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Reviewing the discoverability and accessibility to data and information products linked to Essential Climate Variables

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International Journal of Digital Earth 2020年第2期13卷 236-252页

作者： Maria Teresa Miranda Espinosa Gregory Giuliani nicolas Ray Institute for Environmental Sciences enviroSPACE labUniversity of GenevaGenevaSwitzerland Institute for Environmental Sciences GRID-GenevaUniversity of GenevaGenevaSwitzerland GeoHealth Group Institute of Global HealthFaculty of MedicineUniversity of GenevaGenevaSwitzerland'

Essential Climate Variables(ECVs)are geophysical records generated from systematic Earth Observations associated with climate variations,changes,and *** products support the data and information needs of international frameworks and policies such as the work of the United Nations Framework Convention on Climate Change(UNFCCC)and the Intergovernmental Panel on Climate Change(IPCC).We map the main networks and initiatives publishing ECVs,by presenting an overview of existing satellite-based ECVs,their general data creation characteristics,discoverability and accessibility methods from an end-user *** investigate key initiatives providing or coordinating access to ECV data records,such as the Global Climate Observing System(GCOS),the Committee on Earth Observation Satellites(CEOS),the Coordination Group for Meteorological Satellites(CGMS),Joint Working Group on Climate(WGClimate),the Remote Sensing Systems(REMSS),and the European Space Agency Climate Change Initiative(ESA CCI).We find that ECV data discovery and access is difficult and time consuming due to the lack of common data and metadata *** addition,the selection of fit-for-purpose data records by end-users requires the implementation of interoperable standards and scalable data infrastructures to allow the generation of tailored applications and datadriven information products in support of decision-making processes.

关键词： Essential Climate Variables Climate services discoverability accessibility usability

Effects of absolute fasting on reproduction and survival of the invasive apple snail Pomacea canaliculata in its native range

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Current Zoology 2016年第4期62卷 369-375页

作者： nicolas E. TAMBURI Pablo R. MARTIN INBIOSUR (UNS-CONICET) Universidad Nacional del Sur Departamento de Biologla Bioquimica y Farmacia San Juan 670 8000 Bahia Blanca Argentina

A South American freshwater gastropod, the apple snail Pomacea canaliculata, has become a driver of ecosystemic changes in wetlands and an important rice pest after its introduction to various parts of the world, mainly Asia. The objective of this study was to study the effect of an abrupt interruption in food availability in the short term （up to 4 weeks） and long term （up to 8 months） on survival and re- productive activity. The main results indicate that short-term fasting mainly affects the survival of males, but only when they are raised together with females, probably due to a greater mate-searching activity that increases mortality in the individuals with lower reserves. The number of copulating snails or egg-laying females shows an abrupt drop when fasting and a rapid recovery after the food supply is restored. The strategy of discontinuing reproductive activity prioritizes energy conservation for the survival of the females. Interpopulation variation in resistance to starvation was observed in adults, which can be explained to some extent by the food availability that they experienced in their natural environment. No interpopulational differences in survival were seen in hatchlings. The mean maximum values of survival under starvation were 52.6 days in hatchlings and the 3.3% of adults survive over than 200 days, which may be a relevant trait in dispersal and establishment in new habitats.

关键词： GASTROPODA POMACEA canaliculata WETLANDS STARVATION ENERGY conservation

IO and Its Plasma Torus

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紫金山天文台台刊 1996年第3期15卷 65-86页

作者： nicolas Thomas Max-Planck-Institut Cur Aeronomie D-37189 Katlenburg-LindauGermany

A brief review of our courrent understanding of the interaction between the innermost Galilean satellite,Io,and Jupiter’s magnetosphere is *** consideration is given to the neutral clouds and lo plasma torus which have been monitored by ground-based and Earth-orbiting observations for the past 25 *** investigation of observed phenomena in the neutral clouds has revealed several processes which have a direct bearing on the nature of the interaction and suggest that a revision of the existing concept is *** variability in the torus indicates the presence of complex plasma processes which at present remain *** where further research is necessary are outlined.

关键词： Solary System:satellites Solar System:Io space plasmas observations

Expression and modulation of neuroligin and neurexin in the olfactory organ of the cotton leaf worm Spodoptera fittoralis

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Insect Science 2017年第2期24卷 210-221页

作者： nicolas Durand Thomas Chertemps Francoise Bozzolan Martine Maibeche Sorbonne Universites UPMC - Univ Paris 06 Institut d'Ecologie et des Sciences de 'Environnement de Paris INRA CNRS IRD UPECD6partement d'Ecologie Sensorielle F-75252 Paris France

Carboxylesterases are enzymes widely distributed within living organisms. In insects, they have been mainly involved in dietary metabolism and detoxification function. Interestingly, several members of this family called carboxylesterase-like ad- hesion molecules （CLAMs） have lost their catalytic properties and are mainly involved in neuro/developmental functions. CLAMs include gliotactins, neurotactins, glutactins, and neuroligins. The latter have for binding partner the neurexin. In insects, the function of these proteins has been mainly studied in Drosophila central nervous system or neuro- muscular junction. Some studies suggested a role of neuroligins and neurexin in sensory processing but CLAM expression within sensory systems has not been investigated. Here, we reported the identification of 5 putative CLAMs expressed in the olfactory system of the model pest insect Spodoptera littoralis. One neuroligin, Slnlg4-yll and its putative binding partner neurexin Slnrxl were the most expressed in the antennae and were surprisingly associated with olfactory sensilla. In addition, both transcripts were upregulated in male antennae after mating, known to modulate the sensitivity of the peripheral olfactory system in S. littoralis, suggesting that these molecules could be involved in sensory plasticity.

关键词： carboxylesterase-like adhesion molecules insect neurexin neuroligins olfaction

Mobility affects copulation and oviposition dynamics in Pieris brassicae in seminatural cages

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Insect Science 2019年第4期26卷 743-752页

作者： nicolas Larranaga Michel Baguette Olivier Calvez Delphine Legrand Centre National de la Recherche Scientifique and Universite Paul Sabatier Toulouse III SETE Station d'Ecologie Theorique et Experimentale UMR 5321 Moulis France Museum National d'Histoire Naturelle (Sorbonne Universites) Institut de Systematique Evolution et Biodiversite UMR 7205 57 rue Cuvier 75005 Paris cedex 5 France

When, how often and for how long organisms mate can have strong consequences for individual fitness and are crucial aspects of evolutionary ecology. Such determinants are likely to be of even greater importance in monandrous species and species with short adult life stages. Previous work suggests that mobility, a key dispersal? related trait, may affect the dynamics of copulations, but few studies have investigated the impact of individual mobility on mating latency, copulation duration and oviposition latency simultaneously. In this paper, we monitored the copulation dynamics of 40 males and 40 females, as well as the oviposition dynamics of the females of the Large White butterfly Pieris brassicae, a facultative long-distance disperser butterfly. Individuals from a breeding were selected to create a uniform distribution of mobility and we recorded the timing, number and duration of all copulations in a semiexperimental system. We showed that mobility, measured as the time spent in flight under stressful conditions (a proxy of dispersal tendency), correlates with all aspects of copulation dynamics: mobile males and females mated earlier and for shorter periods than less mobile individuals. In turn, late mating females increased the time between copulation and oviposition. These results feed the previously described mobility syndrome of R brassicae, involving morphological and physiological characters, with life-history traits. We suggest that the reduction of mating latency and copulation duration has an adaptive value in dispersing individuals, as their life expectancy might be shorter than that of sedentary individuals.

关键词： copulation duration life history mating latency mobility syndrome oviposition latency Pieris brassicae

Stem cell therapy in retinal diseases

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Neural Regeneration Research 2023年第7期18卷 1478-1485页

作者： Audrey Voisin Amaury Pénaguin Afsaneh Gaillard nicolas Leveziel Laboratoire de Neurosciences Expérimentales et Cliniques Universitéde PoitiersINSERM 1084PoitiersFrance Department of Ophthalmology CHU PoitiersPoitiersFrance Laboratoires Thea Clermont-FerrandFrance

Alteration of the outer retina leads to various diseases such as age-related macular degeneration or retinitis pigmentosa characterized by decreased visual acuity and ultimately *** intensive research in the field of retinal disorders,there is currently no curative *** therapeutic approaches such as cell-based replacement and gene therapies are currently in *** the context of cell-based therapies,different cell sources such as embryonic stem cells,induced pluripotent stem cells,or multipotent stem cells can be used for *** the vast majority of human clinical trials,retinal pigment epithelial cells and photoreceptors are the cell types considered for replacement cell *** this review,we summarize the progress made in stem cell therapies ranging from the pre-clinical studies to clinical trials for retinal disease.

关键词： age-related macular degeneration cell transplantation clinical trial retinal disease retinal dystrophy stem cell

Thermal behavior of an isolator with mode transition inducing back-pressure of a dual-mode scramjet

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Chinese Journal of Aeronautics 2017年第2期30卷 595-601页

作者： Yang Qingchun Bao Wen Chetehouna Khaled Zhang Silong Gascoin nicolas School of Astronautics Beihang University 100083 China School of Energy Science and Engineering Harbin Institute of Technology 150001 Harbin China INSA Centre Val de Loir 88 Boulevard Lahitolle 18000 Bourges France

Combustion mode transition is a valuable and challenging research area in dual-mode scramjet *** thermal behavior of an isolator with mode transition inducing backpressure is investigated by direct-connect dual-mode scramjet experiments and theoretical *** experiments are conducted under the incoming airflow conditions of total temperature1270 K and Mach 2.A small increment of the fuel equivalence ratio is scheduled to trigger mode ***,the variation of the coolant flow rate is very *** on the measured wall pressures,the heat-transfer model can quantify the thermal state variation of the engine with active *** with the combustor,mode transition has a greater effect on the isolator thermal behavior,and it significantly changes the isolator heat-flux and wall *** further study the isolator thermal behavior from flight Mach 4 to Mach 7,a theoretical analysis is carried *** the critical point of combustion mode transition,sudden changes of the isolator flowfield and thermal state are discussed.

关键词： Combustion mode Dual-mode scramjet Isolator Mode transition Thermal behavior

Decoding hereditary spastic paraplegia pathogenicity through transcriptomic profiling

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Zoological Research 2023年第3期44卷 650-662页

作者： nicolas James Ho Xiao Chen Yong Lei Shen Gu School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Dr.Li Dak Sum-Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejiang 310058China Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province Zhejiang University School of MedicineHangzhouZhejiang 310058China Zhejiang University-University of Edinburgh Institute&School of Basic Medicine Zhejiang University School of MedicineHangzhouZhejiang 310058China Department of Sports Medicine Zhejiang University School of MedicineHangzhouZhejiang 310058China China Orthopedic Regenerative Medicine Group(CORMed) HangzhouZhejiang310058 China School of Medicine The Chinese University of Hong Kong(Shenzhen)ShenzhenGuangdong 518172China The Chinese University of Hong Kong(Shenzhen) Shenzhen Futian Biomedical Innovation R&D CenterShenzhenGuangdong 518172China Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics The Chinese University of Hong KongHong Kong SARChina

Hereditary spastic paraplegia(HSP)is a group of genetic motor neuron diseases resulting from length-dependent axonal degeneration of the corticospinal upper motor *** to the advancement of next-generation sequencing,more than 70 novel HSP disease-causing genes have been identified in the past *** this,our understanding of HSP physiopathology and the development of efficient management and treatment strategies remain *** major challenge in studying HSP pathogenicity is selective neuronal vulnerability,characterized by the manifestation of clinical symptoms that are restricted to specific neuronal populations,despite the presence of germline disease-causing variants in every cell of the ***,disease genes may exhibit ubiquitous expression patterns and involve a myriad of different pathways to cause motor neuron *** the current review,we explore the correlation between transcriptomic data and clinical manifestations,as well as the importance of interspecies models by comparing tissue-specific transcriptomic profiles of humans and mice,expression patterns of different genes in the brain during development,and single-cell transcriptomic data from related ***,we discuss the potential of emerging single-cell RNA sequencing technologies to resolve unanswered questions related to HSP pathogenicity.

关键词： degeneration transcript hereditary

A model-based prognostics method for fatigue crack growth in fuselage panels

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Chinese Journal of Aeronautics 2019年第2期32卷 396-408页

作者： Yiwei WANG Christian GOGU nicolas BINAUD Christian BES Jian FU School of Mechanical Engineering and Automation Beihang University Institut Clément Ader (UMR CNRS 5312) INSA/UPS/ISAE/Mines Albi Université de Toulouse

This paper proposes a model-based prognostics method that couples the Extended Kalman Filter(EKF) and a new developed linearization method. The proposed prognostics method is developed in the context of fatigue crack propagation in fuselage panels where the model parameters are unknown and the crack propagation is affected by different types of uncertainties. The coupled method is composed of two steps. The first step employs EKF to estimate the unknown model parameters and the current damage state. In the second step, the proposed efficient linearization method is applied to compute analytically the statistical distribution of the damage evolution path in some future time. A numerical case study is implemented to evaluate the performance of the proposed method. The results show that the coupled EKF-linearization method provides satisfactory results: the EKF algorithm well identifies the model parameters, and the linearization method gives comparable prediction results to Monte Carlo(MC) method while leading to very significant computational cost saving. The proposed prognostics method for fatigue crack growth can be used for developing predictive maintenance strategy for an aircraft fleet, in which case, the computational cost saving is significantly meaningful.

关键词： Aircraft fuselage panels Extended Kalman filter Fatigue crack propagation Linearization method Model-based prognostics