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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie Runxue Zhou Jin Deng Weihong nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

Effect of Ag Addition on Microstructure,Mechanical and Corrosion Properties of Mg-Nd-Zn-zr Alloy for Orthopedic Application

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Acta Metallurgica Sinica(English Letters) 2023年第2期36卷 295-309页

作者： Yu-Jin nie Jian-Wei Dai Xiao-Bo Zhang School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing211167China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing211167China

The as-extruded Mg-3Nd-0.2Zn-0.4zr-xAg(x=0,0.2,0.5,1 wt%)alloys were prepared for biomedical *** electron microscope,electron backscattered diffraction,X-ray diffraction,tensile test machine,electrochemical workstation,and immersion experiments were used to study microstructures,mechanical properties,and corrosion behavior of the as-extruded *** results indicate that the microstructures of all the as-extruded alloys are composed of coarse undynamic recrystallized grains,fine equiaxed recrystallized grains,and precipitated *** element plays a positive role in promoting dynamic recrystallization and grain *** during the extrusion,all the four alloys generate a //ED fiber *** the increase of Ag element,the volume fraction of Mg_(12)Nd phase increases and then decreases *** increasing Ag addition,both yield strength and ultimate tensile strength of the as-extruded alloys reduce first and then improve,and the elongation improves gradually from 9.4 to 12.7%.More importantly,the addition of Ag accelerates corrosion of the as-extruded alloys in simulated body fluid,and all the as-extruded alloys show uniform corrosion mode.

关键词： Magnesium alloy Hot extrusion Mechanical properties Corrosion resistance

The evolution simulation of zinc finger domain sequence——Application of genetic algorithms in protein structure study

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Chinese Science Bulletin 1997年第22期42卷 1925-1928页

作者： Sun, zr Han, H Tsing Hua Univ Dept Biol Sci & Biotechnol Beijing 100084 Peoples R China

GENETIC algorithms are very efficient search mechanisms. The application of genetic algo-rithms in the protein structure study provides not only a convenience algorithm for the searchof the lowest energy status (accor... 详细信息

关键词： genetic algorithm zinc finger domain evolution simulation protein sequence.

Ameliorating the Strength-Modulus Synergy in GNPs Reinforced Mg-Zn-zr Composites via Multidirectional Forging and Hot Extrusion Deformation

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 425-437页

作者： Yuhao Chen Kaibo nie Kunkun Deng Zhilong Liu Quanxin Shi College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China State Key Laboratory of Compressor Technology(Compressor Technology Laboratory of Anhui Province) Hefei 230031China Instrumental Analysis Center Taiyuan University of TechnologyTaiyuan 030024China

The integration of lightweight and high-modulus magnesium-based materials is becoming increasingly valued as structural materials due to the complexity and intelligence of industrial products like automobiles and *** this study,the graphene nanoplatelets(GNPs)/Mg-Zn-zr composites with 0.5 wt%GNPs were successfully prepared by the combination of multidirectional forging(MDF)and hot extrusion(Ex).The newly-developed composites after multi-step deformation possessed excellent strength and modulus,with a tensile strength exceeding 375 MPa and an elastic modulus reaching 54 *** results revealed that the stripping and thinning of GNPs bands parallel to the extrusion direction occurred after MDF+Ex,which promoted the dynamic recrystallization and the formation of numerous fine *** significant improvement in comprehensive mechanical performances of the composites could be primarily ascribed to the refinement of grain size caused by the optimized distribution of GNPs,and efficient load transfer facilitated by the tight interface.

关键词： Magnesium matrix composites Graphene nanoplatelets(GNPs) Multi-step deformation Microstructure Strength-modulus

Synthesis, structure and conformation of 1,3-difluorotetraphenyl benzene

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Chinese Journal of Chemistry 1996年第2期14卷 160-166页

作者： Zheng, zr Pan, YM Liu, WG Huan, ZW NANKAI UNIV DEPT CHEMNATL KEY LAB ELEMENTOORGAN CHEMTIANJIN 300071PEOPLES R CHINA

The compound trifluoroiodomethane can be activated to react with the electron donor, 1,4-dilithiotetraphenyl butadiene, by means of electron transfer catalysis (ETC). The structure of the product, 1,3-difluorotetraphenyl, benzene (1), was determined by MS, NMR, and X-ray single crystal diffraction. The conformations of compound 1 and its derivatives were analysized by molecular mechanics.

关键词： tetraphenylbenzene conformation molecular mechanics

A FINITE-ELEMENT ANALYSIS OF ELECTROMAGNETIC SHEET METAL-EXPANSION PROCESS

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中国有色金属学会会刊：英文版 1998年第3期8卷 135-140页

作者： Huang, SY Chang, ZH Wang, zr Wang, LF Yang, M Wuhan Automot Polytech Univ Sch Mat Engn Wuhan 430070 Peoples R China Harbin Inst Technol Sch Mat Sci & Engn Harbin 150006 Peoples R China

１ＩＮＴＲＯＤＵＣＴＩＯＮＥｌｅｃｔｒｏｍａｇｎｅｔｉｃｆｏｒｍｉｎｇ，ｅｓｅｎｔｉａｌｙｂｅｉｎｇａｋｉｎｄｏｆａｐｐｌｉｃａｔｉｏｎｏｆｉｍｐｕｌｓｅｉｎｔｅｎｓｉｖｅｃｕｒｅｎｔｔｅｃｈｎｉｑｕｅｉｎｍｅｔａｌ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＥｌｅｃｔｒｏｍａｇｎｅｔｉｃｆｏｒｍｉｎｇ，ｅｓｅｎｔｉａｌｙｂｅｉｎｇａｋｉｎｄｏｆａｐｐｌｉｃａｔｉｏｎｏｆｉｍｐｕｌｓｅｉｎｔｅｎｓｉｖｅｃｕｒｅｎｔｔｅｃｈｎｉｑｕｅｉｎｍｅｔａｌｗｏｒｋｉｎｇ，ｄｅａｌｓｗｉｔｈ...

关键词： finite element analysis electromagnetic forming magnetic pressure

Syntheses and Characterization of Metal Complexes of　L－Lysine－N，N，N＇，N＇－tetraacetic　Acid　and　L－Lysine－N，N，N＇，N＇－tetramethylenepho　sphonic　Acid

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Chemical Research in Chinese Universities 1995年第3期11卷 276-278页

作者： ZHOU, RX LU, zr WEN, J WUHAN UNIV DEPT CHEMWUHAN 430072PEOPLES R CHINA

ＳｙｎｔｈｅｓｅｓａｎｄＣｈａｒａｃｔｅｒｉｚａｔｉｏｎｏｆＭｅｔａｌＣｏｍｐｌｅｘｅｓＯｆＬ－Ｌｙｓｉｎｅ－Ｎ，Ｎ，Ｎ＇，Ｎ＇－ｔｅｔｒａａｃｅｔｉｃＡｃｉｄａｎｄＬ－Ｌｙｓｉｎｅ－Ｎ，Ｎ，Ｎ＇，Ｎ＇－ｔｅｔｒａｍ... 详细信息

ＳｙｎｔｈｅｓｅｓａｎｄＣｈａｒａｃｔｅｒｉｚａｔｉｏｎｏｆＭｅｔａｌＣｏｍｐｌｅｘｅｓＯｆＬ－Ｌｙｓｉｎｅ－Ｎ，Ｎ，Ｎ＇，Ｎ＇－ｔｅｔｒａａｃｅｔｉｃＡｃｉｄａｎｄＬ－Ｌｙｓｉｎｅ－Ｎ，Ｎ，Ｎ＇，Ｎ＇－ｔｅｔｒａｍｅｔｈｙｌｅｎｅｐｈＯｓｐｈｏｎｉ...

关键词： L-Lysine Coniplex Relaxivity

Preparation of Dendrimers from Macromolecular Cores and Papain Immobilization

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Chinese Chemical Letters 1998年第3期9卷 263-264页

作者： Liu, LJ Shi, SH Zhuo, RX Lu, zr Wuhan Univ Dept Chem State Educ Commiss China Lab Biomed Polymer Mat Wuhan 430072 Peoples R China

Using amino-poly(ethylene glycol) and amino-propyl silica gel as initiator cores, two dendrimers were prepared by a two-step procedure. The progress of dendrimers during each step was monitored by infrared spectroscopy and elemental analysis. Papain was crosslinked to the solid dendrimer with silica gel core by glutaraldehyde, and the enzymatic activity of the immobilized papain kept almost unchanged after repeated usage for fifteen times.

关键词： amino-poly(ethylene glycol) amino-propyl silica gel dendrimer immobilized papain

Intermediate-acidic silicate melt found in continental mantle of East China

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Chinese Science Bulletin 1997年第10期42卷 879-880页

作者： Fan, QC Liu, RX Xu, P Lin, zr Department of Earth and Space Sciences University of Science and Technology of China Hefei 230026 China

CO2-RICH fluid inclusions have been found in 6 anhydrous peridotite xenolith minerals in Ceno-zoic basalts of 5 areas in East *** probe backscattering electron image reveals thatseveral inclusions appear in all the rock sections,completely filled with glass or with cavities attheir center part（CO2 has escaped）.Some inclusions show devitrification and daughter miner-als *** have carried out the analysis on the non-devitrification glass in the inclusions.

关键词： Intermediate-acidic silicate melt found in continental mantle of East China