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Antioxidant treatment for oligoasthenoteratozoospermia and varicocele:a dBPC trial to evaluate the impact of age and body mass index

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Asian Journal of Andrology 2024年第3期26卷 239-244页

作者： Gian Maria Busetto Bernarde F Rodrigues Ashraf Virmani Andrea Checchia Antonella Ninivaggi Anna Ricapito Giovanni Barbieri Piero Fischetti Ugo G Falagario Pasquale Annese nicola d’altilia Vito Mancini Matteo Ferro Felice Crocetto Angelo Porreca Carlo Bettocchi Luigi Cormio Ashok Agarwal Giuseppe Carrieri University of Foggia Foggia 71122Italy department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy department of Urology Human Reproduction SectionFederal University of Sao PauloSao Paulo 05403-000Brazil Alfasigma Healthscience Utrecht 3528 BGThe Netherlands Urology Unit “G.Tatarella”HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IEO)IRCCSMilan 20142Italy University of Naples Federico II Naples80126Italy department of Oncological Urology Veneto Institute of Oncology(IOV)IRCCSPadua 35039Italy Urology Unit “L.Bonomo”HospitalAndria 70031Italy Global Andrology Forum Moreland HillsOH 44022USA

Oxidative stress is one of the main mechanisms responsible for male *** conditions such as varicocele,obesity,advanced age,and lifestyle can lead to an increase in reactive oxygen species,causing an oxidative imbalance in the *** are sensitive to reactive oxygen species and require energy to carry out their main function of fertilizingthe *** reactive oxygen species can affect sperm metabolism,leading to immobility,impaired acrosome reaction,and celldeath,thereby impairing reproductive *** double-blind randomized study evaluated the effect of supplementation withL-carnitine,acetyl-L-carnitine,vitamins,and other nutrients on semen quality in 104 infertile patients with or without varicocele,while also investigating the impact of factors such as obesity and advanced age on *** concentration significantlyincreased in the supplemented group compared to the placebo group(P=0.0186).Total sperm count also significantly increasedin the supplemented group(P=0.0117),as did sperm motility(P=0.0120).The treatment had a positive effect on patients upto 35 years of age in terms of sperm concentration(P=0.0352),while a body mass index(BMI)above 25 kg m^(−2) had a negativeeffect on sperm concentration(P=0.0110).Results were not showing a net benefit in stratifying patients in accordance withtheir BMI since sperm quality increase was not affected by this *** conclusion,antioxidant supplementation may bebeneficial for infertile patients and has a more positive effect on younger patients with a normal weight.

关键词： aging antioxidants body mass index oligoasthenoteratozoospermia varicocele

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Minimally invasive surgical therapies(MISTs)for lower urinary tract symptoms(LUTS):promise or panacea?

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Asian Journal of Andrology 2024年第2期26卷 135-143页

作者： Gian Maria Busetto Andrea Checchia Marco Recchia Edoardo Tocci Ugo G Falagario Gennaro Annunziata Pasquale Annese nicola d'altilia Vito Mancini Matteo Ferro Felice Crocetto Octavian Sabin Tataru Luca di Gianfrancesco Angelo Porreca Francesco del Giudice Ettore de Berardinis Carlo Bettocchi Luigi Cormio Giuseppe Carrieri University of Foggia Foggia 71122Italy department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy University of Naples Federico Il Naples 80126Italy G.E.Palade University of Medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania department of Oncological Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy department of Maternal-Infant and Urological Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male *** aim of the present review was to evaluate the efficacy and safety of the most commonly used MisTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTINd).MiSTs are becoming a new promise,even if clinical trials with longer follow-up are still *** of them are still under investigation and,to date,only a few options have been given as a recommendation for *** cannot be considered as standard of care and are not suitable for all *** and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance.

关键词： aquablation iTINd prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy

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dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 101-109页

作者： Mariarosaria d'Amato Gennaro Iengo nicola Massa Chiara Carlomagno department of Oncology Ospedale San Rocco ASL CasertaSessa Aurunca 81037CampaniaItaly department of Clinical Medicine and Surgery University of Naples Federico IINaples 80131CampaniaItaly

BACKGROUNd Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(dPd),encoded by the dPYd *** 7%of the European population is a carrier of dPYd gene polymorphisms associated with reduced dPd enzyme *** To assess the prevalence of dPYd polymorphisms and their impact on fluoropyrimidine tolerability in Italian patients with gastrointestinal *** A total of 300 consecutive patients with a diagnosis of gastrointestinal malignancy and treated with a fluoropyrimidine-based regimen were included in the analysis and divided into two cohorts:(1)149 patients who started fluoropyrimidines after dPYd testing;and(2)151 patients treated without dPYd *** the patients in cohort A,15%tested only the dPYd2A polymorphism,19%tested four polymorphisms(dPYd2A,HapB3,c.2846A>T,and dPYd13),and 66%tested five polymorphisms including *** Overall,14.8%of patients were found to be carriers of a dPYd variant,the most common being dPYd6(12.1%).Patients in cohort A reported≥G3 toxicities(P=0.00098),particularly fewer nonhematological toxicities(P=0.0028)compared with cohort B,whereas there was no statistically significant difference between the two cohorts in hematological toxicities(P=0.6944).Significantly fewer chemotherapy dose reductions(P=0.00002)were observed in cohort A compared to cohort B,whereas there was no statistically significant differences in chemotherapy *** Although this study had a limited sample size,it provides additional information on the prevalence of dPYd polymorphisms in the Italian population and highlights the role of pharmacogenetic testing to prevent severe toxicity.

关键词： dihydropyrimidine dehydrogenase dPYd polymorphisms Fluoropyrimidine Caucasian population Gastrointestinal cancers

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Integrating water use systems and soil and water conservation measures into a hydrological model of an Iranian Wadi system

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Journal of Arid Land 2020年第4期12卷 545-560页

作者： Nariman MAHMOOdI Jens KIESEL Paul d WAGNER nicola FOHRER department of Hydrology and Water Resources Management Institute for Natural Resource ConservationKiel UniversityKiel 24118Germany department of Ecosystem Research Leibniz-Institute of Freshwater Ecology and Inland Fisheries(IGB)Berlin 12489Germany

Water resources are precious in arid and semi-arid areas such as the Wadis of Iran. To sustainably manage these limited water resources, the residents of the Iranian Wadis have been traditionally using several water use systems(WUSs) which affect natural hydrological processes. In this study, WUSs and soil and water conservation measures(SWCMs) were integrated in a hydrological model of the Halilrood Basin in Iran. The Soil and Water Assessment Tool(SWAT) model was used to simulate the hydrological processes between 1993 and 2009 at daily time scale. To assess the importance of WUSs and SWCMs, we compared a model setup without WUSs and SWCMs(default model) with a model setup with WUSs and SWCMs(WUS-SWCM model). When compared to the observed daily stream flow, the number of acceptable calibration runs as defined by the performance thresholds(Nash-Sutcliffe efficiency(NSE)≥0.68, –25%≤percent bias(PBIAS)≤25% and ratio of standard deviation(RSR)≤0.56) is 177 for the default model and 1945 for the WUS-SWCM model. Also, the average Kling–Gupta efficiency(KGE) of acceptable calibration runs for the WUS-SWCM model is higher in both calibration and validation periods. When WUSs and SWCMs are implemented, surface runoff(between 30% and 99%) and water yield(between 0 and 18%) decreased in all sub-basins. Moreover, SWCMs lead to a higher contribution of groundwater flow to the channel and compensate for the extracted water by WUSs from the shallow aquifer. In summary, implementing WUSs and SWCMs in the SWAT model enhances model plausibility significantly.

关键词： SWAT model stream flow Wadis multi-metric framework water use systems soil and water conservation measures Halilrood Basin

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Empirical assessment of the role of the Sun in climate change using balanced multi-proxy solar records

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Geoscience Frontiers 2023年第6期14卷 191-209页

作者： nicola Scafetta department of Earth Sciences Environment and GeoresourcesUniversity of Naples Federico IIComplesso Universitario di Monte S.Angelovia Cinthia21Naples 80126Italy

The role of the Sun in climate change is hotly *** studies suggest its impact is significant,while others suggest it is *** Intergovernmental Panel on Climate Change(IPCC)supports the latter view and suggests that nearly 100%of the observed surface warming from 1850–1900 to 2020 is due to anthropogenic ***,the IPCC’s conclusions are based solely on computer simulations made with global climate models(GCMs)forced with a total solar irradiance(TSI)record showing a low multi-decadal and secular *** same models also assume that the Sun affects the climate system only through radiative forcing–such as TSI–even though the climate could also be affected by other solar *** this paper I propose three“balanced”multi-proxy models of total solar activity(TSA)that consider all main solar proxies proposed in scientific *** optimal signature on global and sea surface temperature records is assessed together with those produced by the anthropogenic and volcanic radiative forcing functions adopted by the CMIP6 *** is done by using a basic energy balance model calibrated with a differential multi-linear regression methodology,which allows the climate system to respond to the solar input differently than to radiative forcings alone,and to evaluate the climate’s characteristic time-response as *** proposed methodology reproduces the results of the CMIP6 GCMs when their original forcing functions are applied under similar physical conditions,indicating that,in such a scenario,the likely range of the equilibrium climate sensitivity(ECS)could be 1.4℃to 2.8℃,with a mean of 2.1℃(using the HadCRUT5 temperature record),which is compatible with the low-ECS CMIP6 GCM ***,if the proposed solar records are used as TSA proxies and the climatic sensitivity to them is allowed to differ from the climatic sensitivity to radiative forcings,a much greater solar impact on climate change is found,along with a significant

关键词： Solar activity changes Solar variability climatic impact Global climate change and modeling Equilibrium climate sensitivity

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Impacts and risks of“realistic”global warming projections for the 21st century

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Geoscience Frontiers 2024年第2期15卷 392-416页

作者： nicola Scafetta department of Earth Sciences Environment and GeoresourcesUniversity of Naples Federico IIComplesso Universitario di Monte S.AngeloVia Vicinale Cupa Cintia2180126 NaplesNAItaly

The IPCC AR6 assessment of the impacts and risks associated with projected climate changes for the 21st century is both alarming and *** to computer projections,global surface temperature may warm from 1.3℃to 8.0℃by 2100,depending on the global climate model(GCM)and the shared socioeconomic pathway(SSP)scenario used for the *** climate-change hazards are estimated to be high and very high if the global surface temperature rises,respectively,more than 2.0℃and 3.0℃above pre-industrial *** studies,however,showed that a substantial number of CMIP6 GCMs run“too hot”because they appear to be too sensitive to radiative forcing,and that the high/extreme emission scenarios SSP3-7.0 and SSP5-8.5 are to be rejected because judged to be unlikely and highly unlikely,***,the IPCC AR6 mostly focused on such alarmistic scenarios for risk *** paper examines the impacts and risks of“realistic”climate change projections for the 21st century generated by assessing the theoretical models and integrating them with the existing empirical knowledge on global warming and the various natural cycles of climate change that have been recorded by a variety of scientists and *** is achieved by combining the SSP2-4.5 scenario(which is the most likely SSP according to the current policies reported by the International Energy Agency)and empirically optimized climate *** to recent research,the GCM macro-ensemble that best hindcast the global surface warming observed from 1980 to 1990 to 2012–2022 should be made up of models that are characterized by a low equilibrium climate sensitivity(ECS)(1.5℃d very likely ECS ranges at 2.5–4.0℃and 2.0–5.0℃,respectively.I show that the low-ECS macro-GCM with the SSP2-4.5 scenario projects a global surface temperature warming of 1.68–3.09℃by 2080–2100 instead of 1.98–3.82℃obtained with the GCMs with ECS in the 2.5–4.0℃range.H

关键词： Climate change Climate models Shared socioeconomic pathways 21st-century climate projections Impacts and risks assessment

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Effect of template shape on metal nanoimprinting:a dislocation dynamics study

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 722-726页

作者： Lucia nicola department of Materials Science and Engineering Delft University of Technology

dislocation dynamics simulations are performed to investigate the effect of template shape on the nanoimprinting of metal layers. To this end, metal thin films are imprinted by a rigid template made of an array of equispaced indenters of various shapes, i.e., rectangular, wedge, and circular. The geometry of the indenters is chosen such that the contact area is approximately the same at the final imprinting depth. Results show that, for all template shapes, the final patterns strongly depend on the dislocation activity, and that each imprint differs from the neighboring ones. Large material pile ups appear between the imprints, such that polishing of the metal layer is suggested for application of the patterns in electronics. Rectangular indenters require the lowest imprinting force and achieve the deepest retained imprints.

关键词： Nanoimprinting dislocation dynamics Simulations

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Transport coefficients of a massive pion gas

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Chinese Physics C 2010年第9期34卷 1453-1455页

作者： d.Fernández-Fraile A.Gómez nicola Institut für Theoretische Physik Johann Wolfgang Goethe-Universitt departamento de Física Teórica II Universidad Complutense

We review our main results concerning the transport coefficients of a light meson gas,in particular we focus on the case of a massive pion *** order results according to the chiral power-counting are presented for the dC electrical conductivity,thermal conductivity,shear viscosity,and bulk *** also comment on the possible correlation between the bulk viscosity and the trace anomaly in QCd,as well as the relation between unitarity and a minimum of the quotient η/s near the phase transition.

关键词： transport coefficients heavy-ion collisions Chiral Perturbation Theory

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Production of metallic iron nanoparticles in a baffled stirred tank reactor: Optimization via computational fluid dynamics simulation

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Particuology 2020年第5期18卷 83-96页

作者： Giorgio Vilardi nicola Verdone Sapienza University of Rome Department of Chemical Engineering Materials EnvironmentVia Eudossiana 1800184RomeItaly

The aim of this work is to optimize iron nanoparticle production in stirred tank reactors equipped with two classical impellers:Rushton and four-pitched blade turbines,which are largely used in batch industrial synthesis and efficient *** main operative parameters of nanoparticle synthesis are the precursor initial concentration,reducing agent/precursor molar ratio,impeller-tank clearance,and impeller rotational *** parameters were varied during the synthesis to find the optimal operating values based on the Fe(0)(%)production,zeta potential,particle size distribution,and powder X-ray diffraction pattern *** found that the optimal operating conditions for nanoparticle production were an impeller velocity of 1500 rpm,initial iron precursor concentration of 20 mM,molar ratio of reducing agent to iron precursor of 3 mol/mol,and impeller clearance of 0.25 and 0.4 times the vessel diameter for Rushton and four-pitched blade impellers,*** these conditions achieved a total conversion of 0.94-0.98 and yielded a product with a unimodal size distribution and average diameters in the range 30-50 *** computational fluid dynamics results agreed with the expectations,and the obtained mixing damkohler numbers show that the process is mixed controlled.

关键词： Nano zero-valent iron Computational fluid dynamics Turbulence Micromixing Length scale

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Covariance analysis of periodic and quasi-periodic orbits around Phobos with applications to the Martian Moons eXploration mission

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Astrodynamics 2023年第3期7卷 363-379页

作者： Edoardo Ciccarelli nicola Baresi Surrey Space Centre University of SurreyGU27XHGuildfordUK

Understanding the internal composition of a celestial body is fundamental for formulating theories regarding its *** knowledge of the distribution of mass under the body’s crust can be achieved by analyzing its moments of inertia and gravity *** this regard,the two moons of the Martian system have not yet been closely studied and continue to pose questions regarding their origin to the space community;thus,they deserve further *** Martian Moons eXploration mission will be the first of its kind to sample and study Phobos over a prolonged *** study aims to demonstrate that the adoption of periodic and quasi-periodic retrograde trajectories would be beneficial for the scientific value of the ***,a covariance analysis was implemented to compare the estimation of high-order gravitational field coefficients from different orbital geometries and for different sets of processed *** was shown that the adoption of low-altitude non-planar quasi-satellite orbits would help to refine the knowledge of the moon’s libration angle and gravitational field.

关键词： covariance analysis Martian system geodetic navigation Martian Moons eXploration(MMX) Phobos

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