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A paper-based microfluidic platform with shapememory-polymer-actuated fluid valves for automated multi-step immunoassays

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Microsystems & Nanoengineering 2019年第1期5卷 238-249页

作者： Hao Fu Pengfei Song Qiyang Wu Chen Zhao Peng Pan Xiao Li nicole ykli-jessen Xinyu Liu Department of Mechanical and Industrial Engineering University of TorontoTorontoONM5S 3G8Canada Department of Mechanical Engineering McGill UniversityMontrealQCH3A 0C3Canada Department of Electrical and Electronic Engineering Xi’an Jiaotong-Liverpool University215123 SuzhouJiangsuChina School of Communication Sciences and Disorders McGill UniversityMontrealQC H3A 1G1Canada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoON M5S 3G9Canada Present address:Department of Chemistry Stanford UniversityStanfordCA 94305USA

Smart fluid manipulation with automatically controlled paper valves will enable automated and multi-step immunoassays on paper-based microfluidic *** this work,we present an integrated paper-based microfluidic platform with shape-memory polymer(SMP)-actuated fluid valves capable of automated colorimetric enzyme-linked immunosorbent assays(ELISAs).A single-layer microfluidic paper-based analytical device(μPAD)was designed to store all the reagents on the chip,and sequentially transfer reagents to a paper test zone following a specific ELISA protocol through automatic fluidic flow control by the multiple SMP-actuated *** actuation of a paper valve was based on the thermally responsive,duel-state shape transformation of a SMP sheet attached to the root of a paper cantilever beam for driving a hydrophilic paper bridge to connect and disconnect two paper channels.A portable colorimetric reader was developed to control the on-chip valve operations,quantify the colorimetric signal output,display the assay result,and wirelessly transmit the data to a smart phone for the application of *** operations of the paper valve and the entireμPAD were demonstrated with success rates of 97%and 93%,respectively.A detection mechanism for valve malfunction was designed and confirmed effective to identify any mal-operation of individual valves,thus rendering our platform reliable in real *** device calibration,we conducted direct ELISAs of rabbit IgG in phosphate-buffered saline(PBS),and achieved a low limit of detection(LOD)of 27 pM(comparable to that of standard and paper-based ELISAs).In order to demonstrate the clinical application of our multi-step immunoassay platform,we also conducted sandwich ELISAs to quantify the protein level of an inflammatory cytokine,namely tumor necrosis factor(TNF)-α,in surgically injured laryngeal tissues of *** protein levels of TNF-αwere shown similar between the conventional andμPAD ELISAs.

关键词： rabbit automated operations

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Long-term follow-up of patients with congenital diaphragmatic hernia

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World Journal of Pediatric Surgery 2024年第2期7卷 100-109页

作者： nicole Cimbak Terry L Buchmiller Department of Pediatric Surgery Boston Children's HospitalBostonMAUSA

Neonates with congenital diaphragmatic hernia encounter a number of surgical and medical morbidities that persist into *** mortality improves for this population,these survivors warrant specialized follow-up for their unique disease-specific *** congenital diaphragmatic hernia clinics are best positioned to address these complex long-term morbidities,provide long-term research outcomes,and help inform standardization of best practices in this cohort of *** review outlines long-term morbidities experienced by congenital diaphragmatic hernia survivors that can be addressed in a comprehensive follow-up clinic.

关键词： hernia congenital patients

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Multi-point temperature measurements in packed beds using phosphor thermometry and ray tracing simulations

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Particuology 2024年第2期85卷 77-88页

作者： Guangtao Xuan Mirko Ebert Simson Julian Rodrigues nicole Vorhauer-Huget Christian Lessig Benoit Fond Institute of Fluid Dynamics and Thermodynamics OVGU MagdeburgUniversitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany Institute of Simulations and Graphics OVGU MagdeburgUniversitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany Institute of Process Engineering OVGU MagdeburgUniversitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany ONERA The French Aerospace LabDepartment of AerodynamicsAeroelasticity and Aeroacoustics(DAAA)Paris-Saclay University8rue des VertugadinsMeudon92190France

Packed bed reactors are commonly found in the process industry,for example in flame-assisted calci-nation for cement *** the heat transfer inside the bed is essential for process control,product quality and energy *** we propose a technique to determine the internal temperature distribution of packed beds based on a combination of lifetime-based phosphor ther-mometry,ray tracing simulations,and assimilation of temperature data using finite element heat transfer *** establish and validate the technique,we considered a reproducible regular packing of 6 mm diameter aluminum spheres,with one of the spheres in the top layer being electrically *** a sphere inside the packing is coated with thermographic phosphors and excitation light is directed to-wards the packing,luminescence from the coated sphere exits the packed bed after multiple reflection and the sphere's temperature can be *** measurements showed that the temper-ature obtained by phosphor thermometry is independent of the luminescent sphere *** imaging the luminescence on a camera,the luminescence distribution in recorded image depended,however,on the position of the ***,in setups with multiple phosphor-coated spheres,their signals can be separated using a least squares *** demonstrate the approach using a setup with three luminescent spheres and validated the temperature readings against thermocouple *** obtain the spatial signatures for individual sphere positions required for the least squares fit,ray tracing simulations were *** provide an efficient alternative to single sphere measurements that are only practical for regular spherical packed ***-point measurements were used as input to a finite element heat transfer simulations to determine parameters such as particle-to-particle air gap *** these,the full temperature distribution inside the bed could be assimilated from the meas

关键词： Packed beds Phosphor thermometry Ray tracing Heat transfer simulation Data assimilation

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Emerging applications of nanofibers electrospun from carbohydrate polymers

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Journal of Future Foods 2024年第4期4卷 289-299页

作者： nicole Angel Songnan Li Lingyan Kong Deparment of Mechanical Engineering.The University of Alabama TuscaloosaAL 35487USA Joint Intemnarional Research Laboratory of Agriculture and Agni-Product Saferty of the Ministry of Education of China Institutes of Agricultural Science and Techmology DevelopmentYangzhou UniversityYangzhou 225009China Deparment of Human Nutrition and Hospitality Management The University of AlabamaTuscaloosaAI 35487USA

Electrospinning is a simple and versatile technique that uses electrostatic forces to create fbers in the nano o micro range from a variety of materials,both synthetic and natural Due to the high surface area to volume ratio,high porosity,and desirable mechanic characteristics of electrospun fbers,they are of current interest for a wide variety of *** of the most signifcant applications of these fbers being researched include tissue *** delivery,wound dressings,environmental and energy applications,and protective ***,electrospun fbers may be specially tailored to better ft their fnal application through the direct 1oading of materials during the spining process as well as by choosing the correct base material for the *** example,it is desirable to use a biocompatible and biodegradable material in fibers desired for applications in the biomedical field;this way the fbers are able to safely interact with the human *** review will explore the applications,as previously listed,with a focus on how fbers are made using carbohydrate polymers(such as alginate,cellulose and its derivatives,chitosan and chitin,starch,pul1ulan,hyaluronic acid,dextran,and 1evan)as their base material,and their applicability and functionality in various applications.

关键词： Electrospinning Tissue engineering Drug delivery Wound dresing Envionment Energy Protective fabric

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Bi-revealed utilities in a defaultable universe: A new point of view on consumption

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Probability, Uncertainty and Quantitative Risk 2024年第1期9卷 13-34页

作者： nicole El Karoui Caroline Hillairet Mohamed Mrad LPSM UMR CNRS 6632Sorbonne Université4 Place Jussieu75005 ParisFrance CREST UMR CNRS 9194Ensae Paris5 Avenue Henry Le Chatelier91120 PalaiseauFrance LAGA UMR CNRS 7539UniversitéSorbonne Paris-Nord99 Avenue Jean Baptiste Clement93430 VilletaneuseFrance

This paper investigates the inverse problem of bi-revealed utilities in a defaultable universe,defined as a standard universe(represented by a filtration F)perturbed by an exogenous defaultable time τ.We assume that the standard universe does not take into account the possibility of the default,thus τ adds an additional source of *** defaultable universe is represented by the filtration G up to time τ(τ included),where G stands for the progressive enlargement of F by *** basic assumption in force is that τ avoids F-stopping *** bi-revealed problem consists in recovering a consistent dynamic utility from the observable characteristic of an *** general results on bi-revealed utilities,first given in a general and abstract framework,are translated in the defaultable G-universe and then are interpreted in the *** decomposition of G-adapted processes X^(G) provides an interpretation of a Gcharacteristic X^(G)_(τ) stopped at τ as a reserve *** to the characterization of G-martingales stopped at τ in terms of F-martingales,we establish a correspondence between G-bi-revealed utilities from characteristic and F-bi-revealed pair of utilities from characteristic and *** a financial framework,characteristic can be interpreted as wealth and reserves as *** result sheds a new light on the consumption in utility criterion:the consumption process can be interpreted as a certain quantity of wealth,or reserves,that are accumulated for the financing of losses at the default time.

关键词： Bi-revealed utilities Defaultable euniverse Enlargement offiltration Preference criteria of wealth and consumption

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Benefits of jejunostomy feeding in patients who underwent gastrectomy for cancer treatment

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2461-2473页

作者： Romain Jaquet Emmanuel Rivkine nicole De Souza Jean Roudié Department of Digestive and Visceral Surgery Nord Essonne Hospital Group-Longjumeau SiteLongjumeau 91160France Department of General and Digestive Surgery Pierre Zobda-Quitman HospitalUniversity Hospital CenterMartiniqueFranceFort de France 97261Martinique

BACKGROUND Gastric cancer is associated with significant undernutrition responsible for an increase in morbidity and mortality after *** To evaluate the impact of enteral nutrition by jejunostomy feeding in patients undergoing gastrectomy for *** Between 2003 and 2017,all patients undergoing gastrectomy for cancer treatment were included retrospectively.A group with jejunostomy(J+group)and a group without jejunostomy(J-group)were *** Of the 172 patients included,60 received ***,the two groups were comparable with respect to the nutritional parameters studied(body mass index,albumin,etc.).In the postoperative period,the J+group lost less weight and albumin:5.74±8.4 vs 9.86±7.5 kg(P=0.07)and 7.2±5.6 vs 14.7±12.7 g/L(P=0.16),*** morbidity was 25%in the J+group and 36.6%in the J-group(P=0.12).The J+group had fewer respiratory,infectious,and grade 3 complications:0%vs 5.4%(P=0.09),1.2%vs 9.3%(P=0.03),and 0%vs 4.7%(P=0.05),*** 30-day mortality was 6.7%in the J+group and 6.3%in the J-group(P=0.91).CONCLUSION Jejunostomy feeding after gastrectomy improves nutritional characteristics and decreases postoperative morbidity.A prospective study could confirm our results.

关键词： Feeding jejunostomy Gastric cancer Undernutrition Morbimortality Survival

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Are school uniforms associated with gender inequalities in physical activity? A pooled analysis of population-level data from 135 countries/regions

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Journal of Sport and Health Science 2024年第4期13卷 590-598页

作者： Mairead Ryan Luiza I.C.Ricardo nicole Nathan Riikka Hofmann Esther van Sluijs Medical Research Council Epidemiology Unit University of CambridgeCambridge CB20QQUK Faculty of Education University of CambridgeCambridge CB28PQUK Hunter New England Population Health WallsendNSW 2287Australia School of Medicine and Public Health College of HealthMedicine and WellbeingUniversity of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute New Lambton HeightsNSW 2305Australia National Centre of Implementation Science University of NewcastleCallaghanNSW 2308Australia

Purpose:It is aimed to assess whether school uniforms are associated with population-level gender inequalities in physical activity,and whether associations differ by school level,country/region income,and assessment ***:An ecological study design was *** collected data about global uniform practices using an online *** searched for country/region-level estimates of school-aged youth meeting physical activity guidelines from international surveillance *** selection was conducted in duplicate using a systematic process,and a random sample of all data was checked to ensure extraction and pooling processes were *** calculated absolute and relative gender inequalities in physical activity for each *** regression examined associations between country/region-level uniform practices(binary yes/no exposure variable) and country/region-level gender inequalities in physical activity guideline compliance(absolute and relative inequalities).We investigated moderation by school level,stratified analyses by income group,and repeated primary analyses using device-measured ***:Pooling data from 135 countries/regions(n=1,089,852),we found no association between population-level uniform practices and gender inequalities in physical activity across all ages(absolute:β=-0.2;95% confidence interval(95%CI):-1.7 to 1.3,p=0.74;relative:β=0.1;95%CI:-0.1 to 0.2,p=0.51).Subgroup analysis suggested a positive association in primary school settings(absolute:β=4.3;95%CI:-0.0 to 8.6,p=0.05).Among high-income countries,absolute inequalities were significantly greater in countries/regions with uniform practices(N=37) compared to those without(N=48)(9.1(SD=3.6) vs.7.8 percentage points(SD=4.3)).Repeating analyses using device-measured data(n=32,130;N=24) did not alter our primary *** initial descriptive statistics,we found that in countries/regions where a maj ority of schools(>50%) reportedly use uniforms,there was lower compli

关键词： School policy Clothing Child Adolescent Accelerometer

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A Golden Touch in the Design of Multifunctional Porphyrin Metallacages:Host-Guest Chemistry for Drug-Target Interactions

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CCS Chemistry 2024年第7期6卷 1662-1671页

作者： Tamara Rodríguez-Prieto Darren Wragg nicole Heiduk Mihyun Park nicole Strittmatter Roland A.Fischer Angela Casini Guillermo Moreno-Alcántar Chair of Medicinal and Bioinorganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Professorship for Analytical Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Chair of Inorganic and MetalOrganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Munich Data Science Institute(MDSI) Technical University of Munich85748 Garching b.München

The use of three-dimensional self-assembled metallacages(MCgs)as multimodal drug platforms holds great ***,the synthesis of MCgs with increased complexity and functionality is a great challenge since understanding of the interaction of MCgs with biological targets is still *** this context,this work reports on the integration of a gold(III)porphyrin scaffold into a prismatic MCg structure and explores its application for multimodal therapy of cancer in vitro,namely enabling both photodynamic therapy and *** experimental approaches with a state-of-the-art metadynamics theoretical study,we discovered that the gold cage shows unprecedented host-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mechanism to pursue in the design of supramolecular drugs.

关键词： gold metallacages porphyrins G4stabili-zation host-guestchemistry anticanceragents

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Novel elastomeric spiropyran‑doped poly(dimethylsiloxane)optical waveguide for UV sensing

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Frontiers of Optoelectronics 2024年第3期17卷 1-15页

作者： Camila Aparecida Zimmermann Kof Novignon Amouzou Dipankar Sengupta Aashutosh Kumar nicole Raymonde Demarquette Bora Ung Department of Electrical Engineering École de Technologie SupérieureMontrealQC H3C 1K3Canada Department of Mechanical Engineering École de Technologie SupérieureMontrealQC H3C 1K3Canada

Novel poly(dimethylsiloxane)(PDMS)doped with two diferent spiropyran derivatives(SP)were investigated as potential candidates for the preparation of elastomeric waveguides with UV-dependent optical ***,free-standing flms were prepared and evaluated with respect to their photochromic response to UV ***,reversibility as well as photofatigue and refractive index of the SP-doped PDMS samples were ***,SP-doped PDMS waveguides were fabricated and tested as UV sensors by monitoring changes in the transmitted optical power of a visible laser(633 nm).UV sensing was successfully demonstrated by doping PDMS using one spiropyran derivative whose propagation loss was measured as 1.04 dB/cm at 633 nm,and sensitivity estimated at 115%change in transmitted optical power per unit change in UV *** decay and recovery time constants were measured at 42 and 107 s,respectively,with an average UV saturation dose of 0.4 J/*** prepared waveguides exhibited a reversible and consistent response even under *** sensor parameters can be tailored by varying the waveguide length up to 21 cm,and are afected by white light and temperatures up to 70℃.This work is relevant to elastomeric optics,smart optical materials,and polymer optical waveguide sensors.

关键词： Spiropyrans PDMS Photochromism Polymer optical waveguides UV detection

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Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging

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Neural Regeneration Research 2025年第3期20卷 794-796页

作者： Neville Ng Michelle Newbery nicole Miles Lezanne Ooi Molecular Horizons and School of Chemistry and Molecular Bioscience University of WollongongWollongongNSWAustralia

Mitochondrial dysfunction and neurodegeneration:Progressive neurodegenerative diseases affect a significant proportion of the population;in a single year,there are as many as 276 million disabilities and 9 million dea... 详细信息

关键词： degenerative diseases Mitochondrial

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