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Targeting prion-like protein spreading in neurodegenerative diseases

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Neural Regeneration Research 2018年第11期13卷 1875-1878页

作者： zhaohui Zhang Shuke nie Liam Chen Department of Neurology Renmin HospitalWuhan University Department of Pathology Johns Hopkins University School of Medicine

The infectious template-mediated protein conversion is a unique mechanism for the onset of rare and fatal neurodegenerative disorders known as transmissible spongiform encephalopathies, or prion diseases, which affect humans and other animal species. However, emerging studies are now demonstrating prion-like mechanisms of self-propagation of protein misfolding in a number of common, non-infectious neurodegenerative diseases such as Alzheimer＇s disease and Parkinson＇s disease. It has been proposed that distinct and unrelated proteins（beta-amyloid, tau, α-synuclein, TAR DNA-binding protein 43 and huntingtin, etc.） associated with common neurodegenerative disorders can seed conversion and spread via cellto-cell transfer, sustaining the transmission of neurotoxic agents along a stereotypic route, sharing features at the heart of the intrinsic nature of prions. Here we review the most recent development on both the molecular mechanisms underlying the pathogenesis of prion-like neurodegenerative diseases as well as innovative methods and strategies for potential therapeutic applications.

关键词： prion-like synuclein tau TAR DNA-binding protein 43 beta-amyloid Parkinson's disease frontotemporal dementia amyotrophic lateral sclerosis Alzheimer's disease neurodegeneration

Low-Rank and Sparse Representation with Adaptive Neighborhood Regularization for Hyperspectral Image Classification

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Journal of Geodesy and Geoinformation Science 2022年第1期5卷 73-90页

作者： zhaohui XUE Xiangyu nie School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China

Low-Rank and Sparse Representation(LRSR)method has gained popularity in Hyperspectral Image(HSI)***,existing LRSR models rarely exploited spectral-spatial classification of *** this paper,we proposed a novel Low-Rank and Sparse Representation with Adaptive Neighborhood Regularization(LRSR-ANR)method for HSI *** the proposed method,we first represent the hyperspectral data via LRSR since it combines both sparsity and low-rankness to maintain global and local data structures *** LRSR is optimized by using a mixed Gauss-Seidel and Jacobian Alternating Direction Method of Multipliers(M-ADMM),which converges faster than *** to incorporate the spatial information,an ANR scheme is designed by combining Euclidean and Cosine distance metrics to reduce the mixed pixels within a ***,the predicted labels are determined by jointly considering the homogeneous pixels in the classification rule of the minimum reconstruction *** results based on three popular hyperspectral images demonstrate that the proposed method outperforms other related methods in terms of classification accuracy and generalization performance.

关键词： Hyperspectral Image(HSI) spectral-spatial classification Low-Rank and Sparse Representation(LRSR) Adaptive Neighborhood Regularization(ANR)

Effects of Nitrogen Sources and Concentrations on the Growth of Different Phytoplankton Taxa

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Journal of Ocean University of China 2021年第3期20卷 721-728页

作者： LIU Lei WANG zhaohui WANG Chaofan LI Weiguo nie Xiangping Department of Ecology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China Engineering Research Center of Tropical and Subtropical Aquatic Ecological Engineering Ministry of EducationGuangzhou 510632China

Effects of different nitrogen(N)compounds and concentrations on the growth of the three different phytoplankton taxa,Skeletonema costatum(Bacillariophyceae),Prorocentrum micans(Dinophyceae),and Chattonella marina(Raphidophyceae),were *** Monod equation was applied to examine effects of N concentrations on the growth of algal *** showed that nitrate(NO_(3)-N)and urea served as good N sources for the three phytoplankton *** grew well on all of the seven N *** can effectively use the two amino acids,glycine(Gly)and serine(Ser),however cannot utilize alanine(Ala),threonine(Thr),and asparaginic acid(Asp).*** cannot grow in five amino acid *** of the three phytoplankton taxa grew well under different proportions of urea-N,and *** grew significantly better in medium with both NO_(3)-and *** values of maximum growth rate(μmax)and half-saturation nutrient concentration(KS)for NO_(3)-N were 0.71 divisions d−1 and 53.55μmolL^(−1) for ***,0.67 divisions d−1 and 23.31μmolL^(−1) for ***,and 0.23 divisionsd−1 and 17.57μmolL^(−1) for ***,*** results suggested that *** had a high N demand for growth,and was capable of using wide ranges of N *** strategy of N utilization for *** may make this species an advantage in N-enriched sea areas especially the dissolved organic nitrogen(DON)rich coastal waters,which might be the reason why *** widely distributes in the cosmo-politan coastal and estuarine sea areas.

关键词： Skeletonema costatum Prorocentrum micans Chattonella marina DON half-saturation constant urea

Vision Sensing-Based Online Correction System for Robotic Weld Grinding

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Chinese Journal of Mechanical Engineering 2023年第5期36卷 97-108页

作者： Jimin Ge zhaohui Deng Shuixian Wang Zhongyang Li Wei Liu Jiaxu nie Hunan Provincial Key Laboratory of High Efciency and Precision Machining of Difcult Machine Material Hunan University of Science and TechnologyXiangtan 411201China Institute of Manufacturing Engineering Huaqiao UniversityXiamen 361021China ZOOMLION Heavy Industry Science and Technology Co. Ltd.Changsha 410000China

The service cycle and dynamic performance of structural parts are afected by the weld grinding accuracy and surface consistency. Because of reasons such as assembly errors and thermal deformation, the actual track of the robot does not coincide with the theoretical track when the weld is ground ofine, resulting in poor workpiece surface quality. Considering these problems, in this study, a vision sensing-based online correction system for robotic weld grinding was developed. The system mainly included three subsystems: weld feature extraction, grinding, and robot real-time control. The grinding equipment was frst set as a substation for the robot using the WorkVisual software. The input/output (I/O) ports for communication between the robot and the grinding equipment were confgured via the I/O mapping function to enable the robot to control the grinding equipment (start, stop, and speed control). Subsequently, the Ethernet KRL software package was used to write the data interaction structure to realize realtime communication between the robot and the laser vision system. To correct the measurement error caused by the bending deformation of the workpiece, we established a surface profle model of the base material in the weld area using a polynomial ftting algorithm to compensate for the measurement data. The corrected extracted weld width and height errors were reduced by 2.01% and 9.3%, respectively. Online weld seam extraction and correction experiments verifed the efectiveness of the system’s correction function, and the system could control the grinding trajectory error within 0.2 mm. The reliability of the system was verifed through actual weld grinding experiments. The roughness, Ra, could reach 0.504 µm and the average residual height was within 0.21 mm. In this study, we developed a vision sensing-based online correction system for robotic weld grinding with a good correction efect and high robustness.

关键词： Online correction system Robot Grinding Weld seam Laser vision sensor

ANALYTICAL AND NUMERICAL INVESTIGATIONS OF TWO SPECIAL CLASSES OF GENERALIZED CONTINUUM MEDIA

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Acta Mechanica Solida Sinica 2011年第4期24卷 326-339页

作者： zhaohui Zhang Zhanli Liu Yuan Gao Junfang nie Zhuo Zhuang Department of Engineering Mechanics School of AerospaceTsinghua UniversityBeijing 100084China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Naval Academy of Armament Beijing 100073China

In this paper,the micromorphic theory and the second gradient theory are proposedwhere the micromorphic model can be reduced to the second gradient model with the vanishing relative deformation between macrodeformation gradient and *** solutions for the simple shear problem in the case of a general small strain isotropic elasticity micromorphic model and the second gradient model are presented,***,uniaxial tension of a constrained layer with two different boundary conditions is also analytically ***,the micromorphic theory is implemented numerically within a two-dimensional plane strain finite element framework by developing two isoparametric elements.

关键词： micromorphic second gradient boundary layer size effect finite element

Growth response and toxic effects of three antibiotics on Selenastrum capricornutum evaluated by photosynthetic rate and chlorophyll biosynthesis

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Journal of Environmental Sciences 2011年第9期23卷 1558-1563页

作者： Binyang Liu Weiqiu Liu Xiangping nie Chao Guan Yufeng Yang zhaohui Wang Wei Liao Engineering Research Center of Tropical and Subtropical Aquatic Ecological Engineering Ministry of Education Institute of Hydrobiology Jinan University Guangzhou 510632 China School of Life sciences Sun Yat-Sen University Guangzhou 510275 China

The effects of three types of antibiotics （erythromycin,ciprofloxacin and sulfamethoxazole） on the photosynthesis of freshwater algae,Selenastrum capricornutum Printz,were investigated by determining the growth rate,chloroplast pigments content,seven main precursors （including δ-aminolevulinic acid,porphobilinogen,uroporphyrinogen III,coproporphyrinogen III,protoporphyrin IX,Mg-proporphyrin IX and protochlorophyllide）,and photosynthetic rate during chlorophyll *** antibiotics significantly decreased the growth rate,chlorophyll content,and photosynthetic *** induced a decreasing effect at a concentration of 0.06 mg/L,while ciprofloxacin and sulfamethoxazole achieved the same results at concentrations higher than 1.5 mg/*** erythromycin significantly inhibited chlorophyll biosynthesis,which indicated that it was considerably more toxic to *** than ciprofloxacin and sulfamethoxazole,and may pose a high potential risk to aquatic ecosystems.

关键词： Selenastrum capricornutum erythromycin lactobionate ciprofloxacin hydrochloride sulfamethoxazole chlorophyll biosynthesis

Clinical applications of MARSALA for preimplantation genetic diagnosis of spinal muscular atrophy

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Journal of Genetics and Genomics 2016年第9期43卷 541-547页

作者： Yixin Ren Xu Zhi Xiaohui Zhu Jin Huang Ying Lian Rong Li Hongyan Jin Yan Zhang Wenxin Zhang Yanli nie Yuan Wei zhaohui Liu Donghong Song Ping Liu Jie Qiao Liying Yan Department of Obstetrics and Gynecology Third Hospital Peking University Key Laboratory of Assisted Reproduction Ministry of Education and Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking-Tsinghua Center for Life Sciences Peking University

Conventional PCR methods combined with linkage analysis based on short tandem repeats （STRs） or Karyomapping with single nucleotide polymorphism （SNP） arrays, have been applied to preimplantation genetic diagnosis （PGD） for spinal muscular atrophy （SMA）, an autosome recessive disorder. However, it has limitations in SMA diagnosis by Karyomapping, and these methods are unable to distinguish wild- type embryos with carriers effectively. Mutated allele revealed by sequencing with aneuploidy and linkage analyses （MARSALA） is a new method allowing embryo selection by a one-step next-generation sequencing （NGS） procedure, which has been applied in PGD for both autosome dominant and X-linked diseases in our group previously. In this study, we carried out PGD based on MARSALA for two carrier families with SMA affected children. As a result, one of the couples has given birth to a healthy baby free of mutations in SMA-causing gene. It is the first time that MARSALA was applied to PGD for SMA, and we can distinguish the embryos with heterozygous deletion （carriers） from the wild-type （normal） ones accurately through this NGS-based method. In addition, direct mutation detection allows us to identify the affected embryos （homozygous deletion）, which can be regarded as probands for linkage analysis, in case that the affected family member is absent, In the future, the NGS-based MARSALA method is expected to be used in PGD for all monogenetic disorders with known pathogenic gene mutation.

关键词： Preimplantation genetic diagnosis Spinal muscular atrophy Next-generation sequencing Mutated allele revealed by sequencing with aneuploidy and linkage analyses

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描述逻辑语义推理机制的应用研究

现代图书情报技术 2006年第11期 61-64页

作者：聂卉龙朝晖中山大学资讯管理系广州510275 中山大学岭南学院广州510275

对基于描述逻辑的语义推理机制进行阐述分析,详细探讨在本体构建过程中,运用基于描述逻辑的语义推理进行一致性判定和相容判定的重要性和实现技术。并以具体的本体构建为例,对构建过程中的推理判定进行了验证。

关键词：本体构建描述逻辑语义推理

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基于本体概念的矢量检索模型研究

图书情报工作 2007年第9期51卷 121-123,134页

作者：聂卉龙朝晖中山大学资讯管理系广州510275 中山大学岭南学院广州510275

针对传统矢量空间模型文本特征值的计算,给出将文本的评价由基于语法的词条空间转化为概念空间的方法和策略:基于领域本体,依据本体概念间的各种关联,先以一定的映射规则,将词条映射到领域的概念术语空间;然后用概念统计和语义归纳替代... 详细信息

针对传统矢量空间模型文本特征值的计算,给出将文本的评价由基于语法的词条空间转化为概念空间的方法和策略:基于领域本体,依据本体概念间的各种关联,先以一定的映射规则,将词条映射到领域的概念术语空间;然后用概念统计和语义归纳替代传统的词频统计,从概念语义的层次计算文本的特征矢量。实验证明,基于本体概念的矢量检索模型能够有效地表达文本的语义内容,获得更好的检索效果。

关键词：本体概念检索矢量检索模型