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Muscle Loss in Cancer Patients: Pathophysiology and Impact on the Outcome

Journal of Nutritional Oncology 2016年第1期1卷 15-20页

作者： Maria Chiara Salandini nicolo pecorelli Paola De Nardi Marco Braga Department of Surgery Vita-Salute San Raffaele University Milan 20132 Italy

A generalized loss of skeletal muscle can be associated with malnutrition, cancer, inflammation or neurodegenerative processes. Most cancer patients undergoing surgery are sarcopenic although only a minority of them suffer from severe weight loss. The cancer stage is a major determinant of sarcopenia, while nutritional factors seem to be less important. In cancer patients sarcopenia has been associated with a worse physical performance, a reduced response to chemotherapy and radiotherapy, a higher postoperative morbidity rate, and a reduced life expectancy.

关键词： Cancer Cachexia Sarcopenia Visceral fat Body composition

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Impact of Neoadjuvant Therapy on Body Composition and Prognosis in Rectal Cancer Patients

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Journal of Nutritional Oncology 2018年第4期3卷 165-169页

作者： Paola De Nardi Mariachiara Salandini Damiano Chiari nicolo pecorelli Giulia Cristel Anna Damascelli Monica Ronzoni Marco Braga Department of Surgery San Raffaele University Hospital Via Olgettina 60 20132 Milan Italy Department of Radiology San Raffaele University Hospital Via Olgettina 60 20132 Milan Italy Department of Medical Oncology San Raffaele University Hospital Via Olgettina 60 20132 Milan Italy

Objectives The aim of this study was to assess the impact of neoadjuvant chemo-radiotherapy (nCRT) on body composition in patients who subsequently underwent curative surgery for low rectal cancer. Methods Thirty-eight consecutive patients who underwent nCRT and subsequent laparoscopic proctectomy for locally advanced low rectal cancer have been studied. In all patients body composition was measured by computed tomography before and after nCRT. Pathology response on CRT, postoperative short-term outcome, overall and disease-free long-term survival were assessed. Results Twelve patients (31.5%) had skeletal muscle loss 2% after nCRT. No correlation was found between changes in body composition and postoperative complications. Skeletal muscle loss after nCRT significantly correlated with a shorter 5-year disease-free survival. Conclusion Preliminary data suggests that skeletal muscle loss after nCRT negatively impacted on disease-free survival in patients with locally advanced rectal cancer.

关键词： Neoadjuvant Therapy Rectal Cancer

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