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Exploring the phytoconstituents targeting TNF-αas potential lead compounds to treat inflammatory diseases:an in-silico approach

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Digital Chinese Medicine 2022年第3期5卷 264-275页

作者： Sumit Arora Pallavi Rushiya Kalpana Tirpude nidhi Sapkal Subhash Yende Abhay Ittadwar Sapan Shah Department of Pharmacognosy and Phytochemistry Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmaceutical Chemistry Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmacology Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmaceutical Chemistry Priyadarshini J.L.College of PharmacyNagpurMaharashtra 440016India

Objective To explore the anti-inflammatory phytoconstituents from various plant sources as tumour necrosis factor-α(TNF-α)-inhibitor,a mediator involved in the inflammatory disorder,by in silico molecular *** Based on previous findings,we performed the in silico assessment of anti-inflammatory phytoconstituents from different medicinal plants to understand their binding patterns against TNF-α(PDB ID:6OP0)using AutoDock *** docking was performed by setting a grid box(25×25×25)Åcentered at[-12.817×(-1.618)×19.009]A with 0.375A of grid ***,Discovery Studio Client 2020 program was utilized to assess two-and three-dimensional(2D and 3D)hydrogen-bond interactions concerning an amino acid of target and *** properties were reported using the Lipinski’s rule and SwissADME database to support the in silico *** From the selected medicinal plants,more than 200 phytocompounds were screened against TNF-α protein with binding scores in the range of -12.3 to -2.5 kcal/*** them,emodin,aloe-emodin,pongamol,purpuritenin,semiglabrin,ellagic acid,imperatorin,α-tocopherol,and octanorcucurbitacin A showed good binding affinity as -10.6,-10.0,-10.5,-10.1,-11.2,-10.3,-10.1,-10.1,and -10.0 kcal/mol,***,the absorption,distribution,metabolism,excretion,and toxicology(ADMET)profiles were well within acceptable *** Based on our preliminary findings,we conclude that the selected phytoconstituents have the potential to be good anti-inflammatory candidates by inhibiting the TNF-α *** compounds can be further optimized and validated as new therapeutic components to develop more effective and safe anti-inflammatory drugs.

关键词： Inflammation Tumour necrosis factor-α(TNF-α) Medicinal plants Phytoconstituents Molecular docking Absorption,distribution,metabolism,excretion,and toxicology(ADMET) studies

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UREA PULPING OF RICE STRAW FOR THE PRODOCTION OF CHEMI-MECHANICAL PULP

UREA PULPING OF RICE STRAW FOR THE PRODOCTION OF CHEMI-MECHA...

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第二届国际非木材纤维制浆造纸会议

作者： Hari Kishore nidhi Rawat K.S. Moorthy R. Pant A. Panda Central Pulp and Paper Research Institute Central Pulp and Paper Research Institute Central Pulp and Paper Research Institute Central Pulp and Paper Research Institute Central Pulp and Paper Research Institute

＜正＞Alternate pulping chemical ’Drea’ was tried to reduce the pollution load and cost of cooking chemica, per ton of pulp. Drea pulping of rice straw was carried out by using 2-24% urea dosage. Dableacbable grade chemi-mechanical pulp 68% pulp field and 35.6%-Mumber could be produced with 8% urea dosage. Pulp produced possessed strength properties suitable for wrapping paper. High tear strength wrapping paper was also produced by blending with long fiber chemi-mechanical pulp of used gunny bags ia different proportionas. Quality of tbe chemi-mecbanical pulp of rice straw produced by 8% urea was found comparable with the palp produced by 4% sodim bydroride. As the present cost of area is about 1/4th to that of sodinm bydroride so the total cost of cbemical per ton of pulp produced is approrieately half in case of urea pulping. Other advantages of urea pulping is negligible pollution load as the sodium free effluent generated can easily be seat to the agricultural fields to take added advantage of aitrogen preseat in the effluent.

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Genome resequencing and transcriptome profiling reveal structural diversity and expression patterns of constitutive disease resistance genes in Huanglongbing-tolerant Poncirus trifoliata and its hybrids

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Horticulture Research 2017年第1期4卷 77-84页

作者： nidhi Rawat Brajendra Kumar Ute Albrecht Dongliang Du Ming Huang Qibin Yu Yi Zhang Yong-Ping Duan Kim D Bowman Fred G Gmitter Jr Zhanao Deng University of Florida IFASGulf Coast Research and Education CenterWimaumaFLUSA Ocimum BioSolutions Ltd. Royal DemeurePlot no.12/2Sector-1HUDA Techno EnclaveMadhapurHyderabadIndia University of Florida IFASSouthwest Florida Research and Education CenterImmokaleeFLUSA University of Florida IFASCitrus Research and Education CenterLake AlfredFLUSA U.S.Department of Agriculture U.S.Horticultural Research LaboratoryAgricultural Research ServiceFort PierceFLUSA

Huanglongbing(HLB)is the most destructive bacterial disease of citrus *** most citrus varieties are susceptible to HLB,Poncirus trifoliata,a close relative of Citrus,and some of its hybrids with Citrus are tolerant to *** specific HLB tolerance genes have been identified in *** but recent studies have shown that constitutive disease resistance(CDR)genes were expressed at much higher levels in HLB-tolerant Poncirus hybrids and the expression of CDR genes was modulated by Candidatus Liberibacter asiaticus(CLas),the pathogen of *** current study was undertaken to mine and characterize the CDR gene family in Citrus and Poncirus and to understand its association with HLB tolerance in *** identified 17 CDR genes in two citrus genomes,deduced their structures,and investigated their phylogenetic *** revealed that the expansion of the CDR family in Citrus seems to be due to segmental and tandem duplication *** genome resequencing and transcriptome sequencing,we identified eight CDR genes in the Poncirus genome(PtCDR1-PtCDR8).The number of SNPs was the highest in PtCDR2 and the lowest in *** of the deletion and insertion events were observed in the UTR regions of Citrus and Poncirus CDR ***2 and PtCDR8 were in abundance in the leaf transcriptomes of two HLB-tolerant Poncirus genotypes and were also upregulated in HLB-tolerant,Poncirus hybrids as revealed by real-time PCR *** two CDR genes seem to be good candidate genes for future studies of their role in citrus-CLas interactions.

关键词： Poncirus citrus Citrus

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Effects of Purified Indian Cattle Tick Rhipicephalus microplus Saliva Toxins on Various Enzymes in Blood Serum, Liver and Muscles of Albino Mice

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Advances in Enzyme Research（酶研究进展） 2023年第2期

作者： nidhi Yadav Ravi Kant Upadhyay

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Evidence based review of type 2 diabetes prevention and management in low and middle income countries

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World Journal of Diabetes 2016年第10期7卷 209-229页

作者： Aimee Afable nidhi Shree Karingula Department of Community Health Sciences SUNY Downstate School of Public Health

AIM:To identify the newest approaches to type 2diabetes(T2DM)prevention and control in the developingworld ***:We conducted a systematic review of published studies of diabetes prevention and control programs in low and middle-income countries,as defined by the World *** searched Pub Med using Medical Subject Headings *** needed to satisfy four criteria:(1)Must be experimental;(2)Must include patients with T2DM or focusing on prevention of T2DM;(3)Must have a lifestyle intervention component;(4)Must be written in English;and(5)Must have measurable outcomes related to ***:A total of 66 studies from 20 developing countries were gathered with publication dates through September *** contributed the largest number of trials(11/66).Of the total 66 studies reviewed,all but 3 studies reported evidence of favorable outcomes in the prevention and control of type 2 *** overwhelming majority of studies reported on diabetes management(56/66),and among these more than half were structured lifestyle education *** evidence suggests that lifestyle education led by allied health professionals(nurses,pharmacists)were as effective as those led by physicians or a team of *** remaining diabetes management interventions focused on diet or exercise,but the evidence to recommend one approach over another was ***:Large experimental diabetes prevention/control studies of dietary and exercise interventions are lacking particularly those that consider quality rather than quantity of carbohydrates and alternative exercise.

关键词： Diabetes prevention and control Low-income countries Middle-income countries Intervention research Systematic reviews

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Tick-borne Diseases,Transmission,Host Immune Responses,Diagnosis and Control

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Journal of Human Physiology 2021年第2期3卷 8-39页

作者： nidhi Yadav Ravi Kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur UniversityGorakhpurUttar Pradesh273009India

Present review article explains tick-borne diseases,transmission,host immune responses,diagnosis and control in relation to climatic *** are hematophagous ectoparasites which suck large volumes of blood from livestock and *** release large numbers of protozoans,bacteria,rickettsia and viral pathogens during blood feeding and transmit disease pathogens through *** to heavy blood sucking by ticks animals face significant blood and weight loss that affect their overall *** to more severe illness,high economic losses were noted in *** article highlights medically important tick borne diseases in man and livestock,its pathogenesis,diagnosis and treatment *** present article emphasizes invasion of hosts,host-pathogen interactions,tick saliva toxin induced host immune responses and biological *** article highlighted various tick control methods *** killing,acaricidal,biological,hormonal,genetic and immunological methods such as administration of protective antibody and vaccines for disease control in human being and his *** authors suggest non-chemical environmentally safe methods for successful control of tick borne diseases to kill cattle,bird and canine invading ticks.

关键词： Tick borne diseases Blood feeding Transmission Pathogenesis Diagnosis Tick control Vaccine therapy

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Development of Green Polymer Electrolyte Through Hot Press Method

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Electrical Science & Engineering 2019年第1期1卷 1-8页

作者： nidhi Asthana Mrigank Mauli Dwivedi Kamlesh Pandey National Centre of Experimental Mineralogy and Petrology University of AllahabadAllahabad211002India

To develop the green polymeric membrane electrolyte,-Polycaprolactone(PCL)was used as a host and the Ionic liquid(IL)(1-Ethyl-3-methylimidazolium tosylate)as a *** IL is a source of mobile charges in the polymer electrolyte *** composite membrane has been prepared by Hot Press method and then we characterised this membrane for ionic *** of nanocomposite system has been ascertained from their XRD *** phenomenon was studied by ATR based FTIR and Laser Raman spectroscopic *** of conductivity with composition and temperature was studied with the aid of impedance spectroscopy data.

关键词： Green polymer electrolyte XRD FTIR Ionic liquid Hot press method

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从漂白浆的生产成本探讨麦草浆蒸煮的脱木素程度

从漂白浆的生产成本探讨麦草浆蒸煮的脱木素程度

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第二届国际非木材纤维制浆造纸学术会议

作者： Gupta Hari Kishore nidhi Rawat Brijesh Kumar R.Pant 刘仁庆印度中央制浆造纸研究所印度中央制浆造纸研究所印度中央制浆造纸研究所印度中央制浆造纸研究所

麦草制浆的条件是:氢氧化钠用量11～18％,液比1:5,在170℃下保温2小时。以未漂浆的卡伯值作为衡量脱木素程度的标准。再把不同卡伯值的未漂浆分别进行CEH三段漂和 H——H两段漂。在不降低漂白浆强度的前提下,比较了不同卡伯值的未漂浆...

麦草制浆的条件是:氢氧化钠用量11～18％,液比1:5,在170℃下保温2小时。以未漂浆的卡伯值作为衡量脱木素程度的标准。再把不同卡伯值的未漂浆分别进行CEH三段漂和 H——H两段漂。在不降低漂白浆强度的前提下,比较了不同卡伯值的未漂浆在蒸煮和漂白过程中耗用化学品的费用,以及漂白浆的物理性能。结果表明,当未漂浆的卡伯值在26-29之间时,采取 CEH三段漂;而当卡伯值在25—27之间时,采取H—H两段漂,其每吨漂白浆耗用纤维原料, 以及蒸煮和漂白化学品的总费用均较低。

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Effect of Higher Mean Arterial Pressure with Norepinephrine on Tissue Oxygenation and Perfusion in Patients of Septic Shock

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International Journal of Clinical Medicine（临床医学国际期刊） 2012年第5期

作者： Sandeep Sharma Mridula Pawar Mohandeep Kaur nidhi Srivastava Saurav Mustafi

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The Response of Consumer Food Price Index(CFPI)due to the Impact of Pandemic COVID-19 on Indian Agriculture Sector

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NASS Journal of Agricultural Sciences 2021年第1期3卷 29-35页

作者： Digvijay Pandey nidhi Verma Tajamul Islam Wegayehu Enbeyle Binay Kumar Pandey PMadhusudana Patra Department of Technical Education IETLucknowIndia Government P.G College for Women RohtakIndia Department of Botany University of KashmirSrinagarJ&K190006India Department of Biostatistics Mizan-Tepi UniversityTepiEthiopia Department of IT GovindBallabh Pant University of Agriculture and TechnologyIndia SRM-DBT Facility SRM Institute of science and technologyChennaiIndia

India is an agricultural country and a core source of income for the world *** Indian economy is greatly depending on agriculture that is decrease day by day due to pandemic *** is a major exporter of many crop ***,Thailand,and Vietnam are the major exports of rice if these stopped exports it reduces the economy up to 15%.A related circumstance is built up with diverse yields too like wheat,sunflower whose fare has been stationary by Kazakhstan,Serbia *** India,the end of April is the main source of income to farmers because they sell their rabi crops(wheat,mustard,maize,lentil,chilies,gram,tomatoes)in the market drastically decreases of CFPI may lead to the distress of Indian agricultural *** change over time in the price of options on wheat futures reveals increased price volatility in response to growing uncertainty about the COVID-19 impacts.

关键词： Coronavirus COVID-19 2019-nCoV Pandemic Public health emergency Middle-Eastern-Respiratory Syndrome(MERS) Consumer food price index(CFPI)

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