检索结果-南通市图书馆

Open j.urnal of Stomatology 2015年第3期5卷 53-61页

作者： Victoria Tamara Perchyonok Vanessa Reher nicolaas j. basson Shengmiao Zhang Sias R. Grobler VTPCHEM PTY LTD Gold Coast Australia School of Dentistry and Oral Health Griffith University Gold Coast Australia Oral and Dental Research Institute Faculty of Dentistry University of the Western Cape Cape Town South Africa School of Material Science and Engineering East China University of Science and Technology Shanghai China

In this work, Bioactive-functionalized interpenetrating network (IPNs) hydrogel (BIOF-INPs) were prepared and investigated in vitro for the free radical detection/defense, therapeutic release as well as shear bond strength to dentine, ability to re-mineralize surface of the dentin after application of these bio-inspired materials using a biologically inspired mineralization process in vitro as well as investigating antimicrobial properties of the BIOF-INPs against S. aureous. The aim of this investigation was to evaluate the suitability and flexibility of the designer materials to act as an “in vitro” probe to gain insights into molecular origin of TMD and associated disorders.

关键词： TMD Functionalized IPNs Bio-Adhesion Drug Release Build in Free Radical Detection and Defense

Insights into chitosan based gels as functional restorative biomaterials prototypes: <i>In vitro</i>approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open j.urnal of Stomatology 2013年第9期3卷 22-30页

作者： Victoria Tamara Perchyonok Shengmiao Zhang nicolaas j. basson Sias Grobler Theunis Oberholzer Ward Massey Oral and Dental Research Institute Faculty of Dentistry University of the Western Cape Cape Town South Africa School of Dentistry and Oral Health Griffith University Gold Coast Australia School of Material Science and Engineering East China University of Science and Technology Shanghai China

Restorative materials in the new era aim to be “bioactive” and long-lasting. The purpose of the study was to design and evaluate novel chitosan hydrogels containing melatonin and/or propolis (antioxidant containing material), nystatin (antifungal), naproxen (pain relieve medication) and combinations thereof (chitosan-H-melatonin, chitosan-H-melatonin-naproxen, chitosan-H-propolis, chitosan-H-propolisnaproxen, chitosan-H-naproxen-propolis-melatonin, Chitosan/Propolis/Nystatin, Chitosan/Melatonin/Propolis/Nystatin, Chitosan/Propolis/BSA/Nystatin, Chitosan/Melatonin/BSA/Nystatin) as functional additive prototypes for further development of “dual function restorative materials”, to determine their effect on the dentin bond strength of a composite, to evaluate stability of the encapsulated antioxidants as well as evaluate antimicrobial properties of the selected group of “designer” functional materials. Materials and Methods: The above mentioned hydrogels were prepared by dispersion of the corresponding component in glycerol and acetic acid with the addition of chitosan gelling agent. The surface morphology (SEM), drug-polymer solid state interaction (FT-IR spectroscopy), released behaviours (physiological pH and also in acidic conditions), stability of the therapeutic agent-antioxidant-chitosan and the effect of the hydrogels on the shear bond strength of dentin were also evaluated. Results: The release of naproxen confers the added benefit of synergistic action of a functional therapeutic delivery when comparing the newly designed chitosan-based hydrogel restorative materials to the commercially available products alone. Neither the release of naproxen or the antioxidant stability was affected by storage over a 6-month period. The hydrogel formulations have a uniform distribution of drug content, homogenous texture and yellow colour (SEM study). All chitosan dentin treated hydrogels gave significantly

关键词： Therapeutic Polymers Adhesives Chitosan Hydrogels Propolis Melatonin Naproxen Antimicrobial Dentin Bonding Antioxidants Bioactive

Emerging non-invasive therapeutic approaches targeting hypocholinergic neural systems in Parkinson's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第4期18卷 809-810页

作者： nicolaas I.Bohnen Alison j.Yarnall Departments of Radiology and Neurology University of MichiganAnn Arbor VAMCAnn ArborMIUSA Translational and Clinical Research Institute Newcastle UniversityNewcastle upon TyneUK

Cholinergic system associated DOPA-refractory motor and cognitive symptoms-a need for novel therapeutic approaches:Accumulating evidence points to significant motor and non-motor morbidities associated with hypocholinergic deficits in central and peripheral neural systems in Parkinson’s disease(PD)(Bohnen et al.,2018,2022).This so-called“malignant”hypocholinergic disease phenotype is associated with DOPA-refractory dementia and mobility disturbances,such as falls and freezing of gait,and augur novel therapeutic approaches targeting cholinergic systems in *** pharmacotherapy in PD has been an interest for a long ***,the development of cholinergic augmentation pharmacotherapy has been hampered by limited clinical efficacy,the presumption that changes in cholinergic activity are homogeneous in the central nervous system(CNS)and peripheral nervous system,tolerance or safety of cholinesterase inhibitor drugs,low CNS penetrance,high rate of peripheral autonomic side-effects and clinical *** development of nicotinic or muscarinic receptor modulating drugs appears more promising but is still in the development *** the current unmet need for managing DOPA-refractory cognitive and mobility impairments associated with hypocholinergic neural systems,there is a need for novel and complementary therapeutic and more personalized approaches.

关键词： cholinergic therapeutic drugs

国际糖尿病足工作组:指南的制定和方法学(2023)——《国际糖尿病足工作组:糖尿病相关的足病预防与管理指南(2023)》的一部分

在线全文

学校读者我要写书评

暂无评论

感染、炎症、修复 2024年第1期25卷 72-79页

作者： Sicco A.Bus Matilde Monteiro-Soares Fran Game j.ap j.van Netten j.n Apelqvist Robert Fitridge Eric Senneville nicolaas C.Schaper on behalf of the IWGDF Editorial Board 朱虹何洁(译) 刘芳(审校) Amsterdam UMC University of AmsterdamDepartment of Rehabilitation MedicineAmsterdamthe Netherlands Amsterdam Movement Sciences program Rehabilitation&DevelopmentAmsterdamthe Netherlands Higher School of Health of the Portuguese Red Cross LisbonPortugal Department of Community Medicine Information and Health Decision Sciences(MEDCIDS)Faculty of MedicineUniversity of PortoPortoPortugal RISE@CINTESIS Faculty of MedicineOporto UniversityPortoPortugal Department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK Department of Endocrinology University Hospital of MalmöSweden Discipline of Surgery The University of Adelaide and Vascular and Endovascular ServiceRoyal Adelaide HospitalAustralia Department of Infectious Diseases Gustave Dron HospitalTourcoingFrance Division of Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtthe Netherlands 不详温州医科大学附属第一医院内分泌科浙江温州325000 上海交通大学医学院附属第一医院内分泌代谢科上海200080

糖尿病相关的足病是造成糖尿病患者经济负担和增加社会成本的主要原因之一。本指南以主要目标为导向,以循证医学为依据,且在全球得到合理实施。践行国际糖尿病相关的足病指南对于减轻患者经济负担和社会成本有着重要影响。国际糖尿病足... 详细信息

糖尿病相关的足病是造成糖尿病患者经济负担和增加社会成本的主要原因之一。本指南以主要目标为导向,以循证医学为依据,且在全球得到合理实施。践行国际糖尿病相关的足病指南对于减轻患者经济负担和社会成本有着重要影响。国际糖尿病足工作组(IWGDF)从1999年起开始发布并随后更新国际指南。2023年更新版指南相关推荐均基于推荐、评估、发展和评价分级(GRADE)系统,包括制定相关临床问题和重要结局,完成系统的文献系统综述和荟萃分析,完成评判表汇总,并且给予具体、明确、操作性强的推荐以及理论依据。本文阐述了《国际糖尿病足工作组:糖尿病相关的足病预防和管理指南(2023版)》(以下简称为指南)的制定过程。指南由7个部分组成,包括预防、糖尿病相关的足溃疡分类、减压、周围动脉病变、感染、创面愈合干预以及活动性夏科神经骨关节病,分别由7个独立的国际专家工作组编写。IWGDF编辑委员会对7个章节进行了整合和简化,形成IWGDF实践指南。指南中的每条推荐均经过IWGDF编辑委员会成员和相关领域的独立的国际专家审阅通过。本文是IWGDF指南的制定和方法学。我们相信,医务人员、公共卫生机构和政策制定者采用和实施2023年IWGDF指南,将会改善糖尿病相关的足病的预防和管理水平,从而减少全球该疾病患者和减轻该疾病引起的全球社会负担。

关键词：指南糖尿病糖尿病相关的足病方法学国际糖尿病足工作组

糖尿病相关的足病的定义和标准(2023年更新版)

在线全文

学校读者我要写书评

暂无评论

感染、炎症、修复 2024年第1期25卷 80-85页

作者： j.ap j.van Netten Sicco A.Bus j.n Apelqvist Pam Chen Vivienne Chuter Robert Fitridge Frances Game Robert j.Hinchliffe Peter A.Lazzarini j.seph Mills Matilde Monteiro-Soares Edgar j.G.Peters Katherine M.Raspovic Eric Senneville Dane K.Wukich nicolaas C.Schaper on behalf of the International Working Group on the Diabetic Foot 张会峰(译) 许樟荣(审校) Department of Rehabilitation Medicine Amsterdam UMCLocation University of AmsterdamAmsterdamthe Netherlands Amsterdam Movement Sciences Program RehabilitationAmsterdamthe Netherlands Department of Endocrinology University Hospital of MalmöMalmöSweden j.ondalup Health Campus Ramsay HealthcareSydneyAustralia Faculty of Health University of TasmaniaHobartAustralia School of Health Sciences Western Sydney UniversitySydneyAustralia Faculty of Health and Medical Sciences University of AdelaideAdelaideAustralia Vascular and Endovascular Service Royal Adelaide HospitalAdelaideAustralia Department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK Department of Vascular Surgery University of BristolBristolUK School of Public Health and Social Work Queensland University of TechnologyBrisbaneAustralia Allied Health Research Collaborative The Prince Charles HospitalBrisbaneAustralia Michael E.DeBakey Department of Surgery Division of Vascular Surgery and Endovascular TherapyBaylor College of MedicineHoustonTexasUSA Portuguese Red Cross School of Health–Lisbon LisbonPortugal MEDCIDS–Departamento de Medicina da Comunidade Informação e Decisão em Saúde Faculty of Medicine of the University of PortoPortoPortugal RISE@CINTESIS Faculty of Medicine Oporto UniversityPortoPortugal Department of Internal Medicine Amsterdam UMCVrije Universiteit AmsterdamSection of Infectious DiseasesAmsterdamthe Netherlands Department of Orthopaedic Surgery University of Texas Southwestern Medical CenterDallasTexasUSA Department of Infectious Diseases Gustave Dron Hospital Tourcoing Univ-lilleTourcoingFrance Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands 不详河南省人民医院内分泌科河南郑州450003 战略支援部队特色医学中心北京100101

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本... 详细信息

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本文介绍2023年IWGDF对这些定义和标准的更新,并建议在临床实践和研究中一致使用,以利于世界各地不同学科人员针对糖尿病相关的足病的专业性交流。

关键词：定义糖尿病糖尿病相关的足病国际糖尿病足工作组

Changes of the Molecular Mobility of Poly(ε-caprolactone) upon Drawing,Studied by Dielectric Relaxation Spectroscopy

在线全文

学校读者我要写书评

暂无评论

Chinese j.urnal of Polymer Science 2018年第5期36卷 665-674页

作者： Xiao-Yan Yang Shao-Shuai Liu AlexANDer V.Korobko Stephen j.Picken nicolaas A.M.Besseling Lucky Research Institute China Lucky Group Corporation Department of Chemical Engineering Delft University of Technology 2628 BL Delft and Dutch Polymer Institute(DPI)

Dielectric relaxation spectroscopy（DRS） of poly（ε-caprolactone） with different draw ratios showed that the mobility of polymer chains in the amorphous part decreases as the draw ratio increases. The activation energy of the α process, which corresponds to the dynamic glass transition, increases upon drawing. The enlarged gap between the activation energies of the α process and the β process results in a change of continuity at the crossover between the high temperature a process and the α and β processes. At low drawing ratios the a process connects with the β process, while at the highest drawing ratio in our measurements, the a process is continuous with the αprocess. This is consistent with X-ray diffraction results that indicate that upon drawing the polymer chains in the amorphous part align and densify upon drawing. As the draw ratio increases, the α relaxation broadens and decreases its intensity, indicating an increasing heterogeneity. We observed slope changes in the α traces, when the temperature decreases below that at which τα≈ 1 s. This may indicate the glass transition from the ‘rubbery＇ state to the non-equilibrium glassy state.

关键词： Semicrystalline polymer Dielectric relaxation spectroscopy Molecular mobility

Single versus combination therapy in acute tocolysis: A prospective randomized controlled trial

在线全文

学校读者我要写书评

暂无评论

Open j.urnal of Obstetrics and Gynecology 2013年第2期3卷 249-256页

作者： Wafa R. Al-Omari Muzibunnisa A. Begam Farsana S. Khan Iman Y. Khudhair nicolaas j. Nagelkerke Department of Community Medicine Faculty of Medicine and Health Sciences UAE University Al Ain UAE Department of Obstetrics & Gynecology Tawam/Johns Hopkins Hospital Al Ain UAE

This is a prospective controlled randomized trial conducted in 92 women with singleton pregnancies in preterm labor. The tocolytic efficacy and safety of combination atosiban and nifedipine was compared with that of the single agent, atosiban. Both lines of intervention was administered for 48 hours. Progression of labor was assessed by the frequency of uterine contractions and cervical changes. For statistical purpose, intent-to-treat (ITT) analysis was used throughout. Efficacy, as determined by the proportion of women in each group who did not deliver after therapy initiation, was comparable with no significant differences, at 48 hrs (91.5% vs. 91.1%) and at 7 days (90.7% vs. 85.7%) for the atosiban and the combination groups respectively. Safety was assessed by the numbers of adverse events. Maternal side effects were reported more in the combination group (34% vs. 64%;P = 0.006). Perinatal outcomes were similar between the groups. We conclude that the addition of nifedipine did not substantially improve the clinical outcomes beyond that were achieved with atosiban alone. Moreover, it has increased maternal side effects. Future research could focus on combination of other tocolytics.

关键词： Atosiban Combination Tocolysis Preterm Labor

Anti-porcine circovirus type 2(PCV2) antibody placental barrier leakage from sow to fetus: impact on the diagnosis of intra-uterine PCV2 infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2014年第2期29卷 136-138页

作者： Dipongkor Saha Rubén Del Pozo Sacristán nicolaas Van Renne Liping Huang Ruben Decaluwe Annelies Michiels Alfonso Lopez Rodriguez Maria j.sé Rodrí-guez Margarita García Durán Ilse Declerk Dominiek Maes Hans j. Nauwynck Laboratory of Virology Faculty of Veterinary Medicine Ghent University Brain Tumor Research Center Department of Molecular Neurosurgery Harvard Medical School and Massachusetts General Hospital Department of Obstetrics Reproduction and Herd Health Faculty of Veterinary Medicine Ghent University Ingenasa Hermanos García Noblejas

Dear Editor,Fetuses develop antibodies when they are infectedwith porcine circovirus type 2(PCV2).At abortion orbirth,both PCV2 and/or anti-PCV2 antibodies can thenbe *** anti-PCV2 antibodies in aborted fe-tuses or stillborn piglets is generally used as evidence ofan intra-uterine PCV2 ***,a recent anal-ysis of fetuses sent in for PCV2 diagnosis and caesare-an-derived,colostrum-deprived pigs revealed that

关键词：猪圆环病毒2型 PCV2 流产胎儿胎盘屏障母猪感染子宫诊断

在线全文

学校读者我要写书评

暂无评论

SPECIAL TRANSDUCERS

中国超声医学杂志 1988年第S1期 14-16页

作者： nicolaas Bom,Charles T. Lancee,Nico de j.ng,Cornells j. Slager Thoraxcenter Erasmus University Rotterdam and Academic Hospital Rotterdam Dij.zigt and the Interuniversity Cardiology Institute of the Netherlands Thoraxcenter Erasmus University Rotterdam and Academic Hospital Rotterdam Dij.zigt and the Interuniversity Cardiology Institute of the Netherlands Thoraxcenter Erasmus University Rotterdam and Academic Hospital Rotterdam Dij.zigt and the Interuniversity Cardiology Institute of the Netherlands Thoraxcenter Erasmus University Rotterdam and Academic Hospital Rotterdam Dij.zigt and the Interuniversity Cardiology Institute of the Netherlands

INTRODUCTION As early as 1969 we started a program to develop two-dimensional real-time ultrasonic imaging. As a result, the first real-time images of the heart were made visible with the linear array in 1971 (1) .Parallel to the development of this nonin- vasive method for observation of the heart,a study on invasive cardiac observation was

关键词： SPECIAL TRANSDUCERS

Voxel Placement Precision for GABA-Edited Magnetic Resonance Spectroscopy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open j.urnal of Radiology 2017年第1期7卷 35-44页

作者： Xue Bai Ashley D.Harris Tao Gong nicolaas A.j.Puts Guangbin Wang Michael Schar Peter B.Barker Richard A.E.Edden Department of Radiology Qilu Hospital of Shandong UniversityJinanChina Russell H.Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of MedicineBaltimoreMDUSA F.M.Kirby Research Center for Functional Brain Imaging Kennedy Krieger InstituteBaltimoreMDUSA Department of MR Shandong Medical Imaging Research InstituteShandong UniversityJinanChina

The purpose of the present study was to assess the reproducibility of voxel placement for GABA-edited MRS. GABA-edited MRS data were acquired in 13 healthy volunteers from (3 cm)3 voxel;and within the same session a second acquisition was independently prescribed. A three-dimensional voxel mask image was reconstructed in T1-image-space using the SVMask tool (in house software). Reproducibility of voxel placement was assessed using the Dice overlap coefficient, both within-subj.ct and between-subj.ct following co-registration of T1 images and transformation of voxel mask images to standard space. Within-subj.ct overlap coefficients were 86% ± 5%. Between-subj.ct overlap coefficients were 75% ± 10%. For the two voxel locations considered (occipital and sensorimotor), voxel overlap was very similar. Between-subj.ct values are higher due to between-session effects, anatomical variability and volume mismatch in standard space. While surprisingly low in terms of volume overlap, the overlap coefficients correspond to acceptable linear displacements.

关键词： MRS Voxel Placement Precision Voxel Prescription Registration