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The Effect of Soaking with Wooden Ash and Malting upon Some Nutritional Properties of Sorghum Flour Used for Impeke,a Traditional Burundian Malt-Based Sorghum Beverage

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Agricultural Sciences in China 2011年第11期10卷 1801-1811页

作者： Irakoze Pierre Clave ZHOU Hui-ming ZHANG Hai-hua ZHU Ke-xue LI Qin Murekatete nicole State Key Laboratory of Food Science and Technology Jiangnan University Wuxi 214122 P.R.China Departement de Technologie des Industries Agro-Alimentaires lnstitut Sup~rieur d＇Agriculture University of Burundi Gitega BP 35Burundi

The objective of the present work was to determine the effect of wooden ash extract on anti-nutritional factors and to assess the effect of soaking with malting on nutritional properties of sorghum flour used for impeke. The addition of wooden ash extract during 24 h of soaking resulted in significant decrease in tannin by 50.2% and the decrease was observed to be progressive as malting time increases. 5 d of malting resulted in significant decrease in tannin by 69.3% and in phytic acid by 66.4% with slight decrease in ash, lipid, fiber, and starch. Malting showed an increased percentage of protein, essential amino acids, and then in vitro protein digestibility were markedly improved with increasing malting time. Sugars analysis proved a significant increase in maltose, glucose, fructose, and structural analysis of sorghum starch displayed porosity on granule＇s surface susceptible to the amylolysis.

关键词： sorghum soaking malting wooden ash anti-nutrient

Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method

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journal of Pharmaceutical Analysis 2021年第1期11卷 77-87页

作者： Christelle Machon Frederic Catez nicole Dalla Venezia Floriane Vanhalle Laetitia Guyot Anne Vincent Maxime Garcia Beatrice Roy jean-jacques Diaz jerome Guitton Laboratoire de Chimie Analytique Faculte de Pharmacie de LyonUniversite Lyon 18 Avenue RockefellerLyon69373France Laboratoire de Biochimie et de Pharmaco-toxicologie Centre Hospitalier Lyon-SudeHCLPierre Benite69495France Inserm U1052 CNRS UMR5286 Centre de Recherche en Cancerologie de LyonF-69000 LyonFrance.Centre Leon BerardF-69008 LyonFranceUniversite de Lyon 1F-69000 LyonFrance Institut des Biomolecules Max Mousseron(IBMM) UMR 5247 CNRSUniversite de MontpellierENSCMCampus TrioletMontpellierFrance Laboratoire de toxicologie Faculte de pharmacie de Lyon8 avenue RockefellerF-69373 LyonFrance

5-Fluorouracil(5-FU)is an anticancer drug extensively used for different *** metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes,DNA and *** this paper,we describe the development of a method based on liquid chromatography coupled with high resolution mass spectrometry suitable for the simultaneous determination of the ten anabolic metabolites(nucleoside,nucleotide and sugar nucleotide)of *** chromatographic separationwas optimized on a porous graphitic carbon column allowing the analysis of the metabolites of 5-FU as well as endogenous *** detection was performed on an Orbitrap■tandem mass *** of the method was verified in intracellular content and in RNA *** limit of detection was equal to 12 pg injected on column for nucleoside metabolites of 5-FU and 150 pg injected on column for mono-and tri-phosphate nucleotide *** effect was evaluated in cellular contents,DNA and RNA extracts for nucleoside and nucleotides *** method was successfully applied to i)measure the proportion of each anabolic metabolite of 5-FU in cellular contents,ii)follow the consequence of inhibition of enzymes on the endogenous nucleotide pools,iii)study the incorporation of metabolites of 5-FU into RNA and DNA,and iv)to determine the incorporation rate of 5-FUrd into 18 S and 28 S sub-units of rRNA.

关键词： 5-Fluorouracil LC-MS-HRMS Nucleotide RNA DNA Incorporation rate

Inhibitive Determination of Heavy Metal Ions by Conductometric Nitrate Reductase Biosensor

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Chemical Research in Chinese Universities 2009年第4期25卷 443-445页

作者： WANG Xue-jiang XIA Si-qing ZHAO jian-fu ZHAO Hong-ning RENAULT nicole jaffrezic State Key Laboratory of Pollution Control and Resources Reuse Tongji University Shanghai 200092 P R. China Laboratoire de Sciences Analytiques（UMR CNRS 5180） Universite Claude Bernard Lyon 1 Universite ＇de Lyon Villeurbanne Cedex 69622 France

A conductometric nitrate biosensor based on methyl viologen/Nafion/nitrate reductase（NR） interdigitated electrode for heavy metal determination was *** activity of NR（EC 1.***.6.2） from Asper gillusniger（***） was assayed as a function of metal concentration in the presence of Cu^2＋,Zn^2＋,Cd^2＋ and Pb^2＋.Parameters influencing the performance of the biosensor were optimized for the application of it in the inhibition determination of heavy metal *** limits for Cu^2＋,Zn^2＋,Cd^2＋ and Pb^2＋ were about 0.05,0.5,0.1 and 1.0 μmol/L,*** results show that NR activity could not be regained after exposure to Cu^2＋,but could be partially recovered after exposure to Zn^2＋,Pb^2＋ and Cd^2＋.

关键词： Conductometric biosensor Heavy metal Nitrate reductase

The impact of fluorination on both donor polymer and non-fullerene acceptor:The more fluorine,the merrier

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Nano Research 2019年第9期12卷 2400-2405页

作者： nicole Bauer Qianqian Zhang jeromy james Rech Shuixing Dai Zhengxing Peng Harald Ade jiayu Wang Xiaowei Zhan Wei You Department of Chemistry University of North Carolina at Chapel HillNorth Carolina 27599USA Department of Materials Science and Engineering College of EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry EducationPeking UniversityBeijing 100871China Department of Physics and ORaCEL North Carolina State UniversityRaleighNorth Carolina 27695USA

Fluorination of the donor polymer or non-fullerene acceptor (NFA) in an organic photovoltaic device is an effective method to improve device *** there have been many studies on donor polymer fluorination,blends containing both a fluorinated donor and fluorinated NFA have rarely been *** this study,we use two donor polymers (4'-FT-HTAZ and 4'-FT-FTAZ) and two NFAs (ITIC-Th and ITIC-Th1) with different amounts of fluorine (from 2F to 6F) to investigate how the degree of fluorination in a blend impacts device *** find that fluorinating the NFA leads to a higher short-circuit current density (jsc) and fill factor (FF),however,the open-circuit voltage (Voc) is decreased due to a depressed lowest unoccupied molecular orbital (LUMO) *** additional fluorine to the donor polymer does not have a large effect on the jsc or FF,but it does lead to an improved *** fluorinating the NFA and having more fluorine on the donor polymer,we obtain both a high jsc and Voc simultaneously,leading to a power conversion efficiency over 10% in the case of 4'-FT-FTAZ:ITIC-Th1,which has the most amount of fluorine (6F).

关键词： organic solar cells non-fullerene acceptors fluorination bulk heterojunction

Analyzing stem cell dynamics： use of cutting edge genetic approaches in model organisms

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Frontiers in Biology 2015年第1期10卷 1-10页

作者： Gary R. HIME nicole SIDDALL Katja HORVAY Helen E. ABUD Department of Anatomy and Neuroseienee University of Melbourne VIC 3010 Australia Department of Anatomy and Developmental Biology Monash University Clayton VIC 3800 Australia

Regeneration of many cell types found in adult organs relies upon the presence of relatively small pools of undifferentiated stem cells. Initial studies that attempted to isolate stem cells and propagate them in vitro have been complemented by analysis of stem cells in their endogenous tissues where they are subject to a variety of regulatory cues. This has been facilitated by the advent of new methods for lineage tracing and genetic manipulation of stem cells and their associated niche cells. The picture that is emerging is that different stem cell populations utilize diverse processes to ensure maintenance of the stem cell pool accompanied by production of cells committed to regenerate differentiated cells.

关键词： stem cells Drosophila mouse testis intestine lineage tracing

Outdoor Universal Thermal Comfort Index Climatology for Alaska

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Atmospheric and Climate Sciences 2019年第4期9卷 558-582页

作者： nicole Molders Geophysical Institute Department of Atmospheric SciencesCollege of Natural Science and MathematicsUniversity of Alaska FairbanksFairbanksUSA

Data from 456 surface meteorological sites in Alaska, eastern Russia and northwest Canada for 1979-2017 were used to model hourly universal thermal comfort indices (UTCIs) under consideration of Alaska-appropriate clothing. The results served to determine a high-resolution climatology of thermal comfort levels for Alaska at various temporal and spatial scales as well as the frequency of thermal stress levels. On 1979-2017 average, various degrees of cold stress occurred with highest percentage on the Alaska West Coast and along the Arctic Ocean. In the continental and Inside Passage region, no thermal stress had the highest percentage of occurrence. In Interior Alaska, both strong heat and extreme cold stress occurred occasionally. At most sites and in all Alaska Köppen-Geiger bio-climate regions, the absolute range between monthly means of daily minimum and maximum UTCIs was larger than that of monthly means of daily minimum and maximum air temperatures. Major contributors to thermal discomfort (shortwave radiation, air temperature, moisture, wind speed) varied among bio-climate regions and in the diurnal and annual courses.

关键词： UTCI Universal Thermal Comfort Index Thermal Stress in Alaska Bio-Climate of Alaska Thermal Stress Climatology of Alaska

Inventory of the Thermo-Physiological Behavior of Fabrics—A Review

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journal of Textile Science and Technology 2023年第2期9卷 127-150页

作者： nicole Mölders Department of Atmospheric Sciences University of Alaska Fairbanks Fairbanks USA Geophysical Institute University of Alaska Fairbanks Fairbanks USA

A comprehensive literature review was performed to create an inventory of thermal-physiological quantities for fabrics from different fiber materials, material blends, and fabric structures. The goal was to derive over-arching concepts that cannot be seen by the individual studies alone. Equations of best fits suggest non-linear changes for fabric thickness, thermal and water-vapor resistance with changes in material blend ratio. Air permeability decreases with increasing fabric density and fabric weight wherein the degree of decrease differs among fabric materials, blend ratio, and fabric structure. Water-vapor transmission rates strongly depend on fabric thickness, material, and blend, but marginally depend on fabric structure as long as the fabric and material thickness remain the same.

关键词： Thermal Resistance of Fabrics Thermal Conductivity of Fabrics Water-Vapor Resistance of Fabrics Water-Vapor Transmission Rate Inventory of Thermal-Physiological Characteristics of Fabrics Energetics of Fabrics

From Sméagol to Gollum: Mechanical Stress and Bone Remodelling

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Open journal of Orthopedics 2018年第4期8卷 148-167页

作者： nicole Pace University of Malta Gozo Malta

This imaginary transformation from Sméagol to Gollum is a dramatization of the illusive repercussions of mechanical stress affecting bone. This paper presents the main ideas of mechanical stress and bone remodelling from a novel’s perspective. The object of this study is to provide evidence for new ways to explore bone’s functional adaptation to mechanical stress made through the copious interpretation and integration of new and existing literature. It tackles the underlying biology of bone cells and how they detect and react to strain stimuli. The different types of mechanical demands in daily activities are sifted through and any misconceptions found fallible in literature are refined. A personal experience of a stress fracture is reviewed to parallel the implications that lead to the incident with the findings on the link between mechanical stress and bone remodelling. Some factors regarding age, gender and ethnicity and the interplay with mechanical stress influencing bone remodelling are considered. Brief overviews of three new medical novelties in bone healing are outlined, hoping that these interventions of proper medical techniques can be a change for the better: one from Gollum to Sméagol rather than vice versa.

关键词： Mechanical Stress Bone Remodelling Cycle Mechanostat Model Stress Fracture

Wastewater analysis for nicotine,cocaine,amphetamines,opioids and cannabis in New York City

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Forensic Sciences Research 2019年第2期4卷 152-167页

作者： nicole Centazzo Bonnie-Marie Frederick Alethea jacox Shu-Yuan Cheng Marta Concheiro-Guisan Department of Sciences John Jay College of Criminal JusticeCity University of New YorkNew YorkNYUSA

According to current surveys and overdoses data,there is a drug crisis in the ***-based epidemiology(WBE)is an evolving discipline that analyses wastewater samples to detect drugs and metabolites to estimate drug consumption in a certain *** study demonstrates how drug relative presence could be tracked by testing wastewater,providing real-time results,in different boroughs in New York City throughout 1 *** developed and fully validated two analytical methods,one for 21 drugs and metabolites,including nicotine,cocaine,amphetamines,opioids and cannabis markers;and another for the normalization factor *** methods were performed by liquid chromatography tandem mass spectrometry(LC-MS/MS)using positive electrospray ionization,achieving a limit of quantification of 5–10 ng/L for drugs and metabolites,and 0.01 mg/L for *** methods were applied to 48 one-time grab wastewater samples collected from six wastewater treatment plants in New York City(Manhattan,The Bronx,Queens and Brooklyn),eight different times throughout 2016,before and after major holidays,including Memorial Day,4th of july,Labour Day and New Year’*** this study,the drug group normalized concentrations present in the wastewater samples,in decreasing order,were cocaine,nicotine,opioids,cannabis and *** looking at individual compounds,the one with the highest normalized concentration was benzoylecgonine(BE),followed by cotinine,morphine and 11-nor-9-carboxy-tetrahydrocannabinol(THCCOOH).To estimate community use,these concentrations were multiplied by the corresponding correction factor,and the most present were THCCOOH,followed by BE,cotinine and *** comparing the treatment plants by drug group(nicotine,cocaine,amphetamines,opioids and cannabis),samples collected from The Bronx had the highest normalized concentrations for nicotine,cocaine and opioids;The Bronx and Manhattan for cannabis;and Manhattan and Queens for *** mo

关键词： Forensic sciences forensic toxicology wastewaterbased epidemiology(WBE) nicotine cocaine amphetamines opioids cannabis LC-MS/MS