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Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model

International journal of Oral Science 2018年第4期10卷 212-222页

作者： R.nicole Howie Samuel Herberg Emily Durham Zachary Grey Grace Bennfors Mohammed Elsalanty Amanda C.LaRue William D.Hill james j.Cray Oral Health Sciences Medical University of South CarolinaCharlestonSCUSA Biomedical Engineering Case Western Reserve UniversityClevelandOHUSA Cellular Biology and Anatomy Augusta UniversityAugustaGAUSA Oral Biology Augusta UniversityAugustaGAUSA Orthopaedic Surgery Augusta UniversityAugustaGAUSA Pathology and Laboratory Medicine Medical University of South CarolinaCharlestonSCUSA Institute for Regenerative and Reparative Medicine Augusta UniversityAugustaGAUSA Research Service of the Ralph H johnson VA Medical Center CharlestonSCUSA Charlie Norwood VA Medical Center AugustaGAUSA Department of Regenerative Medicine and Cellular Biology CharlestonSCUSA Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNCUSA Division of Anatomy College of MedicineOhio State UniversityColumbusOHUSA

Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors(SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients’ ability to heal after sustaining trauma. Here, we investigate the effect of the SSRI sertraline on bone healing through pre-treatment with(10 mg·kg-1sertraline in drinking water, n = 26) or without(control, n = 30) SSRI followed by the creation of a 5-mm calvarial defect. Animals were randomized into three surgical groups:(a) empty/sham,(b) implanted with a DermaMatrix scaffold soak-loaded with sterile PBS or(c) DermaMatrix soak-loaded with542.5 ng BMP2. SSRI exposure continued until sacrifice in the exposed groups at 4 weeks after surgery. Sertraline exposure resulted in decreased bone healing with significant decreases in trabecular thickness, trabecular number and osteoclast dysfunction while significantly increasing mature collagen fiber formation. These findings indicate that sertraline exposure can impair bone wound healing through disruption of bone repair and regeneration while promoting or defaulting to scar formation within the defect site.

关键词： Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model

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Anatomic relationship of extensor indicis propius and extensor digitorum communis: Implications for tendon transfer

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World journal of Orthopedics 2022年第11期13卷 978-985页

作者： joanne Zhou Christopher Frey nicole Segovia jeffrey Yao Department of Orthopaedic Surgery Stanford University Medical CenterStanford UniversityRedwood cityCA 94063United States

BACKGROUND The extensor indicis proprius(EIP)tendon is a frequently used donor for a variety of tendon transfers,most commonly for reconstruction of the extensor pollicis longus(EPL).EIP is known to have frequent anatomic variants including split tendons and variations in tendon *** To characterize the anatomy of the EIP at the level of the extensor retinaculum,where tendon harvest is often performed,and share our preferred technique for EIP to EPL *** Twenty-nine fresh-frozen cadaveric forearms without history of forearm or hand injury or surgery were *** circumference and relationship of the EIP and extensor digitorum communis to the index(EDCI)at the metacarpophalangeal(MCP)joint and the distal extensor retinaculum were *** from the distal extensor retinaculum to the EIP myotendinous junction was *** EIP was ulnar to the EDCI in 96.5%of specimens(28/29)at the distal edge of the extensor *** the remaining specimen,EIP was volar to *** circumference at the distal extensor retinaculum averaged(9.3 mm±1.7 mm)for EDCI and 11.1 mm(±2.7 mm)for EIP(P=0.0010).The tendon circumference at the index MCP joint averaged 11.0 mm(±1.7 mm)for EDCI and 10.6 mm(±2.1 mm)for EIP(P=0.33).EIP had a greater circumference in 76%(22/29)of specimens at the distal extensor retinaculum whereas EIP had a greater circumference in only 31%(9/29)of specimens at the MCP *** The EIP tendon is frequently ulnar to and greater in circumference than the EDCI at the distal extensor retinaculum,which can be taken into consideration for tendon transfers involving EIP.

关键词： Surgical anatomy Tendon transfer Extensor digitorum communis Extensor indicis proprius Tendon harvest Cadaveric Dissection

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US economic and trade sanctions against China: A loss-loss confrontation

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Economic and Political Studies 2023年第1期11卷 17-44页

作者： Liang Guo Sizhu Wang nicole Z.Xu jack H.Brown College of Business and Public Administration California State UniversitySan BernardinoCAUSA School of Finance Renmin University of ChinaBeijingChina Chinese American Youth Association AtlantaGAUSA

The economic and trade sanctions implemented by the United States(US)against China have lasted for a few decades and the structural imbalance of the US–China trade relationship has ultim-ately been escalated to a trade war *** examine the eco-nomic impacts of US sanctions against China on both sponsor and target countries during the last 20 *** find that such impacts have significantly changed over *** one hand,US economic sanctions have gradually extended from China’s labour-intensive to high value-added products and they have largely slowed down China’s trade growth for the last *** the other hand,US consumers and businesses have faced higher pri-ces and production costs for Chinese imports(or import substi-tutes)in the wake of the increasing US trade sanctions,leading to great deadweight losses to the sponsor *** addition,US economic and trade sanctions against China have largely impacted other economies involved in US–China trade as *** intermediary status of the Hong Kong SAR has been greatly ***,US economic and trade sanctions have caused pain on both China and the US,but their impact on China(the target country)has been largely weakened.

关键词： Economic sanctions US–China trade war export control

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长白山天池火山千年大喷发岩浆含水量研究——熔融包裹体含水量的红外光谱测试

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岩石学报 2006年第6期22卷 1465-1472页

作者：李霓 nicole MéTRICH 樊祺诚中国地震局地质研究所 Laboratoire Pierre Süe CEA-CNRSSaclay91191 Gif sur YvetteFrance

长白山天池火山在公元一千年左右曾发生过大规模喷发,其产物为大面积分布的灰白色碱流质浮岩和碎屑流,在其斑晶矿物橄榄石、钙铁辉石和碱性长石中均可见到熔融包裹体。在最主要的斑晶矿物——碱性长石中含有数量众多且个体也较大的熔融... 详细信息

长白山天池火山在公元一千年左右曾发生过大规模喷发,其产物为大面积分布的灰白色碱流质浮岩和碎屑流,在其斑晶矿物橄榄石、钙铁辉石和碱性长石中均可见到熔融包裹体。在最主要的斑晶矿物——碱性长石中含有数量众多且个体也较大的熔融包裹体,多数含有一个以上的气泡,其中部分含有子晶,根据形貌特征的不同可分为截然不同的两组包裹体。这些熔融包裹体带有大量喷发前地下岩浆的信息,成为研究地下深部的岩浆在复杂的溢流-爆炸喷发中所发生变化的最好媒介,也是本文的研究对象,通过其中挥发份尤其是水的含量,可以推知天池火山发生大喷发的原因。经nicolet Magna-IR 550红外光谱仪测定,这些熔融包裹体的含水量较高,达1．6%～3．6%,为当时天池火山发生了巨大规模爆炸喷发的原因提供了强有力的证据。但目前红外光谱仪的应用范围还比较有限,有待今后拓宽其应用领域。

关键词：长白山天池火山千年大喷发碱性长石熔融包裹体红外光谱测试

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Robotic-assisted microsurgery for lymphedema treatment

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Plastic and Aesthetic Research 2023年第1期10卷 543-550页

作者： Epameinondas Gousopoulos Lisanne Grünherz Pietro Giovanoli nicole Lindenblatt Department of Plastic Surgery and Hand Surgery University Hospital ZurichZurich CH-8091Switzerland

The recent development of robotic-assisted microsurgery and supermicrosurgery has raised great expectations to support some of the most demanding microsurgical procedures,which are applied in lymphatic reconstructive surgery to restore lymphatic vascular integrity and treat *** such as the establishment of lymphovenous anastomosis(LVA),the harvest of lymph nodes from anatomic locations that reduce donor-side morbidity and the transplantation of the vascularized lymph node flaps(VLNT)present procedures necessitating extreme precision and dexterity in often difficult-to-reach areas,thus pushing the physical limitations of the performing *** being limited in number,recent preclinical and clinical studies of independent groups using different robotic systems demonstrate the feasibility of robotic technology to perform supermicrosurgical procedures *** robotic assistance offers unparalleled precision,refining the surgical techniques and minimizing potential side effects,with clinical outcomes comparable to the conventional *** the relative disadvantages of robotic assistance mostly appear to be related to adequate training and the prolonged learning curve,the technology promises to revolutionize the field of supermicrosurgery and improve the clinical outcomes of lymphatic reconstructive surgery.

关键词： Robotic microsurgery robotic supermicrosurgery lymphatic reconstruction lymphatic surgery lymphedema lymphovenous vascularized lymph node transfer robotic-assisted surgery

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Outlining key inflammation-associated parameters during early phase of an experimental gram-negative sepsis model in rhesus macaques(Macaca mulatta)

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Animal Models and Experimental Medicine 2019年第4期2卷 326-333页

作者： jose j.Rosado-Franco Marcos j.Ramos-Benitez Laura M.Parodi Derick Rosario nicole Compo Luis D.Giavedoni Ana M.Espino Department of Microbiology and Medical Zoology Medical Sciences CampusUniversity of Puerto RicoSan JuanPuerto Rico Southwest National Primate Research Center Texas Biomedical Research InstituteSan AntonioTXUSA Chemistry Department Rio Piedras CampusUniversity of Puerto RicoSan JuanPuerto Rico Medical Sciences Campus Caribbean Primate Research Center University of Puerto RicoToa BajaPuerto Rico

The aim of this study was to identify inflammation-associated markers during the early phase of sepsis in rhesus macaque. Four rhesus macaques were given an intravenous dose of 1010 CFU/kg of E. coli. Blood samples were collected before, or 30 minutes, 2, 4, 6 and 8 hours after E. coli infusion. Physiological parameters, bacteremia, endotoxemia, C-reactive protein(CRP), procalcitonin(PCT), and plasma cytokines/chemokines were determined for each animal. Bacteremia was present in all animals from 30 minutes to 3 hours after E. coli infusion whereas endotoxin was detected during the full-time course. CRP and PCT levels remained at detectable levels during the whole experimental window suggesting an ongoing inflammatory process. Signature cytokines and chemokines such as TNF-α, MIP-1α, and MIP-1β peaked about 2 hours after E. coli infusion and decreased thereafter. Plasma IL-6, IL-12 p40, IFN-γ, and IL-1 Ra, as well as I-TAC, MIG, IP-10 and MCP-1, remained at detectable levels after 4 hours of E. coli infusion. This nonhuman primate model could be useful for the assessment of new therapeutics aiming to suppress key inflammatory markers throughout sepsis early phases.

关键词： chemokines cytokines Macaca mulatta sepsis

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作者署名的最佳实践

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中国科学基金 2018年第6期32卷 560-561页

作者： Hans Zauner nicole A Nogoy scott C Edmunds 周红玲 Laurie Goodman GigaScience编辑部中国香港深圳华大生命科学研究院深圳518120

在科技论文发表的科学实践中,决定谁应该成为作者,以及如何排序,是体现学术贡献的关键,也是一个艰难的过程。作者署名不仅关系到对研究贡献的认可,在现阶段也可能与作者的事业和基金资助机会挂钩,更是科研诚信的基石。

关键词：作者科学实践论文发表学术贡献基金资助

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Insertion of Ontological Knowledge to Improve Automatic Summarization Extraction Methods

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journal of Intelligent Learning Systems and Applications 2011年第3期3卷 131-138页

作者： jésus Antonio Motta Laurence Capus nicole Tourigny 不详

The vast availability of information sources has created a need for research on automatic summarization. Current methods perform either by extraction or abstraction. The extraction methods are interesting, because they are robust and independent of the language used. An extractive summary is obtained by selecting sentences of the original source based on information content. This selection can be automated using a classification function induced by a machine learning algorithm. This function classifies sentences into two groups: important or non-important. The important sentences then form the summary. But, the efficiency of this function directly depends on the used training set to induce it. This paper proposes an original way of optimizing this training set by inserting lexemes obtained from ontological knowledge bases. The training set optimized is reinforced by ontological knowledge. An experiment with four machine learning algorithms was made to validate this proposition. The improvement achieved is clearly significant for each of these algorithms.

关键词： Automatic Summarization Ontology Machine Learning Extraction Method

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Seasonal shifts in the solute ion ratios of vadose zone rock moisture from the Eel River Critical Zone Observatory

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Acta Geochimica 2017年第3期36卷 385-388页

作者： jennifer L.Druhan nicole Fernandez jia Wang William E.Dietrich Daniella Rempe Department of Geology University of Illinois Urbana Champaign Department of Earth and Planetary Science University of California Berkeley jackson School of Geosciences University of Texas at Austin

One of the greatest challenges in critical zone studies is to document the moisture dynamics, water flux,and solute chemistry of the unsaturated, fractured and weathered bedrock that lies between the soil and groundwater table. The central impediment to quantifying this component of the subsurface is the difficulty associated with direct observations. Here, we report solute chemistry as a function of depth collected over a full year across the shale-derived vadose zone of the Eel River Critical Zone Observatory using a set of novel sub-horizontal wellbores,referred to as the vadose zone monitoring system. The results of this first geochemical glimpse into the deep vadose zone indicate a dynamic temporal and depth-resolved structure. Major cation concentrations reflect seasonal changes in precipitation and water saturation, and normalized ratios span the full range of values reported for the world's largest rivers.

关键词： Vadose zone Solute ion ratios Critical Zone Observatory Seasonal solute dynamics

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Antibiotic-loaded amphora-shaped pores on a titanium implant surface enhance osteointegration and prevent infections

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Bioactive Materials 2021年第8期6卷 2331-2345页

作者： Viviane Ständert Kai Borcherding nicole Bormann Gerhard Schmidmaier Ingo Grunwald Britt Wildemann julius Wolff Institute BIH Center for Regenerative TherapiesCharitéUniversitätsmedizin BerlinCorporate Member of Freie Universität BerlinHumboldt-Universität zu BerlinBerlin Institute of Health13353BerlinGermany Department of Adhesive Bonding Technology and Surfaces Fraunhofer Institute for Manufacturing Technology and Advanced Materials(IFAM)28359BremenGermany Center for Orthopedics Trauma Surgery and Spinal Cord InjuryHTRG-Heidelberg Trauma Research GroupHeidelberg University Hospital69118HeidelbergGermany Industrial and Environmental Biology Hochschule Bremen-City University of Applied Sciences28199BremenGermany Experimental Trauma Surgery Department of TraumaHand and Reconstructive SurgeryJena University HospitalFriedrich Schiller University Jena07747JenaGermany

Artificial prostheses for joint replacement are indispensable in orthopedic ***,the implanted surface is attractive to not only host cells but also *** enable better osteointegration,a mechanically stable porous structure was created on a titanium surface using laser treatment and metallic silver particles were embedded in a hydrophilic titanium oxide layer on *** laser structuring resulted in unique amphora-shaped *** to their hydrophilic surface conditions and capillary forces,the pores can be loaded preoperative with the antibiotic of choice/need,such as *** and differentiation assays with primary human osteoblast-like cells revealed no negative effect of the surface modification with or without gentamicin *** in vivo biocompatibility study showed significantly enhanced osteointegration as measured by push-out testing and histomorphometry 56 days after the implantation of the K-wires into rat *** a *** infection model,the porous,silver-coated K-wires slightly reduced the signs of bone destruction,while the wires were still colonized after 28 *** the amphora-shaped pores with gentamicin significantly reduced the histopathological signs of bone destruction and no bacteria were detected on the *** together,this novel surface modification can be applied to new or established orthopedic *** enables preoperative loading with the antibiotic of choice/need without further equipment or post-coating,and supports osteointegration without a negative effect of the released dug,such as gentamicin.

关键词： Titanium implants Laser structuring Amphora-shaped pores Gentamicin loading Antimicrobial silver particles

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