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Neural Regeneration Research 2024年第9期19卷 1908-1918页

作者： marcello Serra nicola.Simola Alexia E.Pollack Giulia Costa Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Preclinical and clinical studies indicate that psychostimulants,in addition to having abuse potential,may elicit brain dysfunctions and/or neurotoxic *** toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and *** present review provides an overview of recent research,conducted between 2018 and 2023,focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine,cocaine,methamphetamine,3,4-methylenedioxymethamphetamine,methylphenidate,caffeine,and *** elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.

关键词： 3,4-methylenedioxymethamphetamine amphetamine caffeine cell cultures cocaine methamphetamine methylphenidate neurotoxicity nicotine

Interdisciplinary approaches based on imaging radar enable cutting-edge cultural heritage applications

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National Science Review 2021年第9期8卷 18-20页

作者： Fulong Chen Huadong Guo Deodato Tapete nicola.masini Francesca Cigna Rosa Lasaponara Salvatore Piro Hui Lin Peifeng ma Key Laboratory of Digital Earth Science Aerospace Information Research Institute Chinese Academy of Sciences Institute of Science of Cultural Heritage National Research Council Institute of Atmospheric Sciences and Climate National Research Council School of Geography and Environment Jiangxi Normal University Institute of Space and Earth Information Science The Chinese University of Hong Kong

Heritage assets reflecting memories of the past are increasingly sustained by societies as a necessary condition for the continuing evolution of people’s *** call for ‘strengthening efforts to protect and safeguard the world’s cultural and natural heritage’ in United Nations Sustainable Development Goal (SDG)11 [1] is a clear acknowledgement of the role of heritage in sustaining resilient societies and lifestyles.

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Seismic damage zone and width-throw scaling along the strike-slip faults in the Ordovician carbonates in the Tarim Basin

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Petroleum Science 2019年第4期16卷 752-762页

作者： De-Bo ma Guang-Hui Wu nicola.Scarselli Xin-Sheng Luo Jian-Fa Han Zhi-Yong Chen School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China Fault Dynamics Research Group Department of Earth SciencesRoyal Holloway University of LondonEgham TW20 0EXUK PetroChina Tarim Oilfield Company Korla 841000XinjiangChina

Understanding the scaling relation of damage zone width with displacement of faults is important for predicting subsurface faulting mechanisms and fluid flow processes. The understanding of this scaling relationship is influenced by the accuracy of the methods and types of data utilized to investigate faults. In this study, seismic reflection data are used to investigate the throw and damage zone width of five strike-slip faults a ecting Ordovician carbonates of the Tarim intracraton basin,NW China. The results indicate that fault slips with a throw less than 200 m had formed wide damage zones up to 3000 m in width. Also, damage zone width is found to have both a positive correlation and a power-law relation with throw of two orders of magnitude, with a ratio of these values varying in a range of 2–15. The relationship between throw and damage zone width is not a simple power-law and changes its slope from small to larger size faults. The results indicate that throw scales well with damage zone width for the studied faults, and hence these can be used to predict fault geometries in the Tarim Basin. The study of the wide carbonate damage zones presented here provides new insights into scaling of large-size faults, which involve multiple faulting stages.

关键词： Fault damage zone Carbonate Throw Scaling Evolution Tarim Basin

Components of complex interventions for healthcare: A narrative synthesis of qualitative studies

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 181-188页

作者： Sisi ma He Yu Ning Liang Sijia Zhu Xun Li nicola.Robinson Jianping Liu Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China School of Health and Social Care London South Bank UniversityLondonSE10AAUnited Kingdom

Objective:Qualitative research on therapeutic components is necessary to evaluate the efficacy of complex interventions in *** few qualitative syntheses have been conducted,this study aimed to derive a new conceptual framework for understanding the components of complex interventions and provide evidence for the implementation and evaluation of complex healthcare ***:A systematic search of seven databases was conducted to identify qualitative studies that explored components of complex healthcare ***-ethnography was used to analyze the data and thematic analysis was used to build the conceptual ***:Of the 35 included studies,most complex interventions were non-pharmacological,with cancer accounting for 22%,mental health for 14%,and stroke for 8%.Half of the studies were conducted in the United *** main categories emerged:what should healthcare workers do?what qualifications should they have?and what should patients do?Five main themes were identified:psychological,biological,cognitive and behavioral,environmental,and social ***:This analysis provides a reference for designing components of complex interventions in further studies.

关键词： Therapeutic component Psychological support Social support Cognitive and behavioral support Complex interventions

Assimilation of NDVI data in a land surface-Vegetation model for leaf area index predictions in a tree-grass ecosystem

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International Journal of Digital Earth 2023年第1期16卷 3810-3837页

作者： nicola.Montaldo Andrea Gaspa Roberto Corona Dipartimento di Ingegneria civile ambientale e architetturaUniversita di CagliariCagliariItaly

Periodic observations of vegetation index,such as the normalized difference vegetation index(NDVI),can be used for data assimilation in heterogenous ***,the new Sentinel 2 Multispectral instrument and Landsat 8 Operational Land Imager sensor data are available at such high temporal and spatial resolutions that can be used to detect the patches of the main vegetation components(grass and trees)of heterogenous ecosystems,and capture their *** demonstrate the possibility to merge grass and tree NDVI observations and models,to optimally provide robust predictions of grass and tree leaf area *** proposed assimilation approach assimilates NDVI data through the Ensemble Kalman filter(EnKF)and dynamically calibrates a key vegetation dynamic model parameter,the maintenance respiration coeffcient(ma).In the presence of large bias of the grass and tree ma base values,only the use of the proposed assimilation approach removes the large bias in the biomass balance,dynamically calibrating maintenance respiration coefficients,and corrects the *** performance of a land surface-vegetation model was improved by assimilating observations of *** effective impact of the proposed assimilation approach on the evapotranspiration and CO_(2) uptake predictions in the heterogenous ecosystem is also demonstrated.

关键词： Data assimilation leaf area index heterogenous ecosystem vegetation dynamic model Landsat 8 Sentinel 2

Water and lysozyme： Some results from the bending and stretching vibrational modes

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Frontiers of physics 2015年第5期10卷 27-34页

作者： Francescomallamace Carmelo Corsaro Domenico mallamace Cirino Vasi nicola.Cicero H. Eugene Stanley Dipartimento di Fisica e Scienze della Terra Universita di Messina 1-98166 Messina Italy Department of Nuclear Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA Center for Polymer Studies and Department of Physics Boston University Boston MA 02215 USA Consiglio Nazionale delle Ricerche-IPCF Messina 1-98166 Messina Italy Dipartimento di Scienze dell'Ambiente della Sicurezza del Territorio degli Alimenti e della Salute Universita di Messina Viale F. Stagno d'Alcontres 31 98166 Messina Italy

The dynamic or glass transition in biomolecules is important to their functioning. Also essential is the transition between the protein native state and the unfolding process. To better understand these transitions, we use Fourier transform infrared spectroscopy to study the vibrational bending and stretching modes of hydrated lysozymes across a wide temperature range. We find that these transitions are triggered by the strong hydrogen bond coupling between the protein and hydration water. More precisely, we demonstrate that in both cases the water properties dominate the evolution of the system. We find that two characteristic temperatures are relevant： in the supercooled regime of confined water, the fragile-to-strong dynamic transition occurs at TL, and in the stable liquid phase, T＊ 315 ± 5 K characterizes the behavior of both isothermal compressibility KT（T, P） and the coefficient of thermal expansion ap（T, P）.

关键词： protein unfolding hydration water infrared spectroscopy

Dynamical changes in hydration water accompanying lysozyme thermal denaturation

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Frontiers of physics 2015年第5期10卷 35-41页

作者： Francesco mallamace Carmelo Corsaro Domenico mallamace nicola.Cicero Sebastiano Vasi Giacomo Dugo H. Eugene Stanley CNR-IPCF Messina Istituto per i Processi Chimico-Fisici Viale F. Stagno D'Alcontres 37 98158 Messina Italy Dipartimento di Fisica e Scienze della Terra Universitd di Messina Viale F. Stagno D'Alcontres 31 98166 Messina Italy Center for Polymer Studies and Department of Physics Boston University Boston MA 02215 USA Dipartimento di Scienze dell'Ambiente della Sicurezza del Territorio degli Alimenti e della Salute Universita di Messina Viale F. Stagno d'Alcontres 31 98166 Messina Italy

We study the dynanfics of the first hydration shell of lysozyme to determine the role of hydra- tion water that accompanies lysozyme thermal denaturation. We use nuclear magnetic resonance spectroscopy to investigate both the translational and rotational contributions. Data on proton self-diffusion and reorentational correlation time indicate that the kinetics of the lysozyme fold- ing/unfolding process is controlled by the dynamics of the water molecules in the first hydration shell. When the hydration water dynamics change, because of the weakening of the hydrogen bond network, the three-dimensional structure of the lysozyme is lost and denaturation is triggered. Our data indicates that at temperatures above approximately 315 K, water behaves as a simple liquid and is no longer a good solvent.

关键词： lysozyme unfolding hydration water NMR correlation time solvent dynamics

Novel single-ion conducting polymer electrolytes with high toughness and high resistance against lithium dendrites

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Nano Research 2023年第6期16卷 8457-8468页

作者： David Fraile-Insagurbe nicola.Boaretto Itziar Aldalur Iñigo Raposo Francisco Javier Bonilla Michel Armand maría martínez-Ibañez Centre for Cooperative Research on Alternative Energies CIC energiGUNEBasque Research and Technology Alliance(BRTA)Alava Technology ParkAlbert Einstein 48Vitoria-Gasteiz 01510Spain University of the Basque Country(UPV/EHU) Barrio Sarrienas/nLeioa 48940Spain

Solid-state polymer electrolytes are considered as an alternative to classic liquid electrolytes,particularly for application in highenergy lithium metal *** respect to common dual-ion conductors,single-ion conducting polymer electrolytes(SICPEs)are less affected by lithium dendrites growth and thus are particularly interesting for application in lithium metal *** this work,novel SIC-PEs are developed,based on an ionomer having poly(ethylene-alt-maleimide)backbone and lithium phenylsulfonyl(trifluoromethanesulfonyl)imide pendant moieties,further blended with poly(ethylene oxide)(PEO)and poly(ethylene glycol)dimethyl ether(PEGDME).These SIC-PEs exhibit ionic conductivity around~7×10^(−6)S·cm^(−1) at 70℃,lithium transference number close to unity,and excellent mechanical properties,with fracture toughness over 30 J·cm^(−3).Additionally,the electrolytes show very high resistance against lithium dendrites growth,by cycling for more than 1200 h in Li°symmetric cells at a current density of 0.1 ma·cm^(−2).LiFePO4||Li°cells with these SIC-PEs were cycled at 70℃ and C/10,showing initial capacity of almost 160 mah·g^(−1)and residual capacity of 45%after 100 *** work shows that single-ion conducting polymer electrolytes based on poly(ethylene-alt-maleimide)backbone are promising materials for application as electrolytes or catholytes in lithium metal polymer batteries.

关键词： single-ion conductors solid-state Li metal batteries polymer electrolytes lithium dendrites transference number mechanical properties

Laser particles with omnidirectional emission for cell tracking

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Light(Science & Applications) 2021年第2期10卷 197-207页

作者： Shui-Jing Tang Paul H.Dannenberg Andreas C.Liapis nicola.martino Yue Zhuo Yun-Feng Xiao Seok-Hyun Yun Harvard Medical School and Wellman Center for Photomedicine Massachusetts General HospitalBostonMAUSA State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking University100871 BeijingChina Harvard-MIT Health Sciences and Technology Massachusetts Institute of TechnologyCambridgeMAUSA

The ability to track individual cells in space over time is crucial to analyzing heterogeneous cell ***,microlaser particles have emerged as unique optical probes for massively multiplexed single-cell ***,the microlaser far-field emission is inherently direction-dependent,which causes strong intensity fluctuations when the orientation of the particle varies randomly inside ***,we demonstrate a general solution based on the incorporation of nanoscale light scatterers into *** schemes are developed by introducing either boundary defects or a scattering layer into microdisk *** resulting laser output is omnidirectional,with the minimum-to-maximum ratio of the angle-dependent intensity improving from 0.007(-24 dB)to>0.23(-6dB).After transfer into live cells in vitro,the omnidirectional laser particles within moving cells could be tracked continuously with high signal-to-noise ratios for 2 h,while conventional microlasers exhibited frequent signal loss causing tracking failure.

关键词： scattering directional intensity

Electrical programmable multilevel nonvolatile photonic random-access memory

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Light(Science & Applications) 2023年第11期12卷 2325-2334页

作者： Jiawei Meng Yaliang Gui Behrouz Movahhed Nouri Xiaoxuan ma Yifei Zhang Cosmin-Constantin Popescu Myungkoo Kang mario Miscuglio nicola.Peserico Kathleen Richardson Juejun Hu Hamed Dalir Volker J.Sorger Department of Electrical and Computer Engineering George Washington UniversityWashington DC 20052USA Florida Semiconductor Institute University of FloridaGainesvilleFL 32603USA Department of Electrical and Computer Engineering University of FloridaGainesvilleFL 32603USA Department of materials Science&Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA CREOL The College of Optics&PhotonicsUniversity of Central FloridaOrlandoFL 32816USA

Photonic Random-Access Memories(P-RAM)are an essential component for the on-chip non-von Neumann photonic computing by eliminating optoelectronic conversion losses in data *** Phase-Change materials(PCMs)have been showed multilevel memory capability,but demonstrations still yield relatively high optical loss and require cumbersome WRITE-ERASE approaches increasing power consumption and system package *** we demonstrate a multistate electrically programmed low-loss nonvolatile photonic memory based on a broadband transparent phase-change material(Ge2Sb2Se5,GSSe)with ultralow absorption in the amorphous state.A zero-staticpower and electrically programmed multi-bit P-RAM is demonstrated on a silicon-on-insulator platform,featuring efficient amplitude modulation up to 0.2 dB/μm and an ultralow insertion loss of total 0.12 dB for a 4-bit memory showing a 100×improved signal to loss ratio compared to other phase-change-materials based photonic *** further optimize the positioning of dual microheaters validating performance *** we demonstrate a half-a-million cyclability test showcasing the robust approach of this material and ***-loss photonic retention-of-state adds a key feature for photonic functional and programmable circuits impacting many applications including neural networks,LiDAR,and sensors for example.

关键词： retention random eliminating