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Research and developments of laser assisted methods for translation into clinical application

Frontiers of Optoelectronics 2017年第3期10卷 239-254页

作者： Ronald SROKA Nikolas DOMINIK Max EISEL Anna ESIPOVA Christian FREYMULLER Christian HECKL Georg HENNIG Christian HOMANN nicolas hoehne Robert KAMMERER Thomas KELLERER Alexander LANG Niklas MARKWARDT Heike POHLA Thomas PONGRATZ Claus-Georg SCHMEDT Herbert STEPP Stephan STROBL Keerthanan ULAGANATHAN Wolfgang ZIMMERMANN Adrian RUEHM Laser-Forschungslabor LIFE-Center Hospital of University Ludwig-Maximilians University Munich Munich Germany Department of Urology Hospital of University Ludwig-Maximilians University Munich Munich Germany Department of Vascular Surgery Diakonie Klinikum Schwaibisch Hall Germany Labor fur Tumorimmunologie LIFE-Center Hospital of University Ludwig-Maximilians University Munich Munich Germany Friedrich-Loeftter-Institute Federal Research Institute for Animal-Health Greifswald- Insel Riems Germany

Biophotonics and laser medicine are very dynamic and continuously increasing fields ecologically as well as economically. Direct communication with medical doctors is necessary to identify specific requests and unmet needs. Information on innovative, new or renewed techniques is necessary to design medical devices for introduction into clinical application and finally to become established after positive clinical trials as well as medical approval. The long-term endurance in developing light based innovative clinical concepts and devices are described based on the Munich experience. Fluorescence technologies for laboratory medicine to improve non- invasive diagnosis or for online monitoring are described according with new approaches in improving photody- namic therapeutic aspects related to immunology. Regard- ing clinically related thermal laser applications, the introduction of new laser wavelengths and laser parameters showed potential in the treatment of varicose veins as well as in lithotripsy. Such directly linked research and development are possible when researchers and medical doctors perform their daily work in immediate vicinity, thus have the possibility to share their ideas in meetings by day.

关键词： translational biophotonics thermal laser appli-cation fluorescence diagnosis on-line monitoring litho-tripsy phlebology photodynamic therapy (PDT),laboratory medicine

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