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Clinical nutrition in the hepatogastroenterology curriculum

World journal of Gastroenterology 2016年第5期22卷 1729-1735页

作者： Chris jj Mulder Geert jA Wanten Carol E Semrad Palle B jeppesen Hinke M Kruizenga nicolette j wierdsma Matthijs E Grasman Adriaan A van Bodegraven Department of Gastroenterology and Hepatology VU University Medical Center Amsterdam1007 MD AmsterdamThe Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center6500 HB NijmegenThe Netherlands Department of Medicine GI Section The University of ChicagoChicagoIL 60637United States Department of Medical Gastroenterology Rigshospitalet University Hospital of Copenhagen2100 KHB CopenhagenDenmark Department of Dietetic VU University Medical Center Amsterdam1081 HZ AmsterdamThe Netherlands Department of Internal Medicine Gastroenterologyand GeriatricsORBIS Medical Center6130 MB Sittard-GeleenThe Netherlands

Gastroenterology(GE) used to be considered a subspecialty of internal medicine. Today, GE is generally recognized as a wide-ranging specialty incorporating capacities, such as hepatology, oncology and interventional endoscopy, necessitating GEexpert differentiation. Although the European Board of Gastroenterology and Hepatology has defined specific expertise areas in Advanced endoscopy, hepatology, digestive oncology and clinical nutrition, training for the latter topic is lacking in the current hepatogastroenterology(HGE) curriculum. Given its relevance for HGE practice, and being at the core of gastrointestinal functioning, there is an obvious need for training in nutrition and related issues including the treatment of disease-related malnutrition and obesity and its associated metabolic derangements. This document aims to be a starting point for the integration of nutritional expertise in the HGE curriculum, allowing a central role in the management of malnutrition and obesity. We suggest minimum endpoints for nutritional knowledge and expertise in the standard curriculum and recommend a focus period of training in nutrition issues in order to produce well-trained HGE specialists. This article provides a road map for the organization of such a training program. We would highly welcome the World Gastroenterology Organisation, the European Board of Gastroenterology and Hepatology, the American Gastroenterology Association and other(inter)national Gastroenterology societies support the necessary certifications for this item in the HGE-curriculum.

关键词： Gastroenterology Training Clinical nutrition Malnutrition Metabolism Curriculum Targeted therapy Enteral feeding Parenteral feeding Obesity

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Current and future opportunities for liquid biopsy of circulating biomarkers to aid in early cancer detection

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journal of Cancer Metastasis and Treatment 2022年第1期8卷 334-344页

作者： Susan H.Gawel Laurel jackson nicolette jeanblanc Gerard j.Davis Abbott Diagnostics Division Abbott LaboratoriesAbbott ParkIL 60064USA

Early diagnosis of cancer can significantly improve treatment and survival *** and tissue biopsy are the gold standard diagnostic approaches but are costly,invasive,and often unable to detect early-stage *** past decade has marked an acceleration in the discovery and development of liquid biopsy tests for aiding in the detection of various types of tumor markers in non-tissue samples,such as *** biopsy markers include circulating tumor cells,as well as tumor cell fragments,nucleic acids,and *** biopsy may be useful in screening patients considered to be at high risk of developing cancer,for refining diagnosis when combined with other test results,and for early detection of *** in big data analytics,informatics,and artificial intelligence will make it possible to combine patient history,clinical data,and liquid biopsy marker profiles to achieve more accurate and earlier *** this review,we summarize the current use of liquid biopsy in cancer care,including the development of multi-analyte panels to improve diagnostic accuracy and detect several cancer types in a single *** highlight recent advances for potential future applications of liquid biopsy to aid in the diagnosis of early-stage lung *** also discuss the opportunities and challenges of integrating liquid biopsy into current algorithms for cancer screening and diagnosis.

关键词： Cancer early detection diagnostic algorithm biomarkers blood serum analyte

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Nanocellulose-Based Biosensors: Design, Preparation, and Activity of Peptide-Linked Cotton Cellulose Nanocrystals Having Fluorimetric and Colorimetric Elastase Detection Sensitivity

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Engineering（科研） 2013年第9期5卷 20-28页

作者： j. Vincent Edwards nicolette Prevost Alfred French Monica Concha Anthony DeLucca Qinglin Wu outhern Regional Research Center USDA-ARS New Orleans USA School of Renewable Natural Resources Louisiana State University Agricultural Center Baton Rouge USA Southern Regional Research Center USDA-ARS New Orleans USA

Nanocrystalline cellulose is an amphiphilic, high surface area material that can be easily functionalized and is biocompatible and eco-friendly. It has been used singularly and in combination with other nanomaterials to optimize biosensor design. The attachment of peptides and proteins to nanocrystalline cellulose and their proven retention of activity provide a route to bioactive conjugates useful in designs for point of care biosensors. Elastase is a biomarker for a number of inflammatory diseases including chronic wounds, and its rapid sensitive detection with a facile approach to sensing is of interest. An increased interest in the use of elastase sensors for point of care diagnosis is resulting in a variety of approaches to elsastase sensors utilizing different detection technologies. Here elastase substrate peptide-celluose conjugates synthesized as colorimetric and fluorescent sensors on cotton cellulose nanocrystals are compared. The structure of the sensor peptide-nanocellulose crystals when modeled with computational crystal structure parameters demonstrates the spatio-stoichiometric features of the nanocrystalline surface that allows ligand to active site protease interacttion. An understanding of the structure/function relations of enzyme and conjugate substrate of the peptides covalently attached to nancellulose has implications for enhancing the biomolecular transducer. The potential applications of both fluorescent and colorimetric detection to markers like elastase using peptide cotton cellulose nanocrystals as a transducer surface to model point of care biosensors for protease detection are discussed.

关键词： Cellulose Nanocrystal Cotton Human Neutrophil Elastase Fluorescent Colorimetric Point of Care Biosensor Peptide-Cellulose Conjugate

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考试与评价（英语高考专刊） 2016年第12期 1-1页

作者： nicolette j.Proffitt

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