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Assessment of CareStart G6PD rapid diagnostic test and CareStart G6PD biosensor in Mauritania

Infectious Diseases of Poverty 2021年第4期10卷 33-45页

作者： Oum Kelthoum Mamadou Djigo Yacoub Ould Khalef Mohamed Salem Ould Ahmedou Salem nicolas gomez Leonardo Basco Sebastien Briolant Ali Ould Mohamed Salem Boukhary Unite de Recherche"Genomes et Milieux"(Jeune Equipe Associee a I'lnstitut de Recherche pour le Developpement) Faculte des Sciences et lechniquesUniversite de Nouakchott Al-AasriyaNouakchottMauritania Service de Pediatrie Centre Hospitalier Mere et EnfantNouakchottMauritania IHU Mediterrande InfectionMarseilleFrance Aix Marseille Univ IRDAP-HMSSAVITROMEMarseilleFrance Unite de Parasitologie Entomologie Departement de Microbiologie et Maladies InfectieusesInstitut de Recherche Biomedicale des Armees(IRBA)MarseilleFrance

Background::The elimination of Plasmodium vivax malaria requires 8-aminoquinolines,which are contraindicated in patients with glucose-6-phosphate dehydrogenase(G6PD)deficiency due to the risk of acute haemolytic *** point-of-care devices have been developed to detect G6PD *** objective of the present study was to evaluate the performance of two of these devices against G6PD genotypes in ***::Outpatients were screened for G6PD deficiency using CareStart?rapid diagnostic test(RDT)and CareStart?G6PD biosensor in Nouakchott,Mauritania,in ***-type and Mediterranean-type G6PD genotypes commonly observed in Africa were determined by polymerase chain reaction-restriction fragment length polymorphism and *** variables were compared using Fisher’s exact ***::Of 323 patients(74 males and 249 females),5 males and 2 homozygous females had the African-type A-genotype:A-(202)in 3 males and 2 females and G6PD A-(968)in 2 *** heterozygous females,13 carried G6PD A-(202),12 G6PD A-(968),and 3 G6PD A-(542)*** had the Mediterranean-type G6PD *** had a positive G6PD RDT result,including all 7 hemizygous males and homozygous females with A-or A-A-(0.12 to 2.34 IU/g haemoglobin,according to G6PD biosensor),but RDT performed poorly(sensitivity,11.1%at the cutoff level of<30%)and yielded many false negative ***-seven(50.0%)males and 141(56.6%)females were *** adjusted median values of G6PD activity were 5.72 and 5.34 IU/g haemoglobin in non-anaemic males(n=35)and non-anaemic males and females(n=130)with normal G6PD genotypes using G6PD biosensor,*** on the adjusted median of 5.34 IU/g haemoglobin,the performance of G6PD biosensor against genotyping was as follows:at 30%cut-off,the sensitivity and specificity were 85.7%and 91.7%,respectively,and at 80%cut-off,the sensitivity was 100%while the specificity was 64.9%.Conclusions::Although this pilot study

关键词： Glucose-6-phosphate dehydrogenase Malaria Plasmodium vivax Primaquine Tafenoquine

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Correlating the global increase in type 1 diabetes incidence across age groups with national economic prosperity: A systematic review

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World Journal of Diabetes 2019年第12期10卷 560-580页

作者： Natalia gomez-Lopera nicolas Pineda-Trujillo Paula Andrea Diaz-Valencia Grupo Mapeo Genetico Departamento de PediatríaFacultad de MedicinaUniversidad de AntioquiaMedellín 050010470Colombia Epidemiology Group.School of Public Health.Universidad de Antioquia Medellín 050010470Colombia

BACKGROUND The global epidemiology of type 1 diabetes(T1D)is not yet well known,as no precise data are available from many countries.T1D is,however,characterized by an important variation in incidences among countries and a dramatic increase of these incidences during the last decades,predominantly in younger *** the United States and Europe,the increase has been associated with the gross domestic product(GDP)per *** our previous systematic review,geographical variation of incidence was correlated with socio-economic *** To investigate variation in the incidence of T1D in age categories and search to what extent these variations correlated with the GDP per *** A systematic review was performed to retrieve information about the global incidence of T1D among those younger than 14 years of *** study was carried out according to the PRISMA *** the analysis,the incidence was organized in the periods:1975-1999 and *** searched the incidence of T1D in the age-groups 0-4,5-9 and *** compared the incidences in countries for which information was available for the two *** obtained the GDP from the World *** analysed the relationship between the incidence of T1D with the GDP in countries reporting data at the national *** We retrieved information for 84 out of 194 countries around the *** found a wide geographic variation in the incidence of T1D and a worldwide increase during the two *** largest contribution to this increase was observed in the youngest group of children with T1D,with a relative increase of almost double when comparing the two periods(P value=2.5×e-5).Twenty-six countries had information on the incidence of T1D at the national level for the two *** was a positive correlation between GDP and the incidence of T1D in both periods(Spearman correlation=0.52 from 1975-1999 and Spearman correlation=0.53 from 2000-2017).CONCLUSION The incidence increase was

关键词： Type 1 diabetes Incidence Children Age categories Gross domestic product per capita

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Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia

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World Journal of Diabetes 2019年第11期10卷 534-545页

作者： Natalia gomez-Lopera Juan M Alfaro Suzanne M Leal nicolas Pineda-Trujillo Departamento de Pediatría Facultad de MedicinaUniversidad de AntioquiaMedellín 050010470Colombia Sección de Endocrinología Pediátrica Departamento de PediatríaFacultad de MedicinaUniversidad de AntioquiaMedellín 050010470Colombia Center for Statistical Genetics Columbia UniversityNew YorkNY 10032United States

BACKGROUND Type 1 diabetes(T1D)is a complex disease with a higher incidence in Europeans than other *** Colombians Living in Medellin(CLM)is admixed with ancestry contributions from Europeans,Native Americans(NAT)and Africans(AFR).AIM Our aim was to analyze the genetic admixture component at candidate T1D loci in Colombian individuals with the *** Seventy-four ancestry informative markers(AIMs),which tagged 41 T1D candidate loci/genes,were tested by studying a cohort of 200 Northwest Colombia diseased individuals.T1D status was classified by testing for glutamic acid decarboxylase(GAD-65 kDa)and protein tyrosine-like antigen-2 autoantibodies in serum *** loci/genes included HLA,INS,PTPN22,CTLA4,IL2RA,SUMO4,CLEC16A,IFIH1,EFR3B,IL7R,NRP1 and RNASEH1,amongst *** 1,000 genome database was used to analyze data from 94 individuals corresponding to the reference *** the data did not comply with a normal distribution,medians were compared between groups using the Mann-Whitney *** Both T1D patients and individuals from CLM displayed mainly European ancestry(61.58 vs 62.06)followed by Native American(27.34 vs 27.46)and to a lesser extent the AFR ancestry(10.28 vs 10.65)***,compared to CLM,ancestry of T1D patients displayed a decrease of NAT ancestry at gene EFR3B(24.30 vs 37.10)and an increase at genes IFIH1(32.07 vs 14.99)and IL7R(52.18 vs 39.18).Also,for gene NRP1(36.67 vs 0.003),we observed a non-AFR contribution(attributed to NAT).Autoimmune patients(positive for any of two auto-antibodies)displayed lower NAT ancestry than idiopathic patients at the MHC region(20.36 vs 31.88).Also,late onset patients presented with greater AFR ancestry than early onset patients at gene IL7R(19.96 vs 6.17).An association analysis showed that,even after adjusting for admixture,an association exists for at least seven such AIMs,with the strongest findings on chromosomes 5 and 10(gene IL7R,P=5.56×10-6 and gene NRP1,P=8.

关键词： Type 1 diabetes Genetic admixture Native American Idiopathic Colombia

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From the epididymis to the egg： participation of CRISP proteins in mammalian fertilization

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Asian Journal of Andrology 2015年第5期17卷 711-715,I0005页

作者： Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D gomez-Elias Debora J Cohen Patricia S Cuasnicu Instituto de Biologi y Medicina Experimental (IByME-CONICET) Buenos Aires C1428ADN Argentina

Mammalian fertilization is a complex process that involves different steps of interaction between the male and female gametes. In spite of its relevance, the molecular mechanisms underlying this process still remain to be elucidated. The present review describes the contribution of our laboratory to the understanding of mammalian fertilization using Cysteine-Rlch Secretory Proteins （CRISP） as model molecules. Substantial evidence obtained from in vitro assays and knockout models shows that epididymal CRISP1 associates with the sperm surface with two different affinities during maturation, and participates in the regulation of signaling pathways during capacitation as well as in both sperm-zona pellucida interaction and gamete fusion. These observations can be extended to humans as judged by our findings showing that the human homolog of the rodent protein （hCRISP1） is also involved in both stages of fertilization. Evidence supports that other members of the CRISP family secreted in the testis （CRISP2）, epididymis （CRISP3-4） or during ejaculation （CRISP3） are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. Together, our observations indicate that CRISP proteins accompany spermatozoa along their transit through both the male and female reproductive tracts. We believe these results not only contribute to a better mechanistic understanding of fertilization but also support CRISP proteins as excellent candidates for future research on infertility and contraception.

关键词： Cysteine-Rlch Secretory Proteins epididymal proteins fertilization sperm

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Fast and reliable identification of atomically thin layers of TaSe2 crystals

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Nano Research 2013年第3期6卷 191-199页

作者： Andres Castellanos-gomez Efren Navarro-Moratalla Guillermo Mokry Jorge Quereda Elena Pinilla-Cienfuegos nicolas Agrait Herre S. J. van der Zant Eugenio Coronado Gary A. Steele Gabino Rubio-Bollinger Kavli Institute of Nanoscience Delft University of Technology Lorentzweg 1 2628 CJ Delft The Netherlands Instituto Ciencia Molecular (ICMol) Univ. Valencia C/Catedrdtico Jose Beltrdn 2 E-46980 Paterna Spain Departamento de Fisica de la Materia Condensada (C-III). UniversidadAutonoma de Madrid Campus de Cantoblanco 28049 Madrid Spain Instituto Madrileno de Estudios Avanzados en Nanociencia IMDEA-Nanociencia E-28049 Madrid Spain

Deposition of clean and defect-free atomically thin two-dimensional crystalline flakes on surfaces by mechanical exfoliation of layered bulk materials has proven to be a powerful technique, but it requires a fast, reliable and non-destructive way to identify the atomically thin flakes among a crowd of thick flakes. In this work, we provide general guidelines to identify ultrathin flakes of TaSe2 by means of optical microscopy and Raman spectroscopy. Additionally, we determine the optimal substrates to facilitate the optical identification of atomically thin TaSe2 crystals. Experimental realization and isolation of ultrathin layers of TaSe2 enables future studies on the role of the dimensionality in interesting phenomena such as superconductivity and charge density waves.

关键词： atomically thin layer metal dichalcogenide layered superconductor TaSe2 optical microscopy Raman spectroscopy

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Morphological control of cadmium sulfide nanostructures by electrophoretic deposition

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Particuology 2016年第1期14卷 73-77页

作者： Alejandro Vazquez Thelma Serrano Boris Kharisov Idalia gomez Universidad Autonoma de Nuevo Leon UANL Facultad de Ciencias Quimicas Av. Universidad S/N San Nicolas de los Garza Nuevo Leon 66451 Mexico

Thin films and one-dimensional CdS nanostructures were formed by electrophoretic deposition of nanoparticles with morphological control, Particles less than 1Ohm in diameter were prepared by a microwave assisted synthesis using trisodium citrate as capping agent. The particles were character- ized by UV-Vis spectrophotometry, dynamic light scattering, and X-ray diffraction. Nanoparticles in the resulting aqueous dispersion were electrodeposited without any further treatment on aluminum plates. The nanostructures consisted of thin films with surface roughness being tuned with the applied voltage. One-dimensional nanostructures were formed by varying the applied voltage and by changing the molar ratio of the precursors in the nanocrystal synthesis. These results illustrate two different mechanisms of electrophoretic deposition that lead to the formation of different nanostructures,

关键词： Electrophoretic deposition Nanostructure Nanoparticle

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Erratum to:Influence of metal support in-plane symmetry on the corrugation of hexagonal boron nitride and graphene monolayers

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Nano Research 2019年第5期12卷 1217-1218页

作者： Antonio J.Martinez-Galera Jose M.gomez-Rodriguez Departamento de Fisica de la Materia Condensada Universidad Autonoma de MadridMadrid E-28049Spain Condensed Matter Physics Center(IFIMAC) Universidad Autonoma de MadridMadrid E-28049Spain Instituto nicolas Cabrera Universidad Autonoma de MadridMadrid E-28049Spain

The writings of the text on the last line,left column on the 4^th page and the text on lines 8^th,10^th,11^th and 16^th in the 4^th paragraph,left column and on lines from 1st to 8^th in the 1st paragraph,right column on the 5^th page,and the text on line 4^th in the 1^st paragraph,left column on the 9^th page,and Fig.3 and its caption on the 5^th page in the original version of this article were unfortunately incorrect.

关键词： corrugation hexagonal boron nitride graphene monolayers

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Hybridization increases genetic diversity in Schistosoma haematobium populations infecting humans in Cameroon

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Infectious Diseases of Poverty 2022年第2期11卷 100-100页

作者： Felicite Flore Djuikwo Teukeng Manon Blin nicolas Bech Marta Reguera gomez Rima Zein-Eddine Alain Michel Kouam Simo Jean-Francois Allienne Louis Albert Tchuem‑Tchuente Jerome Boissier Faculty of Heath Science Mountain UniversityP.O.Box 208BangangteCameroon 不详

Background:Hybrids between Schistosoma haematobium(Sh)and ***(Sb)have been found in several African countries as well as in *** the consequences of this hybridization are still unknown,this study aims to verify the presence of such hybrids in Cameroonian humans,to describe the structure of *** populations on a large geographic scale,and to examine the impact of these hybrids on genetic diversity and structure of these ***:From January to April 2019,urine from infected children was collected in ten geographically distinct popu‑*** were collected from eggs in this *** detect the presence of hybrids among these miracidia we genotyped both Cox1(RD-PCR)and ITS2 gene(PCR-RFLP).Population genetic diversity and structure was assessed by genotyping each miracidium with a panel of 14 microsatellite *** diversity was measured using both heterozygosity and allelic richness indexes,and genetic structure was analyzed using paired Fst,PCA and Bayesian ***:Of the 1327 miracidia studied,88.7% were identifed as pure genotypes of ***(Sh_Sh/Sh)while the remaining 11.3% were hybrids(7.0% with Sh_Sh/Sb,3.7% with Sb_Sb/Sh and 0.4% with Sb_Sh/Sb).No miracidium has been identifed as a pure genotype of *** richness ranged from 5.55(Loum population)to 7.73(MattaBarrage)and difered signifcantly between *** heterozygosity ranged from 53.7%(Loum)to 59%(Matta Barrage)with no signifcant *** overall genetic diferentiation inferred either by a principal compo‑nent analysis or by the Bayesian approach shows a partial *** populations(Loum and Matta Bar‑rage)were clearly separated from other localities but genetic diferentiation between northern localities was limited,certainly due to the geographic proximity between these ***:Hybrids between *** and *** were identifed in 11.3% of miracidia that hatched from eggs present in the urine o

关键词： Schistosoma haematobium Schistosoma bovis Genetic diversity Hybridization Miracidium Cameroon

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Species richness and community structure of class Polyplacophora at the intertidal rocky shore on the marine priority region no.33,Mexico

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Open Journal of Ecology 2014年第2期4卷 43-52页

作者： Lizeth Galeana-Rebolledo Rafael Flores-Garza Adriana Reyes-gomez Sergio Garcia-Ibanez Pedro Flores-Rodriguez Carmina Torreblanca-Ramirez Arcadio Valdes-Gonzalez Unidad Academica de Ecologia Marina Universidad Autonoma de GuerreroAcapulcoMexico Universidad Autonoma de Nuevo Leon Laboratorio de AcuaculturaFacultad de Ciencias BiologicasCiudad UniversitariaSan Nicolas de los GarzaMexico

Marine Priority Region No. 33 (MPR 33) lies in the State of Guerrero, where the National Commission for Knowledge and Use of Biodiversity has declared a lack of information on marine species, Class POLYPLACOPHORA among others. This program was carried out on the rocky intertidal zone of MPR 33 with the objectives to: 1) determine species richness, 2) community composition based on families represented, 3) estimate the density, 4) index of diversity, 5) analyze body proportions and 6) geographic distribution of species. Three surveys on five sites were conducted during 2009 and 2012, using one mt2 quadrant for systematic sampling procedure;collecting all POLYPLACOPHORA specimens found within the quadrants, then proceeding with their preservation. 441 organisms were analyzed where 17 species were identified, on nine genera within six families. Fifteen new species were recorded for the MPR 33. Family ISCHNOCHITONIDAE Dall, 1889 was the best represented in species richness and CHITONIDAE Rafinesque, 1815 in abundance. Density of 8.82 organisms/m2, the H′ index was 2.38 bits/individuals and J′ = 0.57. The species Chiton (Chiton) articulatus Sowerby, 1832 showed the highest density, greater size and was found in all five collection sites. Three species, (Chiton (C.) articulatus, Ischnochiton (Ischnochiton) muscarius (Reeve, 1847) and Chiton (Chiton) alboli-neatus Broderip & Sowerby, 1829), were considered wide. Intertidal species richness was associated with habitat stability and wave intensity;the more unstable sites had greater richness while most stable sites lower. Species inventory and understanding the communities’ interactions of the marine fauna of the State of Guerrero are important;therefore these efforts must be continued.

关键词： Polyplacophora New Records Methodology RMP 33 Guerrero

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Plasmonic metasurface Luneburg lens

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Photonics Research 2019年第10期7卷 1112-1118页

作者： C.E.GARCIA-ORTIZ R.CORTES J.E.gomez-CORREA E.PISANO J.FIUTOWSKI D.A.GARCIA-ORTIZ V.RUIZ-CORTES H.-G.RUBAHN V.COELLO CICESE Unidad MonterreyAlianza Centro 504PIITApodacaNL 66629Mexico Catedras CONACYT-Centro de Investigaciones enoptica Alianza Centro 504PIITApodacaNL 66629Mexico Mads Clausen Institute University of Southern DenmarkNanoSYDAlsion 2 DK6400S?nderborgDenmark CICFIM-UANL Av Universidad S/NSan Nicolas de los GarzaNL 66450Mexico Departamento deoptica CICESEEnsenadaBC 22860Mexico

We present a new design of a plasmonic Luneburg lens made from a gradient-index metasurface that was constructed with an array of nanometer-sized holes in a dielectric thin film. The fabricated structure consists of a planar lens with a diameter of 8.7 μm composed of a rectangular array of holes with a periodicity of 300 nm. The experimental characterization includes leakage-radiation microscopy imaging in the direction and frequency space. The former allows for characterization of the point spread function and phase distribution,whereas the latter grants access to qualitative measurements of the effective mode indices inside the plasmonic lens. The experimental results presented here are in good agreement with the expected average performance predicted by the numerical calculations. Nevertheless, the robustness of the characterization techniques presented here is also exploited to determine deviations from the design parameters.

关键词： space. film. characterization

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