPólo das Ciências da SaúdeAzinhaga de Santa Comba3000‑548 CoimbraPortugal CEb‑Centre of biological Engineering University of MinhoCampus de Gualtar4710‑057 BragaPortugal Tiradentes Institute 150 Mt Vernon StDorchesterMA 02125USA

Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown *** short,personalized medicine is a term that describes medical treatment that is tuned to the *** possible way to realize personalized medicine is 3D *** using materials that can be tuned upon stimulation,4D printing is *** recent years,many studies have been exploring a new field that combines 3D and 4D printing with *** has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an ***,the first 3D printed drug,Spritam®,has already found its way to the *** review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.

关键词： Drug delivery systems 3D/4D printing Drug-eluting implants Microneedles Oral formulations

Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan

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Forensic Sciences Research 2022年第2期7卷 202-206页

作者： Muhammad Adnan Shan Julie Mechlenborg Rebecca Roen Claus bosting niels Morling Section of Forensic Genetics Department of Forensic MedicineFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Centre for Applied Molecular biology(CA Mb) University of the PunjabLahorePakistan

We investigated the forensic efficacy of the 30 insertion/deletion(Indel)markers included in the Qiagen Investigator■DIPplex kit in 529 Pakistani individuals from five major subpopulations in Pakistan(Punjabi,Pashtun,Sindhi,Saraiki,and baloch).In the Sindhi population,the distribution of HLD81 and HLD97 alleles deviated from Hardy-Weinberg equilibrium after bonferroni *** combined match probability ranged from 2.0E-12(Pashtun and baloch)to 1.0E-12(Sindhi),and the mean paternity exclusion power varied from 0.995(Punjabi,Sindhi,and Saraiki)to 0.996(Pashtun and baloch).The high combined power of discrimination(0.99999999999997)and low combined match probability(1.7E-12)for all subpopulations studied support the utility of the 30 Indel markers for forensic identification in the studied *** allele frequencies of the Indel markers in the Pakistani subpopulations were compared with those from 18 other *** results show that the populations clustered according to *** subpopulations investigated in this work showed a close genetic relationship with others from Pakistan,as well as with South Central Asian and Middle Eastern *** results suggest that the Investigator■DIPplex kit can be useful as a supplementary tool for human identification in the five Pakistani subpopulations investigated in this study.

关键词： Forensic sciences forensic genetics Qiagen investigator■DIPplex kit anthropology population genetics individual identification

Global mapping of volumetric water retention at 100,330 and 15000 cm suction using the WoSIS database

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International Soil and Water Conservation Research 2023年第2期11卷 225-239页

作者： Maria Eliza Turek Laura Poggio niels H.batjes Robson Andre Armindo Quirijn de Jong van Lier Luis de Sousa Gerard b.M.Heuvelink ISRIC-World Soll Information Wageningemthe Netherlands Graduate Program in Environmental Engineering Federal University of ParunaCurtibaR Brazil Soll Geography and Landscope Group Wageningen University Wageningenthe Netherlands Department of Physics Federul University of LavrasMGBrarll CENA-Universiy of Sao Poulo PinacicabasaoBrazil

Present global maps of soil water retention(SWR)are mostly derived from pedotransfer functions(PTFs)applied to maps of other basic soil *** an alternative,'point-based'mapping of soil water content can improve global soil data availability and *** developed point-based global maps with estimated uncertainty of the volumetric SWR at 100,330 and 15000 cm suction using measured SWR data extracted from the WoSIS Soil Profile Database together with data estimated by a random forest PTF(PTF-RF).The point data was combined with around 200 environmental covariates describing vegetation,terrain morphology,climate,geology,and hydrology using *** total,we used 7292,33192 and 42016 SWR point observations at 100,330 and 15000 cm,respectively,and complemented the dataset with 436108 estimated values at each *** cross-validation yielded a Root Mean Square Error(RMSE)of6380,7.112 and 6.48510^(-2)cm^(3)cm^(-3),and a Model Efficiency Coefficient(MEC)of0.430,0386,and 0.471,respectively,for 100,330 and 15000 *** results were also compared to three published global maps of SWR to evaluate differences between point-based and map-based mapping ***-based mapping performed better than the three map-based mapping approaches for 330 and 15000 cm,while for 100 cm results were similar,possibly due to the limited number of SWR observa-tions for 100 *** sources or uncertainty identified included the geographical clustering of the data and the limitation of the covariates to represent the naturally high variation of SWR.

关键词： Digital soil mapping Soil hydraulic properties Pedometrics SoilGrids

The status of Eustachian tube balloon dilations in Nordic countries

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第3期5卷 148-151页

作者： Juha T.Silvola Saku T.Sinkkonen Jens Wanscher Eva Westman niels H.Holm Therese ovesen Akershus University Hospital ENT Dept.and Campus AhusUniversity of OsloNorway Department of Otorhinolaryngology-Head and Neck Surgery Head and Neck CenterHelsinki University HospitalUniversity of HelsinkiHelsinkiFinland Odense University Hospital ENT Dept.OdenseDenmark University of Ume(a) Dept.of Clinical ScienceENTSite SundsvallUme(a)Sweden Region Hospital West Jutland ENT DepartmentHolstebro Denmark University of Aarhus Dept.of Clinical MedicineAarhusDenmark

There is no unanimous consensus for indications of eustachian tube balloon dilation(ETbD).Nordic countries have relatively similar hospital organizations and treatment ***,it was logical to organize a consensus meeting of *** symposium:Nordic Experiences on Eustachian Tube balloon Dilation,in Copenhagen,30-31 March,*** panellists from Denmark,Finland,Norway and Sweden and the attendees of the meeting agreed a consensus on the following issues:Candidates,Definition of Eustachian Tube Dysfunction,Diagnostic Work up,Differential Diagnosis,Contraindications,ETbD Procedure,Complications,Follow-up,and *** article also presents the status for ETbD in each of these *** the consensus statement has been discussed in the national societies and meetings for ear surgeons in each of these *** can be assumed that surgeons in the hospitals of these Nordic countries generally follow the recommendations from the consensus meeting.

关键词： Eustachian tube Eustachian tube dysfunction balloon dilation Nordic consensus

Efficacy and biosafety assessment of neuropeptide CAPA analogues against the peach-potato aphid (Myzus persicae)

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Insect Science 2022年第2期29卷 521-530页

作者： Yan Shi Ronald J.Nachman Shun-Hua Gui niels Piot Krzysztof Kaczmarek Janusz Zabrocki Julian A.T.Dow Shireen-A.Davies Guy Smagghe College of Plant Health and Medicine Qingdao Agricultural UniversityQingdaoShandongChina Laboratory of Agrozoology Department of Plants and CropsFaculty of Bioscience EngineeringGhent UniversityGhentBelgium U.S.Department of Agriculture Insect Neuropeptide LaboratoryInsect Control and Cotton Disease Research UnitSouthern Plains Agricultural Research CenterCollege StationAustinTexasUSA Institute of Entomology Guizhou UniversityGuiyangGuizhouChina Institute of Organic Chemistry Lodz University of TechnologyLodz90-924 Poland College of Medical Veterinary and Life SciencesInstitute of MolecularCell and Systems BiologyUniversity of GlasgowGlasgowUK

Insect CAPA neuropeptidesare considered to affect water and ion balance by mediating the physiological metabolism activities of the Malpighian *** previous studies,the CAPA-PK analogue 1895(2Abf-Suc-FGPRLamide)was reported to decrease aphid fitness when administered through microinjection or via topical ***,a further statistically significant decrease in the fitness of aphids and an increased mortality could not be established with pairwise combinations of 1895 with other CAPA *** this study,we assessed the topical application of new combinations of 1895 with five CAPA-PVK analogues on the fitness of *** found that 1895 and CAPA-PVK analogue 2315(ASG-[β3L]-VAFPRVamide)was statistically the most effective combination to control the peach potato aphid Myzus persicae nymphs via topical application,leading to 72%***,the combination(1895+2315)was evaluated against a selection of beneficial insects,that is,a pollinator(bombus terrestris)and three natural enemies(Chrysoperla carnea,Nasonia vitripennis,and Adalia bipunctata).We found no significant influence on food intake,weight increase,and survival for the pollinator and the three representative natural *** results could facilitate to further establish and generate CAPA analogues as alternatives to broad spectrum and less friendly insecticides.

关键词： biosafety assessment insecticidal agents Myzus persicae neuropeptide CAP2b analogues