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An automated dispensing system for improving medication timing in the emergency department

World journal of Emergency Medicine 2012年第2期3卷 102-107页

作者： Michael j.Ward jeremy S.Boyd nicole j.harger john M.Deledda Carol L.Smith Susan M.Walker jeffrey D.Hice Kimberly W.Hart Christopher j.Lindsell Stewart W.Wright Department of Emergency Medicine University of Cincinnati Pharmacy Division University of Cincinnati Air Care and Mobile Care University HospitalUniversity of Cincinnati

BACKGROUND:Numerous medical conditions require timely medication administration in the emergency department(ED).Automated dispensing systems(ADSs)store premixed common doses at the point-of-care to minimize time to administration,but the use of such automation to improved time to medication administration has not been *** vancomycin is a commonly used empiric antimicrobial,we sought to quantify the effect of using an ADS on time to drug delivery in patients presenting to the *** study aimed to determine the efficacy of utilizing an ADS to improve time to administration of vancomycin and determine any negative effects on dosing ***:The institional review board approved the retrospective quality improvement study took place in a single,urban academic tertiary care ED with an annual census of 80 *** subjects were all patients receiving vancomycin for the management of sepsis between March 1 to September 30,2008 and the same time period in *** primary outcome was the proportion of patients who received vancomycin within one hour of bed placement and the secondary outcome was dosing ***:Sixty-three patients had weight and dosing information available(29 before and 34after intervention)and were included in the *** intervention,no patient received vancomycin in less than 60 minutes,while after intervention 14.7%of the patients received it in less than 60minutes(difference in proportions 14.7%,95%CI 0.39%-30.0%,P=0.04).A similar proportion of the patients received correct dosing before and after intervention(44.8%vs.41.2%,difference in proportions 3.7%,95%CI-20.0%-26.7%,P=0.770).CONCLUSION:The use of an ADS may improve the timing of medication administration in patients presenting to the ED without affecting dosing appropriateness.

关键词： Automatic dispensing system Pharmaceutical Process improvement Efficiency

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Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： Melissa A.Stephen Chris R.Burke jennie E.Pryce nicole M.Steele Peter R.Amer Susanne Meier Claire V.C.Phyn Dorian j.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae Centre for Genetics and Breeding-Massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background Many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler Markov-chain Monte Carlo(MCMC) Puberty

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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer j.Allen Stephanie M.Ntoukas Gordon j.Bell jessica McNeil Qinggang Wang Margaret L.McNeely jeff K.Vallance Lin Yang S.nicole Culos-Reed Leanne Dickau john R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(p<0.001),poor sleep quality(p=0.009),significant fatigue(p=0.008),any symptom(p<0.001),and multiple symptoms(p<0.001).VO_(2peak)demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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Outcomes of a non-randomised audit of single pigtail suture stents in urolithiasis management of Asian patients in Singapore

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Asian journal of Urology 2024年第2期11卷 324-330页

作者： Ee jean Lim Zhen Wei Choo Reshma Mangat Pradeep Durai Sarvajit Biligere Yiquan Tan Loh Hin Yeung Marcus nicole Andrea Seet Li Ting Chin Tiong Heng Stefania Ferreti Vineet Gauhar Urology Department Singapore General HospitalSingapore Urology Department Tan Tock Seng HospitalSingapore Urology Department Ng Teng Fong HospitalSingapore Urology Department Azienda Ospedaliera-Uiversitaria(Hospital and University of Parma)ParmaItaly

Objective:Double-j(Dj)ureteric stents are commonly placed perioperatively for semirigid or flexible ureteroscopic renal *** is believed that lesser stent material within the bladder mitigates stent-related *** study aimed to evaluate the j-Fil ureteral stent,a single pigtail suture stent compared with conventional Dj stent in relation to stent symptoms in an Asian population undergoing ureterorenal ***:Based on internal audit committee recommendation approval,the records of 50 patients retrieved,available data of 41 patients who were prospectively enrolled into two groups(Group 1[j-Fil stent group],n=21 and Group 2[Dj stent group],n=20)between August 2020 to january 2021,were *** compared were nature of procedure,stone location and size,ease of deployment or removal,and complications.A modified universal stent symptom questionnaire was used to assess morbidity of stent symptoms within 48 h of insertion and at ***:Both groups had similar median age,distribution in male to female ratio,and stone *** overall median universal stent symptom questionnaire score at insertion was similar for bladder pain,flank or loin pain,and quality of life between Group 1 and 2;however,at removal Group 1 fared significantly better than Group 2,especially for flank or loin pain and pain at *** groups had similar ease in insertion with no hospital ***:Our audit favoured the single pigtail suture stent in Asian ureters in mitigating stent-related *** showed a good safety profile with easy deployment and *** promises a new standard in stenting.

关键词： Stent Ureteroscopy Pigtail suture stent Asianpatient Flexible ureteroscopic renal surgery

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Comment on: Effect of intubation in patients with functional epiphora after endoscopic dacryocystorhinostomy

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International journal of Ophthalmology(English edition) 2024年第8期17卷 1576-1576页

作者： Mansooreh jamshidian-Tehrani Hossein Ghahvehchian Christopher j Compton jeremy D Clark nicole L West Mohsen Bahmani Kashkouli Department of Ophthalmology Eye Research CenterThe Five Senses Health InstituteRassoul Akram HospitalIran University of Medical SciencesTehran ***Iran Department of Ophthalmology and Visual Sciences University of Louisville School of MedicineLouisville 40202KentuckyUSA

Dear Editor,We read with interest the article by Han et al[1]in which they retrospectively assessed the effect of bicanalicular intubation for functional epiphora after a failed endoscopic dacryocystorhinostomy(DCR).They confirmed the post-DCR“functional obstruction”based on fluorescein dye disappearance(FDDT)and irrigation test[1].

关键词： intubation assessed endoscopic

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Assessing the microbiota of recycled bedding sand on a Wisconsin dairy farm

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journal of Animal Science and Biotechnology 2022年第2期13卷 601-612页

作者： Hannah E.Pilch Andrew j.Steinberger Donald C.Sockett nicole Aulik Garret Suen Charles j.Czuprynski Department of Pathobiological Sciences School of Veterinary MedicineUniversity of Wisconsin-MadisonMadison 53706USA Department of Bacteriology University of Wisconsin-MadisonMadison 53706USA Microbiology Doctoral Training Program University of Wisconsin-MadisonMadison 53706USA Wisconsin Veterinary Diagnostic Laboratory School of Veterinary MedicineUniversity of Wisconsin-MadisonMadison 53706USA

Background:Sand is often considered the preferred bedding material for dairy cows as it is thought to have lower bacterial counts than organic bedding materials and cows bedded on sand experience fewer cases of lameness and *** can also be efficiently recycled and reused,making it ***,some studies have suggested that the residual organic material present in recycled sand can serve as a reservoir for commensal and pathogenic bacteria,although no studies have yet characterized the total bacterial community *** we sought to characterize the bacterial community composition of a Wisconsin dairy farm bedding sand recycling system and its dynamics across several stages of the recycling process during both summer and winter using 16S rRNA gene amplicon ***:Bacterial community compositions of the sand recycling system differed by both seasons and *** samples had higher richness and distinct community compositions,relative to winter *** both summer and winter samples,the diversity of recycled sand decreased with time drying in the recycling ***,summer sand 14 d post-recycling was enriched in operational taxonomic units(OTUs)belonging to the genera Acinetobacter and Pseudomonas,relative to freshly washed sand and sand from cow *** contrast,no OTUs were found to be enriched in winter *** sand recycling system contained an overall core microbiota of 141 OTUs representing 68.45%±10.33%SD of the total bacterial relative abundance at each sampled *** 4 most abundant genera in this core microbiota included Acinetobacter,Psychrobacter,Corynebacterium,and *** was present in greater abundance in summer samples,whereas Psychrobacter and Corynebacterium had higher relative abundances in winter *** had consistent relative abundances across both ***:These findings highlight the potential of recycled bedding sand as a bacterial reservo

关键词： Bovine Dairy farm Microbiota Recycled bedding sand 16S rRNA sequencing

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SEISMIC RANDOM VIBRATION ANALYSIS OF STOCHASTIC STRUCTURES USING RANDOM FACTOR METHOD

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Chinese journal of Mechanical Engineering 2006年第1期19卷 1-8页

作者： KESSISSOGLOU nicole j School of Mechanical and Manufacturing Engineering

Seismic random vibration analysis of stochastic truss structures is presented. A new method called random factor method is used for dynamic analysis of structures with uncertain parameters, due to variability in their material properties and geometry. Using the random factor method, the natural frequencies and modeshapes of a stochastic structure can be respectively described by the product of two parts, corresponding to the random factors of the structural parameters with uncertainty, and deterministic values of the natural frequencies and modeshapes obtained by conventional finite element analysis. The stochastic truss structure is subjected to stationary or non-stationary random earthquake excitation. Computational expressions for the mean and standard deviation of the mean square displacement and mean square stress are developed by means of the random variable＇s functional moment method and the algebra synthesis method. An antenna and a truss bridge are used as practical engineering examples to illustrate the application of the random factor method in the seismic response analysis of random structures under stationary or non-stationary random earthquake excitation.

关键词： Seismic random vibration Uncertainty structures Random factor methodNon-stationary ground motion

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Kalihioxepanes A-G:Seven Kalihinene Diterpenoids from Marine Sponge Acanthella cavernosa Collected off the South China Sea

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Chinese journal of Chemistry 2022年第15期40卷 1785-1792页

作者： Zhe Wang Xiao Han Guoping Liu Di Zhang Huiyue Hou Li Xiao nicole j.de Voogd Xuli Tang Pinglin Li Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong 266003China Laboratory of Marine Drugs and Biological Products National Laboratory for Marine Science and TechnologyQingdaoShandong 266235China National Museum of Natural History 2300 RA LeidenThe Netherlands College of Chemistry and Chemical Engineering Ocean Universityof ChinaQingdaoShandong 266100China

Comprehensive Summary Seven new kalihinene diterpenoids,kalihioxepanes A-G(1-7)bearing a rare oxepane ring,were isolated from sponge Acanthella cavernosa collected from the South China *** structures and absolute configurations were elucidated by comprehensive spectroscopic analysis,single crystal X-ray diffraction,and quantum chemical calculation *** A(1)displayed strong cytotoxicity against H69 and K562 tumor cells,while kalihioxepane B(2)showed moderate cytotoxicity against K562 cells.

关键词： Acanthella cavernosa Kalihinenes Configuration determination Cytotoxicity Natural products

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Forecasting the development of boreal paludified forests in response to climate change: a case study using Ontario ecosite classification

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Forest Ecosystems 2015年第1期2卷 45-55页

作者： Benoit Lafleur nicole j Fenton Yves Bergeron Institut de recherche sur les forêts Université du Québec en Abitibi-Témiscamingue 445 boul. de l’Université Rouyn-Noranda QC J9X 5E4 Canada Centre d’étude de la forêt Université du Québec à Montréal 141 Avenue du Président-Kennedy Montréal QC H2X 1Y4 Canada

Background：Successional paludification,a dynamic process that leads to the formation of peatlands,is influenced by climatic factors and site features such as surficial deposits and soil *** boreal regions,projected climate change and corresponding modifications in natural fire regimes are expected to influence the paludification process and forest *** objective of this study was to forecast the development of boreal paludified forests in northeastern North America in relation to climate change and modifications in the natural fire regime for the period 2011–***：A paludification index was built using static（*** deposits and soil texture）and dynamic（*** regime and soil organic layer thickness）stand scale factors available from forest *** index considered the effects of three temperature increase scenarios（i.e.＋1°C,＋3°C and＋6°C）and progressively decreasing fire cycle（from 300 years for 2011–2041,to 200 years for 2071–2100）on peat accumulation rate and soil organic layer（SOL）thickness at the stand level,and paludification at the landscape ***：Our index show that in the context where in the absence of fire the landscape continues to paludify,the negative effect of climate change on peat accumulation resulted in little modification to SOL thickness at the stand level,and no change in the paludification level of the study area between 2011 and ***,including decreasing fire cycle to the index resulted in declines in paludified ***,the index predicts a slight to moderate decrease in the area covered by paludified forests in 2100,with slower rates of ***：Slower paludification rates imply greater forest productivity and a greater potential for forest harvest,but also a gradual loss of open paludified stands,which could impact the carbon balance in paludified ***,as the thick Sphagnum layer typical of paludified forests may protect soil organic layer from dr

关键词： Boreal forest Canada Carbon sequestration Paludification Peat forests Forest harvest

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Pediatric dog bite injuries in the USA: a systematic review

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World journal of Pediatric Surgery 2022年第2期5卷 46-53页

作者： Kelli nicole Patterson Kyle Z Horvath Peter C Minneci Rajan Thakkar LeeAnn Wurster Dana L Noffsinger Tran Bourgeois Katherine j Deans Center for Surgical Outcomes Research and Department of Surgery Nationwide Children's HospitalColumbusOhioUSA

Introduction Dog bites are one of the leading causes of non-fatal emergency room visits in *** injuries not only cause physical harm but can lead to long-term psychological *** study evaluated the current literature related to pediatric dog bite injuries to identify research gaps which should be prioritized to improve a major public health *** We performed a keyword search of PubMed,Scopus,and OVID Medline databases(january 1980-March 2020)for all published studies focused on dog bite injuries in the pediatric population(≤18 years of age)using the Preferred Reporting Items for Systematic Reviews and *** Out of 1859 abstracts screened,43 studies involving 86880 patients were ***-nine studies were retrospective chart reviews characterizing the epidemiology of dog bites and their associated treatment outcomes;six were prospective cohort studies;two were cross-sectional studies;and six were experimental *** results demonstrate that childrenjuries,with childrenjuries involving the head,neck,and *** Studies analyzing the prevention or psychosocial consequences of dog bites injuries are needed.

关键词： injuries consequences prevention

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