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Predictors of multiple injuries in individual distance runners:A retrospective study of 75,401 entrants in 4 annual races-SAFER XX

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Journal of Sport and Health Science 2022年第3期11卷 339-346页

作者： Sonja Swanevelder nicola Sewry Martin Schwellnus Esme Jordaan Biostatistics Unit South African Medical Research CouncilParow 7575South Africa Sport Exercise Medicine and Lifestyle Institute(SEMLI)Faculty of Health SciencesUniversity of PretoriaPretoria 0081South Africa International Olympic Committee(IOC)Research Centre Pretoria 0081South Africa Emeritus Professor of Sport and Exercise Medicine Faculty of Health SciencesUniversity of Cape TownBellville 7535South Africa Statistics and Population Studies Department University of the Western CapeBellville 7535South Africa

Background There are limited data on factors that predict an increased risk of multiple injuries among distance *** objective of this study was to determine risk factors that are predictive of individual runners with a high annual multiple injury risk(MIR).Methods A retrospective,cross-sectional study at 4 annual(2012-2015)Two Oceans 21.1 km and 56.0 km races in South Africa with 75,401 consenting race ***-related injury data were collected retrospectively through an online pre-race medical screening *** average number of injuries for each runner every year was calculated by taking a runner's race entry history and injury history into account and categorizing entrants into 4 MIR categories(high,intermediate,low,and very low(reference)).Multiple logistic regression modeling(odds ratios)was used to determine whether the following factors were predictive of a high MIR(average>1 injury/year):demographics,training and racing,chronic-disease history(composite chronic disease score(CCDS)),and history of *** Of all entrants,9.2%reported at least 1 injury,and 0.4%of entrants were in the high MIR category;the incidence rate was 2.5 injuries per 10 runner-years(95%confidence interval(95%CI):2.4-2.7).Significant factors predictive of runners in the high MIR category were:running for>20 years:OR=2.0(95%CI:1.3-3.1;p=0.0010);a higher CCDS:OR=2.2(95%CI:2.0-2.4;p20 years and those with multiple chronic diseases or a history of allergies were at higher risk of multiple running-related *** high-risk group can be targeted for further study and possible injury-prevention interventions.

关键词： Allergies Chronic diseases Multiple injuries Risk factors SAFER study

Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans:an overview of recent findings

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Neural Regeneration Research 2024年第9期19卷 1908-1918页

作者： Marcello Serra nicola Simola Alexia E.Pollack Giulia Costa Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Preclinical and clinical studies indicate that psychostimulants,in addition to having abuse potential,may elicit brain dysfunctions and/or neurotoxic *** toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and *** present review provides an overview of recent research,conducted between 2018 and 2023,focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine,cocaine,methamphetamine,3,4-methylenedioxymethamphetamine,methylphenidate,caffeine,and *** elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.

关键词： 3,4-methylenedioxymethamphetamine amphetamine caffeine cell cultures cocaine methamphetamine methylphenidate neurotoxicity nicotine

Numerical visco-elastoplastic constitutive modelization of creep recovery tests on hot mix asphalt

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Journal of Traffic and Transportation Engineering(English Edition) 2016年第5期3卷 390-397页

作者： Marco Pasetto nicola Baldo Department of Civil Architectural and Environmental EngineeringUniversity of Padua Polytechnic Department of Engineering and Architecture University of Udine

This paper discusses a visco-elastoplastic constitutive model to analyze the creep deformability of asphalt concretes at high service temperatures, finalized to improve the interpretation of permanent deformation phenomenon and performance design of road pavements. A three dimensional constitutive visco-elastoplastic model is introduced, in tensor as well as in numerical form. The associated uniaxial model is used to arrange a plastic element in series with the viscoelastic component. The latter is defined by an elastic spring placed in parallel with three Maxwell elements. Three different hardening laws, namely isotropic, kinematic and mixed hardening, are included in the constitutive model to compare the creep deformability. The proposed constitutive model has been calibrated and validated on the basis of uniaxial creep-recovery test results at 40℃. This is performed with a high performance hot mix asphalt concrete （HP-HMA） at different stresses and loading times. Depending on the hardening law considered, permanent deformation data predicted by the proposed model results are reasonably consistent with the experimental creep-recovery data. A rational constitutive model that is physically congruent with the creep phenomenon of asphalt concretes was developed and calibrated to achieve a deeper understanding of the stress-strain response of such materials. The fundamental relevance of an appropriate plastic response modeling, in the study of the creep behavior of asphalt concretes for highway and road pavements.

关键词： Hot mix asphalt Visco-elastoplastic model Hardening law Creep-recovery test

Organic petrographic and mineralogical composition of the No. 6 coal seam of the Soutpansberg Coalfield, South Africa: Insights into paleovegetation and depositional environment

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International Journal of Coal Science & Technology 2024年第3期11卷 190-207页

作者： Sanki Biswas nicola J.Wagner Ofentse M.Moroeng DSI-NRF CIMERA/PPM Research Group Department of GeologyUniversity of JohannesburgJohannesburgSouth Africa

This study investigates the paleodepositional conditions of the No.6 Seam of the Madzaringwe Formation in Makhado and Voorburg south area of the Soutpansberg Coalfield(Limpopo Province,South Africa)utilizing organic petrography and inorganic geochemical *** coals are predominantly high-volatile bituminous B-A rank with high ash yields(avg.36.1 wt%),characterized by high-vitrinite(~41.5 vol%),moderate-to-high inertinite(9.8 vol%–33.7 vol%)and low liptinite(~2.3 vol%).The distribution of inertinite varies among different coal horizons(from bottom-lower to middle-upper),suggesting differential oxidation conditions and/or paleofire ***-to-inertinite(V/I)ratio,tissue preservation–gelification index(TPI–GI),and groundwater–vegetation index(GWI–VI)plots,indicate that the peat-forming forest-swamp vegetation accumulated under mesotrophic-to-rheotrophic hydrological *** presence of structured macerals(i.e.,telinite,collotelinite,fusinite,and semifusinite)suggests well-preserved plant tissues,whereas framboidal pyrite and sulphur content(0.24 wt%–2.16 wt%)point to brackish-water influence at the peat *** coals contain quartz,kaolinite,siderite,muscovite,dolomite,calcite,and pyrite minerals,most of which were likely sourced from felsic igneous *** Al/(Al+Fe+Mn)and(Fe+Mn)/Ti ratios for the studied samples range between 0.24–0.97 and 0.57–70.10,*** ratios,Al–Fe–Mn plot,and presence of massive botryoidal-type pyrite imply some influence of meteoric waters or fluids from hydrothermal activity ***,the chemical index of alteration(CIA:98.25–99.67),chemical index of weathering(CIW:92.04–97.66),and A–CN–K ternary diagram suggest inorganic matter suffered strong chemical weathering,indicating warm paleoclimatic conditions during the coal formation.

关键词： Macerals Coal facies Geochemical-indices Hydrothermal Madzaringwe formation Soutpansberg Coalfield

Generating soil thickness maps by means of geomorphological-empirical approach and random forest algorithm in Wanzhou County,Three Gorges Reservoir

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Geoscience Frontiers 2023年第2期14卷 47-58页

作者： Ting Xiao Samuele Segoni Xin Liang Kunlong Yin nicola Casagli Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha 410083China Faculty of Engineering China University of GeosciencesWuhan 430074China Department of Earth Sciences University of FlorenceFlorence 50121Italy

Soil thickness,intended as depth to bedrock,is a key input parameter for many environmental ***,it is often difficult to obtain a reliable spatially exhaustive soil thickness map in widearea applications,and existing prediction models have been extensively applied only to test sites with shallow soil *** study addresses this limitation by showing the results of an application to a section of Wanzhou County(Three Gorges Reservoir Area,China),where soil thickness varies from 0 to40 *** different approaches were used to derive soil thickness maps:a modified version of the geomorphologically indexed soil thickness(GIST)model,purposely customized to better account for the peculiar setting of the test site,and a regression performed with a machine learning algorithm,i.e.,the random forest,combined with the geomorphological parameters of GIST(GIST-RF).Additionally,the errors of the two models were quantified,and validation with geophysical data was carried *** results showed that the GIST model could not fully contend with the high spatial variability of soil thickness in the study area:the mean absolute error was 10.68 m with the root-mean-square error(RMSE)of 12.61 m,and the frequency distribution residuals showed a tendency toward *** contrast,GIST-RF returned a better performance with the mean absolute error of 3.52 m and RMSE of 4.56 *** derived soil thickness map could be considered a critical fundamental input parameter for further analyses.

关键词： Soil thickness Soil thickness mapping Geomorphologically indexed soil thickness Random forest

Endoscopic debridement for non-insertional Achilles tendinopathy with and without platelet-rich plasma

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Journal of Sport and Health Science 2023年第2期12卷 275-280页

作者： Hajo Thermann Ralph Fischer Nikolaos Gougoulias Lucio Cipollaro nicola Maffulli HKF-International Center for Hip Foot and Knee SurgeryBismarckstrae 9-1569115 HeidelbergGermany Footsurgery Clinic 54631 ThessalonikiGreece Department of Musculoskeletal Disorders Faculty of Medicine and SurgeryUniversity of SalernoSalerno 89100Italy Department of Medicine Surgery and DentistryUniversity of SalernoVia S.Allende84081 Baronissi(SA)Italy Centre for Sports and Exercise Medicine Barts and The London School of Medicine and DentistryMile End Hospital275 Bancroft RoadLondon E14DGQueen Mary University of LondonLondonUK School of Pharmacy and Bioengineering Keele University Faculty of MedicineThornburrow DriveStoke on TrentST47QBUK

Background:When non-operative management fails to improve symptoms in patients with non-insertional Achilles tendinopathy,surgery may be *** open and endoscopic techniques have been proposed,and platelet-rich plasma(PRP)injections have been proposed as an adjunct to aid tendon ***:Thirty-six patients with mid-portion Achilles tendinopathy were randomized to undergo endoscopic debridement alone(n=19)or in combination with intraoperative PRP application(n=17).Clinical outcome measures included the Visual Analogue Scale for pain,function,and satisfaction and the Victorian Institute of Sports Assessment-Achilles(VISA-A)*** were followed-up at 6 weeks,3months,6 months,and 12 months after *** MRI examination at 3 and 12 months was used to assess signal alterations within the ***:Both groups showed significant clinical improvement(p<0.05)after surgery,with no difference between the 2 *** diameter increased at 3 months and decreased at 12 *** tendinopathy area increased at 3 months and decreased at 12 months below baseline level in both *** was no significant difference between the groups regarding the MRI *** thickening and MRIdetected signal alteration persisted after surgery,with no association between imaging and clinical *** minor complications were reported:2 in the PRP group and 3 in the control ***:Endoscopic debridement of the Achilles tendon improved clinical outcomes in patients with mid-portion *** addition of PRP did not improve outcomes compared to debridement *** parameters showed no association with clinical outcomes.

关键词： Achilles tendon Endoscopic Non-insertional PRP Tendinopathy

Fluid dynamic and thermal comfort analysis in an actual operating room with unidirectional airflow system

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Building Simulation 2021年第4期14卷 1127-1146页

作者： nicola Massarotti Alessandro Mauro Salahudeen Mohamed Andrzej J.Nowak Domenico Sainas Dipartimento di Ingegneria Universitàdegli Studi di Napoli“Parthenope”Centro DirezionaleIsola C480143NapoliItaly Institute of Thermal Technology Silesian University of TechnologyKonarskiego 2244-100GliwicePoland

Air velocity and temperature distributions inside operating rooms (ORs) play a crucial role to reduce the risk of infections and to ensure adequate comfort conditions for patient and medical staff. In this work, the authors have developed a three-dimensional thermo-fluid dynamic model to simulate airflow and thermal comfort in an actual OR equipped with High-Efficiency Particulate Air (HEPA) filters. The model takes into account the presence of surgical lights, people and equipment within the room. An experimental campaign is carried out inside the actual OR to measure velocity and temperature, to be employed as boundary conditions for the numerical model. The experimental data have also been used to validate the numerical results. The validated model has been used to analyze the effects of human shape, thermal boundary conditions and buoyancy forces on the main thermal and fluid dynamic quantities in the OR. The thermal comfort is evaluated based on Predicted Mean Vote (PMV) and Predicted Percentage of Dissatisfied (PPD) indices. The results prove that the present experimental-numerical approach is useful to analyze and improve the thermal comfort conditions for medical staff and patient.

关键词： heat and mass transfer thermal comfort operating room LAF system human body validation

Increased number of symptoms during the acute phase of SARS-CoV-2 infection in athletes is associated with prolonged time to return to full sports performance—AWAREⅧ

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Journal of Sport and Health Science 2024年第3期13卷 280-287,I0001页

作者： Carolette Snyders Marlise Dyer nicola Sewry Esme Jordaan Martin Schwellnus Sport Exercise Medicine and Lifestyle Institute(SEMLI)Faculty of Health SciencesUniversity of PretoriaPretoria 0083South Africa Section Sports Medicine Faculty of Health SciencesUniversity of PretoriaPretoria 0083South Africa IOC Research Centre of South Africa Pretoria 0083South Africa Biostatistics Unit South African Medical Research CouncilTygerberg 7505South Africa Statistics and Population Studies Department University of the Western CapeCape Town 7535South Africa

Purpose The aim of the study was to identify factors associated with prolonged time to return to full performance(RTFP)in athletes with recent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** Prospective cohort study with cross sectional analysis.A total of 84 athletes with confirmed SARS-CoV-2 infection assessed at a coronavirus disease 2019 recovery clinic gave a history of age,sex,type/level of sport,co-morbidities,pre-infection training hours,and 26 acute SARS-CoV-2 symptoms from 3 categories(“nose and throat”,“chest and neck”,and“whole body”/systemic).Data on days to RTFP were obtained by structured *** associated with RTFP were demographics,sport participation,history of co-morbidities,pre-infection training history,and acute symptoms(type,number).Outcomes were:(a)days to RTFP(median,interquartile range(IQR))in asymptomatic(n=7)and symptomatic athletes(n=77),and(b)hazard ratios(HRs;95%confidence interval)for symptomatic athletes with *** a factor(univariate,multiple models).HR0.05).Factors associated with prolonged RTFP(univariate models)were:females(HR=0.57;p=0.014),endurance athletes(HR=0.41;p<0.0001),co-morbidity number(HR=0.75;p=0.001),and respiratory disease history(HR=0.54;p=0.026).In symptomatic athletes,prolonged RTFP(multiple models)was significantly associated with increased“chest and neck”(HR=0.85;p=0.017)and“nose and throat”(HR=0.84;p=0.013)symptoms,but the association was more profound between prolonged RFTP and increased total number of“all symptoms”(HR=0.91;p=0.001)and“whole body”/systemic(HR=0.82;p=0.007)*** A larger number of total symptoms and specifically“whole body”/systemic symptoms during the acute phase of SARS-CoV-2 infection in athletes is associated with prolonged RTFP.

关键词： Athletes COVID-19 Performance Recovery Return to play

Opto-fluidically multiplexed assembly and micro-robotics

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Light(Science & Applications) 2024年第3期13卷 544-554页

作者： Elena Erben Weida Liao Antonio Minopoli nicola Maghelli Eric Lauga Moritz Kreysing Max Planck Institute of Molecular Cell Biology and Genetics Dresden 01307Germany Center for Systems Biology Dresden 01307Germany Institute of Biological and Chemical Systems–Biological Information Processing.Karlsruhe Institute of Technology(KIT) Eggenstein-Leopoldshafen 76344Germany Department of Applied Mathematics and Theoretical Physics University of CambridgeCambridge CB30WAUK

Techniques for high-definition micromanipulations,such as optical tweezers,hold substantial interest across a wide range of ***,their applicability remains constrained by material properties and laser *** while microfluidic manipulations have been suggested as an alternative,their inherent capabilities are limited and further hindered by practical challenges of implementation and *** we show that the iterative application of laser-induced,localized flow fields can be used for the relative positioning of multiple micro-particles,irrespectively of their material *** to the standing theoretical proposal,our method keeps particles mobile,and we show that their precision manipulation is non-linearly accelerated via the multiplexing of temperature stimuli below the heat diffusion *** resulting flow fields are topologically rich and mathematically *** represent unprecedented microfluidic control capabilities that are illustrated by the actuation of humanoid micro-robots with up to 30 degrees of freedom,whose motions are sufficiently well-defined to reliably communicate personal characteristics such as gender,happiness and *** results constitute high-definition micro-fluidic manipulations with transformative potential for assembly,micro-manufacturing,the life sciences,robotics and optohydraulically actuated micro-factories.

关键词： manipulation fluid assembly