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Hypoallergenic formula with Lactobacillus rhamnosus GGfor babies with colic:A pilot study of recruitment,retention,and fecal biomarkers

Open Journal of Obstetrics and Gynecology（妇产科期刊） 2020年第8期

作者： Arturo Anguiano Boris t. Wang Kylin Y. Lammers Loretta W. Mahon nicole truitt Lindsay Dohany Fatih Z. Boyar

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World Journal of Gastrointestinal Pathophysiology 2016年第1期7卷 160-170页

作者： nicole Y Fatheree Yuying Liu Michael Ferris Melissa Van Arsdall Valarie McMurtry Marcela Zozaya Chunyan Cai Mohammad H Rahbar Manouchehr Hessabi ta Vu Christine Wong Juleen Min Dat Q tran Fernando Navarro Wallace Gleason Sara Gonzalez J Marc Rhoads Department of Pediatrics the University of Texas Health Science Center at Houston Medical SchoolHoustonTX 77030United States Biostatistics/Epidemiology/Research Design Core Center for Clinical and Translational Sciencesthe University of Texas Health Science Center at HoustonHoustonTX 77030United States Division of Epidemiology Human Genetics and Environmental Sciencesthe University of Texas School of Public Health at HoustonHoustonTX 77030United States Department of Pediatrics Louisiana State University Health Science Center and the Research Institute for ChildrenNew OrleansLA 70112United States Investigational Drug Services Pharmacy Memorial Hermann HospitalHoustonTX 77030United States

AIM: to investigate recruitment, retention, and estimates for effects of formula supplementation with Lactobacillus rhamnosus GG(LGG) on inflammatory biomarkers and fecal microbial community in infants with colic. MEtHODS: A prospective, double-blind, placebocontrolled trial was conducted in otherwise healthy infants with colic. We screened 74 infants and randomized and analyzed results in 20 infants [9 receiving LGG(LGG+) and 11 not receiving LGG(LGG-)]. LGG was incorporated in the formula(Nutramigen~®)(minimum of 3 × 107 CFU/d) in the LGG+ group. Fecal microbiota and inflammatory biomarkers, including fecal calprotectin(FC), plasma cytokines, circulating regulatory t cells(tregs), and crying + fussing time were analyzed to determine optimal time points and effect sizes for a larger trial. RESULtS: Recruitment in this population was slow, with about 66% of eligible infants willing to enroll; subject retention was better(75%). these rates were influenced by parents' reluctance to volunteer their infant for a clinical trial and by their tendency to change formulas. the maximal difference of crying + fussing time was observed at day 14, comparing the 2 groups, with a mean difference of-91(95%CI:-76, 259) min(P = NS). FC showed no significant difference, but the optimal time to determine a potential effect was at day 90 [with a mean difference of 121(95%CI:-48, 291) μg/g stool], observing a lower level of FC in the LGG+ group. the fecal microbial communities were chaotic, as determined by Shannon's diversity index and not apparently influenced by the probiotic. No significant change was observed in plasma inflammatory cytokines or tregs, comparing LGG+ to LGG- groups. CONCLUSION: Designing future colic trials involving a probiotic-supplemented formula for infants in the United States will require consideration for difficult enrollment. Infants with colic have major variations in feal microbiota and calprotectin, both of which improve with time, with optimal time p

关键词： Barr diary Regulatory t cells Cytokines Crying Fussing Probiotic Inflammation Biomarker Newborn Intestine

Investigation of Plasmodium falciparum Resistance Biomarkers among Primary School Children in Western Kenya

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American Journal of Molecular Biology 2022年第2期12卷 43-53页

作者： Otilmoi Poul Stephen tonny teya Nyandwaro Robinson Mugasiali Irekwa Rebecca Wanjiku Waihenya Matthew Mutinda Munyao Peter Kipkemboi Rotich Caroline Wangui Njoroge Anne Wanjiru Mwangi Joanne Jepkemei Yego nicole Sian tanchu Dawala Koromtili Oumar Grace Ngendo Kanyita Primrose Muthoni Ndungu Samson Muuo Nzou Department of Molecular Biology and Biotechnology Pan-African University Institute of Basic Sciences Technology and Innovation Nairobi Kenya Innovation Technology Transfer Department Kenya Medical Research Institute (ITTD-KEMRI) Nairobi Kenya Zoology Department School of Biological Sciences College of Pure and Applied Sciences Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Production Department KEMRI Nairobi Kenya Centre for Microbiology Research Kenya Medical Research Institute Nairobi Kenya Nagasaki University Institute of tropical Medicine Kenya Medical Research Institute (NUITM-KEMRI) Nairobi Kenya Department of Biochemistry Microbiology and Biotechnology Kenyatta University Nairobi Kenya Department of Pharmacology and Pharmacognosy University of Nairobi Nairobi Kenya

Background: A marked decrease in malaria-related deaths worldwide has been attributed to the administration of effective antimalarials against Plasmodium falciparum. However, the continuous spread of P. falciparum resistance to anti-malarial drugs is raising a serious problem in controlling Malaria to the vulnerable children’s immune system. In recent studies, Plasmodium falciparum Kelch 13 propeller gene (Pfk13) has been reported to develop resistance to artemisinin in South Asia. In this study, we checked Plasmodium falciparum chloroquine resistance transporter gene (Pfcrt) involved in chloroquine (CQ) resistance. Method: In this study, archived 280 samples were collected from Alupe primary school children in Busia, Western Kenya from May, 2016 to November, 2016. Genomic DNA was extracted using the MightyPrep reagent. the samples were investigated for P. falciparum positivity out of which 67 of them tested positive giving a prevalence rate of 24%. the sixty-seven were subjected to PCR amplification for the molecular marker resistance to Pfcrt. After PCR amplification, the amplicons were purified and sequenced using Sanger Sequencing. the sequence data were analyzed using BioEdit software to identify point mutations. Results: 14 samples sequences were analyzed on Bioedit software giving the following amino acid changes F76C, Y66H, L70A, Y58C, t59V, V65I, P67L, t81L, Y60S, Y66S, P67t and I71F). New mutations have been reported at position 76 leading to an amino acid change, one of Pfcrt gold standard biomarkers. However, amino acid changes Y66H, L70A, Y58C, t59V, V65I, P67L, t81L, Y60S, Y66S, P67t and I71F are newly reported giving an increase in Pfcrt prevalence of concern from zero to 5.0%. A phylogenetic evolutionary relationship was constructed as shown below. Generally, the results showed a continuous resistance of *** to Pfcrt which calls for robust continuous monitoring and surveillance. Conclusion: Due to the increase of the resistant Pfcrt gene pre

关键词： P. falciparum Chloroquine Drug Resistance Malaria P. falciparum Chloroquine Resistance transporter Gene Mutations

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t-Force国际原创设计师人赛

服装设计师 2012年第6期 19-19页

作者： nicole(编译)

4月22日，t--Force国际原创设计师大赛在广州举行。以第一名的成绩拿到法国巴黎ESMOD服装学院创意制版硕士学位的中国旅法青年时装设计师方威篪夺得该大赛最重要的奖项——设计概念奖，并获得在巴黎时装周上举办个人时装展的殊荣。方威... 详细信息

4月22日，t--Force国际原创设计师大赛在广州举行。以第一名的成绩拿到法国巴黎ESMOD服装学院创意制版硕士学位的中国旅法青年时装设计师方威篪夺得该大赛最重要的奖项——设计概念奖，并获得在巴黎时装周上举办个人时装展的殊荣。方威篪此次参赛的系列题为“皮毛”．表达设计师对二战的牺牲者的追思．表达对和平与环保的向往的态度．呼吁人类大爱无疆。其运用人造纤维与人造皮革替代真发与皮革，表达了作者对环保的提倡与杀戮的抵制。

关键词：时装设计师原创国际人造皮革 ESMOD 巴黎时装周设计概念硕士学位

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5cm×0044首度合作

服装设计师 2011年第8期 19-19页

作者： nicole（译）

It旗下的自家品牌5cm自面世以来深受时装支持者爱戴．5cm×0044系列除包含男女各一款的白色t-shirt和男装pocket tee和索带短裤以外．还推出颈饰一款。

关键词： 5cm×0044 服装设计艺术审美观 5cm

辛迪·克劳馥演绎tSUM 2010秋季广告系列

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服装设计师 2010年第11期 27-27页

作者： nicole（译）

前不久，堪称t台女王辛迪·克劳馥用美丽的蓝色短裙，别致的皮手套和华丽的黑色小礼服，以及深色紧身衣与羊毛开衫的组合，演绎出一系列迷人大片。

关键词：演绎广告秋季皮手套紧身衣短裙礼服黑色

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“应大杯”第二届时尚皮装设计大赛圆满落幕

服装设计师 2010年第12期 28-28页

作者： nicole（译）

10月30日．由天津应大国际服饰有限公司，中国服装设计师协会联合主办的”应大杯”第二届中国时尚皮装设计大赛决赛在北京饭店举行。20名入围决赛的选手们用自己的优秀作品．让现场的观众充分感受到了皮革设计在t台上所散发出的别样魅... 详细信息

10月30日．由天津应大国际服饰有限公司，中国服装设计师协会联合主办的”应大杯”第二届中国时尚皮装设计大赛决赛在北京饭店举行。20名入围决赛的选手们用自己的优秀作品．让现场的观众充分感受到了皮革设计在t台上所散发出的别样魅力。来自东北电力大学艺术学院（袁大鹏工作室）的董帅获得了金奖．来自北京服装学院的杨潇萌和田甜获得了银奖．来自天津工业大学艺术与服装学院和北京工业大学艺术设计学院的汤惟琼和赵洁获得了铜奖。

关键词：皮装设计中国服装设计师协会时尚北京工业大学天津工业大学北京服装学院艺术学院设计学院