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Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery

World Journal of Gastroenterology 2015年第14期21卷 4150-4158页

作者： Susan lapthorne Julie E Bines Fiona Fouhy nicole l dellios Guineva Wilson Sarah l Thomas Michelle Scurr Catherine Stanton Paul D Cotter Prue M Pereira-Fantini Intestinal Failure and Clinical Nutrition group Murdoch Childrens Research InstituteRoyal Children’s Hospital Intestinal Failure and Clinical Nutrition group Murdoch Childrens Research Institute Department of Paediatrics the University of Melbourne Department of Gastroenterology and Clinical Nutrition Royal Children’s Hospital Teagasc Food Research Centre MooreparkFermoyCorkIreland Department of Microbiology University College Cork Department of Surgery Monash Medical Centre Alimentary Pharmabiotic Centre University College Cork

AIM: To investigate the impact of minor abdominal surgery on the caecal microbial population and on markers of gut ***: Four week old piglets were randomly allocated to a no-surgery "control" group(n = 6) or a "transection surgery" group(n = 5).During the transection surgery procedure, a conventional midline incision of the lower abdominal wall was made and the small intestine was transected at a site 225 cm proximal to the ileocaecal valve, a 2 cm segment was removed and the intestine was *** received a polymeric infant formula diet throughout the study period and were sacrificed at two weeks *** outcomes including weight, stool consistency and presence of stool fat globules were *** throughput DNA sequencing of colonic content was used to detect surgery-relateddisturbances in microbial composition at phylum, family and genus *** and richness estimates were calculated for the control and minor surgery *** disturbances in the gut microbial community are linked to inflammation we compared the gene expression of key inflammatory cytokines(TNF, Il1 B, Il18, Il12, Il8, Il6 and Il10) in ileum, terminal ileum and colon mucosal extracts obtained from control and abdominal surgery groups at two weeks ***: Changes in the relative abundance of bacterial species at family and genus level were confined to bacterial members of the Proteobacteria and Bacteroidetes *** level compositional shifts included a reduction in the relative abundance of Enterobacteriaceae(22.95 ± 5.27 vs 2.07 ± 0.72, P llaceae(0.40 ± 0.14 vs 0.00 ± 0.00, P llowing transection ***, at the genus level, changes associated with transection surgery were restricted to members of the Proteobacteria and Bacteroidetes phyla and included decreased relative abundance of Enterobacteriaceae(29.20 ± 6.74 vs 2.88 ±

关键词： Surgery Intestinal Microbiota Dysbiosis Inflammati

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Comment on: Effect of intubation in patients with functional epiphora after endoscopic dacryocystorhinostomy

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1576-1576页

作者： Mansooreh Jamshidian-Tehrani Hossein Ghahvehchian Christopher J Compton Jeremy D Clark nicole l West Mohsen Bahmani Kashkouli Department of Ophthalmology Eye Research CenterThe Five Senses Health InstituteRassoul Akram HospitalIran University of Medical SciencesTehran ***Iran Department of Ophthalmology and Visual Sciences University of Louisville School of MedicineLouisville 40202KentuckyUSA

Dear Editor,We read with interest the article by Han et al[1]in which they retrospectively assessed the effect of bicanalicular intubation for functional epiphora after a failed endoscopic dacryocystorhinostomy(DCR).They confirmed the post-DCR“functional obstruction”based on fluorescein dye disappearance(FDDT)and irrigation test[1].

关键词： intubation assessed endoscopic

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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer J.Allen Stephanie M.Ntoukas Gordon J.Bell Jessica McNeil Qinggang Wang Margaret l.McNeely Jeff K.Vallance lin Yang S.nicole Culos-Reed leanne Dickau John R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(pleep quality(p=0.009),significant fatigue(p=0.008),any symptom(pltiple symptoms(pld associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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OTX2 stimulates adult retinal ganglion cell regeneration

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Neural Regeneration Research 2022年第3期17卷 690-696页

作者： Raoul Torero Ibad nicole Quenech’du Alain Prochiantz Kenneth l.Moya Centre for Interdisciplinary Research in Biology(CIRB) Collége de FranceCNRS UMR 7241INSERM U1050Labex MemoLifeParis Sciences et Lettres Research UniversityParisFrance

Retinal ganglion cell(RGC) axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the *** axon degeneration occurs in a number of blinding diseases and the ability to stimulate axon regeneration from surviving ganglion cells could provide the anatomic substrate for restoration of ***2 is a homeoprotein transcription factor expressed in the retina and previous studies showed that,in response to stress,exogenous OTX2 increases the in vitro and in vivo survival of *** we examined and quantified the effects of OTX2 on adult RGC axon regeneration in vitro and in *** results show that exogenous OTX2 stimulates the regrowth of axons from RGCs in cultures of dissociated adult retinal cells and from explants of adult retinal tissue and that RGCs respond directly to OTX2 as regrowth is observed in cultures of purified adult rat ***,after nerve crush in vivo,we observed a positive effect of OTX2 on the number of regenerating axons up to the optic chiasm within 14 days post crush and a very modest level of acuity absent in control *** effect of OTX2 on RGC survival and regeneration is of potential interest for degenerative diseases affecting this cell *** animal procedures were approved by the local "Comié d'éιthique en expérimentation animale n°59" and authorization n° 00702.01 delivered March 28,2014 by the French "Ministére de l'enseignement supérieur et de la recherche".

关键词： axon regeneration dissociated retinal culture GAP-43 homeoprotein optic nerve crush OTX2 retinal explants retinal ganglion cell

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Plant physiological changes along an encroachment gradient: an assessment of US Mid-Atlantic serpentine barrens

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Journal of Plant Ecology 2018年第6期11卷 853-865页

作者： nicole A.Havrilchak Jessica l.Schedlbauer Department of Biology West Chester University750 S.Church StreetWest ChesterPA 19383USA

Aims Serpentine barrens of the Mid-Atlantic United States are globally rare,grass-dominated ecosystems thought to exclude C3 spe-cies and characterized by unique soil ***,like many grassland ecosystems globally,these sites are presently facing encroachment by surrounding *** this ecosystem,the tendril climbing vine,Smilax rotundifolia,forms dense thickets around bar-rens that typically precede forest *** numerous factors speculatively initiate and promote encroachment in these systems,few studies have examined photosynthetic responses of serpentine grasses to changes in resource availability initiated by encroachers or physiological ability of encroaching *** to colonize high-light barren *** sought to under-stand both environmental and physiological dynamics of encroach-ment along an irradiance gradient in these *** At three serpentine barren sites in southeastern Pennsylvania,physiological responses of the native grasses Sorghastrum nutans and Schizachyrium scoparium to increased shading by ***-folia were ***,the physiological performance of *** in the forest understory was compared to that in sunlit barrens ***-saturated photosynthesis(A_(sat)),stomatal conductance(g_(s)),instantaneous transpiration efficiency(ITE),maximum efficiency of photosystem II(F_(v)/F_(m)),midday leaf water potential(ψ_(leaf))and specific leaf area(SlA)were measured for all species over the course of the 2014 growing ***-way analyses of variance were used to assess changes in these param-eters across growing environments,as well as seasonally for each *** regression analyses were also performed to inves-tigate the influence of vapor pressure deficit(D)and leaf tempera-ture(T_(leaf))on A_(sat) and *** Findings light-saturated photosynthesis was significantly greater in ***-difolia growing in sun than in the shade(Ply in th

关键词： encroachment photosynthesis serpentine barren Schizachyrium scoparium Smilax rotundifolia Sorghastrum nutans

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MicroRNA-let-7a promotes E2F-mediated cell proliferation and NFKB activation in vitro

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Cellular & Molecular Immunology 2014年第1期11卷 79-93页

作者： Cristen B Chafin nicole l Regna David l Caudell Christopher M Reilly Department of Biomedical Sciences & Pathobiology Virginia-Maryland Regional College of Veterinary Medicine Virginia Polytechnic Institute and StateUniversity Blacksburg VA USA Department of Pathology/Comparative Medicine Wake Forest University Primate Center Wake Forest School ofMedicine Winston-Salem NC USA Edward Via College of Osteopathic Medicine Blacksburg VA USA

Epigenetic factors, including altered microRNA （miRNA） expression, may contribute to aberrant immune cell function in systemic lupus erythematosus （SlE）. MiRNA-let-7a （let-7a） has been shown to directly alter cell cycle progression and proinflammatory cytokine production. Due to the crucial role of let-7a in cell division and inflammation, we investigated let-7a-mediated proliferation and NFKB translocation in J774A. 1 macrophages and MES 13 mesangial cells in vitro. In immune-stimulated cells transfected with let-7a, cell proliferation was significantly increased over time. There was a significant increase in the number of immune-stimulated cells in S and G2 phases. Immune-stimulated cells overexpressing let-7a had increased nuclear translocation of NFKB. Bioinformatical analysis revealed that the E2F family, critical regulators of the G1-S transition, has potential binding sites for let-7a in their mRNA transcripts. let-7a overexpression significantly increased the expression of the cell cycle activator E2F2 and increased retinoblastoma protein （Rb） phosphorylation in immune-stimulated cells. The cell cycle inhibitor E2F5 was significantly decreased in let-7a-transfected cells that were immune-stimulated. Bioinformatical analysis revealed E2F2 and NFKB are transcription factors predicted to regulate the let-7a promoter. We analyzed transcriptional regulation of let-7a by real-time RT-PCR using chromatin immunoprecipitation with E2F2 and NFKB antibodies. There was an increase in E2F2 and NFKB binding in DNA enriched for the let-7a promoter in immune-stimulated cells. Silencing E2F2 or NFKB significantly decreased let-7a expression and Il-6 production in immune-stimulated cells. Taken together, our results suggest that overexpression of let-7a may contribute to hyperplasia and the proinflammatory response in SlE.

关键词： cell proliferation E2F microRNA-let-7a NF~:B systemic lupus erythematosus

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Pediatric dog bite injuries in the USA: a systematic review

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World Journal of Pediatric Surgery 2022年第2期5卷 46-53页

作者： Kelli nicole Patterson Kyle Z Horvath Peter C Minneci Rajan Thakkar leeAnn Wurster Dana l Noffsinger Tran Bourgeois Katherine J Deans Center for Surgical Outcomes Research and Department of Surgery Nationwide Children's HospitalColumbusOhioUSA

Introduction Dog bites are one of the leading causes of non-fatal emergency room visits in *** injuries not only cause physical harm but can lead to long-term psychological *** study evaluated the current literature related to pediatric dog bite injuries to identify research gaps which should be prioritized to improve a major public health *** We performed a keyword search of PubMed,Scopus,and OVID Medline databases(January 1980-March 2020)for all published studies focused on dog bite injuries in the pediatric population(≤18 years of age)using the Preferred Reporting Items for Systematic Reviews and *** Out of 1859 abstracts screened,43 studies involving 86880 patients were ***-nine studies were retrospective chart reviews characterizing the epidemiology of dog bites and their associated treatment outcomes;six were prospective cohort studies;two were cross-sectional studies;and six were experimental *** results demonstrate that childrenldrenlving the head,neck,and *** Studies analyzing the prevention or psychosocial consequences of dog bites injuries are needed.

关键词： injuries consequences prevention

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Physiological effects of climate warming on flowering plants and insect pollinators and potential consequences for their interactions

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Current Zoology 2013年第3期59卷 418-426页

作者： Victoria l. SCAVEN nicole E. RAFFERTY Department of Soil Water and Environmental Science University of Arizona Tucson AZ 85721 USA Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ 85721 USA Center for Insect Science University of Arizona Tucson AZ 85721 USA

Growing concern about the influence of climate change on flowering plants, pollinators, and the mutualistic interactions between them has led to a recent surge in research. Much of this research has addressed the consequences of warming for phenological and distributional shifts. In contrast, relatively little is known about the physiological responses of plants and insect pollinators to climate warming and, in particular, how these responses might affect plant-pollinator interactions. Here, we summarize the direct physiological effects of temperature on flowering plants and pollinating insects to highlight ways in which plant and pollinator responses could affect floral resources for pollinators, and pollination success for plants, respectively. We also consider the overall effects of these responses on plant-pollinator interaction networks. Plant responses to warming, which include altered flower, nectar, and pollen production, could modify floral resource availability and reproductive output of pollinating insects. Similarly, pollinator responses, such as altered foraging activity, body size, and life span, could affect patterns of pollen flow and pollination success of flowering plants. As a result, network structure could be altered as interactions are gained and lost, weakened and strengthened, even without the gain or loss of species or temporal overlap. Future research that addresses not only how plant and pollinator physiology are affected by warming but also how responses scale up to affect interactions and networks should allow us to better understand and predict the effects of climate change on this important ecosystem service.

关键词：授粉昆虫相互作用植物开花气候变暖生理效应生理反应植物授粉花卉资源

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Reducing psychiatric illness in the perinatal period:A review and commentary

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World Journal of Psychiatry 2023年第4期13卷 149-160页

作者： Jessica Rohr Farhaan S Vahidy nicole Bartek Katelynn A Bourassa Namrata R Nanavaty Danielle D Antosh Konrad P Harms Jennifer l Stanley Alok Madan Department of Psychiatry and Behavioral Health Houston MethodistHoustonTX 77030United States Department of Neurosurgery Houston MethodistHoustonTX 77030United States Department of Obstetrics and Gynecology Houston MethodistHoustonTX 77030United States

This brief overview highlights the global crisis of perinatal psychiatric illness(PPI).PPI is a major contributor to many adverse pregnancy,childbirth,and childhood development *** contributes to billions of dollars in spending worldwide each year and has a significant impact on the individual,their family,and their *** is also highly *** recommendations for intervention and management of PPI are limited and vary considerably from country to ***,there are several significant challenges associated with implementation of these *** challenges are magnified in number and consequence among women of color and/or minority populations,who experience persistent and negative health disparities during pregnancy and the postpartum *** paper aims to provide a broad overview of the current state of recommendations and implementation challenges for PPI and layout a framework for overcoming these *** equityinformed model of care that provides universal intervention for pregnant women may be one solution to address the preventable consequences of PPI on child and maternal ***,this model emphasizes the importance of managing and eliminating known barriers to traditional health care *** and contextually specific challenges must be overcome to fully realize the impact of improved management of PPI.

关键词： Perinatal psychiatric illness Postpartum depression Equity-oriented care Minority populations Maternal mortality Pregnancy

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